Amino acid dipepetide frequency for halophilic archaeon J07HB67

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.546AlaAla: 16.546 ± 0.242	0.731AlaCys: 0.731 ± 0.034	10.823AlaAsp: 10.823 ± 0.161	8.495AlaGlu: 8.495 ± 0.139	3.638AlaPhe: 3.638 ± 0.082	11.195AlaGly: 11.195 ± 0.151	1.825AlaHis: 1.825 ± 0.059	3.034AlaIle: 3.034 ± 0.081	1.288AlaLys: 1.288 ± 0.044	9.098AlaLeu: 9.098 ± 0.161	1.635AlaMet: 1.635 ± 0.054	2.298AlaAsn: 2.298 ± 0.068	4.306AlaPro: 4.306 ± 0.09	2.095AlaGln: 2.095 ± 0.067	7.234AlaArg: 7.234 ± 0.11	5.211AlaSer: 5.211 ± 0.086	8.668AlaThr: 8.668 ± 0.118	13.452AlaVal: 13.452 ± 0.175	1.097AlaTrp: 1.097 ± 0.043	2.463AlaTyr: 2.463 ± 0.065	0.04AlaXaa: 0.04 ± 0.008
Cys	0.666CysAla: 0.666 ± 0.034	0.092CysCys: 0.092 ± 0.012	0.515CysAsp: 0.515 ± 0.028	0.545CysGlu: 0.545 ± 0.026	0.134CysPhe: 0.134 ± 0.015	0.951CysGly: 0.951 ± 0.044	0.183CysHis: 0.183 ± 0.017	0.165CysIle: 0.165 ± 0.017	0.065CysLys: 0.065 ± 0.011	0.6CysLeu: 0.6 ± 0.027	0.063CysMet: 0.063 ± 0.01	0.16CysAsn: 0.16 ± 0.016	0.557CysPro: 0.557 ± 0.034	0.146CysGln: 0.146 ± 0.015	0.786CysArg: 0.786 ± 0.039	0.471CysSer: 0.471 ± 0.025	0.378CysThr: 0.378 ± 0.021	0.635CysVal: 0.635 ± 0.03	0.103CysTrp: 0.103 ± 0.013	0.16CysTyr: 0.16 ± 0.015	0.002CysXaa: 0.002 ± 0.002
Asp	9.446AspAla: 9.446 ± 0.127	0.663AspCys: 0.663 ± 0.035	8.243AspAsp: 8.243 ± 0.145	7.034AspGlu: 7.034 ± 0.114	1.517AspPhe: 1.517 ± 0.054	9.332AspGly: 9.332 ± 0.143	2.203AspHis: 2.203 ± 0.059	1.76AspIle: 1.76 ± 0.059	0.609AspLys: 0.609 ± 0.033	5.86AspLeu: 5.86 ± 0.103	0.891AspMet: 0.891 ± 0.038	1.274AspAsn: 1.274 ± 0.041	5.158AspPro: 5.158 ± 0.099	1.88AspGln: 1.88 ± 0.053	8.263AspArg: 8.263 ± 0.133	3.552AspSer: 3.552 ± 0.069	6.109AspThr: 6.109 ± 0.104	6.318AspVal: 6.318 ± 0.117	1.043AspTrp: 1.043 ± 0.045	1.837AspTyr: 1.837 ± 0.053	0.025AspXaa: 0.025 ± 0.006
Glu	7.892GluAla: 7.892 ± 0.135	0.48GluCys: 0.48 ± 0.027	3.681GluAsp: 3.681 ± 0.099	5.443GluGlu: 5.443 ± 0.135	2.632GluPhe: 2.632 ± 0.067	4.635GluGly: 4.635 ± 0.077	1.371GluHis: 1.371 ± 0.054	3.415GluIle: 3.415 ± 0.105	1.257GluLys: 1.257 ± 0.052	7.672GluLeu: 7.672 ± 0.119	1.688GluMet: 1.688 ± 0.046	1.597GluAsn: 1.597 ± 0.051	4.354GluPro: 4.354 ± 0.09	2.418GluGln: 2.418 ± 0.065	7.292GluArg: 7.292 ± 0.123	4.8GluSer: 4.8 ± 0.092	8.454GluThr: 8.454 ± 0.125	5.421GluVal: 5.421 ± 0.096	1.028GluTrp: 1.028 ± 0.043	2.003GluTyr: 2.003 ± 0.065	0.023GluXaa: 0.023 ± 0.005
Phe	3.471PheAla: 3.471 ± 0.084	0.269PheCys: 0.269 ± 0.019	3.406PheAsp: 3.406 ± 0.084	2.765PheGlu: 2.765 ± 0.071	0.892PhePhe: 0.892 ± 0.044	3.343PheGly: 3.343 ± 0.08	0.623PheHis: 0.623 ± 0.033	0.475PheIle: 0.475 ± 0.029	0.314PheLys: 0.314 ± 0.025	2.711PheLeu: 2.711 ± 0.075	0.345PheMet: 0.345 ± 0.021	0.518PheAsn: 0.518 ± 0.026	1.282PhePro: 1.282 ± 0.046	0.738PheGln: 0.738 ± 0.031	1.942PheArg: 1.942 ± 0.053	1.465PheSer: 1.465 ± 0.054	1.802PheThr: 1.802 ± 0.058	3.154PheVal: 3.154 ± 0.079	0.323PheTrp: 0.323 ± 0.021	0.751PheTyr: 0.751 ± 0.033	0.008PheXaa: 0.008 ± 0.003
Gly	8.218GlyAla: 8.218 ± 0.12	0.754GlyCys: 0.754 ± 0.038	7.135GlyAsp: 7.135 ± 0.11	7.135GlyGlu: 7.135 ± 0.109	3.24GlyPhe: 3.24 ± 0.082	8.721GlyGly: 8.721 ± 0.16	1.715GlyHis: 1.715 ± 0.052	2.972GlyIle: 2.972 ± 0.073	1.371GlyLys: 1.371 ± 0.044	7.577GlyLeu: 7.577 ± 0.129	1.532GlyMet: 1.532 ± 0.047	1.666GlyAsn: 1.666 ± 0.05	3.623GlyPro: 3.623 ± 0.078	2.102GlyGln: 2.102 ± 0.054	6.552GlyArg: 6.552 ± 0.125	5.305GlySer: 5.305 ± 0.092	6.052GlyThr: 6.052 ± 0.108	10.441GlyVal: 10.441 ± 0.152	1.149GlyTrp: 1.149 ± 0.038	2.474GlyTyr: 2.474 ± 0.069	0.034GlyXaa: 0.034 ± 0.007
His	2.012HisAla: 2.012 ± 0.061	0.149HisCys: 0.149 ± 0.014	2.062HisAsp: 2.062 ± 0.058	1.572HisGlu: 1.572 ± 0.048	0.394HisPhe: 0.394 ± 0.024	1.858HisGly: 1.858 ± 0.062	0.532HisHis: 0.532 ± 0.031	0.323HisIle: 0.323 ± 0.022	0.202HisLys: 0.202 ± 0.016	1.529HisLeu: 1.529 ± 0.055	0.211HisMet: 0.211 ± 0.019	0.397HisAsn: 0.397 ± 0.026	1.258HisPro: 1.258 ± 0.049	0.406HisGln: 0.406 ± 0.024	1.508HisArg: 1.508 ± 0.048	0.758HisSer: 0.758 ± 0.032	1.254HisThr: 1.254 ± 0.045	1.886HisVal: 1.886 ± 0.048	0.22HisTrp: 0.22 ± 0.017	0.482HisTyr: 0.482 ± 0.023	0.009HisXaa: 0.009 ± 0.004
Ile	3.335IleAla: 3.335 ± 0.077	0.229IleCys: 0.229 ± 0.02	2.988IleAsp: 2.988 ± 0.077	2.715IleGlu: 2.715 ± 0.085	0.588IlePhe: 0.588 ± 0.03	2.718IleGly: 2.718 ± 0.073	0.58IleHis: 0.58 ± 0.032	0.52IleIle: 0.52 ± 0.035	0.423IleLys: 0.423 ± 0.026	1.812IleLeu: 1.812 ± 0.058	0.285IleMet: 0.285 ± 0.021	0.622IleAsn: 0.622 ± 0.033	1.318IlePro: 1.318 ± 0.046	0.829IleGln: 0.829 ± 0.039	2.025IleArg: 2.025 ± 0.059	1.366IleSer: 1.366 ± 0.054	1.795IleThr: 1.795 ± 0.051	3.072IleVal: 3.072 ± 0.086	0.195IleTrp: 0.195 ± 0.016	0.602IleTyr: 0.602 ± 0.029	0.003IleXaa: 0.003 ± 0.002
Lys	1.208LysAla: 1.208 ± 0.047	0.089LysCys: 0.089 ± 0.011	0.623LysAsp: 0.623 ± 0.032	0.772LysGlu: 0.772 ± 0.036	0.454LysPhe: 0.454 ± 0.03	0.888LysGly: 0.888 ± 0.04	0.231LysHis: 0.231 ± 0.018	0.469LysIle: 0.469 ± 0.03	0.289LysLys: 0.289 ± 0.022	1.402LysLeu: 1.402 ± 0.047	0.255LysMet: 0.255 ± 0.018	0.406LysAsn: 0.406 ± 0.027	0.62LysPro: 0.62 ± 0.031	0.531LysGln: 0.531 ± 0.034	1.292LysArg: 1.292 ± 0.044	0.811LysSer: 0.811 ± 0.035	1.037LysThr: 1.037 ± 0.044	0.803LysVal: 0.803 ± 0.037	0.16LysTrp: 0.16 ± 0.016	0.415LysTyr: 0.415 ± 0.024	0.005LysXaa: 0.005 ± 0.003
Leu	11.548LeuAla: 11.548 ± 0.165	0.608LeuCys: 0.608 ± 0.029	7.266LeuAsp: 7.266 ± 0.114	5.117LeuGlu: 5.117 ± 0.102	2.791LeuPhe: 2.791 ± 0.072	7.563LeuGly: 7.563 ± 0.126	1.346LeuHis: 1.346 ± 0.042	2.191LeuIle: 2.191 ± 0.064	1.12LeuLys: 1.12 ± 0.049	8.174LeuLeu: 8.174 ± 0.158	1.037LeuMet: 1.037 ± 0.035	1.48LeuAsn: 1.48 ± 0.053	4.497LeuPro: 4.497 ± 0.087	1.977LeuGln: 1.977 ± 0.066	6.391LeuArg: 6.391 ± 0.104	5.794LeuSer: 5.794 ± 0.088	5.211LeuThr: 5.211 ± 0.101	8.34LeuVal: 8.34 ± 0.136	0.792LeuTrp: 0.792 ± 0.035	1.908LeuTyr: 1.908 ± 0.061	0.02LeuXaa: 0.02 ± 0.006
Met	1.485MetAla: 1.485 ± 0.056	0.129MetCys: 0.129 ± 0.012	0.972MetAsp: 0.972 ± 0.045	0.903MetGlu: 0.903 ± 0.041	0.412MetPhe: 0.412 ± 0.028	1.112MetGly: 1.112 ± 0.049	0.242MetHis: 0.242 ± 0.02	0.485MetIle: 0.485 ± 0.029	0.306MetLys: 0.306 ± 0.025	1.254MetLeu: 1.254 ± 0.047	0.215MetMet: 0.215 ± 0.022	0.417MetAsn: 0.417 ± 0.026	0.626MetPro: 0.626 ± 0.03	0.426MetGln: 0.426 ± 0.027	1.026MetArg: 1.026 ± 0.041	1.474MetSer: 1.474 ± 0.047	1.302MetThr: 1.302 ± 0.04	1.12MetVal: 1.12 ± 0.045	0.117MetTrp: 0.117 ± 0.014	0.323MetTyr: 0.323 ± 0.027	0.006MetXaa: 0.006 ± 0.003
Asn	2.248AsnAla: 2.248 ± 0.066	0.208AsnCys: 0.208 ± 0.021	1.472AsnAsp: 1.472 ± 0.052	1.426AsnGlu: 1.426 ± 0.045	0.557AsnPhe: 0.557 ± 0.026	1.702AsnGly: 1.702 ± 0.062	0.358AsnHis: 0.358 ± 0.024	0.517AsnIle: 0.517 ± 0.03	0.311AsnLys: 0.311 ± 0.024	1.66AsnLeu: 1.66 ± 0.062	0.278AsnMet: 0.278 ± 0.019	0.531AsnAsn: 0.531 ± 0.034	1.254AsnPro: 1.254 ± 0.045	0.466AsnGln: 0.466 ± 0.025	1.452AsnArg: 1.452 ± 0.053	0.838AsnSer: 0.838 ± 0.036	1.268AsnThr: 1.268 ± 0.047	2.242AsnVal: 2.242 ± 0.064	0.268AsnTrp: 0.268 ± 0.02	0.523AsnTyr: 0.523 ± 0.029	0.005AsnXaa: 0.005 ± 0.003
Pro	5.958ProAla: 5.958 ± 0.108	0.275ProCys: 0.275 ± 0.021	4.674ProAsp: 4.674 ± 0.098	4.597ProGlu: 4.597 ± 0.078	1.594ProPhe: 1.594 ± 0.054	4.366ProGly: 4.366 ± 0.081	0.958ProHis: 0.958 ± 0.04	1.302ProIle: 1.302 ± 0.052	0.551ProLys: 0.551 ± 0.029	3.443ProLeu: 3.443 ± 0.069	0.643ProMet: 0.643 ± 0.031	1.017ProAsn: 1.017 ± 0.039	2.871ProPro: 2.871 ± 0.094	1.055ProGln: 1.055 ± 0.04	3.02ProArg: 3.02 ± 0.084	3.032ProSer: 3.032 ± 0.071	4.425ProThr: 4.425 ± 0.093	5.085ProVal: 5.085 ± 0.091	0.431ProTrp: 0.431 ± 0.026	1.046ProTyr: 1.046 ± 0.045	0.026ProXaa: 0.026 ± 0.006
Gln	2.229GlnAla: 2.229 ± 0.056	0.151GlnCys: 0.151 ± 0.015	0.934GlnAsp: 0.934 ± 0.04	1.352GlnGlu: 1.352 ± 0.052	1.237GlnPhe: 1.237 ± 0.039	1.38GlnGly: 1.38 ± 0.052	0.437GlnHis: 0.437 ± 0.027	0.997GlnIle: 0.997 ± 0.044	0.489GlnLys: 0.489 ± 0.028	2.358GlnLeu: 2.358 ± 0.056	0.545GlnMet: 0.545 ± 0.03	0.629GlnAsn: 0.629 ± 0.036	1.292GlnPro: 1.292 ± 0.047	0.84GlnGln: 0.84 ± 0.041	2.098GlnArg: 2.098 ± 0.056	1.609GlnSer: 1.609 ± 0.051	2.383GlnThr: 2.383 ± 0.065	1.829GlnVal: 1.829 ± 0.053	0.318GlnTrp: 0.318 ± 0.025	0.742GlnTyr: 0.742 ± 0.033	0.005GlnXaa: 0.005 ± 0.003
Arg	8.049ArgAla: 8.049 ± 0.125	0.566ArgCys: 0.566 ± 0.033	5.515ArgAsp: 5.515 ± 0.096	7.446ArgGlu: 7.446 ± 0.125	2.302ArgPhe: 2.302 ± 0.055	5.486ArgGly: 5.486 ± 0.103	1.603ArgHis: 1.603 ± 0.054	2.454ArgIle: 2.454 ± 0.062	0.986ArgLys: 0.986 ± 0.039	7.72ArgLeu: 7.72 ± 0.142	1.249ArgMet: 1.249 ± 0.038	1.389ArgAsn: 1.389 ± 0.048	3.429ArgPro: 3.429 ± 0.074	2.274ArgGln: 2.274 ± 0.062	8.206ArgArg: 8.206 ± 0.18	3.926ArgSer: 3.926 ± 0.098	4.475ArgThr: 4.475 ± 0.09	7.192ArgVal: 7.192 ± 0.124	0.822ArgTrp: 0.822 ± 0.036	1.878ArgTyr: 1.878 ± 0.061	0.042ArgXaa: 0.042 ± 0.009
Ser	5.218SerAla: 5.218 ± 0.089	0.36SerCys: 0.36 ± 0.024	3.806SerAsp: 3.806 ± 0.081	4.103SerGlu: 4.103 ± 0.086	1.894SerPhe: 1.894 ± 0.055	5.009SerGly: 5.009 ± 0.094	1.046SerHis: 1.046 ± 0.036	1.655SerIle: 1.655 ± 0.053	0.868SerLys: 0.868 ± 0.038	4.889SerLeu: 4.889 ± 0.089	0.862SerMet: 0.862 ± 0.037	1.22SerAsn: 1.22 ± 0.045	2.941SerPro: 2.941 ± 0.079	1.268SerGln: 1.268 ± 0.046	3.968SerArg: 3.968 ± 0.082	3.128SerSer: 3.128 ± 0.108	3.694SerThr: 3.694 ± 0.075	6.034SerVal: 6.034 ± 0.101	0.651SerTrp: 0.651 ± 0.033	1.412SerTyr: 1.412 ± 0.052	0.02SerXaa: 0.02 ± 0.006
Thr	9.277ThrAla: 9.277 ± 0.148	0.357ThrCys: 0.357 ± 0.024	7.031ThrAsp: 7.031 ± 0.117	5.475ThrGlu: 5.475 ± 0.104	2.077ThrPhe: 2.077 ± 0.064	6.775ThrGly: 6.775 ± 0.114	1.392ThrHis: 1.392 ± 0.047	1.872ThrIle: 1.872 ± 0.052	0.722ThrLys: 0.722 ± 0.033	6.538ThrLeu: 6.538 ± 0.08	0.954ThrMet: 0.954 ± 0.04	1.431ThrAsn: 1.431 ± 0.052	4.512ThrPro: 4.512 ± 0.084	1.483ThrGln: 1.483 ± 0.049	4.406ThrArg: 4.406 ± 0.09	2.986ThrSer: 2.986 ± 0.06	6.146ThrThr: 6.146 ± 0.116	9.275ThrVal: 9.275 ± 0.137	0.518ThrTrp: 0.518 ± 0.032	1.409ThrTyr: 1.409 ± 0.048	0.034ThrXaa: 0.034 ± 0.007
Val	12.841ValAla: 12.841 ± 0.19	0.92ValCys: 0.92 ± 0.038	8.717ValAsp: 8.717 ± 0.133	7.786ValGlu: 7.786 ± 0.113	3.226ValPhe: 3.226 ± 0.078	9.706ValGly: 9.706 ± 0.135	1.598ValHis: 1.598 ± 0.053	2.648ValIle: 2.648 ± 0.064	1.106ValLys: 1.106 ± 0.04	7.488ValLeu: 7.488 ± 0.129	1.174ValMet: 1.174 ± 0.045	1.765ValAsn: 1.765 ± 0.057	4.812ValPro: 4.812 ± 0.084	1.983ValGln: 1.983 ± 0.059	6.737ValArg: 6.737 ± 0.113	5.891ValSer: 5.891 ± 0.091	7.857ValThr: 7.857 ± 0.135	11.558ValVal: 11.558 ± 0.184	0.923ValTrp: 0.923 ± 0.042	2.134ValTyr: 2.134 ± 0.058	0.049ValXaa: 0.049 ± 0.009
Trp	0.954TrpAla: 0.954 ± 0.036	0.134TrpCys: 0.134 ± 0.015	0.625TrpAsp: 0.625 ± 0.032	0.749TrpGlu: 0.749 ± 0.037	0.377TrpPhe: 0.377 ± 0.023	0.817TrpGly: 0.817 ± 0.034	0.217TrpHis: 0.217 ± 0.018	0.348TrpIle: 0.348 ± 0.023	0.165TrpLys: 0.165 ± 0.014	1.152TrpLeu: 1.152 ± 0.042	0.194TrpMet: 0.194 ± 0.018	0.302TrpAsn: 0.302 ± 0.02	0.468TrpPro: 0.468 ± 0.029	0.349TrpGln: 0.349 ± 0.024	0.988TrpArg: 0.988 ± 0.042	0.577TrpSer: 0.577 ± 0.03	0.809TrpThr: 0.809 ± 0.032	0.857TrpVal: 0.857 ± 0.038	0.165TrpTrp: 0.165 ± 0.017	0.351TrpTyr: 0.351 ± 0.024	0.002TrpXaa: 0.002 ± 0.002
Tyr	2.54TyrAla: 2.54 ± 0.075	0.202TyrCys: 0.202 ± 0.021	2.508TyrAsp: 2.508 ± 0.063	2.114TyrGlu: 2.114 ± 0.055	0.629TyrPhe: 0.629 ± 0.035	2.174TyrGly: 2.174 ± 0.057	0.557TyrHis: 0.557 ± 0.028	0.409TyrIle: 0.409 ± 0.026	0.315TyrLys: 0.315 ± 0.022	2.197TyrLeu: 2.197 ± 0.057	0.288TyrMet: 0.288 ± 0.018	0.46TyrAsn: 0.46 ± 0.029	1.169TyrPro: 1.169 ± 0.045	0.578TyrGln: 0.578 ± 0.026	1.78TyrArg: 1.78 ± 0.051	1.018TyrSer: 1.018 ± 0.044	1.534TyrThr: 1.534 ± 0.057	2.171TyrVal: 2.171 ± 0.058	0.268TyrTrp: 0.268 ± 0.02	0.68TyrTyr: 0.68 ± 0.032	0.003TyrXaa: 0.003 ± 0.002
Xaa	0.031XaaAla: 0.031 ± 0.007	0.011XaaCys: 0.011 ± 0.004	0.022XaaAsp: 0.022 ± 0.005	0.014XaaGlu: 0.014 ± 0.005	0.011XaaPhe: 0.011 ± 0.004	0.037XaaGly: 0.037 ± 0.008	0.005XaaHis: 0.005 ± 0.002	0.011XaaIle: 0.011 ± 0.004	0.005XaaLys: 0.005 ± 0.003	0.034XaaLeu: 0.034 ± 0.007	0.008XaaMet: 0.008 ± 0.003	0.005XaaAsn: 0.005 ± 0.003	0.02XaaPro: 0.02 ± 0.006	0.009XaaGln: 0.009 ± 0.004	0.045XaaArg: 0.045 ± 0.007	0.034XaaSer: 0.034 ± 0.007	0.02XaaThr: 0.02 ± 0.005	0.032XaaVal: 0.032 ± 0.006	0.006XaaTrp: 0.006 ± 0.003	0.002XaaTyr: 0.002 ± 0.002	2.189XaaXaa: 2.189 ± 0.134

Statistics based on 2831 proteins (650011 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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