Amino acid dipepetide frequency for Mucilaginibacter mallensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.488AlaAla: 6.488 ± 0.081
0.674AlaCys: 0.674 ± 0.021
4.821AlaAsp: 4.821 ± 0.051
3.935AlaGlu: 3.935 ± 0.051
3.464AlaPhe: 3.464 ± 0.052
5.787AlaGly: 5.787 ± 0.082
1.286AlaHis: 1.286 ± 0.03
5.777AlaIle: 5.777 ± 0.072
4.711AlaLys: 4.711 ± 0.061
6.8AlaLeu: 6.8 ± 0.071
1.724AlaMet: 1.724 ± 0.036
4.029AlaAsn: 4.029 ± 0.053
2.572AlaPro: 2.572 ± 0.042
3.091AlaGln: 3.091 ± 0.05
2.342AlaArg: 2.342 ± 0.038
4.655AlaSer: 4.655 ± 0.082
4.464AlaThr: 4.464 ± 0.085
4.904AlaVal: 4.904 ± 0.063
0.889AlaTrp: 0.889 ± 0.023
3.161AlaTyr: 3.161 ± 0.041
0.0AlaXaa: 0.0 ± 0.0
Cys
0.516CysAla: 0.516 ± 0.018
0.146CysCys: 0.146 ± 0.009
0.415CysAsp: 0.415 ± 0.015
0.346CysGlu: 0.346 ± 0.015
0.434CysPhe: 0.434 ± 0.019
0.646CysGly: 0.646 ± 0.02
0.199CysHis: 0.199 ± 0.013
0.694CysIle: 0.694 ± 0.023
0.538CysLys: 0.538 ± 0.017
0.824CysLeu: 0.824 ± 0.022
0.206CysMet: 0.206 ± 0.01
0.421CysAsn: 0.421 ± 0.015
0.313CysPro: 0.313 ± 0.014
0.215CysGln: 0.215 ± 0.01
0.305CysArg: 0.305 ± 0.015
0.554CysSer: 0.554 ± 0.022
0.456CysThr: 0.456 ± 0.02
0.466CysVal: 0.466 ± 0.017
0.098CysTrp: 0.098 ± 0.007
0.35CysTyr: 0.35 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
4.11AspAla: 4.11 ± 0.048
0.423AspCys: 0.423 ± 0.015
2.919AspAsp: 2.919 ± 0.046
3.397AspGlu: 3.397 ± 0.045
3.066AspPhe: 3.066 ± 0.045
3.977AspGly: 3.977 ± 0.054
1.103AspHis: 1.103 ± 0.025
4.167AspIle: 4.167 ± 0.05
3.928AspLys: 3.928 ± 0.059
4.718AspLeu: 4.718 ± 0.066
1.257AspMet: 1.257 ± 0.028
3.141AspAsn: 3.141 ± 0.042
2.373AspPro: 2.373 ± 0.039
1.937AspGln: 1.937 ± 0.034
1.961AspArg: 1.961 ± 0.033
3.157AspSer: 3.157 ± 0.05
2.937AspThr: 2.937 ± 0.046
3.49AspVal: 3.49 ± 0.042
0.823AspTrp: 0.823 ± 0.021
2.737AspTyr: 2.737 ± 0.044
0.0AspXaa: 0.0 ± 0.0
Glu
3.775GluAla: 3.775 ± 0.058
0.313GluCys: 0.313 ± 0.013
2.463GluAsp: 2.463 ± 0.041
2.765GluGlu: 2.765 ± 0.056
2.172GluPhe: 2.172 ± 0.041
2.875GluGly: 2.875 ± 0.042
1.053GluHis: 1.053 ± 0.028
3.953GluIle: 3.953 ± 0.056
3.922GluLys: 3.922 ± 0.065
5.158GluLeu: 5.158 ± 0.065
1.32GluMet: 1.32 ± 0.03
2.831GluAsn: 2.831 ± 0.043
1.607GluPro: 1.607 ± 0.034
2.277GluGln: 2.277 ± 0.043
2.105GluArg: 2.105 ± 0.04
2.567GluSer: 2.567 ± 0.034
2.729GluThr: 2.729 ± 0.038
3.242GluVal: 3.242 ± 0.046
0.64GluTrp: 0.64 ± 0.02
1.986GluTyr: 1.986 ± 0.036
0.0GluXaa: 0.0 ± 0.0
Phe
3.325PheAla: 3.325 ± 0.045
0.483PheCys: 0.483 ± 0.017
2.962PheAsp: 2.962 ± 0.045
2.417PheGlu: 2.417 ± 0.04
2.413PhePhe: 2.413 ± 0.043
3.377PheGly: 3.377 ± 0.046
0.86PheHis: 0.86 ± 0.022
3.64PheIle: 3.64 ± 0.064
3.295PheLys: 3.295 ± 0.047
4.091PheLeu: 4.091 ± 0.068
1.062PheMet: 1.062 ± 0.027
3.196PheAsn: 3.196 ± 0.047
1.762PhePro: 1.762 ± 0.033
1.314PheGln: 1.314 ± 0.027
1.674PheArg: 1.674 ± 0.029
3.534PheSer: 3.534 ± 0.047
3.321PheThr: 3.321 ± 0.048
2.782PheVal: 2.782 ± 0.05
0.616PheTrp: 0.616 ± 0.02
2.233PheTyr: 2.233 ± 0.039
0.0PheXaa: 0.0 ± 0.0
Gly
4.643GlyAla: 4.643 ± 0.068
0.628GlyCys: 0.628 ± 0.023
3.668GlyAsp: 3.668 ± 0.054
3.079GlyGlu: 3.079 ± 0.047
3.644GlyPhe: 3.644 ± 0.048
5.172GlyGly: 5.172 ± 0.077
1.324GlyHis: 1.324 ± 0.03
5.594GlyIle: 5.594 ± 0.064
5.157GlyLys: 5.157 ± 0.063
6.297GlyLeu: 6.297 ± 0.066
1.645GlyMet: 1.645 ± 0.034
3.954GlyAsn: 3.954 ± 0.06
1.885GlyPro: 1.885 ± 0.038
2.253GlyGln: 2.253 ± 0.037
2.37GlyArg: 2.37 ± 0.045
4.61GlySer: 4.61 ± 0.07
4.552GlyThr: 4.552 ± 0.075
4.496GlyVal: 4.496 ± 0.054
1.039GlyTrp: 1.039 ± 0.026
3.367GlyTyr: 3.367 ± 0.054
0.0GlyXaa: 0.0 ± 0.0
His
1.177HisAla: 1.177 ± 0.026
0.187HisCys: 0.187 ± 0.009
1.065HisAsp: 1.065 ± 0.028
1.0HisGlu: 1.0 ± 0.023
1.158HisPhe: 1.158 ± 0.027
1.226HisGly: 1.226 ± 0.026
0.551HisHis: 0.551 ± 0.019
1.545HisIle: 1.545 ± 0.029
1.098HisLys: 1.098 ± 0.027
1.865HisLeu: 1.865 ± 0.036
0.422HisMet: 0.422 ± 0.017
1.038HisAsn: 1.038 ± 0.027
1.025HisPro: 1.025 ± 0.026
0.769HisGln: 0.769 ± 0.022
0.683HisArg: 0.683 ± 0.022
1.112HisSer: 1.112 ± 0.025
1.129HisThr: 1.129 ± 0.025
1.016HisVal: 1.016 ± 0.024
0.263HisTrp: 0.263 ± 0.013
0.926HisTyr: 0.926 ± 0.024
0.0HisXaa: 0.0 ± 0.0
Ile
6.201IleAla: 6.201 ± 0.073
0.744IleCys: 0.744 ± 0.022
4.45IleAsp: 4.45 ± 0.048
3.825IleGlu: 3.825 ± 0.054
3.243IlePhe: 3.243 ± 0.049
4.989IleGly: 4.989 ± 0.073
1.361IleHis: 1.361 ± 0.026
5.695IleIle: 5.695 ± 0.065
5.25IleLys: 5.25 ± 0.058
6.226IleLeu: 6.226 ± 0.075
1.431IleMet: 1.431 ± 0.028
4.85IleAsn: 4.85 ± 0.05
3.224IlePro: 3.224 ± 0.045
2.328IleGln: 2.328 ± 0.041
2.782IleArg: 2.782 ± 0.039
5.296IleSer: 5.296 ± 0.057
5.29IleThr: 5.29 ± 0.058
4.302IleVal: 4.302 ± 0.051
0.755IleTrp: 0.755 ± 0.023
2.927IleTyr: 2.927 ± 0.042
0.0IleXaa: 0.0 ± 0.0
Lys
5.111LysAla: 5.111 ± 0.069
0.328LysCys: 0.328 ± 0.014
4.003LysAsp: 4.003 ± 0.056
3.824LysGlu: 3.824 ± 0.063
2.585LysPhe: 2.585 ± 0.036
4.457LysGly: 4.457 ± 0.057
1.281LysHis: 1.281 ± 0.026
4.992LysIle: 4.992 ± 0.055
5.091LysLys: 5.091 ± 0.072
6.105LysLeu: 6.105 ± 0.066
1.762LysMet: 1.762 ± 0.035
4.06LysAsn: 4.06 ± 0.051
2.846LysPro: 2.846 ± 0.044
2.817LysGln: 2.817 ± 0.04
2.559LysArg: 2.559 ± 0.039
3.816LysSer: 3.816 ± 0.051
4.151LysThr: 4.151 ± 0.052
4.282LysVal: 4.282 ± 0.049
0.821LysTrp: 0.821 ± 0.025
2.979LysTyr: 2.979 ± 0.044
0.0LysXaa: 0.0 ± 0.0
Leu
6.608LeuAla: 6.608 ± 0.068
0.817LeuCys: 0.817 ± 0.023
4.504LeuAsp: 4.504 ± 0.053
3.964LeuGlu: 3.964 ± 0.062
4.662LeuPhe: 4.662 ± 0.076
5.711LeuGly: 5.711 ± 0.065
1.707LeuHis: 1.707 ± 0.03
6.756LeuIle: 6.756 ± 0.088
6.903LeuLys: 6.903 ± 0.073
9.154LeuLeu: 9.154 ± 0.095
2.105LeuMet: 2.105 ± 0.04
5.682LeuAsn: 5.682 ± 0.074
4.081LeuPro: 4.081 ± 0.049
3.605LeuGln: 3.605 ± 0.05
3.324LeuArg: 3.324 ± 0.041
6.623LeuSer: 6.623 ± 0.068
5.731LeuThr: 5.731 ± 0.075
5.331LeuVal: 5.331 ± 0.057
0.994LeuTrp: 0.994 ± 0.025
3.442LeuTyr: 3.442 ± 0.053
0.0LeuXaa: 0.0 ± 0.0
Met
1.852MetAla: 1.852 ± 0.035
0.163MetCys: 0.163 ± 0.01
1.23MetAsp: 1.23 ± 0.032
1.19MetGlu: 1.19 ± 0.031
0.812MetPhe: 0.812 ± 0.02
1.511MetGly: 1.511 ± 0.029
0.472MetHis: 0.472 ± 0.016
1.578MetIle: 1.578 ± 0.033
1.849MetLys: 1.849 ± 0.031
2.145MetLeu: 2.145 ± 0.038
0.561MetMet: 0.561 ± 0.02
1.243MetAsn: 1.243 ± 0.026
1.11MetPro: 1.11 ± 0.026
0.999MetGln: 0.999 ± 0.027
0.914MetArg: 0.914 ± 0.024
1.325MetSer: 1.325 ± 0.03
1.051MetThr: 1.051 ± 0.024
1.419MetVal: 1.419 ± 0.031
0.198MetTrp: 0.198 ± 0.012
0.703MetTyr: 0.703 ± 0.02
0.0MetXaa: 0.0 ± 0.0
Asn
4.239AsnAla: 4.239 ± 0.057
0.451AsnCys: 0.451 ± 0.019
3.212AsnAsp: 3.212 ± 0.043
2.803AsnGlu: 2.803 ± 0.042
2.672AsnPhe: 2.672 ± 0.037
4.466AsnGly: 4.466 ± 0.07
1.116AsnHis: 1.116 ± 0.026
4.484AsnIle: 4.484 ± 0.058
3.723AsnLys: 3.723 ± 0.047
4.94AsnLeu: 4.94 ± 0.057
1.222AsnMet: 1.222 ± 0.029
3.871AsnAsn: 3.871 ± 0.06
2.923AsnPro: 2.923 ± 0.047
2.178AsnGln: 2.178 ± 0.042
2.113AsnArg: 2.113 ± 0.04
3.628AsnSer: 3.628 ± 0.058
3.69AsnThr: 3.69 ± 0.06
3.422AsnVal: 3.422 ± 0.049
0.85AsnTrp: 0.85 ± 0.025
2.967AsnTyr: 2.967 ± 0.047
0.0AsnXaa: 0.0 ± 0.0
Pro
3.61ProAla: 3.61 ± 0.063
0.216ProCys: 0.216 ± 0.01
2.759ProAsp: 2.759 ± 0.043
2.601ProGlu: 2.601 ± 0.042
1.923ProPhe: 1.923 ± 0.032
3.207ProGly: 3.207 ± 0.051
0.736ProHis: 0.736 ± 0.022
2.505ProIle: 2.505 ± 0.039
2.176ProLys: 2.176 ± 0.042
3.369ProLeu: 3.369 ± 0.048
0.749ProMet: 0.749 ± 0.022
2.191ProAsn: 2.191 ± 0.039
1.251ProPro: 1.251 ± 0.032
1.574ProGln: 1.574 ± 0.034
1.045ProArg: 1.045 ± 0.027
2.298ProSer: 2.298 ± 0.038
2.211ProThr: 2.211 ± 0.05
3.5ProVal: 3.5 ± 0.047
0.481ProTrp: 0.481 ± 0.018
1.747ProTyr: 1.747 ± 0.035
0.0ProXaa: 0.0 ± 0.0
Gln
2.813GlnAla: 2.813 ± 0.05
0.212GlnCys: 0.212 ± 0.011
1.722GlnAsp: 1.722 ± 0.03
1.648GlnGlu: 1.648 ± 0.033
1.729GlnPhe: 1.729 ± 0.028
2.135GlnGly: 2.135 ± 0.035
0.835GlnHis: 0.835 ± 0.023
2.566GlnIle: 2.566 ± 0.038
2.515GlnLys: 2.515 ± 0.045
3.857GlnLeu: 3.857 ± 0.049
0.936GlnMet: 0.936 ± 0.023
2.202GlnAsn: 2.202 ± 0.044
1.573GlnPro: 1.573 ± 0.031
2.245GlnGln: 2.245 ± 0.067
1.363GlnArg: 1.363 ± 0.031
2.313GlnSer: 2.313 ± 0.038
2.317GlnThr: 2.317 ± 0.046
2.458GlnVal: 2.458 ± 0.041
0.493GlnTrp: 0.493 ± 0.019
1.673GlnTyr: 1.673 ± 0.03
0.0GlnXaa: 0.0 ± 0.0
Arg
2.356ArgAla: 2.356 ± 0.036
0.229ArgCys: 0.229 ± 0.01
1.902ArgAsp: 1.902 ± 0.034
1.938ArgGlu: 1.938 ± 0.035
1.899ArgPhe: 1.899 ± 0.037
1.964ArgGly: 1.964 ± 0.032
0.669ArgHis: 0.669 ± 0.021
2.845ArgIle: 2.845 ± 0.043
2.5ArgLys: 2.5 ± 0.044
3.501ArgLeu: 3.501 ± 0.051
0.926ArgMet: 0.926 ± 0.02
2.038ArgAsn: 2.038 ± 0.034
1.297ArgPro: 1.297 ± 0.033
1.332ArgGln: 1.332 ± 0.028
1.395ArgArg: 1.395 ± 0.029
2.147ArgSer: 2.147 ± 0.036
1.892ArgThr: 1.892 ± 0.034
2.259ArgVal: 2.259 ± 0.035
0.483ArgTrp: 0.483 ± 0.017
1.706ArgTyr: 1.706 ± 0.031
0.0ArgXaa: 0.0 ± 0.0
Ser
4.991SerAla: 4.991 ± 0.066
0.607SerCys: 0.607 ± 0.018
3.116SerAsp: 3.116 ± 0.046
2.743SerGlu: 2.743 ± 0.036
3.482SerPhe: 3.482 ± 0.043
5.111SerGly: 5.111 ± 0.071
1.187SerHis: 1.187 ± 0.032
4.972SerIle: 4.972 ± 0.054
3.822SerLys: 3.822 ± 0.055
6.069SerLeu: 6.069 ± 0.067
1.263SerMet: 1.263 ± 0.023
3.347SerAsn: 3.347 ± 0.052
2.704SerPro: 2.704 ± 0.046
2.084SerGln: 2.084 ± 0.04
2.239SerArg: 2.239 ± 0.04
4.14SerSer: 4.14 ± 0.063
3.996SerThr: 3.996 ± 0.071
4.106SerVal: 4.106 ± 0.052
0.781SerTrp: 0.781 ± 0.021
2.943SerTyr: 2.943 ± 0.046
0.0SerXaa: 0.0 ± 0.0
Thr
5.119ThrAla: 5.119 ± 0.111
0.434ThrCys: 0.434 ± 0.019
3.702ThrAsp: 3.702 ± 0.053
2.81ThrGlu: 2.81 ± 0.047
2.883ThrPhe: 2.883 ± 0.041
5.152ThrGly: 5.152 ± 0.076
1.112ThrHis: 1.112 ± 0.023
4.743ThrIle: 4.743 ± 0.061
3.217ThrLys: 3.217 ± 0.044
5.548ThrLeu: 5.548 ± 0.076
1.071ThrMet: 1.071 ± 0.023
3.335ThrAsn: 3.335 ± 0.053
2.848ThrPro: 2.848 ± 0.059
2.114ThrGln: 2.114 ± 0.038
1.846ThrArg: 1.846 ± 0.03
3.93ThrSer: 3.93 ± 0.062
4.048ThrThr: 4.048 ± 0.088
4.276ThrVal: 4.276 ± 0.073
0.715ThrTrp: 0.715 ± 0.023
2.757ThrTyr: 2.757 ± 0.054
0.0ThrXaa: 0.0 ± 0.0
Val
4.743ValAla: 4.743 ± 0.065
0.544ValCys: 0.544 ± 0.019
3.433ValAsp: 3.433 ± 0.048
2.983ValGlu: 2.983 ± 0.051
3.13ValPhe: 3.13 ± 0.051
3.687ValGly: 3.687 ± 0.047
1.091ValHis: 1.091 ± 0.029
5.065ValIle: 5.065 ± 0.056
4.513ValLys: 4.513 ± 0.051
5.841ValLeu: 5.841 ± 0.069
1.456ValMet: 1.456 ± 0.033
3.925ValAsn: 3.925 ± 0.046
2.461ValPro: 2.461 ± 0.032
2.053ValGln: 2.053 ± 0.04
2.058ValArg: 2.058 ± 0.033
4.428ValSer: 4.428 ± 0.06
4.133ValThr: 4.133 ± 0.07
4.124ValVal: 4.124 ± 0.052
0.748ValTrp: 0.748 ± 0.024
2.617ValTyr: 2.617 ± 0.038
0.0ValXaa: 0.0 ± 0.0
Trp
0.857TrpAla: 0.857 ± 0.024
0.141TrpCys: 0.141 ± 0.009
0.744TrpAsp: 0.744 ± 0.021
0.606TrpGlu: 0.606 ± 0.02
0.611TrpPhe: 0.611 ± 0.024
0.921TrpGly: 0.921 ± 0.024
0.307TrpHis: 0.307 ± 0.014
0.774TrpIle: 0.774 ± 0.025
0.816TrpLys: 0.816 ± 0.022
1.221TrpLeu: 1.221 ± 0.034
0.36TrpMet: 0.36 ± 0.012
0.726TrpAsn: 0.726 ± 0.021
0.404TrpPro: 0.404 ± 0.014
0.619TrpGln: 0.619 ± 0.019
0.488TrpArg: 0.488 ± 0.016
0.695TrpSer: 0.695 ± 0.022
0.674TrpThr: 0.674 ± 0.02
0.758TrpVal: 0.758 ± 0.023
0.226TrpTrp: 0.226 ± 0.011
0.544TrpTyr: 0.544 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.041TyrAla: 3.041 ± 0.047
0.4TyrCys: 0.4 ± 0.014
2.528TyrAsp: 2.528 ± 0.037
1.876TyrGlu: 1.876 ± 0.036
2.375TyrPhe: 2.375 ± 0.038
3.007TyrGly: 3.007 ± 0.043
1.007TyrHis: 1.007 ± 0.026
2.825TyrIle: 2.825 ± 0.039
2.848TyrLys: 2.848 ± 0.039
3.974TyrLeu: 3.974 ± 0.048
0.846TyrMet: 0.846 ± 0.022
2.89TyrAsn: 2.89 ± 0.046
1.889TyrPro: 1.889 ± 0.037
1.803TyrGln: 1.803 ± 0.036
1.713TyrArg: 1.713 ± 0.032
2.877TyrSer: 2.877 ± 0.042
2.888TyrThr: 2.888 ± 0.046
2.4TyrVal: 2.4 ± 0.04
0.581TyrTrp: 0.581 ± 0.02
2.196TyrTyr: 2.196 ± 0.043
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4954 proteins (1761396 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski