Amino acid dipepetide frequency for Aureobasidium melanogenum CBS 110374

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.405AlaAla: 9.405 ± 0.058	1.152AlaCys: 1.152 ± 0.019	4.406AlaAsp: 4.406 ± 0.036	5.228AlaGlu: 5.228 ± 0.036	3.285AlaPhe: 3.285 ± 0.031	5.626AlaGly: 5.626 ± 0.042	1.843AlaHis: 1.843 ± 0.021	4.405AlaIle: 4.405 ± 0.039	4.317AlaLys: 4.317 ± 0.036	7.922AlaLeu: 7.922 ± 0.052	2.055AlaMet: 2.055 ± 0.02	3.214AlaAsn: 3.214 ± 0.03	4.859AlaPro: 4.859 ± 0.04	3.772AlaGln: 3.772 ± 0.034	4.808AlaArg: 4.808 ± 0.035	7.584AlaSer: 7.584 ± 0.054	5.397AlaThr: 5.397 ± 0.034	5.419AlaVal: 5.419 ± 0.039	1.201AlaTrp: 1.201 ± 0.019	2.355AlaTyr: 2.355 ± 0.025	0.0AlaXaa: 0.0 ± 0.0
Cys	1.005CysAla: 1.005 ± 0.017	0.244CysCys: 0.244 ± 0.008	0.679CysAsp: 0.679 ± 0.012	0.621CysGlu: 0.621 ± 0.012	0.568CysPhe: 0.568 ± 0.013	0.941CysGly: 0.941 ± 0.019	0.331CysHis: 0.331 ± 0.01	0.752CysIle: 0.752 ± 0.014	0.59CysLys: 0.59 ± 0.014	1.272CysLeu: 1.272 ± 0.018	0.288CysMet: 0.288 ± 0.008	0.496CysAsn: 0.496 ± 0.01	0.668CysPro: 0.668 ± 0.015	0.466CysGln: 0.466 ± 0.011	0.724CysArg: 0.724 ± 0.016	0.933CysSer: 0.933 ± 0.017	0.729CysThr: 0.729 ± 0.015	0.798CysVal: 0.798 ± 0.015	0.201CysTrp: 0.201 ± 0.007	0.37CysTyr: 0.37 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	4.947AspAla: 4.947 ± 0.035	0.658AspCys: 0.658 ± 0.013	4.371AspAsp: 4.371 ± 0.044	4.611AspGlu: 4.611 ± 0.04	2.29AspPhe: 2.29 ± 0.019	3.756AspGly: 3.756 ± 0.029	1.262AspHis: 1.262 ± 0.017	3.042AspIle: 3.042 ± 0.029	2.68AspLys: 2.68 ± 0.027	5.155AspLeu: 5.155 ± 0.036	1.434AspMet: 1.434 ± 0.017	2.062AspAsn: 2.062 ± 0.023	3.191AspPro: 3.191 ± 0.03	2.084AspGln: 2.084 ± 0.024	2.921AspArg: 2.921 ± 0.032	4.131AspSer: 4.131 ± 0.031	3.098AspThr: 3.098 ± 0.026	3.714AspVal: 3.714 ± 0.029	0.942AspTrp: 0.942 ± 0.015	1.68AspTyr: 1.68 ± 0.019	0.0AspXaa: 0.0 ± 0.0
Glu	5.414GluAla: 5.414 ± 0.041	0.597GluCys: 0.597 ± 0.013	4.362GluAsp: 4.362 ± 0.038	5.241GluGlu: 5.241 ± 0.048	1.871GluPhe: 1.871 ± 0.019	3.512GluGly: 3.512 ± 0.033	1.522GluHis: 1.522 ± 0.018	2.941GluIle: 2.941 ± 0.032	3.807GluLys: 3.807 ± 0.036	5.121GluLeu: 5.121 ± 0.042	1.51GluMet: 1.51 ± 0.017	2.259GluAsn: 2.259 ± 0.024	2.601GluPro: 2.601 ± 0.026	2.767GluGln: 2.767 ± 0.026	3.73GluArg: 3.73 ± 0.034	4.063GluSer: 4.063 ± 0.032	3.437GluThr: 3.437 ± 0.028	3.505GluVal: 3.505 ± 0.032	0.87GluTrp: 0.87 ± 0.013	1.663GluTyr: 1.663 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	3.3PheAla: 3.3 ± 0.028	0.599PheCys: 0.599 ± 0.013	2.369PheAsp: 2.369 ± 0.021	2.231PheGlu: 2.231 ± 0.024	1.654PhePhe: 1.654 ± 0.021	2.902PheGly: 2.902 ± 0.033	0.836PheHis: 0.836 ± 0.014	1.787PheIle: 1.787 ± 0.022	1.582PheLys: 1.582 ± 0.022	3.366PheLeu: 3.366 ± 0.031	0.812PheMet: 0.812 ± 0.015	1.501PheAsn: 1.501 ± 0.019	1.801PhePro: 1.801 ± 0.023	1.285PheGln: 1.285 ± 0.015	1.829PheArg: 1.829 ± 0.02	3.019PheSer: 3.019 ± 0.024	2.169PheThr: 2.169 ± 0.019	2.493PheVal: 2.493 ± 0.026	0.657PheTrp: 0.657 ± 0.014	1.113PheTyr: 1.113 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	5.157GlyAla: 5.157 ± 0.04	0.883GlyCys: 0.883 ± 0.016	3.353GlyAsp: 3.353 ± 0.027	3.317GlyGlu: 3.317 ± 0.032	2.752GlyPhe: 2.752 ± 0.029	5.164GlyGly: 5.164 ± 0.046	1.62GlyHis: 1.62 ± 0.022	3.42GlyIle: 3.42 ± 0.031	3.409GlyLys: 3.409 ± 0.029	5.82GlyLeu: 5.82 ± 0.042	1.607GlyMet: 1.607 ± 0.025	2.518GlyAsn: 2.518 ± 0.027	2.951GlyPro: 2.951 ± 0.03	2.526GlyGln: 2.526 ± 0.028	3.672GlyArg: 3.672 ± 0.031	5.315GlySer: 5.315 ± 0.039	3.762GlyThr: 3.762 ± 0.032	4.236GlyVal: 4.236 ± 0.039	1.146GlyTrp: 1.146 ± 0.017	2.157GlyTyr: 2.157 ± 0.025	0.0GlyXaa: 0.0 ± 0.0
His	1.919HisAla: 1.919 ± 0.022	0.345HisCys: 0.345 ± 0.009	1.427HisAsp: 1.427 ± 0.019	1.422HisGlu: 1.422 ± 0.015	0.927HisPhe: 0.927 ± 0.016	1.627HisGly: 1.627 ± 0.021	0.838HisHis: 0.838 ± 0.016	1.237HisIle: 1.237 ± 0.015	1.047HisLys: 1.047 ± 0.017	2.259HisLeu: 2.259 ± 0.025	0.545HisMet: 0.545 ± 0.011	0.961HisAsn: 0.961 ± 0.015	1.537HisPro: 1.537 ± 0.019	1.005HisGln: 1.005 ± 0.015	1.407HisArg: 1.407 ± 0.016	1.772HisSer: 1.772 ± 0.024	1.334HisThr: 1.334 ± 0.02	1.485HisVal: 1.485 ± 0.016	0.354HisTrp: 0.354 ± 0.009	0.715HisTyr: 0.715 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	4.384IleAla: 4.384 ± 0.036	0.788IleCys: 0.788 ± 0.014	2.98IleAsp: 2.98 ± 0.024	2.938IleGlu: 2.938 ± 0.025	2.0IlePhe: 2.0 ± 0.025	3.195IleGly: 3.195 ± 0.031	1.196IleHis: 1.196 ± 0.016	2.51IleIle: 2.51 ± 0.028	2.414IleLys: 2.414 ± 0.024	4.389IleLeu: 4.389 ± 0.036	1.087IleMet: 1.087 ± 0.016	1.96IleAsn: 1.96 ± 0.023	2.824IlePro: 2.824 ± 0.029	1.865IleGln: 1.865 ± 0.02	2.628IleArg: 2.628 ± 0.024	3.879IleSer: 3.879 ± 0.029	2.933IleThr: 2.933 ± 0.023	3.224IleVal: 3.224 ± 0.032	0.757IleTrp: 0.757 ± 0.013	1.436IleTyr: 1.436 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	4.536LysAla: 4.536 ± 0.037	0.531LysCys: 0.531 ± 0.012	3.084LysAsp: 3.084 ± 0.03	3.484LysGlu: 3.484 ± 0.033	1.51LysPhe: 1.51 ± 0.019	2.958LysGly: 2.958 ± 0.03	1.278LysHis: 1.278 ± 0.017	2.392LysIle: 2.392 ± 0.025	3.594LysLys: 3.594 ± 0.047	4.187LysLeu: 4.187 ± 0.034	1.089LysMet: 1.089 ± 0.014	1.938LysAsn: 1.938 ± 0.024	2.803LysPro: 2.803 ± 0.034	2.187LysGln: 2.187 ± 0.026	3.393LysArg: 3.393 ± 0.03	3.645LysSer: 3.645 ± 0.034	3.065LysThr: 3.065 ± 0.028	2.966LysVal: 2.966 ± 0.023	0.68LysTrp: 0.68 ± 0.013	1.42LysTyr: 1.42 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	7.94LeuAla: 7.94 ± 0.047	1.241LeuCys: 1.241 ± 0.016	5.37LeuAsp: 5.37 ± 0.04	5.408LeuGlu: 5.408 ± 0.046	3.325LeuPhe: 3.325 ± 0.031	5.656LeuGly: 5.656 ± 0.039	2.178LeuHis: 2.178 ± 0.021	3.949LeuIle: 3.949 ± 0.034	4.27LeuLys: 4.27 ± 0.032	8.178LeuLeu: 8.178 ± 0.065	1.823LeuMet: 1.823 ± 0.019	3.324LeuAsn: 3.324 ± 0.029	5.351LeuPro: 5.351 ± 0.031	3.845LeuGln: 3.845 ± 0.03	5.557LeuArg: 5.557 ± 0.041	7.245LeuSer: 7.245 ± 0.043	4.872LeuThr: 4.872 ± 0.04	5.33LeuVal: 5.33 ± 0.041	1.188LeuTrp: 1.188 ± 0.017	2.397LeuTyr: 2.397 ± 0.025	0.0LeuXaa: 0.0 ± 0.0
Met	2.272MetAla: 2.272 ± 0.024	0.258MetCys: 0.258 ± 0.007	1.315MetAsp: 1.315 ± 0.017	1.223MetGlu: 1.223 ± 0.017	0.807MetPhe: 0.807 ± 0.015	1.392MetGly: 1.392 ± 0.019	0.545MetHis: 0.545 ± 0.012	1.068MetIle: 1.068 ± 0.015	0.985MetLys: 0.985 ± 0.015	2.01MetLeu: 2.01 ± 0.021	0.584MetMet: 0.584 ± 0.012	0.877MetAsn: 0.877 ± 0.013	1.387MetPro: 1.387 ± 0.019	0.986MetGln: 0.986 ± 0.017	1.266MetArg: 1.266 ± 0.015	2.018MetSer: 2.018 ± 0.02	1.343MetThr: 1.343 ± 0.017	1.322MetVal: 1.322 ± 0.018	0.27MetTrp: 0.27 ± 0.007	0.569MetTyr: 0.569 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	3.412AsnAla: 3.412 ± 0.027	0.436AsnCys: 0.436 ± 0.011	2.18AsnAsp: 2.18 ± 0.022	2.065AsnGlu: 2.065 ± 0.023	1.482AsnPhe: 1.482 ± 0.02	2.833AsnGly: 2.833 ± 0.031	0.941AsnHis: 0.941 ± 0.014	2.184AsnIle: 2.184 ± 0.024	1.84AsnLys: 1.84 ± 0.022	3.43AsnLeu: 3.43 ± 0.031	0.937AsnMet: 0.937 ± 0.017	1.722AsnAsn: 1.722 ± 0.022	2.42AsnPro: 2.42 ± 0.023	1.463AsnGln: 1.463 ± 0.02	1.862AsnArg: 1.862 ± 0.021	2.856AsnSer: 2.856 ± 0.029	2.47AsnThr: 2.47 ± 0.026	2.43AsnVal: 2.43 ± 0.024	0.566AsnTrp: 0.566 ± 0.01	1.14AsnTyr: 1.14 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	5.224ProAla: 5.224 ± 0.038	0.503ProCys: 0.503 ± 0.011	3.099ProAsp: 3.099 ± 0.026	3.68ProGlu: 3.68 ± 0.034	1.972ProPhe: 1.972 ± 0.022	3.431ProGly: 3.431 ± 0.033	1.273ProHis: 1.273 ± 0.019	2.457ProIle: 2.457 ± 0.028	2.686ProLys: 2.686 ± 0.028	4.515ProLeu: 4.515 ± 0.037	1.084ProMet: 1.084 ± 0.017	2.134ProAsn: 2.134 ± 0.027	4.434ProPro: 4.434 ± 0.062	2.536ProGln: 2.536 ± 0.031	3.074ProArg: 3.074 ± 0.029	5.791ProSer: 5.791 ± 0.047	3.942ProThr: 3.942 ± 0.032	3.444ProVal: 3.444 ± 0.029	0.707ProTrp: 0.707 ± 0.012	1.522ProTyr: 1.522 ± 0.018	0.0ProXaa: 0.0 ± 0.0
Gln	3.698GlnAla: 3.698 ± 0.027	0.462GlnCys: 0.462 ± 0.011	2.337GlnAsp: 2.337 ± 0.022	2.553GlnGlu: 2.553 ± 0.027	1.246GlnPhe: 1.246 ± 0.015	2.431GlnGly: 2.431 ± 0.027	1.231GlnHis: 1.231 ± 0.02	1.962GlnIle: 1.962 ± 0.02	2.235GlnLys: 2.235 ± 0.021	3.46GlnLeu: 3.46 ± 0.033	0.946GlnMet: 0.946 ± 0.015	1.708GlnAsn: 1.708 ± 0.02	2.575GlnPro: 2.575 ± 0.031	2.758GlnGln: 2.758 ± 0.046	2.652GlnArg: 2.652 ± 0.024	3.235GlnSer: 3.235 ± 0.032	2.525GlnThr: 2.525 ± 0.024	2.179GlnVal: 2.179 ± 0.02	0.571GlnTrp: 0.571 ± 0.011	1.214GlnTyr: 1.214 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	4.517ArgAla: 4.517 ± 0.033	0.723ArgCys: 0.723 ± 0.016	3.148ArgAsp: 3.148 ± 0.029	3.567ArgGlu: 3.567 ± 0.029	2.046ArgPhe: 2.046 ± 0.02	3.298ArgGly: 3.298 ± 0.034	1.487ArgHis: 1.487 ± 0.018	2.819ArgIle: 2.819 ± 0.025	3.51ArgLys: 3.51 ± 0.029	5.264ArgLeu: 5.264 ± 0.033	1.326ArgMet: 1.326 ± 0.019	2.25ArgAsn: 2.25 ± 0.023	3.246ArgPro: 3.246 ± 0.031	2.617ArgGln: 2.617 ± 0.024	4.561ArgArg: 4.561 ± 0.046	4.483ArgSer: 4.483 ± 0.044	3.177ArgThr: 3.177 ± 0.028	3.151ArgVal: 3.151 ± 0.026	0.866ArgTrp: 0.866 ± 0.014	1.605ArgTyr: 1.605 ± 0.019	0.0ArgXaa: 0.0 ± 0.0
Ser	7.083SerAla: 7.083 ± 0.051	0.946SerCys: 0.946 ± 0.016	4.327SerAsp: 4.327 ± 0.03	4.049SerGlu: 4.049 ± 0.033	2.972SerPhe: 2.972 ± 0.026	5.286SerGly: 5.286 ± 0.042	1.926SerHis: 1.926 ± 0.023	4.061SerIle: 4.061 ± 0.031	3.845SerLys: 3.845 ± 0.034	7.093SerLeu: 7.093 ± 0.047	1.752SerMet: 1.752 ± 0.021	3.198SerAsn: 3.198 ± 0.027	5.124SerPro: 5.124 ± 0.051	3.319SerGln: 3.319 ± 0.034	4.731SerArg: 4.731 ± 0.038	8.987SerSer: 8.987 ± 0.096	5.853SerThr: 5.853 ± 0.051	4.645SerVal: 4.645 ± 0.037	1.128SerTrp: 1.128 ± 0.017	2.143SerTyr: 2.143 ± 0.022	0.0SerXaa: 0.0 ± 0.0
Thr	5.357ThrAla: 5.357 ± 0.036	0.804ThrCys: 0.804 ± 0.014	2.893ThrAsp: 2.893 ± 0.025	3.071ThrGlu: 3.071 ± 0.028	2.356ThrPhe: 2.356 ± 0.025	3.993ThrGly: 3.993 ± 0.034	1.329ThrHis: 1.329 ± 0.018	3.236ThrIle: 3.236 ± 0.029	2.848ThrLys: 2.848 ± 0.029	5.314ThrLeu: 5.314 ± 0.031	1.216ThrMet: 1.216 ± 0.016	2.358ThrAsn: 2.358 ± 0.021	4.22ThrPro: 4.22 ± 0.036	2.288ThrGln: 2.288 ± 0.025	3.112ThrArg: 3.112 ± 0.024	5.644ThrSer: 5.644 ± 0.053	4.514ThrThr: 4.514 ± 0.051	3.711ThrVal: 3.711 ± 0.032	0.883ThrTrp: 0.883 ± 0.014	1.708ThrTyr: 1.708 ± 0.021	0.0ThrXaa: 0.0 ± 0.0
Val	5.279ValAla: 5.279 ± 0.038	0.845ValCys: 0.845 ± 0.014	3.701ValAsp: 3.701 ± 0.027	3.741ValGlu: 3.741 ± 0.032	2.474ValPhe: 2.474 ± 0.026	3.8ValGly: 3.8 ± 0.036	1.399ValHis: 1.399 ± 0.017	2.918ValIle: 2.918 ± 0.029	3.05ValLys: 3.05 ± 0.022	5.581ValLeu: 5.581 ± 0.039	1.357ValMet: 1.357 ± 0.016	2.288ValAsn: 2.288 ± 0.023	3.437ValPro: 3.437 ± 0.03	2.443ValGln: 2.443 ± 0.027	3.287ValArg: 3.287 ± 0.028	4.685ValSer: 4.685 ± 0.036	3.524ValThr: 3.524 ± 0.028	4.261ValVal: 4.261 ± 0.034	0.879ValTrp: 0.879 ± 0.015	1.798ValTyr: 1.798 ± 0.02	0.0ValXaa: 0.0 ± 0.0
Trp	1.086TrpAla: 1.086 ± 0.015	0.213TrpCys: 0.213 ± 0.006	0.866TrpAsp: 0.866 ± 0.018	0.796TrpGlu: 0.796 ± 0.014	0.569TrpPhe: 0.569 ± 0.011	0.882TrpGly: 0.882 ± 0.015	0.372TrpHis: 0.372 ± 0.008	0.803TrpIle: 0.803 ± 0.013	0.816TrpLys: 0.816 ± 0.014	1.384TrpLeu: 1.384 ± 0.018	0.39TrpMet: 0.39 ± 0.009	0.656TrpAsn: 0.656 ± 0.011	0.588TrpPro: 0.588 ± 0.013	0.633TrpGln: 0.633 ± 0.012	0.906TrpArg: 0.906 ± 0.013	1.149TrpSer: 1.149 ± 0.017	0.943TrpThr: 0.943 ± 0.014	0.815TrpVal: 0.815 ± 0.014	0.284TrpTrp: 0.284 ± 0.007	0.454TrpTyr: 0.454 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.316TyrAla: 2.316 ± 0.021	0.449TyrCys: 0.449 ± 0.011	1.761TyrAsp: 1.761 ± 0.02	1.549TyrGlu: 1.549 ± 0.018	1.196TyrPhe: 1.196 ± 0.016	2.1TyrGly: 2.1 ± 0.025	0.758TyrHis: 0.758 ± 0.013	1.444TyrIle: 1.444 ± 0.021	1.215TyrLys: 1.215 ± 0.015	2.728TyrLeu: 2.728 ± 0.025	0.654TyrMet: 0.654 ± 0.011	1.244TyrAsn: 1.244 ± 0.018	1.492TyrPro: 1.492 ± 0.017	1.134TyrGln: 1.134 ± 0.017	1.539TyrArg: 1.539 ± 0.017	2.037TyrSer: 2.037 ± 0.022	1.766TyrThr: 1.766 ± 0.023	1.62TyrVal: 1.62 ± 0.018	0.457TyrTrp: 0.457 ± 0.011	0.969TyrTyr: 0.969 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 10583 proteins (4696349 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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