Amino acid dipepetide frequency for Actinomyces sp. 2119

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.611AlaAla: 19.611 ± 0.244	1.25AlaCys: 1.25 ± 0.045	7.433AlaAsp: 7.433 ± 0.098	7.056AlaGlu: 7.056 ± 0.104	2.768AlaPhe: 2.768 ± 0.064	12.44AlaGly: 12.44 ± 0.162	2.399AlaHis: 2.399 ± 0.06	2.774AlaIle: 2.774 ± 0.061	1.513AlaLys: 1.513 ± 0.054	13.816AlaLeu: 13.816 ± 0.182	2.349AlaMet: 2.349 ± 0.05	1.686AlaAsn: 1.686 ± 0.043	6.788AlaPro: 6.788 ± 0.111	5.415AlaGln: 5.415 ± 0.079	10.636AlaArg: 10.636 ± 0.141	8.231AlaSer: 8.231 ± 0.113	7.538AlaThr: 7.538 ± 0.109	13.193AlaVal: 13.193 ± 0.158	1.961AlaTrp: 1.961 ± 0.058	2.4AlaTyr: 2.4 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	1.049CysAla: 1.049 ± 0.042	0.095CysCys: 0.095 ± 0.011	0.447CysAsp: 0.447 ± 0.021	0.39CysGlu: 0.39 ± 0.023	0.207CysPhe: 0.207 ± 0.018	0.897CysGly: 0.897 ± 0.035	0.199CysHis: 0.199 ± 0.016	0.169CysIle: 0.169 ± 0.017	0.066CysLys: 0.066 ± 0.009	0.988CysLeu: 0.988 ± 0.039	0.121CysMet: 0.121 ± 0.011	0.099CysAsn: 0.099 ± 0.01	0.488CysPro: 0.488 ± 0.026	0.316CysGln: 0.316 ± 0.019	0.541CysArg: 0.541 ± 0.027	0.519CysSer: 0.519 ± 0.029	0.517CysThr: 0.517 ± 0.029	0.686CysVal: 0.686 ± 0.03	0.126CysTrp: 0.126 ± 0.014	0.171CysTyr: 0.171 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	6.781AspAla: 6.781 ± 0.115	0.413AspCys: 0.413 ± 0.023	3.304AspAsp: 3.304 ± 0.078	3.173AspGlu: 3.173 ± 0.066	1.365AspPhe: 1.365 ± 0.046	5.35AspGly: 5.35 ± 0.095	1.372AspHis: 1.372 ± 0.049	1.732AspIle: 1.732 ± 0.053	0.821AspLys: 0.821 ± 0.039	6.742AspLeu: 6.742 ± 0.098	0.909AspMet: 0.909 ± 0.03	0.974AspAsn: 0.974 ± 0.035	4.412AspPro: 4.412 ± 0.087	2.053AspGln: 2.053 ± 0.057	3.889AspArg: 3.889 ± 0.079	3.507AspSer: 3.507 ± 0.073	3.388AspThr: 3.388 ± 0.06	5.202AspVal: 5.202 ± 0.096	0.812AspTrp: 0.812 ± 0.031	1.438AspTyr: 1.438 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	8.298GluAla: 8.298 ± 0.136	0.327GluCys: 0.327 ± 0.023	3.729GluAsp: 3.729 ± 0.077	4.587GluGlu: 4.587 ± 0.079	0.98GluPhe: 0.98 ± 0.041	4.873GluGly: 4.873 ± 0.087	1.344GluHis: 1.344 ± 0.043	1.902GluIle: 1.902 ± 0.053	0.924GluLys: 0.924 ± 0.042	5.448GluLeu: 5.448 ± 0.092	0.994GluMet: 0.994 ± 0.035	0.782GluAsn: 0.782 ± 0.03	3.167GluPro: 3.167 ± 0.069	2.168GluGln: 2.168 ± 0.048	4.617GluArg: 4.617 ± 0.087	2.51GluSer: 2.51 ± 0.068	2.889GluThr: 2.889 ± 0.07	6.063GluVal: 6.063 ± 0.098	0.628GluTrp: 0.628 ± 0.028	0.863GluTyr: 0.863 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	2.523PheAla: 2.523 ± 0.064	0.232PheCys: 0.232 ± 0.016	1.515PheAsp: 1.515 ± 0.042	1.111PheGlu: 1.111 ± 0.041	0.785PhePhe: 0.785 ± 0.036	2.174PheGly: 2.174 ± 0.065	0.523PheHis: 0.523 ± 0.026	0.812PheIle: 0.812 ± 0.04	0.323PheLys: 0.323 ± 0.022	2.575PheLeu: 2.575 ± 0.059	0.481PheMet: 0.481 ± 0.025	0.516PheAsn: 0.516 ± 0.027	1.188PhePro: 1.188 ± 0.042	0.641PheGln: 0.641 ± 0.031	1.419PheArg: 1.419 ± 0.04	1.663PheSer: 1.663 ± 0.051	1.729PheThr: 1.729 ± 0.057	2.01PheVal: 2.01 ± 0.059	0.343PheTrp: 0.343 ± 0.022	0.601PheTyr: 0.601 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	11.592GlyAla: 11.592 ± 0.138	0.798GlyCys: 0.798 ± 0.033	4.585GlyAsp: 4.585 ± 0.09	4.848GlyGlu: 4.848 ± 0.084	2.433GlyPhe: 2.433 ± 0.061	8.344GlyGly: 8.344 ± 0.125	2.027GlyHis: 2.027 ± 0.048	3.071GlyIle: 3.071 ± 0.071	1.53GlyLys: 1.53 ± 0.054	9.505GlyLeu: 9.505 ± 0.129	1.957GlyMet: 1.957 ± 0.05	1.45GlyAsn: 1.45 ± 0.05	4.701GlyPro: 4.701 ± 0.083	3.562GlyGln: 3.562 ± 0.064	7.542GlyArg: 7.542 ± 0.104	6.703GlySer: 6.703 ± 0.089	6.947GlyThr: 6.947 ± 0.114	7.998GlyVal: 7.998 ± 0.102	1.661GlyTrp: 1.661 ± 0.051	2.262GlyTyr: 2.262 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	2.255HisAla: 2.255 ± 0.061	0.187HisCys: 0.187 ± 0.015	1.37HisAsp: 1.37 ± 0.044	1.138HisGlu: 1.138 ± 0.038	0.408HisPhe: 0.408 ± 0.025	2.088HisGly: 2.088 ± 0.059	0.63HisHis: 0.63 ± 0.033	0.494HisIle: 0.494 ± 0.025	0.225HisLys: 0.225 ± 0.016	2.451HisLeu: 2.451 ± 0.056	0.353HisMet: 0.353 ± 0.022	0.36HisAsn: 0.36 ± 0.021	1.445HisPro: 1.445 ± 0.044	0.696HisGln: 0.696 ± 0.028	1.826HisArg: 1.826 ± 0.048	1.006HisSer: 1.006 ± 0.037	1.029HisThr: 1.029 ± 0.037	1.854HisVal: 1.854 ± 0.049	0.257HisTrp: 0.257 ± 0.018	0.447HisTyr: 0.447 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	3.565IleAla: 3.565 ± 0.078	0.254IleCys: 0.254 ± 0.018	2.192IleAsp: 2.192 ± 0.06	1.829IleGlu: 1.829 ± 0.054	0.69IlePhe: 0.69 ± 0.034	2.936IleGly: 2.936 ± 0.077	0.575IleHis: 0.575 ± 0.031	1.174IleIle: 1.174 ± 0.044	0.518IleLys: 0.518 ± 0.029	2.602IleLeu: 2.602 ± 0.064	0.591IleMet: 0.591 ± 0.029	0.629IleAsn: 0.629 ± 0.031	1.427IlePro: 1.427 ± 0.043	0.749IleGln: 0.749 ± 0.031	1.881IleArg: 1.881 ± 0.049	1.68IleSer: 1.68 ± 0.046	2.063IleThr: 2.063 ± 0.06	2.583IleVal: 2.583 ± 0.057	0.288IleTrp: 0.288 ± 0.02	0.574IleTyr: 0.574 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	1.726LysAla: 1.726 ± 0.051	0.066LysCys: 0.066 ± 0.009	0.981LysAsp: 0.981 ± 0.037	1.018LysGlu: 1.018 ± 0.037	0.267LysPhe: 0.267 ± 0.019	1.219LysGly: 1.219 ± 0.047	0.252LysHis: 0.252 ± 0.018	0.553LysIle: 0.553 ± 0.03	0.445LysLys: 0.445 ± 0.033	0.821LysLeu: 0.821 ± 0.042	0.236LysMet: 0.236 ± 0.017	0.339LysAsn: 0.339 ± 0.023	0.605LysPro: 0.605 ± 0.026	0.425LysGln: 0.425 ± 0.023	0.937LysArg: 0.937 ± 0.044	0.727LysSer: 0.727 ± 0.032	0.863LysThr: 0.863 ± 0.035	1.378LysVal: 1.378 ± 0.047	0.124LysTrp: 0.124 ± 0.013	0.286LysTyr: 0.286 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	14.918LeuAla: 14.918 ± 0.19	0.833LeuCys: 0.833 ± 0.032	6.269LeuAsp: 6.269 ± 0.109	5.926LeuGlu: 5.926 ± 0.099	2.078LeuPhe: 2.078 ± 0.054	9.84LeuGly: 9.84 ± 0.113	1.912LeuHis: 1.912 ± 0.05	2.619LeuIle: 2.619 ± 0.069	1.122LeuLys: 1.122 ± 0.044	11.002LeuLeu: 11.002 ± 0.173	1.868LeuMet: 1.868 ± 0.053	1.451LeuAsn: 1.451 ± 0.04	6.159LeuPro: 6.159 ± 0.086	2.193LeuGln: 2.193 ± 0.055	8.072LeuArg: 8.072 ± 0.118	6.572LeuSer: 6.572 ± 0.091	6.696LeuThr: 6.696 ± 0.101	10.83LeuVal: 10.83 ± 0.157	1.262LeuTrp: 1.262 ± 0.044	1.61LeuTyr: 1.61 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	2.364MetAla: 2.364 ± 0.049	0.13MetCys: 0.13 ± 0.015	0.967MetAsp: 0.967 ± 0.032	0.94MetGlu: 0.94 ± 0.039	0.434MetPhe: 0.434 ± 0.025	1.48MetGly: 1.48 ± 0.044	0.301MetHis: 0.301 ± 0.02	0.601MetIle: 0.601 ± 0.025	0.273MetLys: 0.273 ± 0.02	1.845MetLeu: 1.845 ± 0.051	0.348MetMet: 0.348 ± 0.021	0.365MetAsn: 0.365 ± 0.022	1.139MetPro: 1.139 ± 0.038	0.384MetGln: 0.384 ± 0.019	1.485MetArg: 1.485 ± 0.048	1.539MetSer: 1.539 ± 0.045	1.728MetThr: 1.728 ± 0.05	1.735MetVal: 1.735 ± 0.052	0.215MetTrp: 0.215 ± 0.015	0.281MetTyr: 0.281 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	1.753AsnAla: 1.753 ± 0.047	0.096AsnCys: 0.096 ± 0.011	0.912AsnAsp: 0.912 ± 0.038	0.829AsnGlu: 0.829 ± 0.033	0.376AsnPhe: 0.376 ± 0.022	1.458AsnGly: 1.458 ± 0.049	0.376AsnHis: 0.376 ± 0.022	0.731AsnIle: 0.731 ± 0.028	0.281AsnLys: 0.281 ± 0.021	1.659AsnLeu: 1.659 ± 0.047	0.284AsnMet: 0.284 ± 0.017	0.313AsnAsn: 0.313 ± 0.02	1.175AsnPro: 1.175 ± 0.043	0.602AsnGln: 0.602 ± 0.027	1.153AsnArg: 1.153 ± 0.036	0.764AsnSer: 0.764 ± 0.031	0.881AsnThr: 0.881 ± 0.038	1.285AsnVal: 1.285 ± 0.04	0.195AsnTrp: 0.195 ± 0.017	0.36AsnTyr: 0.36 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	7.687ProAla: 7.687 ± 0.113	0.357ProCys: 0.357 ± 0.018	3.72ProAsp: 3.72 ± 0.081	3.749ProGlu: 3.749 ± 0.07	1.378ProPhe: 1.378 ± 0.044	7.2ProGly: 7.2 ± 0.13	1.135ProHis: 1.135 ± 0.038	0.934ProIle: 0.934 ± 0.035	0.541ProLys: 0.541 ± 0.028	4.851ProLeu: 4.851 ± 0.082	0.895ProMet: 0.895 ± 0.032	0.659ProAsn: 0.659 ± 0.026	2.843ProPro: 2.843 ± 0.082	2.552ProGln: 2.552 ± 0.062	3.968ProArg: 3.968 ± 0.072	3.802ProSer: 3.802 ± 0.092	3.541ProThr: 3.541 ± 0.077	5.843ProVal: 5.843 ± 0.085	0.949ProTrp: 0.949 ± 0.034	1.062ProTyr: 1.062 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	5.935GlnAla: 5.935 ± 0.103	0.178GlnCys: 0.178 ± 0.015	2.258GlnAsp: 2.258 ± 0.05	2.654GlnGlu: 2.654 ± 0.057	0.541GlnPhe: 0.541 ± 0.026	3.124GlnGly: 3.124 ± 0.062	0.654GlnHis: 0.654 ± 0.033	0.908GlnIle: 0.908 ± 0.038	0.415GlnLys: 0.415 ± 0.024	2.558GlnLeu: 2.558 ± 0.064	0.701GlnMet: 0.701 ± 0.031	0.388GlnAsn: 0.388 ± 0.024	2.061GlnPro: 2.061 ± 0.057	1.26GlnGln: 1.26 ± 0.043	2.795GlnArg: 2.795 ± 0.052	1.293GlnSer: 1.293 ± 0.043	1.64GlnThr: 1.64 ± 0.045	4.102GlnVal: 4.102 ± 0.065	0.513GlnTrp: 0.513 ± 0.026	0.5GlnTyr: 0.5 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	9.187ArgAla: 9.187 ± 0.129	0.622ArgCys: 0.622 ± 0.035	4.117ArgAsp: 4.117 ± 0.086	4.503ArgGlu: 4.503 ± 0.077	1.913ArgPhe: 1.913 ± 0.054	5.934ArgGly: 5.934 ± 0.098	1.919ArgHis: 1.919 ± 0.048	2.338ArgIle: 2.338 ± 0.061	1.115ArgLys: 1.115 ± 0.043	8.711ArgLeu: 8.711 ± 0.114	1.591ArgMet: 1.591 ± 0.039	1.139ArgAsn: 1.139 ± 0.044	4.424ArgPro: 4.424 ± 0.08	3.113ArgGln: 3.113 ± 0.068	7.879ArgArg: 7.879 ± 0.13	5.226ArgSer: 5.226 ± 0.09	4.768ArgThr: 4.768 ± 0.083	6.523ArgVal: 6.523 ± 0.1	1.308ArgTrp: 1.308 ± 0.044	1.737ArgTyr: 1.737 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	7.991SerAla: 7.991 ± 0.116	0.525SerCys: 0.525 ± 0.03	2.961SerAsp: 2.961 ± 0.078	2.725SerGlu: 2.725 ± 0.064	1.749SerPhe: 1.749 ± 0.056	6.588SerGly: 6.588 ± 0.106	1.284SerHis: 1.284 ± 0.038	1.673SerIle: 1.673 ± 0.047	0.753SerLys: 0.753 ± 0.033	6.45SerLeu: 6.45 ± 0.096	1.299SerMet: 1.299 ± 0.036	0.906SerAsn: 0.906 ± 0.033	4.183SerPro: 4.183 ± 0.091	2.664SerGln: 2.664 ± 0.056	5.174SerArg: 5.174 ± 0.088	4.823SerSer: 4.823 ± 0.113	4.167SerThr: 4.167 ± 0.089	5.354SerVal: 5.354 ± 0.091	1.104SerTrp: 1.104 ± 0.036	1.354SerTyr: 1.354 ± 0.048	0.0SerXaa: 0.0 ± 0.0
Thr	8.044ThrAla: 8.044 ± 0.115	0.565ThrCys: 0.565 ± 0.033	3.507ThrAsp: 3.507 ± 0.06	3.063ThrGlu: 3.063 ± 0.08	1.553ThrPhe: 1.553 ± 0.054	6.655ThrGly: 6.655 ± 0.104	1.182ThrHis: 1.182 ± 0.035	2.12ThrIle: 2.12 ± 0.058	0.718ThrLys: 0.718 ± 0.031	5.828ThrLeu: 5.828 ± 0.096	1.139ThrMet: 1.139 ± 0.039	1.036ThrAsn: 1.036 ± 0.041	3.772ThrPro: 3.772 ± 0.096	2.059ThrGln: 2.059 ± 0.048	4.387ThrArg: 4.387 ± 0.086	4.46ThrSer: 4.46 ± 0.082	4.756ThrThr: 4.756 ± 0.101	6.451ThrVal: 6.451 ± 0.109	1.122ThrTrp: 1.122 ± 0.041	1.363ThrTyr: 1.363 ± 0.048	0.0ThrXaa: 0.0 ± 0.0
Val	11.966ValAla: 11.966 ± 0.167	0.822ValCys: 0.822 ± 0.03	5.305ValAsp: 5.305 ± 0.088	5.588ValGlu: 5.588 ± 0.086	2.235ValPhe: 2.235 ± 0.053	7.981ValGly: 7.981 ± 0.103	1.744ValHis: 1.744 ± 0.046	3.222ValIle: 3.222 ± 0.076	1.182ValLys: 1.182 ± 0.04	11.498ValLeu: 11.498 ± 0.161	1.785ValMet: 1.785 ± 0.047	1.682ValAsn: 1.682 ± 0.046	5.879ValPro: 5.879 ± 0.087	2.282ValGln: 2.282 ± 0.047	7.069ValArg: 7.069 ± 0.105	6.578ValSer: 6.578 ± 0.106	6.535ValThr: 6.535 ± 0.101	11.179ValVal: 11.179 ± 0.149	1.092ValTrp: 1.092 ± 0.045	1.647ValTyr: 1.647 ± 0.049	0.0ValXaa: 0.0 ± 0.0
Trp	1.676TrpAla: 1.676 ± 0.049	0.167TrpCys: 0.167 ± 0.014	0.841TrpAsp: 0.841 ± 0.041	0.793TrpGlu: 0.793 ± 0.037	0.451TrpPhe: 0.451 ± 0.027	1.102TrpGly: 1.102 ± 0.043	0.29TrpHis: 0.29 ± 0.019	0.406TrpIle: 0.406 ± 0.024	0.215TrpLys: 0.215 ± 0.016	1.686TrpLeu: 1.686 ± 0.049	0.351TrpMet: 0.351 ± 0.021	0.324TrpAsn: 0.324 ± 0.022	0.692TrpPro: 0.692 ± 0.029	0.626TrpGln: 0.626 ± 0.026	1.217TrpArg: 1.217 ± 0.039	0.973TrpSer: 0.973 ± 0.036	0.857TrpThr: 0.857 ± 0.036	1.296TrpVal: 1.296 ± 0.044	0.366TrpTrp: 0.366 ± 0.026	0.305TrpTyr: 0.305 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.335TyrAla: 2.335 ± 0.066	0.175TyrCys: 0.175 ± 0.016	1.227TyrAsp: 1.227 ± 0.041	1.171TyrGlu: 1.171 ± 0.043	0.552TyrPhe: 0.552 ± 0.028	1.832TyrGly: 1.832 ± 0.049	0.402TyrHis: 0.402 ± 0.021	0.568TyrIle: 0.568 ± 0.029	0.288TyrLys: 0.288 ± 0.02	2.195TyrLeu: 2.195 ± 0.056	0.303TyrMet: 0.303 ± 0.022	0.384TyrAsn: 0.384 ± 0.023	1.12TyrPro: 1.12 ± 0.039	0.72TyrGln: 0.72 ± 0.032	1.579TyrArg: 1.579 ± 0.044	1.15TyrSer: 1.15 ± 0.043	1.249TyrThr: 1.249 ± 0.051	1.708TyrVal: 1.708 ± 0.055	0.304TyrTrp: 0.304 ± 0.019	0.502TyrTyr: 0.502 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2334 proteins (835853 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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