Amino acid dipepetide frequency for Atopobium deltae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.311AlaAla: 12.311 ± 0.239
1.767AlaCys: 1.767 ± 0.072
6.231AlaAsp: 6.231 ± 0.142
5.397AlaGlu: 5.397 ± 0.147
3.576AlaPhe: 3.576 ± 0.097
7.339AlaGly: 7.339 ± 0.149
2.637AlaHis: 2.637 ± 0.081
5.581AlaIle: 5.581 ± 0.12
4.816AlaLys: 4.816 ± 0.12
10.752AlaLeu: 10.752 ± 0.187
2.494AlaMet: 2.494 ± 0.079
3.184AlaAsn: 3.184 ± 0.085
3.809AlaPro: 3.809 ± 0.109
5.742AlaGln: 5.742 ± 0.147
5.746AlaArg: 5.746 ± 0.142
7.108AlaSer: 7.108 ± 0.119
6.22AlaThr: 6.22 ± 0.143
6.297AlaVal: 6.297 ± 0.134
1.028AlaTrp: 1.028 ± 0.05
2.954AlaTyr: 2.954 ± 0.08
0.0AlaXaa: 0.0 ± 0.0
Cys
1.592CysAla: 1.592 ± 0.067
0.308CysCys: 0.308 ± 0.027
1.063CysAsp: 1.063 ± 0.054
0.956CysGlu: 0.956 ± 0.056
0.576CysPhe: 0.576 ± 0.04
1.382CysGly: 1.382 ± 0.065
0.322CysHis: 0.322 ± 0.028
1.035CysIle: 1.035 ± 0.046
0.583CysLys: 0.583 ± 0.041
1.163CysLeu: 1.163 ± 0.061
0.392CysMet: 0.392 ± 0.029
0.422CysAsn: 0.422 ± 0.033
0.564CysPro: 0.564 ± 0.035
0.448CysGln: 0.448 ± 0.035
0.604CysArg: 0.604 ± 0.039
0.895CysSer: 0.895 ± 0.046
0.769CysThr: 0.769 ± 0.04
1.236CysVal: 1.236 ± 0.055
0.18CysTrp: 0.18 ± 0.019
0.431CysTyr: 0.431 ± 0.035
0.0CysXaa: 0.0 ± 0.0
Asp
6.977AspAla: 6.977 ± 0.136
0.695AspCys: 0.695 ± 0.039
3.867AspAsp: 3.867 ± 0.113
5.243AspGlu: 5.243 ± 0.129
2.539AspPhe: 2.539 ± 0.074
4.115AspGly: 4.115 ± 0.1
1.11AspHis: 1.11 ± 0.057
3.94AspIle: 3.94 ± 0.105
3.306AspLys: 3.306 ± 0.096
5.098AspLeu: 5.098 ± 0.126
1.543AspMet: 1.543 ± 0.054
1.788AspAsn: 1.788 ± 0.064
2.779AspPro: 2.779 ± 0.08
1.671AspGln: 1.671 ± 0.065
2.466AspArg: 2.466 ± 0.079
2.839AspSer: 2.839 ± 0.094
3.485AspThr: 3.485 ± 0.092
4.49AspVal: 4.49 ± 0.115
0.646AspTrp: 0.646 ± 0.04
1.713AspTyr: 1.713 ± 0.061
0.0AspXaa: 0.0 ± 0.0
Glu
5.991GluAla: 5.991 ± 0.142
0.599GluCys: 0.599 ± 0.036
2.9GluAsp: 2.9 ± 0.085
3.436GluGlu: 3.436 ± 0.113
2.091GluPhe: 2.091 ± 0.072
3.441GluGly: 3.441 ± 0.098
1.655GluHis: 1.655 ± 0.061
3.14GluIle: 3.14 ± 0.103
4.462GluLys: 4.462 ± 0.097
6.691GluLeu: 6.691 ± 0.14
1.473GluMet: 1.473 ± 0.059
2.047GluAsn: 2.047 ± 0.059
2.047GluPro: 2.047 ± 0.073
3.313GluGln: 3.313 ± 0.107
3.329GluArg: 3.329 ± 0.096
2.471GluSer: 2.471 ± 0.071
2.518GluThr: 2.518 ± 0.081
4.224GluVal: 4.224 ± 0.106
0.478GluTrp: 0.478 ± 0.036
1.639GluTyr: 1.639 ± 0.067
0.0GluXaa: 0.0 ± 0.0
Phe
3.765PheAla: 3.765 ± 0.1
0.634PheCys: 0.634 ± 0.041
2.811PheAsp: 2.811 ± 0.073
2.359PheGlu: 2.359 ± 0.078
1.576PhePhe: 1.576 ± 0.076
3.121PheGly: 3.121 ± 0.087
0.573PheHis: 0.573 ± 0.039
2.536PheIle: 2.536 ± 0.083
1.65PheLys: 1.65 ± 0.063
3.233PheLeu: 3.233 ± 0.099
1.093PheMet: 1.093 ± 0.052
1.268PheAsn: 1.268 ± 0.064
1.257PhePro: 1.257 ± 0.053
0.762PheGln: 0.762 ± 0.04
1.436PheArg: 1.436 ± 0.064
3.003PheSer: 3.003 ± 0.089
2.082PheThr: 2.082 ± 0.073
3.217PheVal: 3.217 ± 0.098
0.413PheTrp: 0.413 ± 0.036
1.147PheTyr: 1.147 ± 0.054
0.0PheXaa: 0.0 ± 0.0
Gly
6.742GlyAla: 6.742 ± 0.15
1.114GlyCys: 1.114 ± 0.053
3.686GlyAsp: 3.686 ± 0.092
3.585GlyGlu: 3.585 ± 0.077
3.087GlyPhe: 3.087 ± 0.094
4.509GlyGly: 4.509 ± 0.136
1.434GlyHis: 1.434 ± 0.064
4.94GlyIle: 4.94 ± 0.123
3.933GlyLys: 3.933 ± 0.101
6.033GlyLeu: 6.033 ± 0.128
2.017GlyMet: 2.017 ± 0.073
2.163GlyAsn: 2.163 ± 0.076
1.732GlyPro: 1.732 ± 0.062
2.266GlyGln: 2.266 ± 0.077
3.525GlyArg: 3.525 ± 0.094
4.213GlySer: 4.213 ± 0.104
4.273GlyThr: 4.273 ± 0.116
5.276GlyVal: 5.276 ± 0.116
0.772GlyTrp: 0.772 ± 0.053
2.18GlyTyr: 2.18 ± 0.076
0.0GlyXaa: 0.0 ± 0.0
His
2.413HisAla: 2.413 ± 0.068
0.294HisCys: 0.294 ± 0.023
1.487HisAsp: 1.487 ± 0.069
1.562HisGlu: 1.562 ± 0.061
0.87HisPhe: 0.87 ± 0.041
1.581HisGly: 1.581 ± 0.063
0.569HisHis: 0.569 ± 0.042
1.536HisIle: 1.536 ± 0.059
1.322HisLys: 1.322 ± 0.058
1.786HisLeu: 1.786 ± 0.068
0.641HisMet: 0.641 ± 0.037
0.932HisAsn: 0.932 ± 0.047
1.119HisPro: 1.119 ± 0.052
0.746HisGln: 0.746 ± 0.044
1.007HisArg: 1.007 ± 0.046
1.224HisSer: 1.224 ± 0.054
1.429HisThr: 1.429 ± 0.064
1.609HisVal: 1.609 ± 0.061
0.2HisTrp: 0.2 ± 0.023
0.636HisTyr: 0.636 ± 0.039
0.0HisXaa: 0.0 ± 0.0
Ile
6.588IleAla: 6.588 ± 0.125
1.117IleCys: 1.117 ± 0.054
4.224IleAsp: 4.224 ± 0.113
3.569IleGlu: 3.569 ± 0.098
2.142IlePhe: 2.142 ± 0.08
3.947IleGly: 3.947 ± 0.121
1.121IleHis: 1.121 ± 0.044
3.539IleIle: 3.539 ± 0.088
2.846IleLys: 2.846 ± 0.106
4.676IleLeu: 4.676 ± 0.119
1.464IleMet: 1.464 ± 0.061
2.201IleAsn: 2.201 ± 0.083
2.609IlePro: 2.609 ± 0.082
1.863IleGln: 1.863 ± 0.062
2.804IleArg: 2.804 ± 0.087
4.08IleSer: 4.08 ± 0.107
3.499IleThr: 3.499 ± 0.082
4.723IleVal: 4.723 ± 0.111
0.45IleTrp: 0.45 ± 0.033
1.655IleTyr: 1.655 ± 0.064
0.0IleXaa: 0.0 ± 0.0
Lys
5.061LysAla: 5.061 ± 0.157
0.375LysCys: 0.375 ± 0.031
2.958LysAsp: 2.958 ± 0.1
2.674LysGlu: 2.674 ± 0.094
1.41LysPhe: 1.41 ± 0.059
3.061LysGly: 3.061 ± 0.103
1.322LysHis: 1.322 ± 0.051
2.856LysIle: 2.856 ± 0.095
3.557LysLys: 3.557 ± 0.14
4.791LysLeu: 4.791 ± 0.114
1.126LysMet: 1.126 ± 0.051
2.383LysAsn: 2.383 ± 0.082
2.543LysPro: 2.543 ± 0.084
2.501LysGln: 2.501 ± 0.085
3.313LysArg: 3.313 ± 0.089
2.884LysSer: 2.884 ± 0.085
4.427LysThr: 4.427 ± 0.113
3.327LysVal: 3.327 ± 0.096
0.336LysTrp: 0.336 ± 0.033
1.226LysTyr: 1.226 ± 0.066
0.0LysXaa: 0.0 ± 0.0
Leu
10.15LeuAla: 10.15 ± 0.143
1.588LeuCys: 1.588 ± 0.062
6.029LeuAsp: 6.029 ± 0.133
5.21LeuGlu: 5.21 ± 0.12
3.56LeuPhe: 3.56 ± 0.102
6.425LeuGly: 6.425 ± 0.14
2.03LeuHis: 2.03 ± 0.073
5.11LeuIle: 5.11 ± 0.111
4.178LeuLys: 4.178 ± 0.106
8.984LeuLeu: 8.984 ± 0.202
2.385LeuMet: 2.385 ± 0.073
2.774LeuAsn: 2.774 ± 0.089
3.935LeuPro: 3.935 ± 0.107
3.728LeuGln: 3.728 ± 0.116
5.061LeuArg: 5.061 ± 0.121
6.66LeuSer: 6.66 ± 0.138
5.273LeuThr: 5.273 ± 0.101
6.945LeuVal: 6.945 ± 0.126
0.867LeuTrp: 0.867 ± 0.043
2.742LeuTyr: 2.742 ± 0.086
0.0LeuXaa: 0.0 ± 0.0
Met
2.376MetAla: 2.376 ± 0.071
0.359MetCys: 0.359 ± 0.031
1.338MetAsp: 1.338 ± 0.058
1.119MetGlu: 1.119 ± 0.049
0.821MetPhe: 0.821 ± 0.047
1.797MetGly: 1.797 ± 0.075
0.767MetHis: 0.767 ± 0.043
1.231MetIle: 1.231 ± 0.047
1.128MetLys: 1.128 ± 0.053
2.648MetLeu: 2.648 ± 0.086
0.639MetMet: 0.639 ± 0.04
0.909MetAsn: 0.909 ± 0.043
1.215MetPro: 1.215 ± 0.054
1.366MetGln: 1.366 ± 0.058
1.553MetArg: 1.553 ± 0.066
1.975MetSer: 1.975 ± 0.067
1.364MetThr: 1.364 ± 0.049
1.732MetVal: 1.732 ± 0.067
0.219MetTrp: 0.219 ± 0.022
0.641MetTyr: 0.641 ± 0.036
0.0MetXaa: 0.0 ± 0.0
Asn
3.481AsnAla: 3.481 ± 0.097
0.396AsnCys: 0.396 ± 0.03
2.044AsnAsp: 2.044 ± 0.08
2.089AsnGlu: 2.089 ± 0.068
1.396AsnPhe: 1.396 ± 0.059
2.208AsnGly: 2.208 ± 0.085
0.72AsnHis: 0.72 ± 0.04
2.124AsnIle: 2.124 ± 0.065
1.947AsnLys: 1.947 ± 0.082
3.056AsnLeu: 3.056 ± 0.097
0.851AsnMet: 0.851 ± 0.053
1.553AsnAsn: 1.553 ± 0.072
2.121AsnPro: 2.121 ± 0.074
1.163AsnGln: 1.163 ± 0.059
1.506AsnArg: 1.506 ± 0.067
1.811AsnSer: 1.811 ± 0.075
2.292AsnThr: 2.292 ± 0.092
2.399AsnVal: 2.399 ± 0.067
0.308AsnTrp: 0.308 ± 0.027
1.103AsnTyr: 1.103 ± 0.052
0.0AsnXaa: 0.0 ± 0.0
Pro
4.448ProAla: 4.448 ± 0.108
0.464ProCys: 0.464 ± 0.035
2.634ProAsp: 2.634 ± 0.087
2.905ProGlu: 2.905 ± 0.084
1.515ProPhe: 1.515 ± 0.057
2.464ProGly: 2.464 ± 0.085
1.084ProHis: 1.084 ± 0.051
1.905ProIle: 1.905 ± 0.064
1.961ProLys: 1.961 ± 0.084
3.408ProLeu: 3.408 ± 0.099
0.783ProMet: 0.783 ± 0.044
1.373ProAsn: 1.373 ± 0.064
0.984ProPro: 0.984 ± 0.058
2.18ProGln: 2.18 ± 0.072
1.814ProArg: 1.814 ± 0.055
2.825ProSer: 2.825 ± 0.078
2.697ProThr: 2.697 ± 0.085
3.04ProVal: 3.04 ± 0.096
0.473ProTrp: 0.473 ± 0.033
1.257ProTyr: 1.257 ± 0.053
0.0ProXaa: 0.0 ± 0.0
Gln
4.998GlnAla: 4.998 ± 0.118
0.385GlnCys: 0.385 ± 0.032
2.007GlnAsp: 2.007 ± 0.065
2.149GlnGlu: 2.149 ± 0.077
1.215GlnPhe: 1.215 ± 0.057
2.497GlnGly: 2.497 ± 0.077
1.117GlnHis: 1.117 ± 0.057
2.24GlnIle: 2.24 ± 0.077
2.59GlnLys: 2.59 ± 0.085
4.133GlnLeu: 4.133 ± 0.108
0.867GlnMet: 0.867 ± 0.046
1.578GlnAsn: 1.578 ± 0.068
1.527GlnPro: 1.527 ± 0.067
2.779GlnGln: 2.779 ± 0.11
2.497GlnArg: 2.497 ± 0.087
2.149GlnSer: 2.149 ± 0.073
2.942GlnThr: 2.942 ± 0.098
2.732GlnVal: 2.732 ± 0.089
0.368GlnTrp: 0.368 ± 0.033
1.037GlnTyr: 1.037 ± 0.048
0.0GlnXaa: 0.0 ± 0.0
Arg
5.024ArgAla: 5.024 ± 0.137
0.779ArgCys: 0.779 ± 0.046
2.807ArgAsp: 2.807 ± 0.091
3.299ArgGlu: 3.299 ± 0.1
2.058ArgPhe: 2.058 ± 0.069
3.184ArgGly: 3.184 ± 0.089
1.135ArgHis: 1.135 ± 0.051
3.42ArgIle: 3.42 ± 0.082
2.492ArgLys: 2.492 ± 0.079
5.012ArgLeu: 5.012 ± 0.143
1.669ArgMet: 1.669 ± 0.072
1.706ArgAsn: 1.706 ± 0.065
2.047ArgPro: 2.047 ± 0.064
1.961ArgGln: 1.961 ± 0.072
3.301ArgArg: 3.301 ± 0.121
3.082ArgSer: 3.082 ± 0.093
2.728ArgThr: 2.728 ± 0.077
3.828ArgVal: 3.828 ± 0.103
0.618ArgTrp: 0.618 ± 0.041
1.723ArgTyr: 1.723 ± 0.067
0.0ArgXaa: 0.0 ± 0.0
Ser
6.653SerAla: 6.653 ± 0.128
1.079SerCys: 1.079 ± 0.051
3.788SerAsp: 3.788 ± 0.102
3.296SerGlu: 3.296 ± 0.091
2.965SerPhe: 2.965 ± 0.081
4.331SerGly: 4.331 ± 0.103
1.38SerHis: 1.38 ± 0.053
3.844SerIle: 3.844 ± 0.094
3.019SerLys: 3.019 ± 0.093
5.623SerLeu: 5.623 ± 0.119
1.688SerMet: 1.688 ± 0.057
2.11SerAsn: 2.11 ± 0.079
1.97SerPro: 1.97 ± 0.069
2.483SerGln: 2.483 ± 0.099
3.101SerArg: 3.101 ± 0.092
4.732SerSer: 4.732 ± 0.148
3.595SerThr: 3.595 ± 0.084
4.585SerVal: 4.585 ± 0.105
0.804SerTrp: 0.804 ± 0.052
2.369SerTyr: 2.369 ± 0.077
0.0SerXaa: 0.0 ± 0.0
Thr
5.576ThrAla: 5.576 ± 0.115
0.935ThrCys: 0.935 ± 0.047
3.329ThrAsp: 3.329 ± 0.093
2.55ThrGlu: 2.55 ± 0.085
2.01ThrPhe: 2.01 ± 0.071
4.236ThrGly: 4.236 ± 0.102
1.536ThrHis: 1.536 ± 0.067
3.746ThrIle: 3.746 ± 0.102
3.217ThrLys: 3.217 ± 0.09
5.767ThrLeu: 5.767 ± 0.105
1.35ThrMet: 1.35 ± 0.058
2.294ThrAsn: 2.294 ± 0.077
3.362ThrPro: 3.362 ± 0.091
2.758ThrGln: 2.758 ± 0.096
2.872ThrArg: 2.872 ± 0.091
4.236ThrSer: 4.236 ± 0.106
4.105ThrThr: 4.105 ± 0.094
3.714ThrVal: 3.714 ± 0.114
0.569ThrTrp: 0.569 ± 0.033
1.802ThrTyr: 1.802 ± 0.075
0.0ThrXaa: 0.0 ± 0.0
Val
7.154ValAla: 7.154 ± 0.144
1.441ValCys: 1.441 ± 0.062
4.462ValAsp: 4.462 ± 0.104
4.045ValGlu: 4.045 ± 0.11
2.886ValPhe: 2.886 ± 0.092
5.08ValGly: 5.08 ± 0.126
1.574ValHis: 1.574 ± 0.059
4.147ValIle: 4.147 ± 0.101
3.07ValLys: 3.07 ± 0.084
7.01ValLeu: 7.01 ± 0.127
1.748ValMet: 1.748 ± 0.066
2.273ValAsn: 2.273 ± 0.074
2.996ValPro: 2.996 ± 0.094
2.485ValGln: 2.485 ± 0.083
3.865ValArg: 3.865 ± 0.108
5.098ValSer: 5.098 ± 0.106
4.066ValThr: 4.066 ± 0.109
6.14ValVal: 6.14 ± 0.134
0.639ValTrp: 0.639 ± 0.041
2.026ValTyr: 2.026 ± 0.071
0.0ValXaa: 0.0 ± 0.0
Trp
0.809TrpAla: 0.809 ± 0.044
0.186TrpCys: 0.186 ± 0.021
0.601TrpAsp: 0.601 ± 0.041
0.522TrpGlu: 0.522 ± 0.034
0.483TrpPhe: 0.483 ± 0.04
0.667TrpGly: 0.667 ± 0.043
0.238TrpHis: 0.238 ± 0.024
0.55TrpIle: 0.55 ± 0.041
0.445TrpLys: 0.445 ± 0.036
1.037TrpLeu: 1.037 ± 0.052
0.301TrpMet: 0.301 ± 0.031
0.436TrpAsn: 0.436 ± 0.031
0.38TrpPro: 0.38 ± 0.032
0.45TrpGln: 0.45 ± 0.037
0.527TrpArg: 0.527 ± 0.034
0.601TrpSer: 0.601 ± 0.042
0.415TrpThr: 0.415 ± 0.029
0.576TrpVal: 0.576 ± 0.036
0.142TrpTrp: 0.142 ± 0.018
0.406TrpTyr: 0.406 ± 0.039
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.879TyrAla: 2.879 ± 0.076
0.406TyrCys: 0.406 ± 0.034
2.042TyrAsp: 2.042 ± 0.073
1.979TyrGlu: 1.979 ± 0.073
1.163TyrPhe: 1.163 ± 0.055
2.093TyrGly: 2.093 ± 0.068
0.639TyrHis: 0.639 ± 0.036
1.697TyrIle: 1.697 ± 0.073
1.609TyrLys: 1.609 ± 0.075
2.73TyrLeu: 2.73 ± 0.084
0.669TyrMet: 0.669 ± 0.042
1.173TyrAsn: 1.173 ± 0.058
1.219TyrPro: 1.219 ± 0.054
1.147TyrGln: 1.147 ± 0.058
1.546TyrArg: 1.546 ± 0.062
1.529TyrSer: 1.529 ± 0.06
1.786TyrThr: 1.786 ± 0.072
2.117TyrVal: 2.117 ± 0.074
0.263TyrTrp: 0.263 ± 0.026
0.879TyrTyr: 0.879 ± 0.05
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1442 proteins (428962 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski