Amino acid dipepetide frequency for Cryobacterium levicorallinum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.193AlaAla: 19.193 ± 0.182	0.713AlaCys: 0.713 ± 0.024	7.473AlaAsp: 7.473 ± 0.103	7.16AlaGlu: 7.16 ± 0.089	3.841AlaPhe: 3.841 ± 0.063	11.59AlaGly: 11.59 ± 0.122	2.309AlaHis: 2.309 ± 0.048	6.108AlaIle: 6.108 ± 0.087	2.785AlaLys: 2.785 ± 0.061	13.923AlaLeu: 13.923 ± 0.143	2.591AlaMet: 2.591 ± 0.051	2.815AlaAsn: 2.815 ± 0.056	5.883AlaPro: 5.883 ± 0.098	4.003AlaGln: 4.003 ± 0.071	8.187AlaArg: 8.187 ± 0.101	7.625AlaSer: 7.625 ± 0.095	7.673AlaThr: 7.673 ± 0.11	10.763AlaVal: 10.763 ± 0.103	1.646AlaTrp: 1.646 ± 0.039	2.257AlaTyr: 2.257 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	0.717CysAla: 0.717 ± 0.026	0.069CysCys: 0.069 ± 0.009	0.347CysAsp: 0.347 ± 0.017	0.265CysGlu: 0.265 ± 0.017	0.186CysPhe: 0.186 ± 0.014	0.63CysGly: 0.63 ± 0.021	0.136CysHis: 0.136 ± 0.012	0.248CysIle: 0.248 ± 0.014	0.098CysLys: 0.098 ± 0.009	0.538CysLeu: 0.538 ± 0.022	0.1CysMet: 0.1 ± 0.01	0.137CysAsn: 0.137 ± 0.01	0.337CysPro: 0.337 ± 0.018	0.147CysGln: 0.147 ± 0.013	0.376CysArg: 0.376 ± 0.017	0.409CysSer: 0.409 ± 0.021	0.389CysThr: 0.389 ± 0.019	0.487CysVal: 0.487 ± 0.022	0.077CysTrp: 0.077 ± 0.009	0.125CysTyr: 0.125 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	7.788AspAla: 7.788 ± 0.103	0.308AspCys: 0.308 ± 0.016	3.512AspAsp: 3.512 ± 0.072	3.605AspGlu: 3.605 ± 0.07	1.917AspPhe: 1.917 ± 0.04	5.128AspGly: 5.128 ± 0.08	1.109AspHis: 1.109 ± 0.034	2.504AspIle: 2.504 ± 0.055	1.099AspLys: 1.099 ± 0.038	6.361AspLeu: 6.361 ± 0.079	0.769AspMet: 0.769 ± 0.025	1.241AspAsn: 1.241 ± 0.032	3.527AspPro: 3.527 ± 0.053	1.84AspGln: 1.84 ± 0.042	3.972AspArg: 3.972 ± 0.074	3.145AspSer: 3.145 ± 0.057	3.107AspThr: 3.107 ± 0.057	4.833AspVal: 4.833 ± 0.07	0.897AspTrp: 0.897 ± 0.03	1.316AspTyr: 1.316 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	6.153GluAla: 6.153 ± 0.08	0.291GluCys: 0.291 ± 0.014	2.197GluAsp: 2.197 ± 0.045	2.318GluGlu: 2.318 ± 0.059	1.835GluPhe: 1.835 ± 0.045	3.182GluGly: 3.182 ± 0.059	1.371GluHis: 1.371 ± 0.035	2.871GluIle: 2.871 ± 0.055	1.431GluLys: 1.431 ± 0.039	6.325GluLeu: 6.325 ± 0.095	0.993GluMet: 0.993 ± 0.029	1.497GluAsn: 1.497 ± 0.035	2.709GluPro: 2.709 ± 0.049	2.096GluGln: 2.096 ± 0.047	4.16GluArg: 4.16 ± 0.071	3.112GluSer: 3.112 ± 0.058	3.189GluThr: 3.189 ± 0.05	4.01GluVal: 4.01 ± 0.072	0.771GluTrp: 0.771 ± 0.03	1.116GluTyr: 1.116 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	4.244PheAla: 4.244 ± 0.064	0.231PheCys: 0.231 ± 0.015	2.454PheAsp: 2.454 ± 0.05	1.779PheGlu: 1.779 ± 0.042	1.2PhePhe: 1.2 ± 0.037	3.441PheGly: 3.441 ± 0.062	0.609PheHis: 0.609 ± 0.022	1.472PheIle: 1.472 ± 0.042	0.618PheLys: 0.618 ± 0.027	3.105PheLeu: 3.105 ± 0.059	0.521PheMet: 0.521 ± 0.022	0.867PheAsn: 0.867 ± 0.029	1.379PhePro: 1.379 ± 0.036	0.86PheGln: 0.86 ± 0.03	1.727PheArg: 1.727 ± 0.036	2.099PheSer: 2.099 ± 0.041	2.293PheThr: 2.293 ± 0.048	2.88PheVal: 2.88 ± 0.056	0.494PheTrp: 0.494 ± 0.024	0.7PheTyr: 0.7 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	9.887GlyAla: 9.887 ± 0.11	0.698GlyCys: 0.698 ± 0.025	4.428GlyAsp: 4.428 ± 0.068	4.261GlyGlu: 4.261 ± 0.061	3.321GlyPhe: 3.321 ± 0.058	7.033GlyGly: 7.033 ± 0.102	1.866GlyHis: 1.866 ± 0.043	4.979GlyIle: 4.979 ± 0.066	2.225GlyLys: 2.225 ± 0.052	9.355GlyLeu: 9.355 ± 0.102	1.895GlyMet: 1.895 ± 0.046	1.947GlyAsn: 1.947 ± 0.048	3.621GlyPro: 3.621 ± 0.06	2.807GlyGln: 2.807 ± 0.052	5.487GlyArg: 5.487 ± 0.079	5.654GlySer: 5.654 ± 0.079	5.735GlyThr: 5.735 ± 0.075	7.429GlyVal: 7.429 ± 0.096	1.456GlyTrp: 1.456 ± 0.044	2.255GlyTyr: 2.255 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	2.269HisAla: 2.269 ± 0.048	0.133HisCys: 0.133 ± 0.012	1.261HisAsp: 1.261 ± 0.033	1.092HisGlu: 1.092 ± 0.035	0.627HisPhe: 0.627 ± 0.022	1.893HisGly: 1.893 ± 0.038	0.469HisHis: 0.469 ± 0.024	0.773HisIle: 0.773 ± 0.025	0.387HisLys: 0.387 ± 0.02	2.08HisLeu: 2.08 ± 0.042	0.329HisMet: 0.329 ± 0.017	0.481HisAsn: 0.481 ± 0.024	1.468HisPro: 1.468 ± 0.042	0.581HisGln: 0.581 ± 0.024	1.501HisArg: 1.501 ± 0.041	1.185HisSer: 1.185 ± 0.033	1.114HisThr: 1.114 ± 0.032	1.59HisVal: 1.59 ± 0.045	0.273HisTrp: 0.273 ± 0.016	0.457HisTyr: 0.457 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	6.824IleAla: 6.824 ± 0.094	0.326IleCys: 0.326 ± 0.013	3.677IleAsp: 3.677 ± 0.054	2.975IleGlu: 2.975 ± 0.057	1.478IlePhe: 1.478 ± 0.043	4.87IleGly: 4.87 ± 0.07	0.822IleHis: 0.822 ± 0.025	2.407IleIle: 2.407 ± 0.061	1.086IleLys: 1.086 ± 0.036	4.386IleLeu: 4.386 ± 0.071	0.82IleMet: 0.82 ± 0.031	1.383IleAsn: 1.383 ± 0.037	2.547IlePro: 2.547 ± 0.051	1.089IleGln: 1.089 ± 0.035	2.958IleArg: 2.958 ± 0.048	2.893IleSer: 2.893 ± 0.054	3.242IleThr: 3.242 ± 0.054	5.047IleVal: 5.047 ± 0.087	0.572IleTrp: 0.572 ± 0.02	0.934IleTyr: 0.934 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	2.62LysAla: 2.62 ± 0.059	0.097LysCys: 0.097 ± 0.009	1.121LysAsp: 1.121 ± 0.039	1.022LysGlu: 1.022 ± 0.032	0.697LysPhe: 0.697 ± 0.026	1.594LysGly: 1.594 ± 0.04	0.535LysHis: 0.535 ± 0.023	1.239LysIle: 1.239 ± 0.037	0.983LysLys: 0.983 ± 0.037	2.265LysLeu: 2.265 ± 0.049	0.517LysMet: 0.517 ± 0.022	0.779LysAsn: 0.779 ± 0.028	1.368LysPro: 1.368 ± 0.041	0.752LysGln: 0.752 ± 0.028	1.748LysArg: 1.748 ± 0.046	1.511LysSer: 1.511 ± 0.039	1.646LysThr: 1.646 ± 0.041	1.821LysVal: 1.821 ± 0.041	0.292LysTrp: 0.292 ± 0.015	0.545LysTyr: 0.545 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	14.801LeuAla: 14.801 ± 0.143	0.603LeuCys: 0.603 ± 0.023	6.447LeuAsp: 6.447 ± 0.077	5.099LeuGlu: 5.099 ± 0.071	3.109LeuPhe: 3.109 ± 0.06	9.571LeuGly: 9.571 ± 0.114	2.038LeuHis: 2.038 ± 0.042	5.174LeuIle: 5.174 ± 0.089	2.334LeuLys: 2.334 ± 0.045	11.067LeuLeu: 11.067 ± 0.163	1.704LeuMet: 1.704 ± 0.043	2.527LeuAsn: 2.527 ± 0.05	5.61LeuPro: 5.61 ± 0.085	2.739LeuGln: 2.739 ± 0.048	6.852LeuArg: 6.852 ± 0.093	6.412LeuSer: 6.412 ± 0.079	6.936LeuThr: 6.936 ± 0.073	9.417LeuVal: 9.417 ± 0.125	1.249LeuTrp: 1.249 ± 0.04	1.791LeuTyr: 1.791 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	2.149MetAla: 2.149 ± 0.041	0.117MetCys: 0.117 ± 0.011	0.815MetAsp: 0.815 ± 0.03	0.685MetGlu: 0.685 ± 0.027	0.58MetPhe: 0.58 ± 0.025	1.345MetGly: 1.345 ± 0.037	0.374MetHis: 0.374 ± 0.018	1.023MetIle: 1.023 ± 0.034	0.553MetLys: 0.553 ± 0.022	2.037MetLeu: 2.037 ± 0.042	0.337MetMet: 0.337 ± 0.018	0.581MetAsn: 0.581 ± 0.022	1.108MetPro: 1.108 ± 0.032	0.595MetGln: 0.595 ± 0.024	1.208MetArg: 1.208 ± 0.031	1.52MetSer: 1.52 ± 0.038	1.754MetThr: 1.754 ± 0.037	1.399MetVal: 1.399 ± 0.033	0.181MetTrp: 0.181 ± 0.012	0.278MetTyr: 0.278 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.954AsnAla: 2.954 ± 0.057	0.16AsnCys: 0.16 ± 0.012	1.424AsnAsp: 1.424 ± 0.037	1.252AsnGlu: 1.252 ± 0.034	0.925AsnPhe: 0.925 ± 0.028	2.393AsnGly: 2.393 ± 0.055	0.432AsnHis: 0.432 ± 0.019	1.142AsnIle: 1.142 ± 0.033	0.591AsnLys: 0.591 ± 0.026	2.554AsnLeu: 2.554 ± 0.053	0.458AsnMet: 0.458 ± 0.018	0.707AsnAsn: 0.707 ± 0.029	1.853AsnPro: 1.853 ± 0.041	0.787AsnGln: 0.787 ± 0.03	1.619AsnArg: 1.619 ± 0.039	1.355AsnSer: 1.355 ± 0.037	1.486AsnThr: 1.486 ± 0.039	2.009AsnVal: 2.009 ± 0.046	0.405AsnTrp: 0.405 ± 0.018	0.579AsnTyr: 0.579 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	6.804ProAla: 6.804 ± 0.1	0.213ProCys: 0.213 ± 0.014	3.328ProAsp: 3.328 ± 0.053	3.295ProGlu: 3.295 ± 0.057	1.69ProPhe: 1.69 ± 0.042	4.772ProGly: 4.772 ± 0.072	1.042ProHis: 1.042 ± 0.031	2.417ProIle: 2.417 ± 0.046	1.194ProLys: 1.194 ± 0.036	4.84ProLeu: 4.84 ± 0.077	0.894ProMet: 0.894 ± 0.027	1.313ProAsn: 1.313 ± 0.037	2.006ProPro: 2.006 ± 0.06	1.458ProGln: 1.458 ± 0.037	3.003ProArg: 3.003 ± 0.053	3.09ProSer: 3.09 ± 0.061	3.616ProThr: 3.616 ± 0.068	4.791ProVal: 4.791 ± 0.066	0.766ProTrp: 0.766 ± 0.026	0.963ProTyr: 0.963 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	3.758GlnAla: 3.758 ± 0.064	0.131GlnCys: 0.131 ± 0.01	1.317GlnAsp: 1.317 ± 0.036	1.223GlnGlu: 1.223 ± 0.035	0.974GlnPhe: 0.974 ± 0.025	2.086GlnGly: 2.086 ± 0.044	0.689GlnHis: 0.689 ± 0.027	1.767GlnIle: 1.767 ± 0.038	0.783GlnLys: 0.783 ± 0.024	3.5GlnLeu: 3.5 ± 0.062	0.566GlnMet: 0.566 ± 0.023	0.931GlnAsn: 0.931 ± 0.032	1.54GlnPro: 1.54 ± 0.042	1.195GlnGln: 1.195 ± 0.038	2.264GlnArg: 2.264 ± 0.056	1.883GlnSer: 1.883 ± 0.041	1.84GlnThr: 1.84 ± 0.04	2.569GlnVal: 2.569 ± 0.049	0.44GlnTrp: 0.44 ± 0.021	0.626GlnTyr: 0.626 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	7.688ArgAla: 7.688 ± 0.113	0.343ArgCys: 0.343 ± 0.021	3.663ArgAsp: 3.663 ± 0.061	3.448ArgGlu: 3.448 ± 0.073	2.281ArgPhe: 2.281 ± 0.047	4.781ArgGly: 4.781 ± 0.062	1.414ArgHis: 1.414 ± 0.038	3.486ArgIle: 3.486 ± 0.054	1.569ArgLys: 1.569 ± 0.045	6.977ArgLeu: 6.977 ± 0.091	1.557ArgMet: 1.557 ± 0.042	1.583ArgAsn: 1.583 ± 0.042	3.217ArgPro: 3.217 ± 0.055	2.142ArgGln: 2.142 ± 0.049	5.197ArgArg: 5.197 ± 0.087	4.34ArgSer: 4.34 ± 0.067	4.053ArgThr: 4.053 ± 0.07	5.387ArgVal: 5.387 ± 0.076	0.957ArgTrp: 0.957 ± 0.03	1.515ArgTyr: 1.515 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	7.709SerAla: 7.709 ± 0.095	0.334SerCys: 0.334 ± 0.02	3.301SerAsp: 3.301 ± 0.061	2.968SerGlu: 2.968 ± 0.05	2.077SerPhe: 2.077 ± 0.039	6.073SerGly: 6.073 ± 0.072	1.113SerHis: 1.113 ± 0.033	3.177SerIle: 3.177 ± 0.057	1.396SerLys: 1.396 ± 0.038	6.125SerLeu: 6.125 ± 0.087	1.316SerMet: 1.316 ± 0.034	1.555SerAsn: 1.555 ± 0.038	3.133SerPro: 3.133 ± 0.06	1.652SerGln: 1.652 ± 0.038	3.822SerArg: 3.822 ± 0.059	3.951SerSer: 3.951 ± 0.071	4.196SerThr: 4.196 ± 0.069	5.444SerVal: 5.444 ± 0.074	0.939SerTrp: 0.939 ± 0.033	1.342SerTyr: 1.342 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	8.052ThrAla: 8.052 ± 0.098	0.301ThrCys: 0.301 ± 0.017	4.074ThrAsp: 4.074 ± 0.056	3.362ThrGlu: 3.362 ± 0.059	2.051ThrPhe: 2.051 ± 0.044	6.101ThrGly: 6.101 ± 0.087	1.242ThrHis: 1.242 ± 0.037	3.289ThrIle: 3.289 ± 0.056	1.411ThrLys: 1.411 ± 0.042	6.518ThrLeu: 6.518 ± 0.084	1.127ThrMet: 1.127 ± 0.033	1.563ThrAsn: 1.563 ± 0.042	3.876ThrPro: 3.876 ± 0.065	1.667ThrGln: 1.667 ± 0.038	3.724ThrArg: 3.724 ± 0.063	3.794ThrSer: 3.794 ± 0.066	4.122ThrThr: 4.122 ± 0.076	6.178ThrVal: 6.178 ± 0.083	0.84ThrTrp: 0.84 ± 0.031	1.171ThrTyr: 1.171 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	11.201ValAla: 11.201 ± 0.119	0.527ValCys: 0.527 ± 0.018	5.126ValAsp: 5.126 ± 0.074	4.219ValGlu: 4.219 ± 0.071	2.892ValPhe: 2.892 ± 0.064	7.056ValGly: 7.056 ± 0.084	1.753ValHis: 1.753 ± 0.039	4.744ValIle: 4.744 ± 0.08	1.837ValLys: 1.837 ± 0.046	9.439ValLeu: 9.439 ± 0.11	1.52ValMet: 1.52 ± 0.037	2.173ValAsn: 2.173 ± 0.046	4.513ValPro: 4.513 ± 0.069	2.392ValGln: 2.392 ± 0.048	5.194ValArg: 5.194 ± 0.078	5.408ValSer: 5.408 ± 0.078	6.056ValThr: 6.056 ± 0.077	7.956ValVal: 7.956 ± 0.111	1.059ValTrp: 1.059 ± 0.032	1.536ValTyr: 1.536 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.478TrpAla: 1.478 ± 0.04	0.085TrpCys: 0.085 ± 0.008	0.71TrpAsp: 0.71 ± 0.031	0.545TrpGlu: 0.545 ± 0.021	0.504TrpPhe: 0.504 ± 0.021	0.94TrpGly: 0.94 ± 0.03	0.307TrpHis: 0.307 ± 0.016	0.712TrpIle: 0.712 ± 0.026	0.36TrpLys: 0.36 ± 0.019	1.752TrpLeu: 1.752 ± 0.051	0.348TrpMet: 0.348 ± 0.02	0.479TrpAsn: 0.479 ± 0.021	0.702TrpPro: 0.702 ± 0.024	0.619TrpGln: 0.619 ± 0.024	1.031TrpArg: 1.031 ± 0.034	0.89TrpSer: 0.89 ± 0.03	0.863TrpThr: 0.863 ± 0.026	1.026TrpVal: 1.026 ± 0.032	0.303TrpTrp: 0.303 ± 0.021	0.289TrpTyr: 0.289 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.248TyrAla: 2.248 ± 0.049	0.138TyrCys: 0.138 ± 0.012	1.303TyrAsp: 1.303 ± 0.032	1.057TyrGlu: 1.057 ± 0.031	0.791TyrPhe: 0.791 ± 0.031	1.863TyrGly: 1.863 ± 0.036	0.333TyrHis: 0.333 ± 0.015	0.799TyrIle: 0.799 ± 0.028	0.413TyrLys: 0.413 ± 0.021	2.333TyrLeu: 2.333 ± 0.054	0.276TyrMet: 0.276 ± 0.014	0.524TyrAsn: 0.524 ± 0.025	1.099TyrPro: 1.099 ± 0.035	0.661TyrGln: 0.661 ± 0.027	1.568TyrArg: 1.568 ± 0.037	1.349TyrSer: 1.349 ± 0.033	1.155TyrThr: 1.155 ± 0.034	1.561TyrVal: 1.561 ± 0.035	0.325TyrTrp: 0.325 ± 0.017	0.462TyrTyr: 0.462 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3509 proteins (1112413 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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