Amino acid dipepetide frequency for Escherichia virus P88_4B11

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.403AlaAla: 9.403 ± 1.337
1.254AlaCys: 1.254 ± 0.309
6.627AlaAsp: 6.627 ± 0.829
7.433AlaGlu: 7.433 ± 0.791
3.672AlaPhe: 3.672 ± 0.648
7.343AlaGly: 7.343 ± 1.255
1.791AlaHis: 1.791 ± 0.399
6.537AlaIle: 6.537 ± 0.745
3.045AlaLys: 3.045 ± 0.601
10.298AlaLeu: 10.298 ± 1.392
2.418AlaMet: 2.418 ± 0.444
2.686AlaAsn: 2.686 ± 0.542
2.328AlaPro: 2.328 ± 0.407
3.492AlaGln: 3.492 ± 0.627
6.268AlaArg: 6.268 ± 1.059
5.104AlaSer: 5.104 ± 0.565
6.358AlaThr: 6.358 ± 1.063
7.254AlaVal: 7.254 ± 1.12
1.701AlaTrp: 1.701 ± 0.498
2.597AlaTyr: 2.597 ± 0.51
0.0AlaXaa: 0.0 ± 0.0
Cys
1.343CysAla: 1.343 ± 0.378
0.179CysCys: 0.179 ± 0.116
0.358CysAsp: 0.358 ± 0.151
0.537CysGlu: 0.537 ± 0.174
0.448CysPhe: 0.448 ± 0.198
1.433CysGly: 1.433 ± 0.424
0.179CysHis: 0.179 ± 0.118
0.537CysIle: 0.537 ± 0.224
0.358CysLys: 0.358 ± 0.182
0.269CysLeu: 0.269 ± 0.204
0.448CysMet: 0.448 ± 0.205
0.537CysAsn: 0.537 ± 0.205
1.075CysPro: 1.075 ± 0.277
0.269CysGln: 0.269 ± 0.163
1.075CysArg: 1.075 ± 0.383
0.269CysSer: 0.269 ± 0.171
0.448CysThr: 0.448 ± 0.234
0.627CysVal: 0.627 ± 0.286
0.09CysTrp: 0.09 ± 0.081
0.358CysTyr: 0.358 ± 0.273
0.0CysXaa: 0.0 ± 0.0
Asp
7.074AspAla: 7.074 ± 0.843
0.179AspCys: 0.179 ± 0.116
3.134AspAsp: 3.134 ± 0.562
4.298AspGlu: 4.298 ± 0.609
2.149AspPhe: 2.149 ± 0.48
5.642AspGly: 5.642 ± 0.642
0.985AspHis: 0.985 ± 0.305
3.403AspIle: 3.403 ± 0.541
2.597AspLys: 2.597 ± 0.583
4.567AspLeu: 4.567 ± 0.536
1.791AspMet: 1.791 ± 0.336
2.149AspAsn: 2.149 ± 0.505
0.895AspPro: 0.895 ± 0.28
1.254AspGln: 1.254 ± 0.307
3.582AspArg: 3.582 ± 0.569
4.119AspSer: 4.119 ± 0.637
3.851AspThr: 3.851 ± 0.576
4.03AspVal: 4.03 ± 0.583
1.075AspTrp: 1.075 ± 0.345
1.254AspTyr: 1.254 ± 0.312
0.0AspXaa: 0.0 ± 0.0
Glu
5.821GluAla: 5.821 ± 0.741
0.716GluCys: 0.716 ± 0.262
2.597GluAsp: 2.597 ± 0.424
2.239GluGlu: 2.239 ± 0.422
1.701GluPhe: 1.701 ± 0.51
3.313GluGly: 3.313 ± 0.68
1.612GluHis: 1.612 ± 0.317
4.388GluIle: 4.388 ± 0.614
3.851GluLys: 3.851 ± 0.607
5.731GluLeu: 5.731 ± 0.67
2.507GluMet: 2.507 ± 0.571
2.418GluAsn: 2.418 ± 0.426
2.149GluPro: 2.149 ± 0.555
3.134GluGln: 3.134 ± 0.61
5.731GluArg: 5.731 ± 0.965
3.761GluSer: 3.761 ± 0.634
4.567GluThr: 4.567 ± 0.635
3.134GluVal: 3.134 ± 0.618
1.254GluTrp: 1.254 ± 0.359
1.612GluTyr: 1.612 ± 0.371
0.0GluXaa: 0.0 ± 0.0
Phe
2.686PheAla: 2.686 ± 0.435
0.716PheCys: 0.716 ± 0.323
1.343PheAsp: 1.343 ± 0.291
1.97PheGlu: 1.97 ± 0.31
1.97PhePhe: 1.97 ± 0.406
2.149PheGly: 2.149 ± 0.509
0.448PheHis: 0.448 ± 0.181
2.149PheIle: 2.149 ± 0.627
2.418PheLys: 2.418 ± 0.517
2.239PheLeu: 2.239 ± 0.375
0.985PheMet: 0.985 ± 0.231
2.328PheAsn: 2.328 ± 0.559
1.075PhePro: 1.075 ± 0.297
1.075PheGln: 1.075 ± 0.285
2.507PheArg: 2.507 ± 0.591
2.866PheSer: 2.866 ± 0.405
3.045PheThr: 3.045 ± 0.49
1.791PheVal: 1.791 ± 0.453
0.537PheTrp: 0.537 ± 0.234
0.985PheTyr: 0.985 ± 0.278
0.0PheXaa: 0.0 ± 0.0
Gly
6.537GlyAla: 6.537 ± 0.628
0.716GlyCys: 0.716 ± 0.312
4.836GlyAsp: 4.836 ± 0.766
5.283GlyGlu: 5.283 ± 0.645
2.597GlyPhe: 2.597 ± 0.495
6.358GlyGly: 6.358 ± 0.887
0.895GlyHis: 0.895 ± 0.283
3.851GlyIle: 3.851 ± 0.61
4.477GlyLys: 4.477 ± 0.522
5.015GlyLeu: 5.015 ± 0.617
1.97GlyMet: 1.97 ± 0.41
3.672GlyAsn: 3.672 ± 0.49
1.791GlyPro: 1.791 ± 0.503
1.791GlyGln: 1.791 ± 0.397
3.94GlyArg: 3.94 ± 0.601
3.492GlySer: 3.492 ± 0.72
4.746GlyThr: 4.746 ± 0.564
4.477GlyVal: 4.477 ± 0.54
1.075GlyTrp: 1.075 ± 0.292
1.701GlyTyr: 1.701 ± 0.449
0.0GlyXaa: 0.0 ± 0.0
His
2.686HisAla: 2.686 ± 0.604
0.0HisCys: 0.0 ± 0.0
0.627HisAsp: 0.627 ± 0.164
1.522HisGlu: 1.522 ± 0.385
0.716HisPhe: 0.716 ± 0.3
1.343HisGly: 1.343 ± 0.299
0.627HisHis: 0.627 ± 0.245
1.075HisIle: 1.075 ± 0.307
0.985HisLys: 0.985 ± 0.321
1.97HisLeu: 1.97 ± 0.437
0.269HisMet: 0.269 ± 0.133
0.806HisAsn: 0.806 ± 0.22
0.895HisPro: 0.895 ± 0.269
1.075HisGln: 1.075 ± 0.251
1.164HisArg: 1.164 ± 0.333
0.627HisSer: 0.627 ± 0.273
1.164HisThr: 1.164 ± 0.341
1.075HisVal: 1.075 ± 0.361
0.269HisTrp: 0.269 ± 0.165
0.448HisTyr: 0.448 ± 0.198
0.0HisXaa: 0.0 ± 0.0
Ile
5.642IleAla: 5.642 ± 0.664
0.985IleCys: 0.985 ± 0.298
3.492IleAsp: 3.492 ± 0.644
3.045IleGlu: 3.045 ± 0.623
1.881IlePhe: 1.881 ± 0.427
4.836IleGly: 4.836 ± 0.71
0.627IleHis: 0.627 ± 0.255
3.582IleIle: 3.582 ± 0.753
2.06IleLys: 2.06 ± 0.511
2.955IleLeu: 2.955 ± 0.545
0.895IleMet: 0.895 ± 0.233
3.045IleAsn: 3.045 ± 0.51
1.254IlePro: 1.254 ± 0.31
2.866IleGln: 2.866 ± 0.371
4.925IleArg: 4.925 ± 0.714
4.298IleSer: 4.298 ± 0.653
4.209IleThr: 4.209 ± 0.559
2.866IleVal: 2.866 ± 0.468
0.627IleTrp: 0.627 ± 0.196
1.97IleTyr: 1.97 ± 0.474
0.0IleXaa: 0.0 ± 0.0
Lys
4.836LysAla: 4.836 ± 0.673
0.806LysCys: 0.806 ± 0.247
2.866LysAsp: 2.866 ± 0.441
2.776LysGlu: 2.776 ± 0.453
1.433LysPhe: 1.433 ± 0.438
2.328LysGly: 2.328 ± 0.501
1.075LysHis: 1.075 ± 0.328
2.597LysIle: 2.597 ± 0.567
3.403LysLys: 3.403 ± 0.602
5.015LysLeu: 5.015 ± 0.633
1.522LysMet: 1.522 ± 0.37
3.313LysAsn: 3.313 ± 0.562
2.149LysPro: 2.149 ± 0.372
2.866LysGln: 2.866 ± 0.635
2.866LysArg: 2.866 ± 0.618
3.313LysSer: 3.313 ± 0.421
3.224LysThr: 3.224 ± 0.431
2.328LysVal: 2.328 ± 0.442
0.895LysTrp: 0.895 ± 0.273
1.522LysTyr: 1.522 ± 0.316
0.0LysXaa: 0.0 ± 0.0
Leu
8.597LeuAla: 8.597 ± 1.281
1.164LeuCys: 1.164 ± 0.341
4.477LeuAsp: 4.477 ± 0.527
4.477LeuGlu: 4.477 ± 0.681
1.881LeuPhe: 1.881 ± 0.506
4.657LeuGly: 4.657 ± 0.798
1.343LeuHis: 1.343 ± 0.386
4.567LeuIle: 4.567 ± 0.603
5.373LeuLys: 5.373 ± 0.579
7.433LeuLeu: 7.433 ± 0.881
2.149LeuMet: 2.149 ± 0.462
4.03LeuAsn: 4.03 ± 0.463
4.477LeuPro: 4.477 ± 0.687
2.686LeuGln: 2.686 ± 0.492
7.791LeuArg: 7.791 ± 1.066
7.88LeuSer: 7.88 ± 0.842
6.448LeuThr: 6.448 ± 0.88
4.567LeuVal: 4.567 ± 0.672
1.881LeuTrp: 1.881 ± 0.423
2.597LeuTyr: 2.597 ± 0.418
0.0LeuXaa: 0.0 ± 0.0
Met
3.582MetAla: 3.582 ± 0.575
0.358MetCys: 0.358 ± 0.279
1.254MetAsp: 1.254 ± 0.248
0.985MetGlu: 0.985 ± 0.338
0.985MetPhe: 0.985 ± 0.27
1.433MetGly: 1.433 ± 0.438
0.448MetHis: 0.448 ± 0.214
1.343MetIle: 1.343 ± 0.396
1.522MetLys: 1.522 ± 0.303
2.06MetLeu: 2.06 ± 0.35
0.716MetMet: 0.716 ± 0.279
1.343MetAsn: 1.343 ± 0.435
1.164MetPro: 1.164 ± 0.428
0.806MetGln: 0.806 ± 0.295
1.881MetArg: 1.881 ± 0.3
2.686MetSer: 2.686 ± 0.556
1.612MetThr: 1.612 ± 0.342
0.895MetVal: 0.895 ± 0.255
0.09MetTrp: 0.09 ± 0.077
0.627MetTyr: 0.627 ± 0.227
0.0MetXaa: 0.0 ± 0.0
Asn
3.134AsnAla: 3.134 ± 0.584
0.269AsnCys: 0.269 ± 0.148
2.239AsnAsp: 2.239 ± 0.482
3.045AsnGlu: 3.045 ± 0.384
1.522AsnPhe: 1.522 ± 0.336
4.119AsnGly: 4.119 ± 0.866
0.806AsnHis: 0.806 ± 0.277
2.597AsnIle: 2.597 ± 0.542
1.522AsnLys: 1.522 ± 0.328
2.418AsnLeu: 2.418 ± 0.37
0.895AsnMet: 0.895 ± 0.307
2.06AsnAsn: 2.06 ± 0.454
3.045AsnPro: 3.045 ± 0.589
1.612AsnGln: 1.612 ± 0.487
2.686AsnArg: 2.686 ± 0.517
2.507AsnSer: 2.507 ± 0.582
3.224AsnThr: 3.224 ± 0.548
2.328AsnVal: 2.328 ± 0.525
1.164AsnTrp: 1.164 ± 0.291
0.627AsnTyr: 0.627 ± 0.264
0.0AsnXaa: 0.0 ± 0.0
Pro
4.119ProAla: 4.119 ± 0.808
0.179ProCys: 0.179 ± 0.142
3.94ProAsp: 3.94 ± 0.542
3.761ProGlu: 3.761 ± 0.635
0.806ProPhe: 0.806 ± 0.278
2.418ProGly: 2.418 ± 0.579
0.806ProHis: 0.806 ± 0.3
0.895ProIle: 0.895 ± 0.232
2.06ProLys: 2.06 ± 0.408
3.761ProLeu: 3.761 ± 0.491
0.716ProMet: 0.716 ± 0.266
0.895ProAsn: 0.895 ± 0.222
1.612ProPro: 1.612 ± 0.387
1.881ProGln: 1.881 ± 0.386
1.791ProArg: 1.791 ± 0.475
1.881ProSer: 1.881 ± 0.407
1.701ProThr: 1.701 ± 0.408
4.209ProVal: 4.209 ± 0.69
0.448ProTrp: 0.448 ± 0.219
1.343ProTyr: 1.343 ± 0.381
0.0ProXaa: 0.0 ± 0.0
Gln
4.567GlnAla: 4.567 ± 0.685
0.537GlnCys: 0.537 ± 0.289
2.776GlnAsp: 2.776 ± 0.427
2.328GlnGlu: 2.328 ± 0.424
1.343GlnPhe: 1.343 ± 0.343
2.149GlnGly: 2.149 ± 0.34
0.537GlnHis: 0.537 ± 0.183
1.97GlnIle: 1.97 ± 0.513
2.866GlnLys: 2.866 ± 0.46
4.925GlnLeu: 4.925 ± 0.665
0.895GlnMet: 0.895 ± 0.312
1.612GlnAsn: 1.612 ± 0.268
1.97GlnPro: 1.97 ± 0.334
2.776GlnGln: 2.776 ± 0.573
2.955GlnArg: 2.955 ± 0.575
1.701GlnSer: 1.701 ± 0.373
2.328GlnThr: 2.328 ± 0.46
1.791GlnVal: 1.791 ± 0.322
0.269GlnTrp: 0.269 ± 0.13
0.627GlnTyr: 0.627 ± 0.256
0.0GlnXaa: 0.0 ± 0.0
Arg
6.895ArgAla: 6.895 ± 0.875
0.537ArgCys: 0.537 ± 0.205
3.672ArgAsp: 3.672 ± 0.803
5.463ArgGlu: 5.463 ± 0.634
3.134ArgPhe: 3.134 ± 0.565
3.403ArgGly: 3.403 ± 0.509
2.149ArgHis: 2.149 ± 0.409
3.851ArgIle: 3.851 ± 0.688
4.836ArgLys: 4.836 ± 0.874
6.716ArgLeu: 6.716 ± 0.675
1.164ArgMet: 1.164 ± 0.275
2.866ArgAsn: 2.866 ± 0.573
2.507ArgPro: 2.507 ± 0.35
2.955ArgGln: 2.955 ± 0.625
4.209ArgArg: 4.209 ± 0.7
3.313ArgSer: 3.313 ± 0.489
4.477ArgThr: 4.477 ± 0.673
5.552ArgVal: 5.552 ± 0.598
0.985ArgTrp: 0.985 ± 0.274
2.507ArgTyr: 2.507 ± 0.521
0.0ArgXaa: 0.0 ± 0.0
Ser
6.448SerAla: 6.448 ± 0.832
0.716SerCys: 0.716 ± 0.355
3.134SerAsp: 3.134 ± 0.491
4.119SerGlu: 4.119 ± 0.765
2.239SerPhe: 2.239 ± 0.531
4.925SerGly: 4.925 ± 0.684
1.164SerHis: 1.164 ± 0.343
3.582SerIle: 3.582 ± 0.583
1.791SerLys: 1.791 ± 0.47
6.985SerLeu: 6.985 ± 0.861
1.075SerMet: 1.075 ± 0.325
1.522SerAsn: 1.522 ± 0.344
2.866SerPro: 2.866 ± 0.474
2.239SerGln: 2.239 ± 0.488
5.015SerArg: 5.015 ± 0.699
4.477SerSer: 4.477 ± 0.751
3.761SerThr: 3.761 ± 0.744
4.119SerVal: 4.119 ± 0.62
1.343SerTrp: 1.343 ± 0.362
1.164SerTyr: 1.164 ± 0.368
0.0SerXaa: 0.0 ± 0.0
Thr
5.91ThrAla: 5.91 ± 0.981
0.537ThrCys: 0.537 ± 0.272
4.209ThrAsp: 4.209 ± 0.57
4.209ThrGlu: 4.209 ± 0.713
2.149ThrPhe: 2.149 ± 0.369
5.642ThrGly: 5.642 ± 0.661
1.075ThrHis: 1.075 ± 0.339
2.597ThrIle: 2.597 ± 0.464
2.597ThrLys: 2.597 ± 0.531
6.806ThrLeu: 6.806 ± 0.647
1.881ThrMet: 1.881 ± 0.438
2.06ThrAsn: 2.06 ± 0.679
4.209ThrPro: 4.209 ± 0.577
2.955ThrGln: 2.955 ± 0.519
5.373ThrArg: 5.373 ± 0.653
4.209ThrSer: 4.209 ± 0.693
4.477ThrThr: 4.477 ± 0.833
4.477ThrVal: 4.477 ± 0.642
0.627ThrTrp: 0.627 ± 0.267
1.254ThrTyr: 1.254 ± 0.336
0.0ThrXaa: 0.0 ± 0.0
Val
5.194ValAla: 5.194 ± 0.753
0.537ValCys: 0.537 ± 0.215
3.761ValAsp: 3.761 ± 0.522
2.955ValGlu: 2.955 ± 0.388
2.866ValPhe: 2.866 ± 0.549
2.686ValGly: 2.686 ± 0.541
1.343ValHis: 1.343 ± 0.3
4.209ValIle: 4.209 ± 0.754
3.492ValLys: 3.492 ± 0.713
4.657ValLeu: 4.657 ± 0.766
2.149ValMet: 2.149 ± 0.592
3.134ValAsn: 3.134 ± 0.642
1.791ValPro: 1.791 ± 0.372
2.418ValGln: 2.418 ± 0.438
4.119ValArg: 4.119 ± 0.52
4.119ValSer: 4.119 ± 0.54
5.463ValThr: 5.463 ± 0.649
3.492ValVal: 3.492 ± 0.691
0.716ValTrp: 0.716 ± 0.226
1.522ValTyr: 1.522 ± 0.267
0.0ValXaa: 0.0 ± 0.0
Trp
0.716TrpAla: 0.716 ± 0.221
0.179TrpCys: 0.179 ± 0.117
0.716TrpAsp: 0.716 ± 0.215
0.627TrpGlu: 0.627 ± 0.225
0.627TrpPhe: 0.627 ± 0.203
0.806TrpGly: 0.806 ± 0.294
1.075TrpHis: 1.075 ± 0.231
0.627TrpIle: 0.627 ± 0.231
1.164TrpLys: 1.164 ± 0.398
2.149TrpLeu: 2.149 ± 0.403
0.537TrpMet: 0.537 ± 0.188
0.537TrpAsn: 0.537 ± 0.224
0.716TrpPro: 0.716 ± 0.244
1.075TrpGln: 1.075 ± 0.332
1.343TrpArg: 1.343 ± 0.411
1.075TrpSer: 1.075 ± 0.322
0.358TrpThr: 0.358 ± 0.182
0.358TrpVal: 0.358 ± 0.169
0.358TrpTrp: 0.358 ± 0.164
0.985TrpTyr: 0.985 ± 0.306
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.418TyrAla: 2.418 ± 0.417
0.269TyrCys: 0.269 ± 0.17
1.97TyrAsp: 1.97 ± 0.339
1.164TyrGlu: 1.164 ± 0.318
1.164TyrPhe: 1.164 ± 0.357
2.239TyrGly: 2.239 ± 0.419
0.358TyrHis: 0.358 ± 0.164
1.791TyrIle: 1.791 ± 0.398
0.716TyrLys: 0.716 ± 0.241
2.507TyrLeu: 2.507 ± 0.596
0.716TyrMet: 0.716 ± 0.229
0.806TyrAsn: 0.806 ± 0.226
1.254TyrPro: 1.254 ± 0.441
1.701TyrGln: 1.701 ± 0.387
1.97TyrArg: 1.97 ± 0.467
0.985TyrSer: 0.985 ± 0.288
1.791TyrThr: 1.791 ± 0.427
1.254TyrVal: 1.254 ± 0.329
0.627TyrTrp: 0.627 ± 0.223
0.537TyrTyr: 0.537 ± 0.229
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 56 proteins (11168 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski