Amino acid dipepetide frequency for Lactobacillus virus ATCC8014

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.931AlaAla: 9.931 ± 1.725
0.428AlaCys: 0.428 ± 0.172
6.421AlaAsp: 6.421 ± 0.752
4.709AlaGlu: 4.709 ± 0.729
3.424AlaPhe: 3.424 ± 0.563
6.763AlaGly: 6.763 ± 1.091
1.712AlaHis: 1.712 ± 0.342
6.934AlaIle: 6.934 ± 1.008
5.051AlaLys: 5.051 ± 0.76
6.164AlaLeu: 6.164 ± 0.844
4.28AlaMet: 4.28 ± 0.848
5.051AlaAsn: 5.051 ± 0.487
2.825AlaPro: 2.825 ± 0.658
3.51AlaGln: 3.51 ± 0.69
3.767AlaArg: 3.767 ± 0.575
4.537AlaSer: 4.537 ± 0.75
6.335AlaThr: 6.335 ± 1.151
6.249AlaVal: 6.249 ± 0.771
0.942AlaTrp: 0.942 ± 0.248
3.339AlaTyr: 3.339 ± 0.49
0.0AlaXaa: 0.0 ± 0.0
Cys
0.514CysAla: 0.514 ± 0.21
0.086CysCys: 0.086 ± 0.08
0.428CysAsp: 0.428 ± 0.19
0.342CysGlu: 0.342 ± 0.167
0.086CysPhe: 0.086 ± 0.082
0.856CysGly: 0.856 ± 0.245
0.342CysHis: 0.342 ± 0.17
0.086CysIle: 0.086 ± 0.099
0.342CysLys: 0.342 ± 0.165
0.171CysLeu: 0.171 ± 0.122
0.086CysMet: 0.086 ± 0.087
0.257CysAsn: 0.257 ± 0.155
0.342CysPro: 0.342 ± 0.176
0.086CysGln: 0.086 ± 0.071
0.599CysArg: 0.599 ± 0.225
0.171CysSer: 0.171 ± 0.108
0.342CysThr: 0.342 ± 0.167
0.428CysVal: 0.428 ± 0.176
0.0CysTrp: 0.0 ± 0.0
0.514CysTyr: 0.514 ± 0.227
0.0CysXaa: 0.0 ± 0.0
Asp
5.479AspAla: 5.479 ± 0.487
0.428AspCys: 0.428 ± 0.221
5.393AspAsp: 5.393 ± 0.951
4.965AspGlu: 4.965 ± 0.692
1.969AspPhe: 1.969 ± 0.425
6.934AspGly: 6.934 ± 0.777
0.942AspHis: 0.942 ± 0.243
4.537AspIle: 4.537 ± 0.599
4.109AspLys: 4.109 ± 0.571
5.051AspLeu: 5.051 ± 0.505
2.483AspMet: 2.483 ± 0.365
4.88AspAsn: 4.88 ± 0.658
2.055AspPro: 2.055 ± 0.557
1.798AspGln: 1.798 ± 0.334
2.311AspArg: 2.311 ± 0.465
3.767AspSer: 3.767 ± 0.611
4.794AspThr: 4.794 ± 0.892
5.051AspVal: 5.051 ± 0.809
0.428AspTrp: 0.428 ± 0.189
3.253AspTyr: 3.253 ± 0.606
0.0AspXaa: 0.0 ± 0.0
Glu
3.082GluAla: 3.082 ± 0.544
0.428GluCys: 0.428 ± 0.189
3.168GluAsp: 3.168 ± 0.536
2.483GluGlu: 2.483 ± 0.51
1.798GluPhe: 1.798 ± 0.333
2.397GluGly: 2.397 ± 0.456
1.199GluHis: 1.199 ± 0.275
3.852GluIle: 3.852 ± 0.742
3.596GluLys: 3.596 ± 0.606
5.993GluLeu: 5.993 ± 0.731
1.969GluMet: 1.969 ± 0.463
2.14GluAsn: 2.14 ± 0.369
1.883GluPro: 1.883 ± 0.455
2.226GluGln: 2.226 ± 0.536
3.253GluArg: 3.253 ± 0.599
2.911GluSer: 2.911 ± 0.442
2.911GluThr: 2.911 ± 0.37
3.852GluVal: 3.852 ± 0.636
0.342GluTrp: 0.342 ± 0.168
2.911GluTyr: 2.911 ± 0.505
0.0GluXaa: 0.0 ± 0.0
Phe
1.798PheAla: 1.798 ± 0.39
0.086PheCys: 0.086 ± 0.088
3.082PheAsp: 3.082 ± 0.459
1.883PheGlu: 1.883 ± 0.39
1.541PhePhe: 1.541 ± 0.309
3.253PheGly: 3.253 ± 0.594
0.685PheHis: 0.685 ± 0.291
2.311PheIle: 2.311 ± 0.75
3.082PheLys: 3.082 ± 0.654
1.969PheLeu: 1.969 ± 0.408
1.284PheMet: 1.284 ± 0.306
2.654PheAsn: 2.654 ± 0.433
0.685PhePro: 0.685 ± 0.221
0.77PheGln: 0.77 ± 0.255
1.541PheArg: 1.541 ± 0.271
1.883PheSer: 1.883 ± 0.372
4.195PheThr: 4.195 ± 0.634
2.483PheVal: 2.483 ± 0.468
0.257PheTrp: 0.257 ± 0.156
1.798PheTyr: 1.798 ± 0.356
0.0PheXaa: 0.0 ± 0.0
Gly
5.565GlyAla: 5.565 ± 1.342
0.428GlyCys: 0.428 ± 0.213
4.88GlyAsp: 4.88 ± 0.558
4.195GlyGlu: 4.195 ± 0.649
3.253GlyPhe: 3.253 ± 0.523
4.366GlyGly: 4.366 ± 0.65
1.113GlyHis: 1.113 ± 0.38
4.709GlyIle: 4.709 ± 0.867
7.448GlyLys: 7.448 ± 0.762
4.709GlyLeu: 4.709 ± 0.827
2.483GlyMet: 2.483 ± 0.592
3.938GlyAsn: 3.938 ± 0.538
1.455GlyPro: 1.455 ± 0.326
2.483GlyGln: 2.483 ± 0.496
3.852GlyArg: 3.852 ± 0.641
4.709GlySer: 4.709 ± 0.734
4.794GlyThr: 4.794 ± 0.48
6.078GlyVal: 6.078 ± 0.982
0.514GlyTrp: 0.514 ± 0.187
4.195GlyTyr: 4.195 ± 0.731
0.0GlyXaa: 0.0 ± 0.0
His
1.712HisAla: 1.712 ± 0.298
0.257HisCys: 0.257 ± 0.146
1.883HisAsp: 1.883 ± 0.42
0.77HisGlu: 0.77 ± 0.244
0.428HisPhe: 0.428 ± 0.17
1.712HisGly: 1.712 ± 0.373
0.428HisHis: 0.428 ± 0.194
0.856HisIle: 0.856 ± 0.256
0.942HisLys: 0.942 ± 0.237
0.599HisLeu: 0.599 ± 0.192
0.599HisMet: 0.599 ± 0.193
0.599HisAsn: 0.599 ± 0.221
0.77HisPro: 0.77 ± 0.253
0.171HisGln: 0.171 ± 0.112
0.942HisArg: 0.942 ± 0.267
1.027HisSer: 1.027 ± 0.297
1.027HisThr: 1.027 ± 0.267
1.027HisVal: 1.027 ± 0.305
0.342HisTrp: 0.342 ± 0.147
1.113HisTyr: 1.113 ± 0.334
0.0HisXaa: 0.0 ± 0.0
Ile
7.02IleAla: 7.02 ± 0.973
0.428IleCys: 0.428 ± 0.198
5.736IleAsp: 5.736 ± 0.564
4.109IleGlu: 4.109 ± 0.63
1.627IlePhe: 1.627 ± 0.339
4.109IleGly: 4.109 ± 1.134
0.942IleHis: 0.942 ± 0.294
3.681IleIle: 3.681 ± 0.621
4.537IleLys: 4.537 ± 0.722
3.596IleLeu: 3.596 ± 0.423
2.311IleMet: 2.311 ± 0.412
2.911IleAsn: 2.911 ± 0.451
1.798IlePro: 1.798 ± 0.326
1.627IleGln: 1.627 ± 0.419
2.226IleArg: 2.226 ± 0.398
3.681IleSer: 3.681 ± 0.579
4.28IleThr: 4.28 ± 0.642
4.88IleVal: 4.88 ± 0.561
0.171IleTrp: 0.171 ± 0.1
1.541IleTyr: 1.541 ± 0.406
0.0IleXaa: 0.0 ± 0.0
Lys
5.907LysAla: 5.907 ± 0.797
0.257LysCys: 0.257 ± 0.148
4.366LysAsp: 4.366 ± 0.577
2.654LysGlu: 2.654 ± 0.503
2.654LysPhe: 2.654 ± 0.488
4.28LysGly: 4.28 ± 0.634
1.541LysHis: 1.541 ± 0.367
3.339LysIle: 3.339 ± 0.733
4.28LysLys: 4.28 ± 0.56
5.821LysLeu: 5.821 ± 0.769
2.397LysMet: 2.397 ± 0.452
3.082LysAsn: 3.082 ± 0.779
2.311LysPro: 2.311 ± 0.496
2.226LysGln: 2.226 ± 0.371
3.681LysArg: 3.681 ± 0.709
3.852LysSer: 3.852 ± 0.599
4.28LysThr: 4.28 ± 0.649
4.965LysVal: 4.965 ± 0.85
0.942LysTrp: 0.942 ± 0.304
2.483LysTyr: 2.483 ± 0.434
0.0LysXaa: 0.0 ± 0.0
Leu
7.277LeuAla: 7.277 ± 0.677
0.514LeuCys: 0.514 ± 0.205
5.051LeuAsp: 5.051 ± 0.652
3.681LeuGlu: 3.681 ± 0.633
2.654LeuPhe: 2.654 ± 0.399
4.623LeuGly: 4.623 ± 0.717
0.856LeuHis: 0.856 ± 0.289
4.195LeuIle: 4.195 ± 0.509
5.137LeuLys: 5.137 ± 0.602
4.28LeuLeu: 4.28 ± 0.474
2.311LeuMet: 2.311 ± 0.412
4.109LeuAsn: 4.109 ± 0.57
2.911LeuPro: 2.911 ± 0.577
2.739LeuGln: 2.739 ± 0.464
2.996LeuArg: 2.996 ± 0.589
4.709LeuSer: 4.709 ± 0.653
3.767LeuThr: 3.767 ± 0.524
5.308LeuVal: 5.308 ± 0.823
0.942LeuTrp: 0.942 ± 0.326
2.996LeuTyr: 2.996 ± 0.613
0.0LeuXaa: 0.0 ± 0.0
Met
3.253MetAla: 3.253 ± 0.637
0.257MetCys: 0.257 ± 0.179
1.798MetAsp: 1.798 ± 0.377
1.541MetGlu: 1.541 ± 0.359
1.798MetPhe: 1.798 ± 0.367
1.541MetGly: 1.541 ± 0.623
0.428MetHis: 0.428 ± 0.194
2.311MetIle: 2.311 ± 0.441
2.739MetLys: 2.739 ± 0.465
2.483MetLeu: 2.483 ± 0.673
1.027MetMet: 1.027 ± 0.239
1.027MetAsn: 1.027 ± 0.298
0.428MetPro: 0.428 ± 0.182
1.798MetGln: 1.798 ± 0.405
1.541MetArg: 1.541 ± 0.453
2.483MetSer: 2.483 ± 0.573
2.825MetThr: 2.825 ± 0.482
1.284MetVal: 1.284 ± 0.351
0.342MetTrp: 0.342 ± 0.183
1.541MetTyr: 1.541 ± 0.392
0.0MetXaa: 0.0 ± 0.0
Asn
6.078AsnAla: 6.078 ± 0.978
0.171AsnCys: 0.171 ± 0.118
4.28AsnAsp: 4.28 ± 0.503
2.654AsnGlu: 2.654 ± 0.499
1.027AsnPhe: 1.027 ± 0.267
6.249AsnGly: 6.249 ± 0.802
0.856AsnHis: 0.856 ± 0.261
2.911AsnIle: 2.911 ± 0.443
2.397AsnLys: 2.397 ± 0.518
4.28AsnLeu: 4.28 ± 0.667
1.798AsnMet: 1.798 ± 0.38
3.596AsnAsn: 3.596 ± 0.707
1.37AsnPro: 1.37 ± 0.445
1.455AsnGln: 1.455 ± 0.362
3.168AsnArg: 3.168 ± 0.481
2.825AsnSer: 2.825 ± 0.486
2.14AsnThr: 2.14 ± 0.408
3.51AsnVal: 3.51 ± 0.513
0.856AsnTrp: 0.856 ± 0.288
2.568AsnTyr: 2.568 ± 0.571
0.0AsnXaa: 0.0 ± 0.0
Pro
2.825ProAla: 2.825 ± 0.564
0.257ProCys: 0.257 ± 0.153
2.483ProAsp: 2.483 ± 0.581
1.627ProGlu: 1.627 ± 0.374
0.856ProPhe: 0.856 ± 0.28
2.568ProGly: 2.568 ± 0.459
0.342ProHis: 0.342 ± 0.141
1.541ProIle: 1.541 ± 0.276
1.712ProLys: 1.712 ± 0.451
2.311ProLeu: 2.311 ± 0.386
1.027ProMet: 1.027 ± 0.301
1.798ProAsn: 1.798 ± 0.355
0.342ProPro: 0.342 ± 0.169
0.942ProGln: 0.942 ± 0.272
1.712ProArg: 1.712 ± 0.297
2.14ProSer: 2.14 ± 0.503
1.712ProThr: 1.712 ± 0.429
3.339ProVal: 3.339 ± 0.521
0.514ProTrp: 0.514 ± 0.239
1.113ProTyr: 1.113 ± 0.254
0.0ProXaa: 0.0 ± 0.0
Gln
3.852GlnAla: 3.852 ± 0.587
0.171GlnCys: 0.171 ± 0.137
0.856GlnAsp: 0.856 ± 0.321
1.455GlnGlu: 1.455 ± 0.36
1.113GlnPhe: 1.113 ± 0.294
2.397GlnGly: 2.397 ± 0.324
0.171GlnHis: 0.171 ± 0.126
1.199GlnIle: 1.199 ± 0.267
1.37GlnLys: 1.37 ± 0.293
2.055GlnLeu: 2.055 ± 0.398
0.77GlnMet: 0.77 ± 0.255
1.284GlnAsn: 1.284 ± 0.312
1.284GlnPro: 1.284 ± 0.283
1.455GlnGln: 1.455 ± 0.366
1.712GlnArg: 1.712 ± 0.327
2.568GlnSer: 2.568 ± 0.484
2.483GlnThr: 2.483 ± 0.477
2.483GlnVal: 2.483 ± 0.509
0.685GlnTrp: 0.685 ± 0.242
1.798GlnTyr: 1.798 ± 0.461
0.0GlnXaa: 0.0 ± 0.0
Arg
4.965ArgAla: 4.965 ± 0.68
0.342ArgCys: 0.342 ± 0.168
2.825ArgAsp: 2.825 ± 0.56
2.397ArgGlu: 2.397 ± 0.548
2.825ArgPhe: 2.825 ± 0.56
3.852ArgGly: 3.852 ± 0.503
1.027ArgHis: 1.027 ± 0.262
2.739ArgIle: 2.739 ± 0.421
2.568ArgLys: 2.568 ± 0.623
4.537ArgLeu: 4.537 ± 0.834
0.942ArgMet: 0.942 ± 0.279
2.397ArgAsn: 2.397 ± 0.391
1.37ArgPro: 1.37 ± 0.292
1.37ArgGln: 1.37 ± 0.331
3.168ArgArg: 3.168 ± 0.639
1.627ArgSer: 1.627 ± 0.32
2.14ArgThr: 2.14 ± 0.437
4.366ArgVal: 4.366 ± 0.734
0.77ArgTrp: 0.77 ± 0.284
2.226ArgTyr: 2.226 ± 0.536
0.0ArgXaa: 0.0 ± 0.0
Ser
4.623SerAla: 4.623 ± 0.795
0.257SerCys: 0.257 ± 0.127
5.137SerAsp: 5.137 ± 0.799
2.654SerGlu: 2.654 ± 0.495
2.739SerPhe: 2.739 ± 0.749
6.164SerGly: 6.164 ± 0.872
1.113SerHis: 1.113 ± 0.252
4.452SerIle: 4.452 ± 0.596
3.339SerLys: 3.339 ± 0.699
4.109SerLeu: 4.109 ± 0.664
2.055SerMet: 2.055 ± 0.372
2.911SerAsn: 2.911 ± 0.589
1.455SerPro: 1.455 ± 0.445
1.798SerGln: 1.798 ± 0.37
1.883SerArg: 1.883 ± 0.398
5.222SerSer: 5.222 ± 1.202
3.082SerThr: 3.082 ± 0.402
4.452SerVal: 4.452 ± 0.594
0.856SerTrp: 0.856 ± 0.323
1.969SerTyr: 1.969 ± 0.402
0.0SerXaa: 0.0 ± 0.0
Thr
6.763ThrAla: 6.763 ± 1.042
0.514ThrCys: 0.514 ± 0.195
4.109ThrAsp: 4.109 ± 0.685
3.082ThrGlu: 3.082 ± 0.388
2.825ThrPhe: 2.825 ± 0.494
4.623ThrGly: 4.623 ± 0.645
0.942ThrHis: 0.942 ± 0.285
4.195ThrIle: 4.195 ± 0.582
3.424ThrLys: 3.424 ± 0.477
4.623ThrLeu: 4.623 ± 0.636
1.199ThrMet: 1.199 ± 0.303
3.681ThrAsn: 3.681 ± 0.625
3.082ThrPro: 3.082 ± 0.623
1.455ThrGln: 1.455 ± 0.283
2.568ThrArg: 2.568 ± 0.542
4.366ThrSer: 4.366 ± 0.569
3.082ThrThr: 3.082 ± 0.45
4.965ThrVal: 4.965 ± 0.803
0.514ThrTrp: 0.514 ± 0.209
3.339ThrTyr: 3.339 ± 0.506
0.0ThrXaa: 0.0 ± 0.0
Val
7.79ValAla: 7.79 ± 0.926
0.428ValCys: 0.428 ± 0.22
4.366ValAsp: 4.366 ± 0.496
3.51ValGlu: 3.51 ± 0.624
2.911ValPhe: 2.911 ± 0.515
4.452ValGly: 4.452 ± 0.601
1.627ValHis: 1.627 ± 0.302
4.366ValIle: 4.366 ± 0.616
5.222ValLys: 5.222 ± 0.491
4.794ValLeu: 4.794 ± 0.644
1.883ValMet: 1.883 ± 0.344
4.452ValAsn: 4.452 ± 0.524
2.654ValPro: 2.654 ± 0.537
1.712ValGln: 1.712 ± 0.345
4.024ValArg: 4.024 ± 0.651
5.051ValSer: 5.051 ± 0.797
5.479ValThr: 5.479 ± 0.757
6.335ValVal: 6.335 ± 0.811
1.284ValTrp: 1.284 ± 0.269
3.168ValTyr: 3.168 ± 0.713
0.0ValXaa: 0.0 ± 0.0
Trp
0.856TrpAla: 0.856 ± 0.304
0.0TrpCys: 0.0 ± 0.0
0.77TrpAsp: 0.77 ± 0.224
0.685TrpGlu: 0.685 ± 0.178
0.257TrpPhe: 0.257 ± 0.152
0.77TrpGly: 0.77 ± 0.29
0.171TrpHis: 0.171 ± 0.11
0.77TrpIle: 0.77 ± 0.279
0.428TrpLys: 0.428 ± 0.191
1.284TrpLeu: 1.284 ± 0.327
0.0TrpMet: 0.0 ± 0.0
0.599TrpAsn: 0.599 ± 0.25
0.257TrpPro: 0.257 ± 0.145
0.171TrpGln: 0.171 ± 0.117
0.685TrpArg: 0.685 ± 0.212
0.942TrpSer: 0.942 ± 0.216
0.77TrpThr: 0.77 ± 0.177
1.37TrpVal: 1.37 ± 0.394
0.086TrpTrp: 0.086 ± 0.081
0.342TrpTyr: 0.342 ± 0.158
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.082TyrAla: 3.082 ± 0.539
0.342TyrCys: 0.342 ± 0.173
3.681TyrAsp: 3.681 ± 0.676
2.996TyrGlu: 2.996 ± 0.539
1.455TyrPhe: 1.455 ± 0.392
3.253TyrGly: 3.253 ± 0.432
0.77TyrHis: 0.77 ± 0.283
2.226TyrIle: 2.226 ± 0.471
3.596TyrLys: 3.596 ± 0.631
2.226TyrLeu: 2.226 ± 0.411
1.455TyrMet: 1.455 ± 0.346
2.825TyrAsn: 2.825 ± 0.482
1.883TyrPro: 1.883 ± 0.394
1.37TyrGln: 1.37 ± 0.359
2.825TyrArg: 2.825 ± 0.682
1.798TyrSer: 1.798 ± 0.495
2.911TyrThr: 2.911 ± 0.478
3.082TyrVal: 3.082 ± 0.577
0.428TyrTrp: 0.428 ± 0.181
1.37TyrTyr: 1.37 ± 0.307
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 60 proteins (11682 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski