Amino acid dipepetide frequency for Nostoc sphaeroides CCNUC1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.852AlaAla: 6.852 ± 0.078
0.77AlaCys: 0.77 ± 0.017
3.933AlaAsp: 3.933 ± 0.044
4.891AlaGlu: 4.891 ± 0.059
2.859AlaPhe: 2.859 ± 0.037
5.211AlaGly: 5.211 ± 0.063
1.198AlaHis: 1.198 ± 0.024
6.861AlaIle: 6.861 ± 0.066
4.163AlaLys: 4.163 ± 0.044
8.203AlaLeu: 8.203 ± 0.07
1.555AlaMet: 1.555 ± 0.026
3.515AlaAsn: 3.515 ± 0.052
2.676AlaPro: 2.676 ± 0.035
3.997AlaGln: 3.997 ± 0.05
3.356AlaArg: 3.356 ± 0.038
4.978AlaSer: 4.978 ± 0.058
4.606AlaThr: 4.606 ± 0.057
5.273AlaVal: 5.273 ± 0.058
1.004AlaTrp: 1.004 ± 0.024
2.228AlaTyr: 2.228 ± 0.032
0.0AlaXaa: 0.0 ± 0.0
Cys
0.626CysAla: 0.626 ± 0.018
0.176CysCys: 0.176 ± 0.008
0.581CysAsp: 0.581 ± 0.017
0.566CysGlu: 0.566 ± 0.017
0.461CysPhe: 0.461 ± 0.014
0.753CysGly: 0.753 ± 0.019
0.264CysHis: 0.264 ± 0.01
0.596CysIle: 0.596 ± 0.017
0.423CysLys: 0.423 ± 0.014
1.145CysLeu: 1.145 ± 0.028
0.155CysMet: 0.155 ± 0.008
0.439CysAsn: 0.439 ± 0.013
0.544CysPro: 0.544 ± 0.02
0.606CysGln: 0.606 ± 0.014
0.519CysArg: 0.519 ± 0.016
0.692CysSer: 0.692 ± 0.016
0.524CysThr: 0.524 ± 0.017
0.604CysVal: 0.604 ± 0.016
0.169CysTrp: 0.169 ± 0.009
0.368CysTyr: 0.368 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
3.589AspAla: 3.589 ± 0.043
0.524AspCys: 0.524 ± 0.015
2.406AspAsp: 2.406 ± 0.053
3.117AspGlu: 3.117 ± 0.044
2.389AspPhe: 2.389 ± 0.033
3.374AspGly: 3.374 ± 0.062
0.699AspHis: 0.699 ± 0.017
3.554AspIle: 3.554 ± 0.048
2.504AspLys: 2.504 ± 0.033
5.428AspLeu: 5.428 ± 0.059
0.721AspMet: 0.721 ± 0.016
2.186AspAsn: 2.186 ± 0.033
2.141AspPro: 2.141 ± 0.032
1.676AspGln: 1.676 ± 0.03
3.095AspArg: 3.095 ± 0.037
3.086AspSer: 3.086 ± 0.039
2.529AspThr: 2.529 ± 0.044
2.935AspVal: 2.935 ± 0.038
0.902AspTrp: 0.902 ± 0.021
1.96AspTyr: 1.96 ± 0.032
0.0AspXaa: 0.0 ± 0.0
Glu
5.135GluAla: 5.135 ± 0.055
0.579GluCys: 0.579 ± 0.014
2.67GluAsp: 2.67 ± 0.035
4.012GluGlu: 4.012 ± 0.052
2.494GluPhe: 2.494 ± 0.03
3.13GluGly: 3.13 ± 0.039
1.009GluHis: 1.009 ± 0.022
5.055GluIle: 5.055 ± 0.057
3.683GluLys: 3.683 ± 0.045
7.082GluLeu: 7.082 ± 0.071
1.31GluMet: 1.31 ± 0.023
2.885GluAsn: 2.885 ± 0.035
2.334GluPro: 2.334 ± 0.038
3.732GluGln: 3.732 ± 0.051
3.409GluArg: 3.409 ± 0.048
3.679GluSer: 3.679 ± 0.047
3.407GluThr: 3.407 ± 0.039
4.28GluVal: 4.28 ± 0.044
0.828GluTrp: 0.828 ± 0.02
1.972GluTyr: 1.972 ± 0.03
0.0GluXaa: 0.0 ± 0.0
Phe
3.094PheAla: 3.094 ± 0.043
0.564PheCys: 0.564 ± 0.015
2.234PheAsp: 2.234 ± 0.033
2.216PheGlu: 2.216 ± 0.033
1.736PhePhe: 1.736 ± 0.029
2.904PheGly: 2.904 ± 0.041
0.737PheHis: 0.737 ± 0.017
2.524PheIle: 2.524 ± 0.032
1.765PheLys: 1.765 ± 0.032
4.181PheLeu: 4.181 ± 0.048
0.723PheMet: 0.723 ± 0.019
1.902PheAsn: 1.902 ± 0.032
1.752PhePro: 1.752 ± 0.028
1.85PheGln: 1.85 ± 0.031
1.821PheArg: 1.821 ± 0.027
3.114PheSer: 3.114 ± 0.046
2.307PheThr: 2.307 ± 0.031
2.459PheVal: 2.459 ± 0.036
0.674PheTrp: 0.674 ± 0.018
1.417PheTyr: 1.417 ± 0.028
0.0PheXaa: 0.0 ± 0.0
Gly
4.505GlyAla: 4.505 ± 0.061
0.785GlyCys: 0.785 ± 0.02
3.452GlyAsp: 3.452 ± 0.063
4.082GlyGlu: 4.082 ± 0.054
2.877GlyPhe: 2.877 ± 0.048
4.872GlyGly: 4.872 ± 0.109
1.161GlyHis: 1.161 ± 0.029
4.955GlyIle: 4.955 ± 0.055
4.11GlyLys: 4.11 ± 0.053
6.572GlyLeu: 6.572 ± 0.057
1.394GlyMet: 1.394 ± 0.026
3.387GlyAsn: 3.387 ± 0.091
1.099GlyPro: 1.099 ± 0.024
2.821GlyGln: 2.821 ± 0.04
3.198GlyArg: 3.198 ± 0.042
4.235GlySer: 4.235 ± 0.05
3.912GlyThr: 3.912 ± 0.066
4.6GlyVal: 4.6 ± 0.055
1.062GlyTrp: 1.062 ± 0.027
2.306GlyTyr: 2.306 ± 0.033
0.0GlyXaa: 0.0 ± 0.0
His
0.975HisAla: 0.975 ± 0.021
0.262HisCys: 0.262 ± 0.01
0.729HisAsp: 0.729 ± 0.017
0.985HisGlu: 0.985 ± 0.024
0.802HisPhe: 0.802 ± 0.017
0.973HisGly: 0.973 ± 0.021
0.538HisHis: 0.538 ± 0.016
1.142HisIle: 1.142 ± 0.02
0.822HisLys: 0.822 ± 0.023
2.201HisLeu: 2.201 ± 0.03
0.199HisMet: 0.199 ± 0.009
0.754HisAsn: 0.754 ± 0.018
1.244HisPro: 1.244 ± 0.025
1.138HisGln: 1.138 ± 0.025
1.071HisArg: 1.071 ± 0.02
1.2HisSer: 1.2 ± 0.023
0.901HisThr: 0.901 ± 0.021
0.767HisVal: 0.767 ± 0.017
0.384HisTrp: 0.384 ± 0.013
0.643HisTyr: 0.643 ± 0.015
0.0HisXaa: 0.0 ± 0.0
Ile
7.18IleAla: 7.18 ± 0.057
0.804IleCys: 0.804 ± 0.019
3.776IleAsp: 3.776 ± 0.04
4.388IleGlu: 4.388 ± 0.049
2.699IlePhe: 2.699 ± 0.037
4.407IleGly: 4.407 ± 0.054
1.236IleHis: 1.236 ± 0.022
4.056IleIle: 4.056 ± 0.052
3.528IleLys: 3.528 ± 0.041
6.828IleLeu: 6.828 ± 0.065
0.944IleMet: 0.944 ± 0.022
3.415IleAsn: 3.415 ± 0.046
3.536IlePro: 3.536 ± 0.052
3.162IleGln: 3.162 ± 0.037
3.146IleArg: 3.146 ± 0.039
4.894IleSer: 4.894 ± 0.054
3.924IleThr: 3.924 ± 0.048
4.226IleVal: 4.226 ± 0.044
0.887IleTrp: 0.887 ± 0.022
2.073IleTyr: 2.073 ± 0.034
0.0IleXaa: 0.0 ± 0.0
Lys
4.113LysAla: 4.113 ± 0.043
0.386LysCys: 0.386 ± 0.012
2.419LysAsp: 2.419 ± 0.044
3.019LysGlu: 3.019 ± 0.046
2.031LysPhe: 2.031 ± 0.034
2.852LysGly: 2.852 ± 0.034
0.887LysHis: 0.887 ± 0.021
3.872LysIle: 3.872 ± 0.049
2.809LysLys: 2.809 ± 0.045
5.896LysLeu: 5.896 ± 0.056
0.991LysMet: 0.991 ± 0.019
2.469LysAsn: 2.469 ± 0.033
2.585LysPro: 2.585 ± 0.037
2.863LysGln: 2.863 ± 0.042
2.53LysArg: 2.53 ± 0.034
3.363LysSer: 3.363 ± 0.044
3.208LysThr: 3.208 ± 0.04
3.294LysVal: 3.294 ± 0.036
0.55LysTrp: 0.55 ± 0.016
1.616LysTyr: 1.616 ± 0.032
0.0LysXaa: 0.0 ± 0.0
Leu
8.964LeuAla: 8.964 ± 0.066
1.02LeuCys: 1.02 ± 0.021
5.198LeuAsp: 5.198 ± 0.056
7.411LeuGlu: 7.411 ± 0.067
3.79LeuPhe: 3.79 ± 0.055
7.494LeuGly: 7.494 ± 0.061
1.866LeuHis: 1.866 ± 0.033
6.825LeuIle: 6.825 ± 0.059
5.885LeuLys: 5.885 ± 0.057
11.2LeuLeu: 11.2 ± 0.097
2.059LeuMet: 2.059 ± 0.027
4.984LeuAsn: 4.984 ± 0.059
5.6LeuPro: 5.6 ± 0.057
5.701LeuGln: 5.701 ± 0.061
5.684LeuArg: 5.684 ± 0.055
7.554LeuSer: 7.554 ± 0.055
6.521LeuThr: 6.521 ± 0.062
6.978LeuVal: 6.978 ± 0.054
1.424LeuTrp: 1.424 ± 0.029
2.749LeuTyr: 2.749 ± 0.037
0.0LeuXaa: 0.0 ± 0.0
Met
1.569MetAla: 1.569 ± 0.026
0.128MetCys: 0.128 ± 0.008
0.657MetAsp: 0.657 ± 0.018
0.979MetGlu: 0.979 ± 0.023
0.542MetPhe: 0.542 ± 0.014
1.255MetGly: 1.255 ± 0.026
0.312MetHis: 0.312 ± 0.011
1.098MetIle: 1.098 ± 0.024
0.957MetLys: 0.957 ± 0.019
1.961MetLeu: 1.961 ± 0.034
0.367MetMet: 0.367 ± 0.011
0.905MetAsn: 0.905 ± 0.022
0.945MetPro: 0.945 ± 0.019
0.945MetGln: 0.945 ± 0.022
0.975MetArg: 0.975 ± 0.023
1.351MetSer: 1.351 ± 0.022
1.269MetThr: 1.269 ± 0.024
1.215MetVal: 1.215 ± 0.024
0.161MetTrp: 0.161 ± 0.008
0.361MetTyr: 0.361 ± 0.011
0.0MetXaa: 0.0 ± 0.0
Asn
3.147AsnAla: 3.147 ± 0.043
0.514AsnCys: 0.514 ± 0.017
2.054AsnAsp: 2.054 ± 0.066
2.07AsnGlu: 2.07 ± 0.035
2.137AsnPhe: 2.137 ± 0.035
2.989AsnGly: 2.989 ± 0.061
0.872AsnHis: 0.872 ± 0.018
3.128AsnIle: 3.128 ± 0.047
2.034AsnLys: 2.034 ± 0.036
5.734AsnLeu: 5.734 ± 0.063
0.699AsnMet: 0.699 ± 0.017
2.414AsnAsn: 2.414 ± 0.048
2.98AsnPro: 2.98 ± 0.041
2.867AsnGln: 2.867 ± 0.032
2.454AsnArg: 2.454 ± 0.033
3.568AsnSer: 3.568 ± 0.047
2.488AsnThr: 2.488 ± 0.039
2.272AsnVal: 2.272 ± 0.036
0.766AsnTrp: 0.766 ± 0.022
1.638AsnTyr: 1.638 ± 0.027
0.0AsnXaa: 0.0 ± 0.0
Pro
2.932ProAla: 2.932 ± 0.041
0.38ProCys: 0.38 ± 0.012
2.783ProAsp: 2.783 ± 0.04
3.679ProGlu: 3.679 ± 0.058
1.759ProPhe: 1.759 ± 0.032
2.724ProGly: 2.724 ± 0.039
0.868ProHis: 0.868 ± 0.019
3.028ProIle: 3.028 ± 0.037
2.395ProLys: 2.395 ± 0.03
4.548ProLeu: 4.548 ± 0.047
0.728ProMet: 0.728 ± 0.017
2.369ProAsn: 2.369 ± 0.037
2.2ProPro: 2.2 ± 0.039
2.536ProGln: 2.536 ± 0.033
1.688ProArg: 1.688 ± 0.028
2.985ProSer: 2.985 ± 0.039
2.876ProThr: 2.876 ± 0.041
3.121ProVal: 3.121 ± 0.04
0.54ProTrp: 0.54 ± 0.016
1.26ProTyr: 1.26 ± 0.023
0.0ProXaa: 0.0 ± 0.0
Gln
4.546GlnAla: 4.546 ± 0.053
0.363GlnCys: 0.363 ± 0.012
2.112GlnAsp: 2.112 ± 0.029
3.675GlnGlu: 3.675 ± 0.052
1.789GlnPhe: 1.789 ± 0.029
3.146GlnGly: 3.146 ± 0.039
0.854GlnHis: 0.854 ± 0.017
3.814GlnIle: 3.814 ± 0.046
2.935GlnLys: 2.935 ± 0.038
5.984GlnLeu: 5.984 ± 0.066
1.086GlnMet: 1.086 ± 0.021
2.265GlnAsn: 2.265 ± 0.032
2.496GlnPro: 2.496 ± 0.034
3.95GlnGln: 3.95 ± 0.061
2.927GlnArg: 2.927 ± 0.042
3.184GlnSer: 3.184 ± 0.044
2.942GlnThr: 2.942 ± 0.037
3.697GlnVal: 3.697 ± 0.037
0.684GlnTrp: 0.684 ± 0.017
1.271GlnTyr: 1.271 ± 0.022
0.0GlnXaa: 0.0 ± 0.0
Arg
3.038ArgAla: 3.038 ± 0.041
0.542ArgCys: 0.542 ± 0.017
2.501ArgAsp: 2.501 ± 0.035
3.288ArgGlu: 3.288 ± 0.041
2.245ArgPhe: 2.245 ± 0.031
2.909ArgGly: 2.909 ± 0.034
0.988ArgHis: 0.988 ± 0.021
3.497ArgIle: 3.497 ± 0.039
2.374ArgLys: 2.374 ± 0.039
6.01ArgLeu: 6.01 ± 0.052
0.965ArgMet: 0.965 ± 0.019
2.201ArgAsn: 2.201 ± 0.034
1.919ArgPro: 1.919 ± 0.03
3.095ArgGln: 3.095 ± 0.035
3.074ArgArg: 3.074 ± 0.039
3.333ArgSer: 3.333 ± 0.035
2.573ArgThr: 2.573 ± 0.031
3.374ArgVal: 3.374 ± 0.042
0.776ArgTrp: 0.776 ± 0.018
1.842ArgTyr: 1.842 ± 0.032
0.0ArgXaa: 0.0 ± 0.0
Ser
4.681SerAla: 4.681 ± 0.048
0.673SerCys: 0.673 ± 0.018
3.382SerAsp: 3.382 ± 0.041
3.879SerGlu: 3.879 ± 0.039
2.619SerPhe: 2.619 ± 0.036
4.76SerGly: 4.76 ± 0.059
1.285SerHis: 1.285 ± 0.023
4.175SerIle: 4.175 ± 0.046
3.211SerLys: 3.211 ± 0.039
7.71SerLeu: 7.71 ± 0.064
1.153SerMet: 1.153 ± 0.021
3.111SerAsn: 3.111 ± 0.042
3.496SerPro: 3.496 ± 0.046
3.867SerGln: 3.867 ± 0.043
3.225SerArg: 3.225 ± 0.036
4.88SerSer: 4.88 ± 0.055
3.78SerThr: 3.78 ± 0.045
4.23SerVal: 4.23 ± 0.049
0.932SerTrp: 0.932 ± 0.021
1.867SerTyr: 1.867 ± 0.028
0.0SerXaa: 0.0 ± 0.0
Thr
4.729ThrAla: 4.729 ± 0.052
0.472ThrCys: 0.472 ± 0.016
2.699ThrAsp: 2.699 ± 0.035
3.35ThrGlu: 3.35 ± 0.037
2.185ThrPhe: 2.185 ± 0.031
4.32ThrGly: 4.32 ± 0.064
1.03ThrHis: 1.03 ± 0.021
3.854ThrIle: 3.854 ± 0.044
2.585ThrLys: 2.585 ± 0.035
6.301ThrLeu: 6.301 ± 0.061
0.788ThrMet: 0.788 ± 0.017
2.515ThrAsn: 2.515 ± 0.036
3.404ThrPro: 3.404 ± 0.047
2.968ThrGln: 2.968 ± 0.04
2.424ThrArg: 2.424 ± 0.032
3.735ThrSer: 3.735 ± 0.044
3.456ThrThr: 3.456 ± 0.05
3.967ThrVal: 3.967 ± 0.047
0.689ThrTrp: 0.689 ± 0.02
1.574ThrTyr: 1.574 ± 0.025
0.0ThrXaa: 0.0 ± 0.0
Val
5.468ValAla: 5.468 ± 0.053
0.663ValCys: 0.663 ± 0.016
3.172ValAsp: 3.172 ± 0.04
4.4ValGlu: 4.4 ± 0.05
2.608ValPhe: 2.608 ± 0.037
4.336ValGly: 4.336 ± 0.049
0.967ValHis: 0.967 ± 0.019
4.485ValIle: 4.485 ± 0.049
3.458ValLys: 3.458 ± 0.046
6.459ValLeu: 6.459 ± 0.061
1.343ValMet: 1.343 ± 0.024
3.123ValAsn: 3.123 ± 0.037
2.702ValPro: 2.702 ± 0.036
2.821ValGln: 2.821 ± 0.039
3.194ValArg: 3.194 ± 0.039
4.222ValSer: 4.222 ± 0.041
3.729ValThr: 3.729 ± 0.044
4.593ValVal: 4.593 ± 0.05
0.838ValTrp: 0.838 ± 0.019
1.802ValTyr: 1.802 ± 0.026
0.0ValXaa: 0.0 ± 0.0
Trp
0.879TrpAla: 0.879 ± 0.022
0.159TrpCys: 0.159 ± 0.008
0.648TrpAsp: 0.648 ± 0.021
0.913TrpGlu: 0.913 ± 0.019
0.57TrpPhe: 0.57 ± 0.016
1.022TrpGly: 1.022 ± 0.027
0.33TrpHis: 0.33 ± 0.012
0.85TrpIle: 0.85 ± 0.021
0.661TrpLys: 0.661 ± 0.017
1.844TrpLeu: 1.844 ± 0.032
0.312TrpMet: 0.312 ± 0.014
0.656TrpAsn: 0.656 ± 0.019
0.245TrpPro: 0.245 ± 0.011
1.106TrpGln: 1.106 ± 0.019
0.831TrpArg: 0.831 ± 0.018
0.831TrpSer: 0.831 ± 0.022
0.567TrpThr: 0.567 ± 0.016
0.946TrpVal: 0.946 ± 0.021
0.24TrpTrp: 0.24 ± 0.011
0.443TrpTyr: 0.443 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.112TyrAla: 2.112 ± 0.029
0.445TyrCys: 0.445 ± 0.014
1.411TyrAsp: 1.411 ± 0.026
1.763TyrGlu: 1.763 ± 0.029
1.381TyrPhe: 1.381 ± 0.025
1.952TyrGly: 1.952 ± 0.03
0.625TyrHis: 0.625 ± 0.015
1.74TyrIle: 1.74 ± 0.03
1.451TyrLys: 1.451 ± 0.029
3.625TyrLeu: 3.625 ± 0.039
0.461TyrMet: 0.461 ± 0.013
1.332TyrAsn: 1.332 ± 0.029
1.501TyrPro: 1.501 ± 0.026
2.017TyrGln: 2.017 ± 0.035
1.924TyrArg: 1.924 ± 0.031
2.031TyrSer: 2.031 ± 0.033
1.526TyrThr: 1.526 ± 0.029
1.549TyrVal: 1.549 ± 0.026
0.542TyrTrp: 0.542 ± 0.015
1.081TyrTyr: 1.081 ± 0.023
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 10233 proteins (2503695 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski