Amino acid dipepetide frequency for Bos taurus papillomavirus 19

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.038AlaAla: 5.038 ± 1.947
1.259AlaCys: 1.259 ± 0.825
3.359AlaAsp: 3.359 ± 0.882
5.038AlaGlu: 5.038 ± 1.466
2.519AlaPhe: 2.519 ± 0.682
2.099AlaGly: 2.099 ± 1.075
0.84AlaHis: 0.84 ± 0.34
2.939AlaIle: 2.939 ± 0.63
5.038AlaLys: 5.038 ± 2.017
4.198AlaLeu: 4.198 ± 1.994
0.42AlaMet: 0.42 ± 0.359
0.84AlaAsn: 0.84 ± 0.718
2.099AlaPro: 2.099 ± 1.208
1.679AlaGln: 1.679 ± 0.301
4.618AlaArg: 4.618 ± 1.896
3.359AlaSer: 3.359 ± 1.643
4.618AlaThr: 4.618 ± 0.799
2.099AlaVal: 2.099 ± 0.988
2.099AlaTrp: 2.099 ± 0.818
1.679AlaTyr: 1.679 ± 0.717
0.0AlaXaa: 0.0 ± 0.0
Cys
1.259CysAla: 1.259 ± 1.454
1.679CysCys: 1.679 ± 0.797
1.259CysAsp: 1.259 ± 0.59
0.84CysGlu: 0.84 ± 0.34
0.42CysPhe: 0.42 ± 0.497
0.0CysGly: 0.0 ± 0.0
0.0CysHis: 0.0 ± 0.0
0.42CysIle: 0.42 ± 0.545
1.679CysLys: 1.679 ± 0.813
3.359CysLeu: 3.359 ± 1.628
0.84CysMet: 0.84 ± 0.536
0.42CysAsn: 0.42 ± 0.497
1.679CysPro: 1.679 ± 0.89
0.84CysGln: 0.84 ± 0.679
1.259CysArg: 1.259 ± 0.825
4.198CysSer: 4.198 ± 1.48
1.259CysThr: 1.259 ± 0.642
1.259CysVal: 1.259 ± 1.636
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
3.778AspAla: 3.778 ± 0.819
1.259AspCys: 1.259 ± 0.419
1.679AspAsp: 1.679 ± 0.68
3.778AspGlu: 3.778 ± 0.721
3.778AspPhe: 3.778 ± 0.941
4.618AspGly: 4.618 ± 1.06
0.0AspHis: 0.0 ± 0.0
3.778AspIle: 3.778 ± 0.584
2.099AspLys: 2.099 ± 1.019
9.236AspLeu: 9.236 ± 1.518
0.84AspMet: 0.84 ± 0.34
2.939AspAsn: 2.939 ± 0.741
4.198AspPro: 4.198 ± 0.794
1.679AspGln: 1.679 ± 1.097
1.259AspArg: 1.259 ± 0.457
4.198AspSer: 4.198 ± 0.637
3.778AspThr: 3.778 ± 1.061
4.618AspVal: 4.618 ± 1.031
1.679AspTrp: 1.679 ± 0.505
1.679AspTyr: 1.679 ± 0.77
0.0AspXaa: 0.0 ± 0.0
Glu
4.618GluAla: 4.618 ± 1.304
1.679GluCys: 1.679 ± 0.869
5.877GluAsp: 5.877 ± 1.623
6.297GluGlu: 6.297 ± 2.245
2.519GluPhe: 2.519 ± 1.285
5.038GluGly: 5.038 ± 1.429
1.679GluHis: 1.679 ± 0.796
4.198GluIle: 4.198 ± 1.349
3.359GluLys: 3.359 ± 1.188
5.458GluLeu: 5.458 ± 2.406
0.84GluMet: 0.84 ± 0.465
5.458GluAsn: 5.458 ± 1.154
2.099GluPro: 2.099 ± 0.846
0.84GluGln: 0.84 ± 0.34
4.198GluArg: 4.198 ± 1.221
5.877GluSer: 5.877 ± 1.917
1.259GluThr: 1.259 ± 0.314
2.939GluVal: 2.939 ± 1.013
0.0GluTrp: 0.0 ± 0.0
0.84GluTyr: 0.84 ± 0.718
0.0GluXaa: 0.0 ± 0.0
Phe
1.679PheAla: 1.679 ± 0.635
0.84PheCys: 0.84 ± 0.623
2.099PheAsp: 2.099 ± 1.208
2.099PheGlu: 2.099 ± 0.988
1.679PhePhe: 1.679 ± 0.81
3.359PheGly: 3.359 ± 0.839
1.259PheHis: 1.259 ± 0.575
1.679PheIle: 1.679 ± 1.435
5.038PheLys: 5.038 ± 2.207
4.198PheLeu: 4.198 ± 1.328
2.099PheMet: 2.099 ± 0.936
1.259PheAsn: 1.259 ± 0.552
1.679PhePro: 1.679 ± 0.834
2.939PheGln: 2.939 ± 0.741
1.259PheArg: 1.259 ± 0.751
2.099PheSer: 2.099 ± 0.685
2.099PheThr: 2.099 ± 0.831
3.778PheVal: 3.778 ± 0.949
1.679PheTrp: 1.679 ± 0.958
2.519PheTyr: 2.519 ± 1.319
0.0PheXaa: 0.0 ± 0.0
Gly
1.679GlyAla: 1.679 ± 0.626
0.84GlyCys: 0.84 ± 0.646
4.618GlyAsp: 4.618 ± 1.43
8.396GlyGlu: 8.396 ± 1.93
2.099GlyPhe: 2.099 ± 0.651
5.877GlyGly: 5.877 ± 2.11
2.519GlyHis: 2.519 ± 1.511
2.519GlyIle: 2.519 ± 1.234
2.939GlyLys: 2.939 ± 0.899
5.458GlyLeu: 5.458 ± 1.55
0.84GlyMet: 0.84 ± 0.993
4.198GlyAsn: 4.198 ± 1.342
3.778GlyPro: 3.778 ± 1.536
1.259GlyGln: 1.259 ± 0.658
4.618GlyArg: 4.618 ± 2.125
5.038GlySer: 5.038 ± 1.365
8.396GlyThr: 8.396 ± 2.215
3.778GlyVal: 3.778 ± 0.86
1.259GlyTrp: 1.259 ± 0.625
1.259GlyTyr: 1.259 ± 0.575
0.0GlyXaa: 0.0 ± 0.0
His
0.84HisAla: 0.84 ± 0.482
0.84HisCys: 0.84 ± 0.385
0.42HisAsp: 0.42 ± 0.399
1.259HisGlu: 1.259 ± 0.825
2.099HisPhe: 2.099 ± 0.604
0.42HisGly: 0.42 ± 0.318
0.42HisHis: 0.42 ± 0.545
0.84HisIle: 0.84 ± 0.34
0.84HisLys: 0.84 ± 0.536
1.679HisLeu: 1.679 ± 0.867
0.42HisMet: 0.42 ± 0.545
1.259HisAsn: 1.259 ± 0.921
1.679HisPro: 1.679 ± 0.69
0.42HisGln: 0.42 ± 0.318
0.84HisArg: 0.84 ± 0.798
1.259HisSer: 1.259 ± 0.443
0.84HisThr: 0.84 ± 0.482
0.84HisVal: 0.84 ± 0.447
0.84HisTrp: 0.84 ± 0.482
0.84HisTyr: 0.84 ± 0.623
0.0HisXaa: 0.0 ± 0.0
Ile
3.359IleAla: 3.359 ± 1.426
0.42IleCys: 0.42 ± 0.318
2.519IleAsp: 2.519 ± 0.784
4.198IleGlu: 4.198 ± 0.527
2.099IlePhe: 2.099 ± 0.685
4.198IleGly: 4.198 ± 2.104
0.42IleHis: 0.42 ± 0.318
3.778IleIle: 3.778 ± 1.877
2.519IleLys: 2.519 ± 1.015
2.939IleLeu: 2.939 ± 1.446
0.42IleMet: 0.42 ± 0.497
1.679IleAsn: 1.679 ± 0.547
2.939IlePro: 2.939 ± 1.262
1.679IleGln: 1.679 ± 0.753
3.359IleArg: 3.359 ± 1.575
5.458IleSer: 5.458 ± 1.184
1.679IleThr: 1.679 ± 0.832
2.939IleVal: 2.939 ± 0.74
0.42IleTrp: 0.42 ± 0.318
1.259IleTyr: 1.259 ± 0.781
0.0IleXaa: 0.0 ± 0.0
Lys
4.198LysAla: 4.198 ± 1.203
0.84LysCys: 0.84 ± 0.34
2.939LysAsp: 2.939 ± 1.325
2.939LysGlu: 2.939 ± 1.08
3.359LysPhe: 3.359 ± 1.186
2.939LysGly: 2.939 ± 0.924
1.259LysHis: 1.259 ± 0.806
1.679LysIle: 1.679 ± 0.505
3.778LysLys: 3.778 ± 1.341
6.297LysLeu: 6.297 ± 2.328
0.84LysMet: 0.84 ± 0.595
2.099LysAsn: 2.099 ± 0.818
0.84LysPro: 0.84 ± 0.646
2.939LysGln: 2.939 ± 0.897
4.618LysArg: 4.618 ± 1.16
4.618LysSer: 4.618 ± 1.319
2.519LysThr: 2.519 ± 0.834
1.679LysVal: 1.679 ± 1.435
0.42LysTrp: 0.42 ± 0.399
3.359LysTyr: 3.359 ± 1.474
0.0LysXaa: 0.0 ± 0.0
Leu
5.458LeuAla: 5.458 ± 0.838
1.679LeuCys: 1.679 ± 1.46
5.038LeuAsp: 5.038 ± 0.967
7.557LeuGlu: 7.557 ± 0.679
5.877LeuPhe: 5.877 ± 1.997
7.137LeuGly: 7.137 ± 2.415
2.519LeuHis: 2.519 ± 1.116
5.877LeuIle: 5.877 ± 1.334
3.778LeuLys: 3.778 ± 1.776
10.915LeuLeu: 10.915 ± 2.451
2.099LeuMet: 2.099 ± 0.614
3.359LeuAsn: 3.359 ± 0.953
3.359LeuPro: 3.359 ± 1.033
4.198LeuGln: 4.198 ± 1.548
6.297LeuArg: 6.297 ± 1.27
6.717LeuSer: 6.717 ± 1.632
6.717LeuThr: 6.717 ± 1.207
5.458LeuVal: 5.458 ± 1.707
0.84LeuTrp: 0.84 ± 0.416
5.038LeuTyr: 5.038 ± 1.587
0.0LeuXaa: 0.0 ± 0.0
Met
0.84MetAla: 0.84 ± 0.796
0.42MetCys: 0.42 ± 0.359
1.259MetAsp: 1.259 ± 0.625
0.84MetGlu: 0.84 ± 0.528
0.84MetPhe: 0.84 ± 0.718
1.679MetGly: 1.679 ± 0.987
0.0MetHis: 0.0 ± 0.0
0.84MetIle: 0.84 ± 0.636
1.679MetLys: 1.679 ± 0.763
1.259MetLeu: 1.259 ± 0.814
0.0MetMet: 0.0 ± 0.0
0.84MetAsn: 0.84 ± 0.34
0.84MetPro: 0.84 ± 0.528
0.42MetGln: 0.42 ± 0.318
1.259MetArg: 1.259 ± 0.906
1.679MetSer: 1.679 ± 0.68
0.84MetThr: 0.84 ± 0.572
2.099MetVal: 2.099 ± 0.819
0.0MetTrp: 0.0 ± 0.0
0.42MetTyr: 0.42 ± 0.359
0.0MetXaa: 0.0 ± 0.0
Asn
2.939AsnAla: 2.939 ± 0.62
1.259AsnCys: 1.259 ± 1.127
2.519AsnAsp: 2.519 ± 0.685
2.519AsnGlu: 2.519 ± 0.962
1.679AsnPhe: 1.679 ± 0.834
2.939AsnGly: 2.939 ± 1.116
0.0AsnHis: 0.0 ± 0.0
2.099AsnIle: 2.099 ± 0.565
1.259AsnLys: 1.259 ± 0.704
4.198AsnLeu: 4.198 ± 1.175
0.42AsnMet: 0.42 ± 0.359
1.259AsnAsn: 1.259 ± 0.838
2.099AsnPro: 2.099 ± 0.604
1.679AsnGln: 1.679 ± 0.68
2.519AsnArg: 2.519 ± 0.976
4.198AsnSer: 4.198 ± 1.247
2.939AsnThr: 2.939 ± 1.064
2.519AsnVal: 2.519 ± 0.496
0.84AsnTrp: 0.84 ± 0.465
1.679AsnTyr: 1.679 ± 0.553
0.0AsnXaa: 0.0 ± 0.0
Pro
4.198ProAla: 4.198 ± 1.845
0.84ProCys: 0.84 ± 0.718
4.198ProAsp: 4.198 ± 1.42
3.778ProGlu: 3.778 ± 0.721
1.679ProPhe: 1.679 ± 0.505
3.778ProGly: 3.778 ± 1.242
1.259ProHis: 1.259 ± 0.706
1.679ProIle: 1.679 ± 0.563
3.359ProLys: 3.359 ± 1.041
6.717ProLeu: 6.717 ± 2.416
0.84ProMet: 0.84 ± 0.447
1.679ProAsn: 1.679 ± 0.301
6.297ProPro: 6.297 ± 1.211
2.099ProGln: 2.099 ± 0.628
1.679ProArg: 1.679 ± 0.77
2.519ProSer: 2.519 ± 1.016
3.778ProThr: 3.778 ± 1.751
3.778ProVal: 3.778 ± 0.769
0.42ProTrp: 0.42 ± 0.359
1.259ProTyr: 1.259 ± 0.929
0.0ProXaa: 0.0 ± 0.0
Gln
2.939GlnAla: 2.939 ± 0.772
1.259GlnCys: 1.259 ± 1.127
3.778GlnAsp: 3.778 ± 0.721
2.939GlnGlu: 2.939 ± 1.352
0.84GlnPhe: 0.84 ± 0.34
1.679GlnGly: 1.679 ± 0.567
0.0GlnHis: 0.0 ± 0.0
1.259GlnIle: 1.259 ± 0.419
0.84GlnLys: 0.84 ± 0.34
4.198GlnLeu: 4.198 ± 1.015
2.519GlnMet: 2.519 ± 1.184
0.84GlnAsn: 0.84 ± 0.482
2.519GlnPro: 2.519 ± 0.665
1.259GlnGln: 1.259 ± 0.443
2.099GlnArg: 2.099 ± 0.846
1.679GlnSer: 1.679 ± 0.914
2.519GlnThr: 2.519 ± 0.71
2.939GlnVal: 2.939 ± 1.077
1.259GlnTrp: 1.259 ± 0.983
0.42GlnTyr: 0.42 ± 0.359
0.0GlnXaa: 0.0 ± 0.0
Arg
2.099ArgAla: 2.099 ± 1.168
2.099ArgCys: 2.099 ± 1.036
3.778ArgAsp: 3.778 ± 1.309
2.099ArgGlu: 2.099 ± 0.83
1.259ArgPhe: 1.259 ± 0.781
6.297ArgGly: 6.297 ± 2.14
2.099ArgHis: 2.099 ± 0.493
1.259ArgIle: 1.259 ± 0.989
4.618ArgLys: 4.618 ± 0.974
7.976ArgLeu: 7.976 ± 1.194
0.42ArgMet: 0.42 ± 0.63
2.939ArgAsn: 2.939 ± 1.495
3.359ArgPro: 3.359 ± 1.467
3.359ArgGln: 3.359 ± 0.947
5.877ArgArg: 5.877 ± 2.458
4.198ArgSer: 4.198 ± 1.662
1.259ArgThr: 1.259 ± 0.786
4.618ArgVal: 4.618 ± 1.486
0.0ArgTrp: 0.0 ± 0.0
1.259ArgTyr: 1.259 ± 0.586
0.0ArgXaa: 0.0 ± 0.0
Ser
3.359SerAla: 3.359 ± 0.38
1.259SerCys: 1.259 ± 0.906
7.137SerAsp: 7.137 ± 2.096
2.099SerGlu: 2.099 ± 0.769
3.359SerPhe: 3.359 ± 1.608
4.618SerGly: 4.618 ± 0.804
1.679SerHis: 1.679 ± 0.931
3.778SerIle: 3.778 ± 0.966
3.359SerLys: 3.359 ± 1.254
7.976SerLeu: 7.976 ± 2.058
1.259SerMet: 1.259 ± 1.077
2.939SerAsn: 2.939 ± 0.701
6.297SerPro: 6.297 ± 1.283
3.359SerGln: 3.359 ± 0.744
4.198SerArg: 4.198 ± 1.378
7.557SerSer: 7.557 ± 1.587
5.038SerThr: 5.038 ± 1.352
2.939SerVal: 2.939 ± 0.686
1.259SerTrp: 1.259 ± 0.806
1.679SerTyr: 1.679 ± 0.816
0.0SerXaa: 0.0 ± 0.0
Thr
2.099ThrAla: 2.099 ± 0.848
2.099ThrCys: 2.099 ± 1.18
2.519ThrAsp: 2.519 ± 1.144
4.198ThrGlu: 4.198 ± 1.242
3.778ThrPhe: 3.778 ± 0.96
6.717ThrGly: 6.717 ± 1.767
0.42ThrHis: 0.42 ± 0.318
2.519ThrIle: 2.519 ± 1.183
2.099ThrLys: 2.099 ± 0.931
4.618ThrLeu: 4.618 ± 1.552
0.42ThrMet: 0.42 ± 0.318
2.519ThrAsn: 2.519 ± 1.004
4.618ThrPro: 4.618 ± 2.163
1.679ThrGln: 1.679 ± 0.796
4.198ThrArg: 4.198 ± 0.527
5.038ThrSer: 5.038 ± 1.244
4.198ThrThr: 4.198 ± 1.536
5.038ThrVal: 5.038 ± 0.992
1.259ThrTrp: 1.259 ± 0.809
2.099ThrTyr: 2.099 ± 0.74
0.0ThrXaa: 0.0 ± 0.0
Val
3.359ValAla: 3.359 ± 1.392
1.679ValCys: 1.679 ± 0.987
3.778ValAsp: 3.778 ± 1.107
2.939ValGlu: 2.939 ± 0.975
2.519ValPhe: 2.519 ± 1.167
3.778ValGly: 3.778 ± 1.062
1.679ValHis: 1.679 ± 0.769
4.198ValIle: 4.198 ± 1.196
2.519ValLys: 2.519 ± 0.707
2.939ValLeu: 2.939 ± 0.741
0.84ValMet: 0.84 ± 0.623
3.359ValAsn: 3.359 ± 1.219
5.038ValPro: 5.038 ± 1.195
2.519ValGln: 2.519 ± 0.558
3.359ValArg: 3.359 ± 1.38
3.778ValSer: 3.778 ± 1.056
5.038ValThr: 5.038 ± 1.982
2.939ValVal: 2.939 ± 0.864
1.259ValTrp: 1.259 ± 0.809
1.679ValTyr: 1.679 ± 0.563
0.0ValXaa: 0.0 ± 0.0
Trp
0.42TrpAla: 0.42 ± 0.318
0.42TrpCys: 0.42 ± 0.399
0.84TrpAsp: 0.84 ± 0.482
0.0TrpGlu: 0.0 ± 0.0
0.84TrpPhe: 0.84 ± 0.447
0.42TrpGly: 0.42 ± 0.318
0.42TrpHis: 0.42 ± 0.399
1.259TrpIle: 1.259 ± 0.552
2.099TrpLys: 2.099 ± 0.937
1.679TrpLeu: 1.679 ± 1.031
0.42TrpMet: 0.42 ± 0.318
0.84TrpAsn: 0.84 ± 0.482
0.0TrpPro: 0.0 ± 0.0
0.42TrpGln: 0.42 ± 0.318
2.099TrpArg: 2.099 ± 0.396
1.259TrpSer: 1.259 ± 0.781
0.84TrpThr: 0.84 ± 0.482
0.42TrpVal: 0.42 ± 0.359
0.0TrpTrp: 0.0 ± 0.0
0.84TrpTyr: 0.84 ± 0.465
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.679TyrAla: 1.679 ± 0.725
0.0TyrCys: 0.0 ± 0.0
1.259TyrAsp: 1.259 ± 0.457
1.259TyrGlu: 1.259 ± 0.677
2.099TyrPhe: 2.099 ± 0.818
3.778TyrGly: 3.778 ± 1.07
0.42TyrHis: 0.42 ± 0.359
1.679TyrIle: 1.679 ± 0.85
1.679TyrLys: 1.679 ± 0.563
4.618TyrLeu: 4.618 ± 1.402
0.84TyrMet: 0.84 ± 0.548
0.84TyrAsn: 0.84 ± 0.416
0.42TyrPro: 0.42 ± 0.545
2.519TyrGln: 2.519 ± 0.462
1.259TyrArg: 1.259 ± 0.659
0.42TyrSer: 0.42 ± 0.33
2.519TyrThr: 2.519 ± 0.904
2.519TyrVal: 2.519 ± 1.144
0.0TyrTrp: 0.0 ± 0.0
1.679TyrTyr: 1.679 ± 0.846
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7 proteins (2383 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski