Amino acid dipepetide frequency for Podoviridae sp. ctcf755

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.477AlaAla: 2.477 ± 0.536
0.598AlaCys: 0.598 ± 0.208
1.965AlaAsp: 1.965 ± 0.391
3.588AlaGlu: 3.588 ± 0.619
2.135AlaPhe: 2.135 ± 0.347
1.623AlaGly: 1.623 ± 0.47
0.513AlaHis: 0.513 ± 0.182
5.04AlaIle: 5.04 ± 0.653
5.381AlaLys: 5.381 ± 0.852
4.1AlaLeu: 4.1 ± 0.557
1.281AlaMet: 1.281 ± 0.388
4.356AlaAsn: 4.356 ± 0.619
1.025AlaPro: 1.025 ± 0.315
1.794AlaGln: 1.794 ± 0.4
1.794AlaArg: 1.794 ± 0.364
3.075AlaSer: 3.075 ± 0.513
3.246AlaThr: 3.246 ± 0.586
2.477AlaVal: 2.477 ± 0.461
0.342AlaTrp: 0.342 ± 0.149
2.221AlaTyr: 2.221 ± 0.425
0.0AlaXaa: 0.0 ± 0.0
Cys
0.513CysAla: 0.513 ± 0.193
0.683CysCys: 0.683 ± 0.282
0.854CysAsp: 0.854 ± 0.33
1.11CysGlu: 1.11 ± 0.347
0.683CysPhe: 0.683 ± 0.219
1.367CysGly: 1.367 ± 0.368
0.171CysHis: 0.171 ± 0.13
1.538CysIle: 1.538 ± 0.375
1.196CysLys: 1.196 ± 0.361
1.025CysLeu: 1.025 ± 0.297
0.0CysMet: 0.0 ± 0.0
0.598CysAsn: 0.598 ± 0.229
0.683CysPro: 0.683 ± 0.279
0.513CysGln: 0.513 ± 0.279
0.513CysArg: 0.513 ± 0.196
1.025CysSer: 1.025 ± 0.303
0.598CysThr: 0.598 ± 0.185
0.769CysVal: 0.769 ± 0.255
0.085CysTrp: 0.085 ± 0.094
0.94CysTyr: 0.94 ± 0.253
0.0CysXaa: 0.0 ± 0.0
Asp
2.648AspAla: 2.648 ± 0.496
1.025AspCys: 1.025 ± 0.374
4.271AspAsp: 4.271 ± 0.654
5.211AspGlu: 5.211 ± 0.655
3.758AspPhe: 3.758 ± 0.564
4.271AspGly: 4.271 ± 0.761
0.683AspHis: 0.683 ± 0.227
3.844AspIle: 3.844 ± 0.515
5.638AspLys: 5.638 ± 1.02
5.467AspLeu: 5.467 ± 0.633
1.025AspMet: 1.025 ± 0.33
4.015AspAsn: 4.015 ± 0.573
1.196AspPro: 1.196 ± 0.356
1.538AspGln: 1.538 ± 0.346
2.648AspArg: 2.648 ± 0.416
3.075AspSer: 3.075 ± 0.434
2.306AspThr: 2.306 ± 0.454
3.502AspVal: 3.502 ± 0.587
0.854AspTrp: 0.854 ± 0.227
4.442AspTyr: 4.442 ± 0.61
0.0AspXaa: 0.0 ± 0.0
Glu
2.904GluAla: 2.904 ± 0.58
0.769GluCys: 0.769 ± 0.311
4.613GluAsp: 4.613 ± 0.684
8.542GluGlu: 8.542 ± 0.78
3.588GluPhe: 3.588 ± 0.63
2.819GluGly: 2.819 ± 0.438
0.854GluHis: 0.854 ± 0.282
8.627GluIle: 8.627 ± 0.812
9.311GluLys: 9.311 ± 0.942
7.517GluLeu: 7.517 ± 1.046
2.819GluMet: 2.819 ± 0.526
6.321GluAsn: 6.321 ± 0.699
1.538GluPro: 1.538 ± 0.349
3.246GluGln: 3.246 ± 0.607
2.477GluArg: 2.477 ± 0.573
3.844GluSer: 3.844 ± 0.498
4.271GluThr: 4.271 ± 0.729
4.1GluVal: 4.1 ± 0.608
1.025GluTrp: 1.025 ± 0.36
4.442GluTyr: 4.442 ± 0.601
0.0GluXaa: 0.0 ± 0.0
Phe
2.733PheAla: 2.733 ± 0.523
1.025PheCys: 1.025 ± 0.327
4.015PheAsp: 4.015 ± 0.639
3.246PheGlu: 3.246 ± 0.452
1.623PhePhe: 1.623 ± 0.43
2.135PheGly: 2.135 ± 0.514
0.683PheHis: 0.683 ± 0.215
3.331PheIle: 3.331 ± 0.548
3.929PheLys: 3.929 ± 0.452
2.819PheLeu: 2.819 ± 0.487
0.513PheMet: 0.513 ± 0.214
3.502PheAsn: 3.502 ± 0.505
0.769PhePro: 0.769 ± 0.238
1.11PheGln: 1.11 ± 0.315
1.196PheArg: 1.196 ± 0.34
3.075PheSer: 3.075 ± 0.493
2.221PheThr: 2.221 ± 0.375
2.221PheVal: 2.221 ± 0.499
0.513PheTrp: 0.513 ± 0.195
2.306PheTyr: 2.306 ± 0.399
0.0PheXaa: 0.0 ± 0.0
Gly
2.733GlyAla: 2.733 ± 0.557
0.769GlyCys: 0.769 ± 0.315
2.819GlyAsp: 2.819 ± 0.539
4.613GlyGlu: 4.613 ± 0.414
2.477GlyPhe: 2.477 ± 0.483
1.965GlyGly: 1.965 ± 0.787
0.769GlyHis: 0.769 ± 0.215
4.869GlyIle: 4.869 ± 0.537
4.954GlyLys: 4.954 ± 0.737
3.246GlyLeu: 3.246 ± 0.56
1.11GlyMet: 1.11 ± 0.298
3.929GlyAsn: 3.929 ± 0.773
0.0GlyPro: 0.0 ± 0.0
1.281GlyGln: 1.281 ± 0.318
2.135GlyArg: 2.135 ± 0.509
2.819GlySer: 2.819 ± 0.4
3.075GlyThr: 3.075 ± 0.599
2.563GlyVal: 2.563 ± 0.463
0.94GlyTrp: 0.94 ± 0.334
3.417GlyTyr: 3.417 ± 0.571
0.0GlyXaa: 0.0 ± 0.0
His
0.598HisAla: 0.598 ± 0.186
0.342HisCys: 0.342 ± 0.163
0.256HisAsp: 0.256 ± 0.148
1.025HisGlu: 1.025 ± 0.31
0.513HisPhe: 0.513 ± 0.165
0.427HisGly: 0.427 ± 0.191
0.513HisHis: 0.513 ± 0.263
1.281HisIle: 1.281 ± 0.397
1.11HisLys: 1.11 ± 0.241
1.11HisLeu: 1.11 ± 0.298
0.171HisMet: 0.171 ± 0.109
1.11HisAsn: 1.11 ± 0.295
0.598HisPro: 0.598 ± 0.22
0.171HisGln: 0.171 ± 0.126
0.171HisArg: 0.171 ± 0.114
0.342HisSer: 0.342 ± 0.176
0.513HisThr: 0.513 ± 0.197
0.342HisVal: 0.342 ± 0.173
0.342HisTrp: 0.342 ± 0.152
0.598HisTyr: 0.598 ± 0.164
0.0HisXaa: 0.0 ± 0.0
Ile
5.552IleAla: 5.552 ± 0.812
1.281IleCys: 1.281 ± 0.342
6.748IleAsp: 6.748 ± 0.631
6.748IleGlu: 6.748 ± 0.803
3.161IlePhe: 3.161 ± 0.569
5.04IleGly: 5.04 ± 0.611
1.11IleHis: 1.11 ± 0.322
7.004IleIle: 7.004 ± 0.704
8.286IleLys: 8.286 ± 0.709
8.029IleLeu: 8.029 ± 1.012
1.879IleMet: 1.879 ± 0.362
7.09IleAsn: 7.09 ± 0.759
2.904IlePro: 2.904 ± 0.602
3.075IleGln: 3.075 ± 0.441
2.648IleArg: 2.648 ± 0.524
5.552IleSer: 5.552 ± 0.754
5.296IleThr: 5.296 ± 0.814
5.723IleVal: 5.723 ± 0.724
1.11IleTrp: 1.11 ± 0.331
2.904IleTyr: 2.904 ± 0.415
0.0IleXaa: 0.0 ± 0.0
Lys
5.381LysAla: 5.381 ± 0.76
1.452LysCys: 1.452 ± 0.354
6.663LysAsp: 6.663 ± 0.842
10.677LysGlu: 10.677 ± 1.357
3.075LysPhe: 3.075 ± 0.443
4.698LysGly: 4.698 ± 0.578
0.342LysHis: 0.342 ± 0.211
9.567LysIle: 9.567 ± 1.0
9.567LysLys: 9.567 ± 1.151
6.236LysLeu: 6.236 ± 1.017
3.075LysMet: 3.075 ± 0.563
6.748LysAsn: 6.748 ± 0.71
1.965LysPro: 1.965 ± 0.447
3.929LysGln: 3.929 ± 0.523
3.758LysArg: 3.758 ± 0.624
4.186LysSer: 4.186 ± 0.749
4.783LysThr: 4.783 ± 0.666
3.417LysVal: 3.417 ± 0.509
1.196LysTrp: 1.196 ± 0.335
3.844LysTyr: 3.844 ± 0.439
0.0LysXaa: 0.0 ± 0.0
Leu
4.186LeuAla: 4.186 ± 0.614
1.11LeuCys: 1.11 ± 0.332
5.381LeuAsp: 5.381 ± 0.658
7.004LeuGlu: 7.004 ± 0.782
3.331LeuPhe: 3.331 ± 0.477
3.929LeuGly: 3.929 ± 0.539
1.025LeuHis: 1.025 ± 0.352
7.004LeuIle: 7.004 ± 0.789
7.859LeuLys: 7.859 ± 0.99
6.406LeuLeu: 6.406 ± 0.936
1.623LeuMet: 1.623 ± 0.298
7.09LeuAsn: 7.09 ± 0.884
1.879LeuPro: 1.879 ± 0.421
4.186LeuGln: 4.186 ± 0.542
2.392LeuArg: 2.392 ± 0.372
5.979LeuSer: 5.979 ± 0.609
4.186LeuThr: 4.186 ± 0.615
3.075LeuVal: 3.075 ± 0.465
0.513LeuTrp: 0.513 ± 0.175
3.417LeuTyr: 3.417 ± 0.465
0.0LeuXaa: 0.0 ± 0.0
Met
1.708MetAla: 1.708 ± 0.377
0.0MetCys: 0.0 ± 0.0
1.196MetAsp: 1.196 ± 0.3
1.11MetGlu: 1.11 ± 0.265
0.683MetPhe: 0.683 ± 0.205
1.11MetGly: 1.11 ± 0.308
0.171MetHis: 0.171 ± 0.137
2.392MetIle: 2.392 ± 0.34
2.392MetLys: 2.392 ± 0.419
1.794MetLeu: 1.794 ± 0.494
0.256MetMet: 0.256 ± 0.133
1.538MetAsn: 1.538 ± 0.346
1.11MetPro: 1.11 ± 0.354
1.196MetGln: 1.196 ± 0.346
0.513MetArg: 0.513 ± 0.201
1.794MetSer: 1.794 ± 0.332
1.367MetThr: 1.367 ± 0.332
1.025MetVal: 1.025 ± 0.309
0.085MetTrp: 0.085 ± 0.093
0.598MetTyr: 0.598 ± 0.194
0.0MetXaa: 0.0 ± 0.0
Asn
4.015AsnAla: 4.015 ± 0.525
1.281AsnCys: 1.281 ± 0.296
4.271AsnAsp: 4.271 ± 0.541
6.492AsnGlu: 6.492 ± 0.674
2.477AsnPhe: 2.477 ± 0.435
5.723AsnGly: 5.723 ± 0.774
0.854AsnHis: 0.854 ± 0.281
5.211AsnIle: 5.211 ± 0.712
6.748AsnLys: 6.748 ± 0.683
5.723AsnLeu: 5.723 ± 0.741
1.623AsnMet: 1.623 ± 0.34
7.09AsnAsn: 7.09 ± 0.923
2.819AsnPro: 2.819 ± 0.633
3.673AsnGln: 3.673 ± 0.507
2.819AsnArg: 2.819 ± 0.525
3.502AsnSer: 3.502 ± 0.726
3.758AsnThr: 3.758 ± 0.734
3.929AsnVal: 3.929 ± 0.457
0.342AsnTrp: 0.342 ± 0.175
3.844AsnTyr: 3.844 ± 0.596
0.0AsnXaa: 0.0 ± 0.0
Pro
0.854ProAla: 0.854 ± 0.236
0.256ProCys: 0.256 ± 0.127
1.196ProAsp: 1.196 ± 0.236
1.623ProGlu: 1.623 ± 0.443
1.367ProPhe: 1.367 ± 0.325
0.683ProGly: 0.683 ± 0.247
0.342ProHis: 0.342 ± 0.183
2.221ProIle: 2.221 ± 0.282
2.648ProLys: 2.648 ± 0.577
1.281ProLeu: 1.281 ± 0.321
0.854ProMet: 0.854 ± 0.273
2.392ProAsn: 2.392 ± 0.43
0.598ProPro: 0.598 ± 0.201
0.769ProGln: 0.769 ± 0.232
0.769ProArg: 0.769 ± 0.238
1.538ProSer: 1.538 ± 0.341
1.196ProThr: 1.196 ± 0.38
1.708ProVal: 1.708 ± 0.326
0.171ProTrp: 0.171 ± 0.112
1.708ProTyr: 1.708 ± 0.428
0.0ProXaa: 0.0 ± 0.0
Gln
1.538GlnAla: 1.538 ± 0.369
0.342GlnCys: 0.342 ± 0.158
2.221GlnAsp: 2.221 ± 0.538
2.99GlnGlu: 2.99 ± 0.55
1.367GlnPhe: 1.367 ± 0.294
1.965GlnGly: 1.965 ± 0.413
0.427GlnHis: 0.427 ± 0.215
4.1GlnIle: 4.1 ± 0.711
3.758GlnLys: 3.758 ± 0.85
2.733GlnLeu: 2.733 ± 0.384
1.538GlnMet: 1.538 ± 0.53
2.819GlnAsn: 2.819 ± 0.461
0.769GlnPro: 0.769 ± 0.207
2.221GlnGln: 2.221 ± 0.468
1.623GlnArg: 1.623 ± 0.425
2.563GlnSer: 2.563 ± 0.515
2.733GlnThr: 2.733 ± 0.615
1.708GlnVal: 1.708 ± 0.392
0.171GlnTrp: 0.171 ± 0.107
2.221GlnTyr: 2.221 ± 0.472
0.0GlnXaa: 0.0 ± 0.0
Arg
1.281ArgAla: 1.281 ± 0.302
0.256ArgCys: 0.256 ± 0.124
1.452ArgAsp: 1.452 ± 0.402
3.075ArgGlu: 3.075 ± 0.564
2.05ArgPhe: 2.05 ± 0.418
1.623ArgGly: 1.623 ± 0.374
0.683ArgHis: 0.683 ± 0.279
3.246ArgIle: 3.246 ± 0.462
3.161ArgLys: 3.161 ± 0.501
3.502ArgLeu: 3.502 ± 0.561
0.769ArgMet: 0.769 ± 0.231
2.563ArgAsn: 2.563 ± 0.485
0.683ArgPro: 0.683 ± 0.249
1.623ArgGln: 1.623 ± 0.428
1.879ArgArg: 1.879 ± 0.42
1.11ArgSer: 1.11 ± 0.237
1.452ArgThr: 1.452 ± 0.341
1.538ArgVal: 1.538 ± 0.308
0.427ArgTrp: 0.427 ± 0.175
2.392ArgTyr: 2.392 ± 0.487
0.0ArgXaa: 0.0 ± 0.0
Ser
1.708SerAla: 1.708 ± 0.481
0.769SerCys: 0.769 ± 0.206
2.477SerAsp: 2.477 ± 0.391
3.758SerGlu: 3.758 ± 0.569
2.99SerPhe: 2.99 ± 0.53
3.246SerGly: 3.246 ± 0.719
0.769SerHis: 0.769 ± 0.201
6.15SerIle: 6.15 ± 0.896
5.296SerLys: 5.296 ± 0.75
4.698SerLeu: 4.698 ± 0.544
1.11SerMet: 1.11 ± 0.326
4.1SerAsn: 4.1 ± 0.678
1.708SerPro: 1.708 ± 0.408
2.306SerGln: 2.306 ± 0.427
1.538SerArg: 1.538 ± 0.289
3.502SerSer: 3.502 ± 0.384
3.246SerThr: 3.246 ± 0.646
3.673SerVal: 3.673 ± 0.554
1.025SerTrp: 1.025 ± 0.271
3.075SerTyr: 3.075 ± 0.529
0.0SerXaa: 0.0 ± 0.0
Thr
3.417ThrAla: 3.417 ± 0.563
1.025ThrCys: 1.025 ± 0.304
3.246ThrAsp: 3.246 ± 0.557
3.844ThrGlu: 3.844 ± 0.576
2.563ThrPhe: 2.563 ± 0.458
2.477ThrGly: 2.477 ± 0.439
0.427ThrHis: 0.427 ± 0.194
5.894ThrIle: 5.894 ± 0.778
4.698ThrLys: 4.698 ± 0.452
4.783ThrLeu: 4.783 ± 0.661
1.025ThrMet: 1.025 ± 0.195
3.758ThrAsn: 3.758 ± 0.632
0.94ThrPro: 0.94 ± 0.346
2.135ThrGln: 2.135 ± 0.463
1.452ThrArg: 1.452 ± 0.415
2.819ThrSer: 2.819 ± 0.46
3.929ThrThr: 3.929 ± 0.57
2.733ThrVal: 2.733 ± 0.443
0.256ThrTrp: 0.256 ± 0.143
2.135ThrTyr: 2.135 ± 0.417
0.0ThrXaa: 0.0 ± 0.0
Val
2.135ValAla: 2.135 ± 0.416
0.769ValCys: 0.769 ± 0.272
4.186ValAsp: 4.186 ± 0.514
3.844ValGlu: 3.844 ± 0.696
1.879ValPhe: 1.879 ± 0.459
2.135ValGly: 2.135 ± 0.431
0.342ValHis: 0.342 ± 0.197
4.954ValIle: 4.954 ± 0.727
4.442ValLys: 4.442 ± 0.682
5.125ValLeu: 5.125 ± 0.687
0.513ValMet: 0.513 ± 0.192
3.502ValAsn: 3.502 ± 0.453
1.794ValPro: 1.794 ± 0.372
2.221ValGln: 2.221 ± 0.358
1.794ValArg: 1.794 ± 0.497
3.929ValSer: 3.929 ± 0.59
1.879ValThr: 1.879 ± 0.402
2.477ValVal: 2.477 ± 0.407
0.598ValTrp: 0.598 ± 0.219
2.05ValTyr: 2.05 ± 0.371
0.0ValXaa: 0.0 ± 0.0
Trp
0.342TrpAla: 0.342 ± 0.15
0.171TrpCys: 0.171 ± 0.119
0.769TrpAsp: 0.769 ± 0.244
1.025TrpGlu: 1.025 ± 0.388
0.342TrpPhe: 0.342 ± 0.154
0.427TrpGly: 0.427 ± 0.309
0.0TrpHis: 0.0 ± 0.0
1.025TrpIle: 1.025 ± 0.268
0.683TrpLys: 0.683 ± 0.249
1.452TrpLeu: 1.452 ± 0.349
0.0TrpMet: 0.0 ± 0.0
0.342TrpAsn: 0.342 ± 0.179
0.0TrpPro: 0.0 ± 0.0
0.769TrpGln: 0.769 ± 0.334
0.427TrpArg: 0.427 ± 0.189
0.342TrpSer: 0.342 ± 0.138
0.683TrpThr: 0.683 ± 0.248
0.94TrpVal: 0.94 ± 0.295
0.342TrpTrp: 0.342 ± 0.154
0.683TrpTyr: 0.683 ± 0.288
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.306TyrAla: 2.306 ± 0.455
0.94TyrCys: 0.94 ± 0.317
2.819TyrAsp: 2.819 ± 0.443
4.1TyrGlu: 4.1 ± 0.523
2.904TyrPhe: 2.904 ± 0.611
2.819TyrGly: 2.819 ± 0.469
0.854TyrHis: 0.854 ± 0.254
3.844TyrIle: 3.844 ± 0.481
3.502TyrLys: 3.502 ± 0.51
4.613TyrLeu: 4.613 ± 0.861
0.769TyrMet: 0.769 ± 0.258
3.331TyrAsn: 3.331 ± 0.493
1.196TyrPro: 1.196 ± 0.322
2.05TyrGln: 2.05 ± 0.372
2.221TyrArg: 2.221 ± 0.41
3.075TyrSer: 3.075 ± 0.486
2.819TyrThr: 2.819 ± 0.519
2.648TyrVal: 2.648 ± 0.432
0.427TyrTrp: 0.427 ± 0.132
2.563TyrTyr: 2.563 ± 0.492
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 48 proteins (11708 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski