Amino acid dipepetide frequency for Solibacter usitatus (strain Ellin6076)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.843AlaAla: 15.843 ± 0.107	1.084AlaCys: 1.084 ± 0.022	5.252AlaAsp: 5.252 ± 0.048	5.938AlaGlu: 5.938 ± 0.061	4.071AlaPhe: 4.071 ± 0.04	10.829AlaGly: 10.829 ± 0.077	2.031AlaHis: 2.031 ± 0.028	5.841AlaIle: 5.841 ± 0.048	3.656AlaLys: 3.656 ± 0.043	11.189AlaLeu: 11.189 ± 0.077	2.697AlaMet: 2.697 ± 0.03	3.514AlaAsn: 3.514 ± 0.042	5.804AlaPro: 5.804 ± 0.06	4.101AlaGln: 4.101 ± 0.039	7.364AlaArg: 7.364 ± 0.065	6.348AlaSer: 6.348 ± 0.061	6.019AlaThr: 6.019 ± 0.071	8.206AlaVal: 8.206 ± 0.059	1.531AlaTrp: 1.531 ± 0.028	2.599AlaTyr: 2.599 ± 0.03	0.0AlaXaa: 0.0 ± 0.0
Cys	1.068CysAla: 1.068 ± 0.019	0.162CysCys: 0.162 ± 0.008	0.461CysAsp: 0.461 ± 0.016	0.446CysGlu: 0.446 ± 0.013	0.335CysPhe: 0.335 ± 0.011	0.956CysGly: 0.956 ± 0.022	0.319CysHis: 0.319 ± 0.019	0.37CysIle: 0.37 ± 0.012	0.223CysLys: 0.223 ± 0.008	0.86CysLeu: 0.86 ± 0.019	0.192CysMet: 0.192 ± 0.008	0.236CysAsn: 0.236 ± 0.009	0.459CysPro: 0.459 ± 0.014	0.226CysGln: 0.226 ± 0.009	0.607CysArg: 0.607 ± 0.016	0.552CysSer: 0.552 ± 0.015	0.486CysThr: 0.486 ± 0.014	0.637CysVal: 0.637 ± 0.014	0.133CysTrp: 0.133 ± 0.007	0.264CysTyr: 0.264 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	5.417AspAla: 5.417 ± 0.041	0.408AspCys: 0.408 ± 0.013	2.228AspAsp: 2.228 ± 0.031	2.552AspGlu: 2.552 ± 0.032	2.21AspPhe: 2.21 ± 0.028	4.571AspGly: 4.571 ± 0.05	1.068AspHis: 1.068 ± 0.018	2.25AspIle: 2.25 ± 0.027	1.454AspLys: 1.454 ± 0.022	5.186AspLeu: 5.186 ± 0.048	0.928AspMet: 0.928 ± 0.018	1.392AspAsn: 1.392 ± 0.024	3.693AspPro: 3.693 ± 0.038	1.691AspGln: 1.691 ± 0.028	3.721AspArg: 3.721 ± 0.038	2.759AspSer: 2.759 ± 0.031	2.407AspThr: 2.407 ± 0.032	3.486AspVal: 3.486 ± 0.031	0.85AspTrp: 0.85 ± 0.021	1.579AspTyr: 1.579 ± 0.026	0.0AspXaa: 0.0 ± 0.0
Glu	5.403GluAla: 5.403 ± 0.06	0.426GluCys: 0.426 ± 0.013	2.231GluAsp: 2.231 ± 0.032	2.835GluGlu: 2.835 ± 0.042	2.256GluPhe: 2.256 ± 0.03	3.658GluGly: 3.658 ± 0.04	1.166GluHis: 1.166 ± 0.021	3.214GluIle: 3.214 ± 0.038	2.289GluLys: 2.289 ± 0.032	5.315GluLeu: 5.315 ± 0.051	1.425GluMet: 1.425 ± 0.021	1.611GluAsn: 1.611 ± 0.023	2.46GluPro: 2.46 ± 0.035	2.127GluGln: 2.127 ± 0.028	4.081GluArg: 4.081 ± 0.045	2.949GluSer: 2.949 ± 0.033	2.792GluThr: 2.792 ± 0.031	3.667GluVal: 3.667 ± 0.042	0.828GluTrp: 0.828 ± 0.017	1.436GluTyr: 1.436 ± 0.025	0.0GluXaa: 0.0 ± 0.0
Phe	4.392PheAla: 4.392 ± 0.046	0.396PheCys: 0.396 ± 0.013	2.453PheAsp: 2.453 ± 0.031	2.128PheGlu: 2.128 ± 0.031	1.686PhePhe: 1.686 ± 0.029	3.771PheGly: 3.771 ± 0.042	0.96PheHis: 0.96 ± 0.02	1.352PheIle: 1.352 ± 0.021	1.001PheLys: 1.001 ± 0.019	3.756PheLeu: 3.756 ± 0.043	0.638PheMet: 0.638 ± 0.014	1.462PheAsn: 1.462 ± 0.029	1.984PhePro: 1.984 ± 0.028	1.5PheGln: 1.5 ± 0.025	2.651PheArg: 2.651 ± 0.034	2.699PheSer: 2.699 ± 0.036	2.669PheThr: 2.669 ± 0.039	2.678PheVal: 2.678 ± 0.031	0.574PheTrp: 0.574 ± 0.014	1.202PheTyr: 1.202 ± 0.021	0.0PheXaa: 0.0 ± 0.0
Gly	8.859GlyAla: 8.859 ± 0.063	0.871GlyCys: 0.871 ± 0.018	4.113GlyAsp: 4.113 ± 0.043	4.16GlyGlu: 4.16 ± 0.044	3.588GlyPhe: 3.588 ± 0.036	7.808GlyGly: 7.808 ± 0.083	1.567GlyHis: 1.567 ± 0.025	4.542GlyIle: 4.542 ± 0.038	3.823GlyLys: 3.823 ± 0.045	7.663GlyLeu: 7.663 ± 0.066	2.142GlyMet: 2.142 ± 0.03	3.047GlyAsn: 3.047 ± 0.044	3.657GlyPro: 3.657 ± 0.04	2.951GlyGln: 2.951 ± 0.041	5.656GlyArg: 5.656 ± 0.046	5.45GlySer: 5.45 ± 0.062	5.419GlyThr: 5.419 ± 0.077	6.351GlyVal: 6.351 ± 0.056	1.403GlyTrp: 1.403 ± 0.025	2.479GlyTyr: 2.479 ± 0.032	0.0GlyXaa: 0.0 ± 0.0
His	2.027HisAla: 2.027 ± 0.024	0.219HisCys: 0.219 ± 0.009	1.032HisAsp: 1.032 ± 0.021	1.047HisGlu: 1.047 ± 0.02	0.913HisPhe: 0.913 ± 0.019	1.816HisGly: 1.816 ± 0.027	0.504HisHis: 0.504 ± 0.017	0.919HisIle: 0.919 ± 0.02	0.508HisLys: 0.508 ± 0.014	1.978HisLeu: 1.978 ± 0.028	0.433HisMet: 0.433 ± 0.01	0.627HisAsn: 0.627 ± 0.014	1.324HisPro: 1.324 ± 0.023	0.653HisGln: 0.653 ± 0.015	1.38HisArg: 1.38 ± 0.023	1.18HisSer: 1.18 ± 0.02	1.043HisThr: 1.043 ± 0.021	1.4HisVal: 1.4 ± 0.025	0.353HisTrp: 0.353 ± 0.012	0.64HisTyr: 0.64 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	6.088IleAla: 6.088 ± 0.052	0.485IleCys: 0.485 ± 0.011	2.88IleAsp: 2.88 ± 0.034	2.762IleGlu: 2.762 ± 0.036	1.8IlePhe: 1.8 ± 0.022	4.151IleGly: 4.151 ± 0.038	1.003IleHis: 1.003 ± 0.021	1.591IleIle: 1.591 ± 0.028	1.313IleLys: 1.313 ± 0.02	4.387IleLeu: 4.387 ± 0.051	0.697IleMet: 0.697 ± 0.018	1.505IleAsn: 1.505 ± 0.029	2.815IlePro: 2.815 ± 0.034	1.661IleGln: 1.661 ± 0.027	3.233IleArg: 3.233 ± 0.035	3.022IleSer: 3.022 ± 0.039	2.976IleThr: 2.976 ± 0.041	3.609IleVal: 3.609 ± 0.036	0.603IleTrp: 0.603 ± 0.014	1.334IleTyr: 1.334 ± 0.023	0.0IleXaa: 0.0 ± 0.0
Lys	3.508LysAla: 3.508 ± 0.041	0.214LysCys: 0.214 ± 0.01	1.774LysAsp: 1.774 ± 0.032	1.76LysGlu: 1.76 ± 0.03	1.249LysPhe: 1.249 ± 0.023	2.485LysGly: 2.485 ± 0.036	0.622LysHis: 0.622 ± 0.015	1.783LysIle: 1.783 ± 0.025	1.49LysLys: 1.49 ± 0.031	3.661LysLeu: 3.661 ± 0.037	1.022LysMet: 1.022 ± 0.022	1.147LysAsn: 1.147 ± 0.022	2.175LysPro: 2.175 ± 0.035	1.296LysGln: 1.296 ± 0.023	2.196LysArg: 2.196 ± 0.027	2.024LysSer: 2.024 ± 0.028	2.067LysThr: 2.067 ± 0.025	2.63LysVal: 2.63 ± 0.031	0.489LysTrp: 0.489 ± 0.013	0.921LysTyr: 0.921 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	12.248LeuAla: 12.248 ± 0.079	0.914LeuCys: 0.914 ± 0.019	5.149LeuAsp: 5.149 ± 0.038	5.227LeuGlu: 5.227 ± 0.051	3.624LeuPhe: 3.624 ± 0.04	7.664LeuGly: 7.664 ± 0.058	1.967LeuHis: 1.967 ± 0.03	4.145LeuIle: 4.145 ± 0.042	3.611LeuLys: 3.611 ± 0.041	9.966LeuLeu: 9.966 ± 0.092	2.019LeuMet: 2.019 ± 0.028	3.168LeuAsn: 3.168 ± 0.038	5.653LeuPro: 5.653 ± 0.049	3.236LeuGln: 3.236 ± 0.034	7.083LeuArg: 7.083 ± 0.073	5.916LeuSer: 5.916 ± 0.052	6.018LeuThr: 6.018 ± 0.068	6.684LeuVal: 6.684 ± 0.061	1.327LeuTrp: 1.327 ± 0.021	2.51LeuTyr: 2.51 ± 0.029	0.0LeuXaa: 0.0 ± 0.0
Met	2.572MetAla: 2.572 ± 0.035	0.152MetCys: 0.152 ± 0.007	0.99MetAsp: 0.99 ± 0.018	1.155MetGlu: 1.155 ± 0.021	0.698MetPhe: 0.698 ± 0.015	1.616MetGly: 1.616 ± 0.027	0.423MetHis: 0.423 ± 0.013	1.094MetIle: 1.094 ± 0.021	1.094MetLys: 1.094 ± 0.019	2.259MetLeu: 2.259 ± 0.028	0.558MetMet: 0.558 ± 0.013	0.766MetAsn: 0.766 ± 0.017	1.36MetPro: 1.36 ± 0.023	0.806MetGln: 0.806 ± 0.017	1.757MetArg: 1.757 ± 0.023	1.322MetSer: 1.322 ± 0.023	1.409MetThr: 1.409 ± 0.026	1.537MetVal: 1.537 ± 0.026	0.249MetTrp: 0.249 ± 0.009	0.449MetTyr: 0.449 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.45AsnAla: 3.45 ± 0.046	0.323AsnCys: 0.323 ± 0.012	1.43AsnAsp: 1.43 ± 0.026	1.315AsnGlu: 1.315 ± 0.02	1.541AsnPhe: 1.541 ± 0.027	3.154AsnGly: 3.154 ± 0.044	0.712AsnHis: 0.712 ± 0.017	1.594AsnIle: 1.594 ± 0.027	0.819AsnLys: 0.819 ± 0.021	3.441AsnLeu: 3.441 ± 0.037	0.635AsnMet: 0.635 ± 0.014	1.295AsnAsn: 1.295 ± 0.032	2.444AsnPro: 2.444 ± 0.034	1.27AsnGln: 1.27 ± 0.024	2.124AsnArg: 2.124 ± 0.027	2.084AsnSer: 2.084 ± 0.036	1.839AsnThr: 1.839 ± 0.032	2.406AsnVal: 2.406 ± 0.033	0.564AsnTrp: 0.564 ± 0.013	1.056AsnTyr: 1.056 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	7.253ProAla: 7.253 ± 0.065	0.361ProCys: 0.361 ± 0.013	3.358ProAsp: 3.358 ± 0.037	3.627ProGlu: 3.627 ± 0.04	2.004ProPhe: 2.004 ± 0.027	5.457ProGly: 5.457 ± 0.05	1.013ProHis: 1.013 ± 0.017	2.211ProIle: 2.211 ± 0.028	1.873ProLys: 1.873 ± 0.032	4.894ProLeu: 4.894 ± 0.042	1.147ProMet: 1.147 ± 0.021	2.018ProAsn: 2.018 ± 0.031	3.176ProPro: 3.176 ± 0.05	1.877ProGln: 1.877 ± 0.029	3.067ProArg: 3.067 ± 0.036	3.073ProSer: 3.073 ± 0.038	2.767ProThr: 2.767 ± 0.035	4.54ProVal: 4.54 ± 0.046	0.73ProTrp: 0.73 ± 0.015	1.466ProTyr: 1.466 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	3.888GlnAla: 3.888 ± 0.037	0.264GlnCys: 0.264 ± 0.012	1.516GlnAsp: 1.516 ± 0.025	1.656GlnGlu: 1.656 ± 0.027	1.511GlnPhe: 1.511 ± 0.025	2.512GlnGly: 2.512 ± 0.031	0.695GlnHis: 0.695 ± 0.015	1.972GlnIle: 1.972 ± 0.026	1.284GlnLys: 1.284 ± 0.022	3.404GlnLeu: 3.404 ± 0.041	0.929GlnMet: 0.929 ± 0.017	1.19GlnAsn: 1.19 ± 0.023	2.078GlnPro: 2.078 ± 0.029	1.664GlnGln: 1.664 ± 0.034	2.46GlnArg: 2.46 ± 0.028	2.159GlnSer: 2.159 ± 0.027	2.121GlnThr: 2.121 ± 0.028	2.725GlnVal: 2.725 ± 0.028	0.532GlnTrp: 0.532 ± 0.014	1.064GlnTyr: 1.064 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	6.875ArgAla: 6.875 ± 0.062	0.57ArgCys: 0.57 ± 0.016	3.517ArgAsp: 3.517 ± 0.04	4.234ArgGlu: 4.234 ± 0.053	2.934ArgPhe: 2.934 ± 0.035	4.763ArgGly: 4.763 ± 0.04	1.426ArgHis: 1.426 ± 0.023	3.781ArgIle: 3.781 ± 0.04	2.653ArgLys: 2.653 ± 0.033	6.82ArgLeu: 6.82 ± 0.06	1.901ArgMet: 1.901 ± 0.029	2.309ArgAsn: 2.309 ± 0.032	3.351ArgPro: 3.351 ± 0.034	2.555ArgGln: 2.555 ± 0.032	5.272ArgArg: 5.272 ± 0.059	3.688ArgSer: 3.688 ± 0.036	3.619ArgThr: 3.619 ± 0.038	4.872ArgVal: 4.872 ± 0.046	1.066ArgTrp: 1.066 ± 0.02	2.135ArgTyr: 2.135 ± 0.025	0.0ArgXaa: 0.0 ± 0.0
Ser	6.61SerAla: 6.61 ± 0.056	0.542SerCys: 0.542 ± 0.017	2.817SerAsp: 2.817 ± 0.029	2.625SerGlu: 2.625 ± 0.035	2.481SerPhe: 2.481 ± 0.035	6.109SerGly: 6.109 ± 0.076	1.122SerHis: 1.122 ± 0.02	2.929SerIle: 2.929 ± 0.035	1.814SerLys: 1.814 ± 0.025	5.856SerLeu: 5.856 ± 0.05	1.273SerMet: 1.273 ± 0.023	1.999SerAsn: 1.999 ± 0.032	3.601SerPro: 3.601 ± 0.045	1.997SerGln: 1.997 ± 0.031	3.809SerArg: 3.809 ± 0.041	3.685SerSer: 3.685 ± 0.046	3.423SerThr: 3.423 ± 0.047	4.535SerVal: 4.535 ± 0.05	0.89SerTrp: 0.89 ± 0.017	1.654SerTyr: 1.654 ± 0.027	0.0SerXaa: 0.0 ± 0.0
Thr	6.618ThrAla: 6.618 ± 0.081	0.502ThrCys: 0.502 ± 0.015	2.636ThrAsp: 2.636 ± 0.035	2.47ThrGlu: 2.47 ± 0.03	2.387ThrPhe: 2.387 ± 0.042	5.784ThrGly: 5.784 ± 0.06	1.032ThrHis: 1.032 ± 0.016	2.975ThrIle: 2.975 ± 0.04	1.537ThrLys: 1.537 ± 0.025	6.01ThrLeu: 6.01 ± 0.062	1.084ThrMet: 1.084 ± 0.021	1.897ThrAsn: 1.897 ± 0.04	3.85ThrPro: 3.85 ± 0.05	1.789ThrGln: 1.789 ± 0.028	3.32ThrArg: 3.32 ± 0.032	3.392ThrSer: 3.392 ± 0.052	3.313ThrThr: 3.313 ± 0.052	4.877ThrVal: 4.877 ± 0.061	0.916ThrTrp: 0.916 ± 0.02	1.569ThrTyr: 1.569 ± 0.025	0.0ThrXaa: 0.0 ± 0.0
Val	7.991ValAla: 7.991 ± 0.062	0.673ValCys: 0.673 ± 0.016	3.736ValAsp: 3.736 ± 0.037	4.169ValGlu: 4.169 ± 0.047	2.778ValPhe: 2.778 ± 0.029	5.047ValGly: 5.047 ± 0.05	1.41ValHis: 1.41 ± 0.024	3.534ValIle: 3.534 ± 0.033	2.587ValLys: 2.587 ± 0.037	7.224ValLeu: 7.224 ± 0.053	1.632ValMet: 1.632 ± 0.029	2.676ValAsn: 2.676 ± 0.038	3.956ValPro: 3.956 ± 0.036	2.432ValGln: 2.432 ± 0.029	5.196ValArg: 5.196 ± 0.051	4.568ValSer: 4.568 ± 0.053	5.006ValThr: 5.006 ± 0.066	5.638ValVal: 5.638 ± 0.051	1.0ValTrp: 1.0 ± 0.019	1.988ValTyr: 1.988 ± 0.029	0.0ValXaa: 0.0 ± 0.0
Trp	1.212TrpAla: 1.212 ± 0.023	0.132TrpCys: 0.132 ± 0.007	0.719TrpAsp: 0.719 ± 0.014	0.688TrpGlu: 0.688 ± 0.015	0.598TrpPhe: 0.598 ± 0.017	0.995TrpGly: 0.995 ± 0.02	0.348TrpHis: 0.348 ± 0.012	0.792TrpIle: 0.792 ± 0.016	0.716TrpLys: 0.716 ± 0.017	1.506TrpLeu: 1.506 ± 0.024	0.426TrpMet: 0.426 ± 0.012	0.612TrpAsn: 0.612 ± 0.017	0.654TrpPro: 0.654 ± 0.016	0.662TrpGln: 0.662 ± 0.017	1.157TrpArg: 1.157 ± 0.022	1.012TrpSer: 1.012 ± 0.022	0.915TrpThr: 0.915 ± 0.018	0.948TrpVal: 0.948 ± 0.018	0.252TrpTrp: 0.252 ± 0.01	0.4TrpTyr: 0.4 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.596TyrAla: 2.596 ± 0.029	0.296TyrCys: 0.296 ± 0.01	1.556TyrAsp: 1.556 ± 0.027	1.373TyrGlu: 1.373 ± 0.026	1.288TyrPhe: 1.288 ± 0.02	2.402TyrGly: 2.402 ± 0.031	0.61TyrHis: 0.61 ± 0.013	1.025TyrIle: 1.025 ± 0.019	0.767TyrLys: 0.767 ± 0.018	2.754TyrLeu: 2.754 ± 0.034	0.489TyrMet: 0.489 ± 0.014	1.025TyrAsn: 1.025 ± 0.025	1.418TyrPro: 1.418 ± 0.021	1.131TyrGln: 1.131 ± 0.024	2.208TyrArg: 2.208 ± 0.03	1.889TyrSer: 1.889 ± 0.028	1.649TyrThr: 1.649 ± 0.026	1.817TyrVal: 1.817 ± 0.026	0.452TyrTrp: 0.452 ± 0.012	0.914TyrTyr: 0.914 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7761 proteins (2980018 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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