Amino acid dipepetide frequency for Moraxella nonliquefaciens

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.512AlaAla: 3.512 ± 0.143
1.164AlaCys: 1.164 ± 0.046
5.622AlaAsp: 5.622 ± 0.092
3.387AlaGlu: 3.387 ± 0.096
3.341AlaPhe: 3.341 ± 0.084
5.919AlaGly: 5.919 ± 0.128
2.163AlaHis: 2.163 ± 0.063
6.217AlaIle: 6.217 ± 0.116
6.137AlaLys: 6.137 ± 0.124
8.999AlaLeu: 8.999 ± 0.15
2.828AlaMet: 2.828 ± 0.077
4.369AlaAsn: 4.369 ± 0.103
2.764AlaPro: 2.764 ± 0.074
3.812AlaGln: 3.812 ± 0.089
3.369AlaArg: 3.369 ± 0.09
4.819AlaSer: 4.819 ± 0.092
4.961AlaThr: 4.961 ± 0.098
5.802AlaVal: 5.802 ± 0.118
1.021AlaTrp: 1.021 ± 0.043
2.671AlaTyr: 2.671 ± 0.058
0.0AlaXaa: 0.0 ± 0.0
Cys
0.767CysAla: 0.767 ± 0.043
0.126CysCys: 0.126 ± 0.016
0.567CysAsp: 0.567 ± 0.037
0.472CysGlu: 0.472 ± 0.034
0.418CysPhe: 0.418 ± 0.024
0.853CysGly: 0.853 ± 0.037
0.433CysHis: 0.433 ± 0.028
0.561CysIle: 0.561 ± 0.032
0.361CysLys: 0.361 ± 0.025
0.957CysLeu: 0.957 ± 0.045
0.243CysMet: 0.243 ± 0.021
0.307CysAsn: 0.307 ± 0.025
0.498CysPro: 0.498 ± 0.033
0.628CysGln: 0.628 ± 0.037
0.372CysArg: 0.372 ± 0.027
0.42CysSer: 0.42 ± 0.028
0.52CysThr: 0.52 ± 0.03
0.72CysVal: 0.72 ± 0.035
0.066CysTrp: 0.066 ± 0.01
0.328CysTyr: 0.328 ± 0.024
0.0CysXaa: 0.0 ± 0.0
Asp
4.319AspAla: 4.319 ± 0.102
0.515AspCys: 0.515 ± 0.027
5.702AspAsp: 5.702 ± 0.13
5.512AspGlu: 5.512 ± 0.111
2.872AspPhe: 2.872 ± 0.076
5.138AspGly: 5.138 ± 0.111
0.977AspHis: 0.977 ± 0.046
4.568AspIle: 4.568 ± 0.099
5.601AspLys: 5.601 ± 0.107
5.122AspLeu: 5.122 ± 0.103
1.622AspMet: 1.622 ± 0.058
3.515AspAsn: 3.515 ± 0.074
1.846AspPro: 1.846 ± 0.055
1.031AspGln: 1.031 ± 0.048
2.156AspArg: 2.156 ± 0.065
2.782AspSer: 2.782 ± 0.065
3.615AspThr: 3.615 ± 0.098
4.478AspVal: 4.478 ± 0.1
0.871AspTrp: 0.871 ± 0.041
2.284AspTyr: 2.284 ± 0.074
0.0AspXaa: 0.0 ± 0.0
Glu
3.414GluAla: 3.414 ± 0.084
0.512GluCys: 0.512 ± 0.031
1.867GluAsp: 1.867 ± 0.062
2.087GluGlu: 2.087 ± 0.069
2.402GluPhe: 2.402 ± 0.07
2.228GluGly: 2.228 ± 0.07
1.603GluHis: 1.603 ± 0.056
3.894GluIle: 3.894 ± 0.087
2.83GluLys: 2.83 ± 0.089
6.314GluLeu: 6.314 ± 0.117
1.644GluMet: 1.644 ± 0.055
2.41GluAsn: 2.41 ± 0.07
1.81GluPro: 1.81 ± 0.07
3.125GluGln: 3.125 ± 0.081
3.292GluArg: 3.292 ± 0.087
2.515GluSer: 2.515 ± 0.075
2.43GluThr: 2.43 ± 0.074
3.045GluVal: 3.045 ± 0.079
0.589GluTrp: 0.589 ± 0.033
1.787GluTyr: 1.787 ± 0.053
0.0GluXaa: 0.0 ± 0.0
Phe
3.705PheAla: 3.705 ± 0.084
0.543PheCys: 0.543 ± 0.035
3.714PheAsp: 3.714 ± 0.097
2.146PheGlu: 2.146 ± 0.067
1.876PhePhe: 1.876 ± 0.071
3.878PheGly: 3.878 ± 0.094
0.818PheHis: 0.818 ± 0.031
3.189PheIle: 3.189 ± 0.097
2.054PheLys: 2.054 ± 0.058
3.579PheLeu: 3.579 ± 0.094
1.112PheMet: 1.112 ± 0.042
2.072PheAsn: 2.072 ± 0.059
0.89PhePro: 0.89 ± 0.045
0.702PheGln: 0.702 ± 0.033
1.238PheArg: 1.238 ± 0.048
2.425PheSer: 2.425 ± 0.063
1.974PheThr: 1.974 ± 0.06
2.946PheVal: 2.946 ± 0.079
0.495PheTrp: 0.495 ± 0.03
1.528PheTyr: 1.528 ± 0.059
0.0PheXaa: 0.0 ± 0.0
Gly
5.286GlyAla: 5.286 ± 0.128
0.716GlyCys: 0.716 ± 0.036
3.882GlyAsp: 3.882 ± 0.109
3.933GlyGlu: 3.933 ± 0.08
3.412GlyPhe: 3.412 ± 0.081
4.981GlyGly: 4.981 ± 0.106
1.618GlyHis: 1.618 ± 0.052
4.596GlyIle: 4.596 ± 0.105
4.571GlyLys: 4.571 ± 0.102
6.911GlyLeu: 6.911 ± 0.118
2.349GlyMet: 2.349 ± 0.069
2.863GlyAsn: 2.863 ± 0.104
0.689GlyPro: 0.689 ± 0.039
3.143GlyGln: 3.143 ± 0.089
3.502GlyArg: 3.502 ± 0.089
3.52GlySer: 3.52 ± 0.095
3.538GlyThr: 3.538 ± 0.101
6.409GlyVal: 6.409 ± 0.12
0.707GlyTrp: 0.707 ± 0.038
2.481GlyTyr: 2.481 ± 0.065
0.0GlyXaa: 0.0 ± 0.0
His
2.551HisAla: 2.551 ± 0.067
0.215HisCys: 0.215 ± 0.019
1.743HisAsp: 1.743 ± 0.06
1.553HisGlu: 1.553 ± 0.053
1.017HisPhe: 1.017 ± 0.045
2.04HisGly: 2.04 ± 0.066
1.21HisHis: 1.21 ± 0.054
1.863HisIle: 1.863 ± 0.048
1.426HisLys: 1.426 ± 0.052
2.804HisLeu: 2.804 ± 0.074
0.475HisMet: 0.475 ± 0.029
1.012HisAsn: 1.012 ± 0.044
1.185HisPro: 1.185 ± 0.047
1.32HisGln: 1.32 ± 0.057
1.133HisArg: 1.133 ± 0.045
1.21HisSer: 1.21 ± 0.049
1.595HisThr: 1.595 ± 0.053
1.487HisVal: 1.487 ± 0.054
0.325HisTrp: 0.325 ± 0.024
0.905HisTyr: 0.905 ± 0.044
0.0HisXaa: 0.0 ± 0.0
Ile
6.22IleAla: 6.22 ± 0.111
0.835IleCys: 0.835 ± 0.047
4.96IleAsp: 4.96 ± 0.091
3.486IleGlu: 3.486 ± 0.089
2.59IlePhe: 2.59 ± 0.078
5.153IleGly: 5.153 ± 0.123
1.953IleHis: 1.953 ± 0.06
5.125IleIle: 5.125 ± 0.118
4.878IleLys: 4.878 ± 0.101
5.979IleLeu: 5.979 ± 0.134
1.672IleMet: 1.672 ± 0.057
3.986IleAsn: 3.986 ± 0.103
2.327IlePro: 2.327 ± 0.072
2.159IleGln: 2.159 ± 0.065
2.754IleArg: 2.754 ± 0.061
4.571IleSer: 4.571 ± 0.104
4.492IleThr: 4.492 ± 0.111
3.887IleVal: 3.887 ± 0.088
0.667IleTrp: 0.667 ± 0.031
2.156IleTyr: 2.156 ± 0.058
0.0IleXaa: 0.0 ± 0.0
Lys
5.23LysAla: 5.23 ± 0.099
0.356LysCys: 0.356 ± 0.028
4.071LysAsp: 4.071 ± 0.108
3.223LysGlu: 3.223 ± 0.075
1.844LysPhe: 1.844 ± 0.052
3.477LysGly: 3.477 ± 0.083
1.485LysHis: 1.485 ± 0.056
4.066LysIle: 4.066 ± 0.082
3.737LysLys: 3.737 ± 0.092
5.473LysLeu: 5.473 ± 0.103
1.646LysMet: 1.646 ± 0.056
3.74LysAsn: 3.74 ± 0.08
2.661LysPro: 2.661 ± 0.067
2.999LysGln: 2.999 ± 0.078
2.789LysArg: 2.789 ± 0.066
3.945LysSer: 3.945 ± 0.083
4.181LysThr: 4.181 ± 0.084
3.553LysVal: 3.553 ± 0.079
0.562LysTrp: 0.562 ± 0.032
1.758LysTyr: 1.758 ± 0.058
0.0LysXaa: 0.0 ± 0.0
Leu
9.478LeuAla: 9.478 ± 0.156
1.002LeuCys: 1.002 ± 0.043
6.494LeuAsp: 6.494 ± 0.124
4.155LeuGlu: 4.155 ± 0.097
3.809LeuPhe: 3.809 ± 0.094
7.027LeuGly: 7.027 ± 0.111
2.246LeuHis: 2.246 ± 0.071
6.586LeuIle: 6.586 ± 0.114
5.181LeuLys: 5.181 ± 0.104
9.283LeuLeu: 9.283 ± 0.17
2.82LeuMet: 2.82 ± 0.081
4.924LeuAsn: 4.924 ± 0.112
5.124LeuPro: 5.124 ± 0.097
3.423LeuGln: 3.423 ± 0.082
3.436LeuArg: 3.436 ± 0.073
7.88LeuSer: 7.88 ± 0.124
6.801LeuThr: 6.801 ± 0.111
5.893LeuVal: 5.893 ± 0.117
1.03LeuTrp: 1.03 ± 0.048
2.672LeuTyr: 2.672 ± 0.081
0.0LeuXaa: 0.0 ± 0.0
Met
2.882MetAla: 2.882 ± 0.07
0.225MetCys: 0.225 ± 0.018
1.421MetAsp: 1.421 ± 0.053
0.821MetGlu: 0.821 ± 0.043
0.815MetPhe: 0.815 ± 0.037
2.256MetGly: 2.256 ± 0.059
0.505MetHis: 0.505 ± 0.031
1.822MetIle: 1.822 ± 0.059
1.346MetLys: 1.346 ± 0.042
2.705MetLeu: 2.705 ± 0.075
1.092MetMet: 1.092 ± 0.047
1.594MetAsn: 1.594 ± 0.045
1.415MetPro: 1.415 ± 0.048
1.174MetGln: 1.174 ± 0.045
1.077MetArg: 1.077 ± 0.045
1.985MetSer: 1.985 ± 0.065
2.246MetThr: 2.246 ± 0.052
1.907MetVal: 1.907 ± 0.061
0.225MetTrp: 0.225 ± 0.019
0.654MetTyr: 0.654 ± 0.036
0.0MetXaa: 0.0 ± 0.0
Asn
4.483AsnAla: 4.483 ± 0.111
0.351AsnCys: 0.351 ± 0.026
3.148AsnAsp: 3.148 ± 0.081
2.545AsnGlu: 2.545 ± 0.072
1.912AsnPhe: 1.912 ± 0.064
3.012AsnGly: 3.012 ± 0.096
1.633AsnHis: 1.633 ± 0.057
3.627AsnIle: 3.627 ± 0.099
3.02AsnLys: 3.02 ± 0.078
4.524AsnLeu: 4.524 ± 0.082
1.154AsnMet: 1.154 ± 0.047
2.748AsnAsn: 2.748 ± 0.105
2.707AsnPro: 2.707 ± 0.071
2.353AsnGln: 2.353 ± 0.089
2.045AsnArg: 2.045 ± 0.061
2.436AsnSer: 2.436 ± 0.077
3.23AsnThr: 3.23 ± 0.096
2.702AsnVal: 2.702 ± 0.084
0.597AsnTrp: 0.597 ± 0.03
1.392AsnTyr: 1.392 ± 0.047
0.0AsnXaa: 0.0 ± 0.0
Pro
2.884ProAla: 2.884 ± 0.082
0.3ProCys: 0.3 ± 0.023
2.371ProAsp: 2.371 ± 0.069
1.753ProGlu: 1.753 ± 0.066
1.684ProPhe: 1.684 ± 0.054
0.867ProGly: 0.867 ± 0.044
0.972ProHis: 0.972 ± 0.041
3.092ProIle: 3.092 ± 0.078
3.104ProLys: 3.104 ± 0.078
3.482ProLeu: 3.482 ± 0.081
1.121ProMet: 1.121 ± 0.044
2.63ProAsn: 2.63 ± 0.07
1.225ProPro: 1.225 ± 0.047
1.39ProGln: 1.39 ± 0.052
1.141ProArg: 1.141 ± 0.049
2.505ProSer: 2.505 ± 0.065
2.905ProThr: 2.905 ± 0.076
2.356ProVal: 2.356 ± 0.071
0.315ProTrp: 0.315 ± 0.022
1.246ProTyr: 1.246 ± 0.054
0.0ProXaa: 0.0 ± 0.0
Gln
4.399GlnAla: 4.399 ± 0.104
0.23GlnCys: 0.23 ± 0.018
2.2GlnAsp: 2.2 ± 0.071
2.099GlnGlu: 2.099 ± 0.066
1.448GlnPhe: 1.448 ± 0.045
2.82GlnGly: 2.82 ± 0.08
0.928GlnHis: 0.928 ± 0.045
3.179GlnIle: 3.179 ± 0.08
2.982GlnLys: 2.982 ± 0.086
3.592GlnLeu: 3.592 ± 0.09
1.451GlnMet: 1.451 ± 0.044
2.497GlnAsn: 2.497 ± 0.081
1.154GlnPro: 1.154 ± 0.046
1.522GlnGln: 1.522 ± 0.053
1.574GlnArg: 1.574 ± 0.053
2.809GlnSer: 2.809 ± 0.068
2.897GlnThr: 2.897 ± 0.083
2.638GlnVal: 2.638 ± 0.066
0.349GlnTrp: 0.349 ± 0.025
1.166GlnTyr: 1.166 ± 0.043
0.0GlnXaa: 0.0 ± 0.0
Arg
3.317ArgAla: 3.317 ± 0.078
0.333ArgCys: 0.333 ± 0.023
2.141ArgAsp: 2.141 ± 0.069
2.323ArgGlu: 2.323 ± 0.064
2.074ArgPhe: 2.074 ± 0.071
2.499ArgGly: 2.499 ± 0.072
1.487ArgHis: 1.487 ± 0.051
2.858ArgIle: 2.858 ± 0.079
1.784ArgLys: 1.784 ± 0.057
5.15ArgLeu: 5.15 ± 0.121
1.19ArgMet: 1.19 ± 0.047
1.299ArgAsn: 1.299 ± 0.045
1.607ArgPro: 1.607 ± 0.052
2.297ArgGln: 2.297 ± 0.068
2.031ArgArg: 2.031 ± 0.059
2.018ArgSer: 2.018 ± 0.056
2.333ArgThr: 2.333 ± 0.067
2.676ArgVal: 2.676 ± 0.078
0.441ArgTrp: 0.441 ± 0.028
1.71ArgTyr: 1.71 ± 0.053
0.0ArgXaa: 0.0 ± 0.0
Ser
5.122SerAla: 5.122 ± 0.099
0.467SerCys: 0.467 ± 0.024
4.037SerAsp: 4.037 ± 0.092
3.11SerGlu: 3.11 ± 0.071
2.563SerPhe: 2.563 ± 0.072
4.232SerGly: 4.232 ± 0.086
1.843SerHis: 1.843 ± 0.056
3.653SerIle: 3.653 ± 0.078
3.036SerLys: 3.036 ± 0.079
5.947SerLeu: 5.947 ± 0.119
1.464SerMet: 1.464 ± 0.045
2.441SerAsn: 2.441 ± 0.076
2.225SerPro: 2.225 ± 0.059
2.745SerGln: 2.745 ± 0.083
2.366SerArg: 2.366 ± 0.066
3.491SerSer: 3.491 ± 0.093
3.268SerThr: 3.268 ± 0.089
4.287SerVal: 4.287 ± 0.08
0.571SerTrp: 0.571 ± 0.032
1.876SerTyr: 1.876 ± 0.057
0.0SerXaa: 0.0 ± 0.0
Thr
5.606ThrAla: 5.606 ± 0.124
0.536ThrCys: 0.536 ± 0.033
4.166ThrAsp: 4.166 ± 0.098
2.308ThrGlu: 2.308 ± 0.066
1.989ThrPhe: 1.989 ± 0.058
4.501ThrGly: 4.501 ± 0.108
2.069ThrHis: 2.069 ± 0.06
3.645ThrIle: 3.645 ± 0.083
3.318ThrLys: 3.318 ± 0.093
6.743ThrLeu: 6.743 ± 0.123
1.215ThrMet: 1.215 ± 0.048
2.786ThrAsn: 2.786 ± 0.1
3.386ThrPro: 3.386 ± 0.083
2.712ThrGln: 2.712 ± 0.076
1.994ThrArg: 1.994 ± 0.06
2.989ThrSer: 2.989 ± 0.08
3.815ThrThr: 3.815 ± 0.103
3.825ThrVal: 3.825 ± 0.09
0.512ThrTrp: 0.512 ± 0.028
1.625ThrTyr: 1.625 ± 0.05
0.0ThrXaa: 0.0 ± 0.0
Val
6.353ValAla: 6.353 ± 0.119
0.726ValCys: 0.726 ± 0.041
3.707ValAsp: 3.707 ± 0.077
2.776ValGlu: 2.776 ± 0.081
2.881ValPhe: 2.881 ± 0.083
5.179ValGly: 5.179 ± 0.11
1.541ValHis: 1.541 ± 0.054
5.006ValIle: 5.006 ± 0.104
3.535ValLys: 3.535 ± 0.084
6.762ValLeu: 6.762 ± 0.123
2.186ValMet: 2.186 ± 0.065
2.918ValAsn: 2.918 ± 0.078
2.359ValPro: 2.359 ± 0.073
2.422ValGln: 2.422 ± 0.061
3.123ValArg: 3.123 ± 0.078
4.437ValSer: 4.437 ± 0.092
2.836ValThr: 2.836 ± 0.076
5.256ValVal: 5.256 ± 0.125
0.749ValTrp: 0.749 ± 0.038
1.958ValTyr: 1.958 ± 0.061
0.0ValXaa: 0.0 ± 0.0
Trp
0.813TrpAla: 0.813 ± 0.036
0.139TrpCys: 0.139 ± 0.015
0.464TrpAsp: 0.464 ± 0.027
0.421TrpGlu: 0.421 ± 0.027
0.505TrpPhe: 0.505 ± 0.027
0.713TrpGly: 0.713 ± 0.038
0.366TrpHis: 0.366 ± 0.022
0.615TrpIle: 0.615 ± 0.034
0.316TrpLys: 0.316 ± 0.023
1.528TrpLeu: 1.528 ± 0.052
0.277TrpMet: 0.277 ± 0.025
0.248TrpAsn: 0.248 ± 0.022
0.085TrpPro: 0.085 ± 0.013
1.144TrpGln: 1.144 ± 0.053
0.562TrpArg: 0.562 ± 0.033
0.472TrpSer: 0.472 ± 0.028
0.502TrpThr: 0.502 ± 0.031
0.898TrpVal: 0.898 ± 0.04
0.131TrpTrp: 0.131 ± 0.014
0.382TrpTyr: 0.382 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.538TyrAla: 2.538 ± 0.067
0.326TyrCys: 0.326 ± 0.024
2.248TyrAsp: 2.248 ± 0.061
1.687TyrGlu: 1.687 ± 0.053
1.433TyrPhe: 1.433 ± 0.046
2.335TyrGly: 2.335 ± 0.059
1.217TyrHis: 1.217 ± 0.055
1.692TyrIle: 1.692 ± 0.053
1.579TyrLys: 1.579 ± 0.053
3.409TyrLeu: 3.409 ± 0.079
0.603TyrMet: 0.603 ± 0.032
1.259TyrAsn: 1.259 ± 0.049
1.387TyrPro: 1.387 ± 0.062
1.833TyrGln: 1.833 ± 0.054
1.612TyrArg: 1.612 ± 0.055
1.513TyrSer: 1.513 ± 0.053
1.6TyrThr: 1.6 ± 0.056
1.945TyrVal: 1.945 ± 0.054
0.362TyrTrp: 0.362 ± 0.023
1.231TyrTyr: 1.231 ± 0.046
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1937 proteins (609924 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski