Amino acid dipepetide frequency for Coxiella burnetii (strain RSA 493 / Nine Mile phase I)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.045AlaAla: 7.045 ± 0.171
1.016AlaCys: 1.016 ± 0.051
3.539AlaAsp: 3.539 ± 0.087
4.712AlaGlu: 4.712 ± 0.119
3.572AlaPhe: 3.572 ± 0.101
5.525AlaGly: 5.525 ± 0.135
1.822AlaHis: 1.822 ± 0.059
6.516AlaIle: 6.516 ± 0.133
4.84AlaLys: 4.84 ± 0.107
9.628AlaLeu: 9.628 ± 0.157
2.066AlaMet: 2.066 ± 0.061
2.839AlaAsn: 2.839 ± 0.081
2.712AlaPro: 2.712 ± 0.074
3.274AlaGln: 3.274 ± 0.087
3.916AlaArg: 3.916 ± 0.094
4.288AlaSer: 4.288 ± 0.098
3.998AlaThr: 3.998 ± 0.086
5.771AlaVal: 5.771 ± 0.113
0.946AlaTrp: 0.946 ± 0.049
2.564AlaTyr: 2.564 ± 0.075
0.0AlaXaa: 0.0 ± 0.0
Cys
0.86CysAla: 0.86 ± 0.048
0.197CysCys: 0.197 ± 0.02
0.54CysAsp: 0.54 ± 0.036
0.665CysGlu: 0.665 ± 0.041
0.538CysPhe: 0.538 ± 0.026
0.903CysGly: 0.903 ± 0.044
0.365CysHis: 0.365 ± 0.03
0.73CysIle: 0.73 ± 0.041
0.505CysLys: 0.505 ± 0.031
1.21CysLeu: 1.21 ± 0.055
0.224CysMet: 0.224 ± 0.021
0.404CysAsn: 0.404 ± 0.027
0.494CysPro: 0.494 ± 0.031
0.497CysGln: 0.497 ± 0.035
0.644CysArg: 0.644 ± 0.035
0.648CysSer: 0.648 ± 0.042
0.476CysThr: 0.476 ± 0.027
0.751CysVal: 0.751 ± 0.039
0.111CysTrp: 0.111 ± 0.015
0.451CysTyr: 0.451 ± 0.031
0.0CysXaa: 0.0 ± 0.0
Asp
3.406AspAla: 3.406 ± 0.092
0.568AspCys: 0.568 ± 0.036
2.183AspAsp: 2.183 ± 0.072
3.149AspGlu: 3.149 ± 0.091
2.333AspPhe: 2.333 ± 0.076
2.489AspGly: 2.489 ± 0.08
1.128AspHis: 1.128 ± 0.05
3.371AspIle: 3.371 ± 0.087
2.755AspLys: 2.755 ± 0.079
4.87AspLeu: 4.87 ± 0.099
0.923AspMet: 0.923 ± 0.047
1.699AspAsn: 1.699 ± 0.065
2.255AspPro: 2.255 ± 0.069
1.933AspGln: 1.933 ± 0.061
2.509AspArg: 2.509 ± 0.076
2.398AspSer: 2.398 ± 0.069
1.935AspThr: 1.935 ± 0.065
2.872AspVal: 2.872 ± 0.077
0.624AspTrp: 0.624 ± 0.039
2.037AspTyr: 2.037 ± 0.059
0.0AspXaa: 0.0 ± 0.0
Glu
5.024GluAla: 5.024 ± 0.104
0.488GluCys: 0.488 ± 0.032
2.343GluAsp: 2.343 ± 0.072
4.419GluGlu: 4.419 ± 0.125
2.15GluPhe: 2.15 ± 0.064
3.566GluGly: 3.566 ± 0.082
1.208GluHis: 1.208 ± 0.045
4.801GluIle: 4.801 ± 0.103
5.806GluLys: 5.806 ± 0.116
6.007GluLeu: 6.007 ± 0.123
1.59GluMet: 1.59 ± 0.068
3.012GluAsn: 3.012 ± 0.076
1.99GluPro: 1.99 ± 0.059
2.468GluGln: 2.468 ± 0.069
3.553GluArg: 3.553 ± 0.088
3.051GluSer: 3.051 ± 0.087
3.293GluThr: 3.293 ± 0.069
3.681GluVal: 3.681 ± 0.079
0.667GluTrp: 0.667 ± 0.034
1.432GluTyr: 1.432 ± 0.053
0.0GluXaa: 0.0 ± 0.0
Phe
3.326PheAla: 3.326 ± 0.098
0.696PheCys: 0.696 ± 0.037
2.226PheAsp: 2.226 ± 0.073
2.421PheGlu: 2.421 ± 0.07
2.484PhePhe: 2.484 ± 0.088
2.925PheGly: 2.925 ± 0.074
1.11PheHis: 1.11 ± 0.049
3.498PheIle: 3.498 ± 0.105
2.365PheLys: 2.365 ± 0.07
4.924PheLeu: 4.924 ± 0.118
1.048PheMet: 1.048 ± 0.048
2.035PheAsn: 2.035 ± 0.065
1.976PhePro: 1.976 ± 0.057
1.633PheGln: 1.633 ± 0.051
1.935PheArg: 1.935 ± 0.068
3.486PheSer: 3.486 ± 0.098
2.361PheThr: 2.361 ± 0.065
2.558PheVal: 2.558 ± 0.073
0.542PheTrp: 0.542 ± 0.039
1.908PheTyr: 1.908 ± 0.061
0.0PheXaa: 0.0 ± 0.0
Gly
5.063GlyAla: 5.063 ± 0.099
0.855GlyCys: 0.855 ± 0.048
2.969GlyAsp: 2.969 ± 0.09
3.654GlyGlu: 3.654 ± 0.088
3.324GlyPhe: 3.324 ± 0.112
4.538GlyGly: 4.538 ± 0.13
1.467GlyHis: 1.467 ± 0.052
4.942GlyIle: 4.942 ± 0.108
4.119GlyLys: 4.119 ± 0.096
6.772GlyLeu: 6.772 ± 0.115
1.666GlyMet: 1.666 ± 0.052
2.179GlyAsn: 2.179 ± 0.07
1.996GlyPro: 1.996 ± 0.072
2.179GlyGln: 2.179 ± 0.063
3.291GlyArg: 3.291 ± 0.089
3.502GlySer: 3.502 ± 0.075
2.997GlyThr: 2.997 ± 0.068
4.688GlyVal: 4.688 ± 0.101
0.989GlyTrp: 0.989 ± 0.045
2.341GlyTyr: 2.341 ± 0.068
0.0GlyXaa: 0.0 ± 0.0
His
1.771HisAla: 1.771 ± 0.056
0.406HisCys: 0.406 ± 0.029
0.944HisAsp: 0.944 ± 0.043
1.258HisGlu: 1.258 ± 0.045
1.307HisPhe: 1.307 ± 0.051
1.541HisGly: 1.541 ± 0.061
0.823HisHis: 0.823 ± 0.045
1.496HisIle: 1.496 ± 0.052
1.003HisLys: 1.003 ± 0.051
2.856HisLeu: 2.856 ± 0.081
0.472HisMet: 0.472 ± 0.031
0.856HisAsn: 0.856 ± 0.039
1.401HisPro: 1.401 ± 0.056
1.153HisGln: 1.153 ± 0.044
1.469HisArg: 1.469 ± 0.058
1.496HisSer: 1.496 ± 0.06
1.079HisThr: 1.079 ± 0.046
1.223HisVal: 1.223 ± 0.047
0.386HisTrp: 0.386 ± 0.028
1.198HisTyr: 1.198 ± 0.05
0.0HisXaa: 0.0 ± 0.0
Ile
6.491IleAla: 6.491 ± 0.125
0.784IleCys: 0.784 ± 0.037
3.998IleAsp: 3.998 ± 0.084
4.556IleGlu: 4.556 ± 0.093
3.305IlePhe: 3.305 ± 0.094
4.883IleGly: 4.883 ± 0.105
1.814IleHis: 1.814 ± 0.07
5.597IleIle: 5.597 ± 0.12
4.552IleLys: 4.552 ± 0.096
7.053IleLeu: 7.053 ± 0.123
1.362IleMet: 1.362 ± 0.049
3.467IleAsn: 3.467 ± 0.086
3.348IlePro: 3.348 ± 0.092
2.784IleGln: 2.784 ± 0.066
3.639IleArg: 3.639 ± 0.079
4.604IleSer: 4.604 ± 0.095
3.986IleThr: 3.986 ± 0.096
4.532IleVal: 4.532 ± 0.1
0.671IleTrp: 0.671 ± 0.031
2.374IleTyr: 2.374 ± 0.069
0.0IleXaa: 0.0 ± 0.0
Lys
4.996LysAla: 4.996 ± 0.129
0.435LysCys: 0.435 ± 0.035
2.755LysAsp: 2.755 ± 0.087
4.595LysGlu: 4.595 ± 0.093
1.803LysPhe: 1.803 ± 0.061
3.549LysGly: 3.549 ± 0.086
1.243LysHis: 1.243 ± 0.046
4.842LysIle: 4.842 ± 0.098
5.428LysLys: 5.428 ± 0.134
5.757LysLeu: 5.757 ± 0.124
1.613LysMet: 1.613 ± 0.059
3.518LysAsn: 3.518 ± 0.083
2.673LysPro: 2.673 ± 0.071
2.702LysGln: 2.702 ± 0.083
3.758LysArg: 3.758 ± 0.101
3.535LysSer: 3.535 ± 0.089
3.953LysThr: 3.953 ± 0.085
3.346LysVal: 3.346 ± 0.087
0.603LysTrp: 0.603 ± 0.031
1.619LysTyr: 1.619 ± 0.055
0.0LysXaa: 0.0 ± 0.0
Leu
9.099LeuAla: 9.099 ± 0.139
1.188LeuCys: 1.188 ± 0.051
4.61LeuAsp: 4.61 ± 0.105
6.118LeuGlu: 6.118 ± 0.138
5.162LeuPhe: 5.162 ± 0.122
6.717LeuGly: 6.717 ± 0.134
2.363LeuHis: 2.363 ± 0.071
8.584LeuIle: 8.584 ± 0.142
7.049LeuLys: 7.049 ± 0.138
12.276LeuLeu: 12.276 ± 0.236
2.634LeuMet: 2.634 ± 0.076
4.811LeuAsn: 4.811 ± 0.102
5.309LeuPro: 5.309 ± 0.111
4.452LeuGln: 4.452 ± 0.106
5.58LeuArg: 5.58 ± 0.096
7.628LeuSer: 7.628 ± 0.155
6.025LeuThr: 6.025 ± 0.113
6.009LeuVal: 6.009 ± 0.129
1.241LeuTrp: 1.241 ± 0.052
3.063LeuTyr: 3.063 ± 0.083
0.0LeuXaa: 0.0 ± 0.0
Met
2.072MetAla: 2.072 ± 0.066
0.178MetCys: 0.178 ± 0.018
0.997MetAsp: 0.997 ± 0.041
1.319MetGlu: 1.319 ± 0.055
0.656MetPhe: 0.656 ± 0.035
1.647MetGly: 1.647 ± 0.06
0.431MetHis: 0.431 ± 0.03
1.594MetIle: 1.594 ± 0.062
1.578MetLys: 1.578 ± 0.051
2.197MetLeu: 2.197 ± 0.072
0.702MetMet: 0.702 ± 0.04
1.102MetAsn: 1.102 ± 0.047
1.196MetPro: 1.196 ± 0.046
1.024MetGln: 1.024 ± 0.041
1.413MetArg: 1.413 ± 0.051
1.434MetSer: 1.434 ± 0.065
1.413MetThr: 1.413 ± 0.051
1.524MetVal: 1.524 ± 0.052
0.178MetTrp: 0.178 ± 0.017
0.425MetTyr: 0.425 ± 0.031
0.0MetXaa: 0.0 ± 0.0
Asn
3.324AsnAla: 3.324 ± 0.078
0.513AsnCys: 0.513 ± 0.031
2.011AsnAsp: 2.011 ± 0.062
2.653AsnGlu: 2.653 ± 0.085
1.969AsnPhe: 1.969 ± 0.063
2.357AsnGly: 2.357 ± 0.063
1.042AsnHis: 1.042 ± 0.051
2.917AsnIle: 2.917 ± 0.089
2.486AsnLys: 2.486 ± 0.079
4.409AsnLeu: 4.409 ± 0.105
0.759AsnMet: 0.759 ± 0.036
1.916AsnAsn: 1.916 ± 0.073
2.464AsnPro: 2.464 ± 0.068
2.017AsnGln: 2.017 ± 0.07
2.318AsnArg: 2.318 ± 0.067
2.232AsnSer: 2.232 ± 0.068
1.928AsnThr: 1.928 ± 0.064
2.382AsnVal: 2.382 ± 0.071
0.574AsnTrp: 0.574 ± 0.033
1.703AsnTyr: 1.703 ± 0.065
0.0AsnXaa: 0.0 ± 0.0
Pro
3.227ProAla: 3.227 ± 0.086
0.341ProCys: 0.341 ± 0.024
2.228ProAsp: 2.228 ± 0.07
2.884ProGlu: 2.884 ± 0.076
2.084ProPhe: 2.084 ± 0.062
2.622ProGly: 2.622 ± 0.069
1.159ProHis: 1.159 ± 0.057
3.034ProIle: 3.034 ± 0.081
2.474ProLys: 2.474 ± 0.075
5.244ProLeu: 5.244 ± 0.104
0.923ProMet: 0.923 ± 0.042
1.816ProAsn: 1.816 ± 0.052
1.953ProPro: 1.953 ± 0.08
1.875ProGln: 1.875 ± 0.06
1.994ProArg: 1.994 ± 0.066
2.913ProSer: 2.913 ± 0.069
2.413ProThr: 2.413 ± 0.064
2.985ProVal: 2.985 ± 0.086
0.544ProTrp: 0.544 ± 0.034
1.508ProTyr: 1.508 ± 0.063
0.0ProXaa: 0.0 ± 0.0
Gln
3.65GlnAla: 3.65 ± 0.096
0.423GlnCys: 0.423 ± 0.03
1.319GlnAsp: 1.319 ± 0.047
2.248GlnGlu: 2.248 ± 0.067
1.777GlnPhe: 1.777 ± 0.061
2.329GlnGly: 2.329 ± 0.065
1.04GlnHis: 1.04 ± 0.045
2.632GlnIle: 2.632 ± 0.061
2.975GlnLys: 2.975 ± 0.077
5.135GlnLeu: 5.135 ± 0.118
0.929GlnMet: 0.929 ± 0.039
1.746GlnAsn: 1.746 ± 0.055
1.75GlnPro: 1.75 ± 0.069
2.31GlnGln: 2.31 ± 0.084
2.614GlnArg: 2.614 ± 0.068
2.423GlnSer: 2.423 ± 0.068
2.201GlnThr: 2.201 ± 0.069
2.333GlnVal: 2.333 ± 0.068
0.698GlnTrp: 0.698 ± 0.035
1.178GlnTyr: 1.178 ± 0.05
0.0GlnXaa: 0.0 ± 0.0
Arg
3.843ArgAla: 3.843 ± 0.082
0.607ArgCys: 0.607 ± 0.037
2.558ArgAsp: 2.558 ± 0.067
3.681ArgGlu: 3.681 ± 0.091
2.62ArgPhe: 2.62 ± 0.068
3.223ArgGly: 3.223 ± 0.092
1.424ArgHis: 1.424 ± 0.056
3.525ArgIle: 3.525 ± 0.084
3.071ArgLys: 3.071 ± 0.086
6.284ArgLeu: 6.284 ± 0.11
1.323ArgMet: 1.323 ± 0.05
2.076ArgAsn: 2.076 ± 0.061
2.056ArgPro: 2.056 ± 0.062
2.378ArgGln: 2.378 ± 0.065
3.428ArgArg: 3.428 ± 0.09
2.829ArgSer: 2.829 ± 0.082
2.322ArgThr: 2.322 ± 0.065
3.258ArgVal: 3.258 ± 0.075
0.788ArgTrp: 0.788 ± 0.043
2.173ArgTyr: 2.173 ± 0.067
0.0ArgXaa: 0.0 ± 0.0
Ser
4.661SerAla: 4.661 ± 0.112
0.611SerCys: 0.611 ± 0.032
2.665SerAsp: 2.665 ± 0.076
3.323SerGlu: 3.323 ± 0.077
2.909SerPhe: 2.909 ± 0.084
4.087SerGly: 4.087 ± 0.093
1.635SerHis: 1.635 ± 0.052
4.122SerIle: 4.122 ± 0.106
3.077SerLys: 3.077 ± 0.077
6.977SerLeu: 6.977 ± 0.145
1.364SerMet: 1.364 ± 0.054
2.238SerAsn: 2.238 ± 0.072
2.913SerPro: 2.913 ± 0.072
2.593SerGln: 2.593 ± 0.079
3.161SerArg: 3.161 ± 0.084
3.756SerSer: 3.756 ± 0.104
2.905SerThr: 2.905 ± 0.078
3.752SerVal: 3.752 ± 0.089
0.687SerTrp: 0.687 ± 0.041
1.957SerTyr: 1.957 ± 0.063
0.0SerXaa: 0.0 ± 0.0
Thr
4.399ThrAla: 4.399 ± 0.093
0.517ThrCys: 0.517 ± 0.034
2.304ThrAsp: 2.304 ± 0.067
2.739ThrGlu: 2.739 ± 0.075
2.13ThrPhe: 2.13 ± 0.062
3.391ThrGly: 3.391 ± 0.076
1.395ThrHis: 1.395 ± 0.05
3.81ThrIle: 3.81 ± 0.086
2.671ThrLys: 2.671 ± 0.08
6.253ThrLeu: 6.253 ± 0.122
1.034ThrMet: 1.034 ± 0.043
1.844ThrAsn: 1.844 ± 0.06
2.944ThrPro: 2.944 ± 0.076
2.142ThrGln: 2.142 ± 0.069
2.339ThrArg: 2.339 ± 0.064
2.79ThrSer: 2.79 ± 0.076
2.86ThrThr: 2.86 ± 0.073
3.603ThrVal: 3.603 ± 0.088
0.517ThrTrp: 0.517 ± 0.033
1.569ThrTyr: 1.569 ± 0.059
0.0ThrXaa: 0.0 ± 0.0
Val
5.09ValAla: 5.09 ± 0.115
0.737ValCys: 0.737 ± 0.036
3.26ValAsp: 3.26 ± 0.076
3.703ValGlu: 3.703 ± 0.096
2.784ValPhe: 2.784 ± 0.081
4.36ValGly: 4.36 ± 0.101
1.29ValHis: 1.29 ± 0.048
5.09ValIle: 5.09 ± 0.116
3.84ValLys: 3.84 ± 0.103
6.321ValLeu: 6.321 ± 0.131
1.574ValMet: 1.574 ± 0.063
2.788ValAsn: 2.788 ± 0.069
2.78ValPro: 2.78 ± 0.074
1.851ValGln: 1.851 ± 0.06
2.928ValArg: 2.928 ± 0.072
3.742ValSer: 3.742 ± 0.095
3.332ValThr: 3.332 ± 0.082
4.505ValVal: 4.505 ± 0.1
0.62ValTrp: 0.62 ± 0.033
1.842ValTyr: 1.842 ± 0.06
0.0ValXaa: 0.0 ± 0.0
Trp
0.808TrpAla: 0.808 ± 0.043
0.139TrpCys: 0.139 ± 0.017
0.464TrpAsp: 0.464 ± 0.033
0.679TrpGlu: 0.679 ± 0.036
0.603TrpPhe: 0.603 ± 0.037
0.78TrpGly: 0.78 ± 0.04
0.347TrpHis: 0.347 ± 0.026
0.89TrpIle: 0.89 ± 0.042
0.644TrpLys: 0.644 ± 0.04
1.645TrpLeu: 1.645 ± 0.064
0.271TrpMet: 0.271 ± 0.023
0.474TrpAsn: 0.474 ± 0.028
0.457TrpPro: 0.457 ± 0.03
0.689TrpGln: 0.689 ± 0.039
0.841TrpArg: 0.841 ± 0.042
0.581TrpSer: 0.581 ± 0.035
0.396TrpThr: 0.396 ± 0.025
0.794TrpVal: 0.794 ± 0.042
0.148TrpTrp: 0.148 ± 0.017
0.371TrpTyr: 0.371 ± 0.027
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.431TyrAla: 2.431 ± 0.066
0.515TyrCys: 0.515 ± 0.029
1.524TyrAsp: 1.524 ± 0.061
1.777TyrGlu: 1.777 ± 0.062
1.947TyrPhe: 1.947 ± 0.071
2.097TyrGly: 2.097 ± 0.074
1.036TyrHis: 1.036 ± 0.049
1.807TyrIle: 1.807 ± 0.067
1.487TyrLys: 1.487 ± 0.051
4.101TyrLeu: 4.101 ± 0.103
0.599TyrMet: 0.599 ± 0.034
1.153TyrAsn: 1.153 ± 0.055
1.555TyrPro: 1.555 ± 0.056
1.756TyrGln: 1.756 ± 0.055
2.14TyrArg: 2.14 ± 0.072
2.052TyrSer: 2.052 ± 0.066
1.381TyrThr: 1.381 ± 0.06
1.871TyrVal: 1.871 ± 0.064
0.484TyrTrp: 0.484 ± 0.028
1.37TyrTyr: 1.37 ± 0.058
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1812 proteins (512564 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski