Amino acid dipepetide frequency for Apple stem pitting virus (isolate PA66) (ASPV)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.982AlaAla: 5.982 ± 3.994
1.329AlaCys: 1.329 ± 0.67
2.326AlaAsp: 2.326 ± 0.92
4.653AlaGlu: 4.653 ± 1.515
3.323AlaPhe: 3.323 ± 1.112
2.991AlaGly: 2.991 ± 1.057
2.326AlaHis: 2.326 ± 0.797
3.988AlaIle: 3.988 ± 1.529
3.988AlaLys: 3.988 ± 1.537
5.982AlaLeu: 5.982 ± 1.198
1.329AlaMet: 1.329 ± 0.47
2.326AlaAsn: 2.326 ± 1.482
3.656AlaPro: 3.656 ± 3.541
2.326AlaGln: 2.326 ± 1.604
2.326AlaArg: 2.326 ± 0.446
6.647AlaSer: 6.647 ± 5.107
3.323AlaThr: 3.323 ± 1.528
6.647AlaVal: 6.647 ± 4.201
0.665AlaTrp: 0.665 ± 0.343
1.662AlaTyr: 1.662 ± 1.26
0.0AlaXaa: 0.0 ± 0.0
Cys
1.662CysAla: 1.662 ± 0.976
0.332CysCys: 0.332 ± 0.844
1.662CysAsp: 1.662 ± 0.858
0.997CysGlu: 0.997 ± 0.515
1.662CysPhe: 1.662 ± 0.858
1.329CysGly: 1.329 ± 0.67
0.0CysHis: 0.0 ± 0.0
0.997CysIle: 0.997 ± 0.515
1.329CysLys: 1.329 ± 0.686
2.991CysLeu: 2.991 ± 2.04
0.665CysMet: 0.665 ± 0.343
1.329CysAsn: 1.329 ± 0.686
0.665CysPro: 0.665 ± 0.343
1.662CysGln: 1.662 ± 0.746
0.665CysArg: 0.665 ± 0.343
1.994CysSer: 1.994 ± 0.869
1.994CysThr: 1.994 ± 1.72
1.662CysVal: 1.662 ± 1.664
0.0CysTrp: 0.0 ± 0.0
0.332CysTyr: 0.332 ± 0.172
0.0CysXaa: 0.0 ± 0.0
Asp
1.662AspAla: 1.662 ± 0.858
0.997AspCys: 0.997 ± 0.68
2.991AspAsp: 2.991 ± 1.544
3.323AspGlu: 3.323 ± 1.351
2.326AspPhe: 2.326 ± 0.446
2.326AspGly: 2.326 ± 0.701
1.662AspHis: 1.662 ± 0.858
2.991AspIle: 2.991 ± 1.06
1.994AspLys: 1.994 ± 0.635
10.302AspLeu: 10.302 ± 3.778
0.997AspMet: 0.997 ± 0.515
2.991AspAsn: 2.991 ± 1.09
2.326AspPro: 2.326 ± 1.157
0.665AspGln: 0.665 ± 0.343
1.994AspArg: 1.994 ± 1.029
3.656AspSer: 3.656 ± 0.927
1.662AspThr: 1.662 ± 0.858
2.659AspVal: 2.659 ± 0.906
0.665AspTrp: 0.665 ± 0.343
1.994AspTyr: 1.994 ± 0.739
0.0AspXaa: 0.0 ± 0.0
Glu
7.311GluAla: 7.311 ± 2.026
1.329GluCys: 1.329 ± 0.686
2.991GluAsp: 2.991 ± 1.43
4.985GluGlu: 4.985 ± 0.998
2.991GluPhe: 2.991 ± 0.599
4.985GluGly: 4.985 ± 1.434
1.662GluHis: 1.662 ± 0.531
2.991GluIle: 2.991 ± 1.057
4.32GluLys: 4.32 ± 2.732
5.65GluLeu: 5.65 ± 2.059
0.665GluMet: 0.665 ± 0.594
2.326GluAsn: 2.326 ± 1.201
2.659GluPro: 2.659 ± 3.093
1.329GluGln: 1.329 ± 0.47
2.659GluArg: 2.659 ± 0.5
5.317GluSer: 5.317 ± 1.588
1.994GluThr: 1.994 ± 0.92
5.65GluVal: 5.65 ± 1.79
0.0GluTrp: 0.0 ± 0.0
2.326GluTyr: 2.326 ± 2.085
0.0GluXaa: 0.0 ± 0.0
Phe
2.991PheAla: 2.991 ± 1.351
0.997PheCys: 0.997 ± 0.515
2.991PheAsp: 2.991 ± 0.623
6.314PheGlu: 6.314 ± 1.639
3.323PhePhe: 3.323 ± 1.062
3.323PheGly: 3.323 ± 2.16
1.662PheHis: 1.662 ± 0.858
4.32PheIle: 4.32 ± 1.973
2.991PheLys: 2.991 ± 1.057
7.311PheLeu: 7.311 ± 2.678
0.332PheMet: 0.332 ± 0.172
3.323PheAsn: 3.323 ± 1.351
3.988PhePro: 3.988 ± 2.83
1.994PheGln: 1.994 ± 0.832
1.994PheArg: 1.994 ± 1.029
5.317PheSer: 5.317 ± 2.299
2.659PheThr: 2.659 ± 0.703
1.662PheVal: 1.662 ± 0.746
0.332PheTrp: 0.332 ± 0.172
1.662PheTyr: 1.662 ± 0.531
0.0PheXaa: 0.0 ± 0.0
Gly
3.656GlyAla: 3.656 ± 0.733
2.326GlyCys: 2.326 ± 1.108
3.988GlyAsp: 3.988 ± 1.182
3.988GlyGlu: 3.988 ± 1.145
4.32GlyPhe: 4.32 ± 1.182
3.656GlyGly: 3.656 ± 2.12
0.997GlyHis: 0.997 ± 0.515
3.323GlyIle: 3.323 ± 1.31
4.653GlyLys: 4.653 ± 0.895
5.317GlyLeu: 5.317 ± 3.561
1.329GlyMet: 1.329 ± 1.633
2.326GlyAsn: 2.326 ± 1.317
2.326GlyPro: 2.326 ± 1.317
1.662GlyGln: 1.662 ± 0.746
5.317GlyArg: 5.317 ± 1.786
5.65GlySer: 5.65 ± 2.813
3.988GlyThr: 3.988 ± 3.311
4.985GlyVal: 4.985 ± 2.531
0.665GlyTrp: 0.665 ± 0.343
1.662GlyTyr: 1.662 ± 0.525
0.0GlyXaa: 0.0 ± 0.0
His
1.329HisAla: 1.329 ± 0.634
0.332HisCys: 0.332 ± 0.623
1.994HisAsp: 1.994 ± 1.029
2.326HisGlu: 2.326 ± 0.846
1.994HisPhe: 1.994 ± 0.832
3.656HisGly: 3.656 ± 1.285
0.665HisHis: 0.665 ± 0.343
1.329HisIle: 1.329 ± 0.686
1.329HisLys: 1.329 ± 0.686
2.326HisLeu: 2.326 ± 1.201
0.0HisMet: 0.0 ± 0.0
1.662HisAsn: 1.662 ± 0.813
0.997HisPro: 0.997 ± 1.333
1.662HisGln: 1.662 ± 0.976
0.997HisArg: 0.997 ± 1.477
3.656HisSer: 3.656 ± 1.501
0.332HisThr: 0.332 ± 0.172
1.662HisVal: 1.662 ± 0.531
0.0HisTrp: 0.0 ± 0.0
0.997HisTyr: 0.997 ± 0.515
0.0HisXaa: 0.0 ± 0.0
Ile
3.656IleAla: 3.656 ± 1.366
1.662IleCys: 1.662 ± 0.746
3.323IleAsp: 3.323 ± 1.715
3.988IleGlu: 3.988 ± 1.966
4.32IlePhe: 4.32 ± 1.152
2.991IleGly: 2.991 ± 1.009
1.994IleHis: 1.994 ± 1.57
3.656IleIle: 3.656 ± 2.103
3.988IleLys: 3.988 ± 1.113
5.65IleLeu: 5.65 ± 2.271
1.994IleMet: 1.994 ± 1.029
1.994IleAsn: 1.994 ± 1.029
2.991IlePro: 2.991 ± 1.057
2.659IleGln: 2.659 ± 0.906
3.656IleArg: 3.656 ± 2.448
4.653IleSer: 4.653 ± 1.361
3.323IleThr: 3.323 ± 1.063
4.32IleVal: 4.32 ± 2.328
0.0IleTrp: 0.0 ± 0.0
1.662IleTyr: 1.662 ± 0.692
0.0IleXaa: 0.0 ± 0.0
Lys
2.659LysAla: 2.659 ± 1.386
1.662LysCys: 1.662 ± 0.858
3.323LysAsp: 3.323 ± 1.715
3.988LysGlu: 3.988 ± 0.678
4.985LysPhe: 4.985 ± 1.5
3.988LysGly: 3.988 ± 1.6
0.665LysHis: 0.665 ± 0.523
3.323LysIle: 3.323 ± 1.062
3.988LysLys: 3.988 ± 1.665
4.653LysLeu: 4.653 ± 1.974
2.326LysMet: 2.326 ± 0.981
3.323LysAsn: 3.323 ± 0.726
4.653LysPro: 4.653 ± 1.182
0.997LysGln: 0.997 ± 0.766
3.323LysArg: 3.323 ± 1.23
3.988LysSer: 3.988 ± 1.048
2.991LysThr: 2.991 ± 1.205
2.991LysVal: 2.991 ± 1.544
0.665LysTrp: 0.665 ± 1.227
0.0LysTyr: 0.0 ± 0.0
0.0LysXaa: 0.0 ± 0.0
Leu
6.979LeuAla: 6.979 ± 2.158
2.326LeuCys: 2.326 ± 1.201
4.985LeuAsp: 4.985 ± 1.5
5.65LeuGlu: 5.65 ± 1.09
5.982LeuPhe: 5.982 ± 1.9
5.65LeuGly: 5.65 ± 2.215
2.991LeuHis: 2.991 ± 1.057
8.641LeuIle: 8.641 ± 1.458
8.973LeuLys: 8.973 ± 2.777
4.653LeuLeu: 4.653 ± 2.452
0.997LeuMet: 0.997 ± 0.467
4.985LeuAsn: 4.985 ± 2.136
4.653LeuPro: 4.653 ± 1.402
1.662LeuGln: 1.662 ± 0.531
4.985LeuArg: 4.985 ± 1.373
8.308LeuSer: 8.308 ± 2.673
5.317LeuThr: 5.317 ± 0.604
5.317LeuVal: 5.317 ± 3.346
0.665LeuTrp: 0.665 ± 0.343
1.662LeuTyr: 1.662 ± 1.26
0.0LeuXaa: 0.0 ± 0.0
Met
1.662MetAla: 1.662 ± 0.858
0.665MetCys: 0.665 ± 0.343
0.0MetAsp: 0.0 ± 0.0
1.329MetGlu: 1.329 ± 0.634
0.332MetPhe: 0.332 ± 1.484
1.329MetGly: 1.329 ± 0.47
0.665MetHis: 0.665 ± 0.343
1.329MetIle: 1.329 ± 0.913
1.662MetLys: 1.662 ± 0.858
1.662MetLeu: 1.662 ± 0.531
0.665MetMet: 0.665 ± 0.343
0.332MetAsn: 0.332 ± 0.623
0.997MetPro: 0.997 ± 0.691
0.665MetGln: 0.665 ± 0.523
2.991MetArg: 2.991 ± 0.988
1.329MetSer: 1.329 ± 1.286
0.665MetThr: 0.665 ± 0.523
1.329MetVal: 1.329 ± 1.046
0.0MetTrp: 0.0 ± 0.0
0.332MetTyr: 0.332 ± 0.623
0.0MetXaa: 0.0 ± 0.0
Asn
1.994AsnAla: 1.994 ± 0.933
1.994AsnCys: 1.994 ± 0.832
0.665AsnAsp: 0.665 ± 0.523
1.662AsnGlu: 1.662 ± 1.057
2.326AsnPhe: 2.326 ± 0.763
3.323AsnGly: 3.323 ± 1.214
1.994AsnHis: 1.994 ± 0.832
4.32AsnIle: 4.32 ± 2.59
0.997AsnLys: 0.997 ± 0.515
4.32AsnLeu: 4.32 ± 1.038
0.997AsnMet: 0.997 ± 0.546
0.997AsnAsn: 0.997 ± 1.477
2.659AsnPro: 2.659 ± 1.438
0.997AsnGln: 0.997 ± 0.467
2.659AsnArg: 2.659 ± 0.906
4.653AsnSer: 4.653 ± 1.755
2.326AsnThr: 2.326 ± 0.92
2.659AsnVal: 2.659 ± 1.372
0.665AsnTrp: 0.665 ± 0.523
1.662AsnTyr: 1.662 ± 0.924
0.0AsnXaa: 0.0 ± 0.0
Pro
4.653ProAla: 4.653 ± 3.223
2.326ProCys: 2.326 ± 0.942
2.991ProAsp: 2.991 ± 0.901
2.991ProGlu: 2.991 ± 1.06
1.662ProPhe: 1.662 ± 1.403
2.659ProGly: 2.659 ± 1.16
1.662ProHis: 1.662 ± 0.813
2.991ProIle: 2.991 ± 0.594
1.329ProLys: 1.329 ± 0.47
3.656ProLeu: 3.656 ± 1.973
0.997ProMet: 0.997 ± 1.667
2.326ProAsn: 2.326 ± 2.179
1.994ProPro: 1.994 ± 1.285
1.994ProGln: 1.994 ± 1.969
2.659ProArg: 2.659 ± 2.381
2.659ProSer: 2.659 ± 0.703
2.326ProThr: 2.326 ± 1.495
2.991ProVal: 2.991 ± 0.988
0.997ProTrp: 0.997 ± 0.515
1.329ProTyr: 1.329 ± 1.714
0.0ProXaa: 0.0 ± 0.0
Gln
3.323GlnAla: 3.323 ± 3.302
0.665GlnCys: 0.665 ± 1.4
0.997GlnAsp: 0.997 ± 0.691
2.326GlnGlu: 2.326 ± 1.201
1.329GlnPhe: 1.329 ± 0.686
1.994GlnGly: 1.994 ± 0.456
0.997GlnHis: 0.997 ± 0.467
0.997GlnIle: 0.997 ± 0.68
1.662GlnLys: 1.662 ± 0.531
2.991GlnLeu: 2.991 ± 1.272
1.329GlnMet: 1.329 ± 1.046
0.997GlnAsn: 0.997 ± 0.766
1.329GlnPro: 1.329 ± 0.913
0.997GlnGln: 0.997 ± 1.477
1.329GlnArg: 1.329 ± 0.634
2.659GlnSer: 2.659 ± 0.939
1.329GlnThr: 1.329 ± 1.203
2.659GlnVal: 2.659 ± 0.691
0.665GlnTrp: 0.665 ± 0.343
0.332GlnTyr: 0.332 ± 0.623
0.0GlnXaa: 0.0 ± 0.0
Arg
3.656ArgAla: 3.656 ± 0.614
1.329ArgCys: 1.329 ± 1.006
2.326ArgAsp: 2.326 ± 0.846
2.991ArgGlu: 2.991 ± 1.544
4.32ArgPhe: 4.32 ± 1.814
2.991ArgGly: 2.991 ± 2.04
1.994ArgHis: 1.994 ± 0.456
4.653ArgIle: 4.653 ± 1.109
2.659ArgLys: 2.659 ± 0.906
4.653ArgLeu: 4.653 ± 1.84
0.332ArgMet: 0.332 ± 0.172
1.994ArgAsn: 1.994 ± 0.92
1.329ArgPro: 1.329 ± 0.686
1.662ArgGln: 1.662 ± 1.675
4.653ArgArg: 4.653 ± 1.354
3.988ArgSer: 3.988 ± 2.144
1.662ArgThr: 1.662 ± 0.746
2.326ArgVal: 2.326 ± 0.92
0.997ArgTrp: 0.997 ± 0.515
2.659ArgTyr: 2.659 ± 0.939
0.0ArgXaa: 0.0 ± 0.0
Ser
4.985SerAla: 4.985 ± 3.583
1.662SerCys: 1.662 ± 0.692
5.65SerAsp: 5.65 ± 0.942
3.656SerGlu: 3.656 ± 1.47
4.653SerPhe: 4.653 ± 1.324
6.314SerGly: 6.314 ± 2.197
2.991SerHis: 2.991 ± 1.205
5.982SerIle: 5.982 ± 1.997
6.314SerLys: 6.314 ± 1.331
6.647SerLeu: 6.647 ± 1.134
1.994SerMet: 1.994 ± 0.951
2.991SerAsn: 2.991 ± 1.926
3.656SerPro: 3.656 ± 1.374
3.323SerGln: 3.323 ± 1.571
4.653SerArg: 4.653 ± 1.361
6.647SerSer: 6.647 ± 2.56
4.32SerThr: 4.32 ± 1.836
4.32SerVal: 4.32 ± 3.292
0.0SerTrp: 0.0 ± 0.0
2.659SerTyr: 2.659 ± 0.703
0.0SerXaa: 0.0 ± 0.0
Thr
3.323ThrAla: 3.323 ± 2.93
0.0ThrCys: 0.0 ± 0.0
1.662ThrAsp: 1.662 ± 0.858
2.326ThrGlu: 2.326 ± 0.92
5.982ThrPhe: 5.982 ± 1.484
4.985ThrGly: 4.985 ± 1.641
1.329ThrHis: 1.329 ± 0.686
1.662ThrIle: 1.662 ± 1.26
2.659ThrLys: 2.659 ± 0.96
5.982ThrLeu: 5.982 ± 1.287
0.997ThrMet: 0.997 ± 0.467
1.994ThrAsn: 1.994 ± 0.635
2.326ThrPro: 2.326 ± 1.848
1.329ThrGln: 1.329 ± 1.759
2.991ThrArg: 2.991 ± 0.594
2.326ThrSer: 2.326 ± 1.495
1.994ThrThr: 1.994 ± 0.456
2.326ThrVal: 2.326 ± 2.299
0.997ThrTrp: 0.997 ± 0.515
0.997ThrTyr: 0.997 ± 0.68
0.0ThrXaa: 0.0 ± 0.0
Val
3.988ValAla: 3.988 ± 3.434
0.997ValCys: 0.997 ± 0.515
2.991ValAsp: 2.991 ± 1.544
4.653ValGlu: 4.653 ± 2.414
2.326ValPhe: 2.326 ± 0.846
5.317ValGly: 5.317 ± 4.004
1.994ValHis: 1.994 ± 0.869
2.659ValIle: 2.659 ± 1.356
2.326ValLys: 2.326 ± 1.279
6.314ValLeu: 6.314 ± 1.563
0.997ValMet: 0.997 ± 0.515
4.32ValAsn: 4.32 ± 1.393
2.659ValPro: 2.659 ± 1.739
2.659ValGln: 2.659 ± 0.5
1.662ValArg: 1.662 ± 0.746
6.979ValSer: 6.979 ± 2.611
3.656ValThr: 3.656 ± 1.069
4.653ValVal: 4.653 ± 2.874
0.332ValTrp: 0.332 ± 0.623
0.665ValTyr: 0.665 ± 1.603
0.0ValXaa: 0.0 ± 0.0
Trp
0.332TrpAla: 0.332 ± 0.172
0.332TrpCys: 0.332 ± 0.172
0.665TrpAsp: 0.665 ± 0.343
0.0TrpGlu: 0.0 ± 0.0
0.997TrpPhe: 0.997 ± 0.515
0.665TrpGly: 0.665 ± 0.343
0.665TrpHis: 0.665 ± 0.709
0.332TrpIle: 0.332 ± 0.172
0.665TrpLys: 0.665 ± 0.343
0.665TrpLeu: 0.665 ± 0.343
0.0TrpMet: 0.0 ± 0.0
0.332TrpAsn: 0.332 ± 0.623
0.665TrpPro: 0.665 ± 0.343
0.0TrpGln: 0.0 ± 0.0
0.332TrpArg: 0.332 ± 0.172
0.332TrpSer: 0.332 ± 0.844
0.665TrpThr: 0.665 ± 0.343
0.997TrpVal: 0.997 ± 0.467
0.332TrpTrp: 0.332 ± 0.172
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.994TyrAla: 1.994 ± 1.569
0.665TyrCys: 0.665 ± 1.165
1.662TyrAsp: 1.662 ± 0.858
1.994TyrGlu: 1.994 ± 0.933
0.332TyrPhe: 0.332 ± 0.172
1.662TyrGly: 1.662 ± 0.531
0.332TyrHis: 0.332 ± 1.484
1.994TyrIle: 1.994 ± 0.832
0.997TyrLys: 0.997 ± 0.68
3.656TyrLeu: 3.656 ± 1.164
0.665TyrMet: 0.665 ± 1.4
0.997TyrAsn: 0.997 ± 0.68
0.665TyrPro: 0.665 ± 0.523
0.665TyrGln: 0.665 ± 1.227
1.329TyrArg: 1.329 ± 0.47
2.659TyrSer: 2.659 ± 2.432
1.662TyrThr: 1.662 ± 0.858
0.332TyrVal: 0.332 ± 0.844
0.332TyrTrp: 0.332 ± 0.172
0.332TyrTyr: 0.332 ± 1.484
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (3010 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski