Amino acid dipepetide frequency for Planococcus rifietoensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.294AlaAla: 8.294 ± 0.105	0.575AlaCys: 0.575 ± 0.023	4.619AlaAsp: 4.619 ± 0.079	6.625AlaGlu: 6.625 ± 0.107	3.924AlaPhe: 3.924 ± 0.076	6.783AlaGly: 6.783 ± 0.094	1.538AlaHis: 1.538 ± 0.039	6.369AlaIle: 6.369 ± 0.077	4.695AlaLys: 4.695 ± 0.077	8.824AlaLeu: 8.824 ± 0.107	2.599AlaMet: 2.599 ± 0.057	2.742AlaAsn: 2.742 ± 0.051	2.676AlaPro: 2.676 ± 0.058	3.057AlaGln: 3.057 ± 0.057	3.19AlaArg: 3.19 ± 0.061	4.827AlaSer: 4.827 ± 0.071	3.883AlaThr: 3.883 ± 0.062	6.842AlaVal: 6.842 ± 0.103	0.788AlaTrp: 0.788 ± 0.03	2.701AlaTyr: 2.701 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	0.426CysAla: 0.426 ± 0.023	0.06CysCys: 0.06 ± 0.008	0.316CysAsp: 0.316 ± 0.016	0.385CysGlu: 0.385 ± 0.022	0.226CysPhe: 0.226 ± 0.016	0.547CysGly: 0.547 ± 0.023	0.15CysHis: 0.15 ± 0.011	0.335CysIle: 0.335 ± 0.019	0.235CysLys: 0.235 ± 0.016	0.479CysLeu: 0.479 ± 0.023	0.137CysMet: 0.137 ± 0.013	0.195CysAsn: 0.195 ± 0.014	0.316CysPro: 0.316 ± 0.018	0.177CysGln: 0.177 ± 0.014	0.287CysArg: 0.287 ± 0.018	0.353CysSer: 0.353 ± 0.02	0.317CysThr: 0.317 ± 0.016	0.334CysVal: 0.334 ± 0.018	0.05CysTrp: 0.05 ± 0.007	0.17CysTyr: 0.17 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	4.403AspAla: 4.403 ± 0.068	0.307AspCys: 0.307 ± 0.017	2.633AspAsp: 2.633 ± 0.064	4.845AspGlu: 4.845 ± 0.081	2.667AspPhe: 2.667 ± 0.051	3.983AspGly: 3.983 ± 0.064	1.189AspHis: 1.189 ± 0.039	3.94AspIle: 3.94 ± 0.061	2.71AspLys: 2.71 ± 0.066	4.864AspLeu: 4.864 ± 0.068	1.623AspMet: 1.623 ± 0.04	1.735AspAsn: 1.735 ± 0.045	2.329AspPro: 2.329 ± 0.046	2.014AspGln: 2.014 ± 0.05	2.677AspArg: 2.677 ± 0.05	2.95AspSer: 2.95 ± 0.058	2.489AspThr: 2.489 ± 0.051	3.929AspVal: 3.929 ± 0.067	0.719AspTrp: 0.719 ± 0.027	2.156AspTyr: 2.156 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	6.822GluAla: 6.822 ± 0.104	0.307GluCys: 0.307 ± 0.017	4.198GluAsp: 4.198 ± 0.066	7.434GluGlu: 7.434 ± 0.123	2.905GluPhe: 2.905 ± 0.057	4.841GluGly: 4.841 ± 0.075	1.581GluHis: 1.581 ± 0.038	4.981GluIle: 4.981 ± 0.079	5.21GluLys: 5.21 ± 0.081	8.168GluLeu: 8.168 ± 0.103	2.468GluMet: 2.468 ± 0.05	3.018GluAsn: 3.018 ± 0.053	2.473GluPro: 2.473 ± 0.058	4.526GluGln: 4.526 ± 0.092	4.228GluArg: 4.228 ± 0.077	3.826GluSer: 3.826 ± 0.061	4.555GluThr: 4.555 ± 0.074	5.077GluVal: 5.077 ± 0.084	0.964GluTrp: 0.964 ± 0.028	2.036GluTyr: 2.036 ± 0.044	0.0GluXaa: 0.0 ± 0.0
Phe	3.668PheAla: 3.668 ± 0.072	0.245PheCys: 0.245 ± 0.016	2.547PheAsp: 2.547 ± 0.051	3.097PheGlu: 3.097 ± 0.066	2.261PhePhe: 2.261 ± 0.06	3.713PheGly: 3.713 ± 0.077	0.992PheHis: 0.992 ± 0.036	3.4PheIle: 3.4 ± 0.061	1.908PheLys: 1.908 ± 0.044	4.459PheLeu: 4.459 ± 0.089	1.242PheMet: 1.242 ± 0.034	1.634PheAsn: 1.634 ± 0.044	1.673PhePro: 1.673 ± 0.038	1.502PheGln: 1.502 ± 0.039	1.756PheArg: 1.756 ± 0.042	3.005PheSer: 3.005 ± 0.06	2.652PheThr: 2.652 ± 0.049	3.199PheVal: 3.199 ± 0.064	0.53PheTrp: 0.53 ± 0.024	1.575PheTyr: 1.575 ± 0.048	0.0PheXaa: 0.0 ± 0.0
Gly	5.829GlyAla: 5.829 ± 0.088	0.487GlyCys: 0.487 ± 0.027	3.783GlyAsp: 3.783 ± 0.067	5.076GlyGlu: 5.076 ± 0.083	3.614GlyPhe: 3.614 ± 0.069	5.437GlyGly: 5.437 ± 0.095	1.549GlyHis: 1.549 ± 0.046	5.81GlyIle: 5.81 ± 0.084	4.59GlyLys: 4.59 ± 0.073	7.032GlyLeu: 7.032 ± 0.115	2.403GlyMet: 2.403 ± 0.046	2.437GlyAsn: 2.437 ± 0.044	1.99GlyPro: 1.99 ± 0.053	2.619GlyGln: 2.619 ± 0.05	3.156GlyArg: 3.156 ± 0.06	4.213GlySer: 4.213 ± 0.067	4.336GlyThr: 4.336 ± 0.075	5.274GlyVal: 5.274 ± 0.065	0.865GlyTrp: 0.865 ± 0.031	2.681GlyTyr: 2.681 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	1.623HisAla: 1.623 ± 0.038	0.167HisCys: 0.167 ± 0.014	1.055HisAsp: 1.055 ± 0.035	1.482HisGlu: 1.482 ± 0.035	1.054HisPhe: 1.054 ± 0.034	1.48HisGly: 1.48 ± 0.042	0.624HisHis: 0.624 ± 0.028	1.387HisIle: 1.387 ± 0.034	0.92HisLys: 0.92 ± 0.031	2.061HisLeu: 2.061 ± 0.046	0.549HisMet: 0.549 ± 0.023	0.642HisAsn: 0.642 ± 0.025	1.24HisPro: 1.24 ± 0.033	0.882HisGln: 0.882 ± 0.025	0.912HisArg: 0.912 ± 0.027	1.176HisSer: 1.176 ± 0.033	1.004HisThr: 1.004 ± 0.034	1.4HisVal: 1.4 ± 0.039	0.216HisTrp: 0.216 ± 0.015	0.799HisTyr: 0.799 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	6.515IleAla: 6.515 ± 0.094	0.468IleCys: 0.468 ± 0.023	4.328IleAsp: 4.328 ± 0.066	5.513IleGlu: 5.513 ± 0.083	2.935IlePhe: 2.935 ± 0.064	5.973IleGly: 5.973 ± 0.092	1.514IleHis: 1.514 ± 0.04	4.669IleIle: 4.669 ± 0.085	2.855IleLys: 2.855 ± 0.062	6.274IleLeu: 6.274 ± 0.094	1.634IleMet: 1.634 ± 0.039	2.316IleAsn: 2.316 ± 0.048	2.983IlePro: 2.983 ± 0.057	2.456IleGln: 2.456 ± 0.049	3.268IleArg: 3.268 ± 0.058	4.362IleSer: 4.362 ± 0.07	3.648IleThr: 3.648 ± 0.062	5.224IleVal: 5.224 ± 0.093	0.584IleTrp: 0.584 ± 0.025	1.958IleTyr: 1.958 ± 0.046	0.0IleXaa: 0.0 ± 0.0
Lys	4.59LysAla: 4.59 ± 0.074	0.216LysCys: 0.216 ± 0.014	3.018LysAsp: 3.018 ± 0.056	5.133LysGlu: 5.133 ± 0.089	1.707LysPhe: 1.707 ± 0.041	3.696LysGly: 3.696 ± 0.067	1.087LysHis: 1.087 ± 0.03	3.362LysIle: 3.362 ± 0.06	4.396LysLys: 4.396 ± 0.083	4.978LysLeu: 4.978 ± 0.079	1.862LysMet: 1.862 ± 0.044	2.29LysAsn: 2.29 ± 0.049	2.08LysPro: 2.08 ± 0.046	2.693LysGln: 2.693 ± 0.052	3.098LysArg: 3.098 ± 0.061	2.964LysSer: 2.964 ± 0.058	3.178LysThr: 3.178 ± 0.062	3.69LysVal: 3.69 ± 0.076	0.72LysTrp: 0.72 ± 0.028	1.436LysTyr: 1.436 ± 0.044	0.0LysXaa: 0.0 ± 0.0
Leu	9.041LeuAla: 9.041 ± 0.108	0.483LeuCys: 0.483 ± 0.023	5.213LeuAsp: 5.213 ± 0.072	7.414LeuGlu: 7.414 ± 0.104	4.713LeuPhe: 4.713 ± 0.091	6.816LeuGly: 6.816 ± 0.09	1.891LeuHis: 1.891 ± 0.044	6.704LeuIle: 6.704 ± 0.124	5.635LeuLys: 5.635 ± 0.086	10.551LeuLeu: 10.551 ± 0.152	2.686LeuMet: 2.686 ± 0.056	3.489LeuAsn: 3.489 ± 0.056	4.256LeuPro: 4.256 ± 0.065	3.447LeuGln: 3.447 ± 0.063	3.85LeuArg: 3.85 ± 0.076	6.731LeuSer: 6.731 ± 0.083	5.525LeuThr: 5.525 ± 0.072	6.684LeuVal: 6.684 ± 0.089	0.894LeuTrp: 0.894 ± 0.033	3.033LeuTyr: 3.033 ± 0.06	0.0LeuXaa: 0.0 ± 0.0
Met	2.653MetAla: 2.653 ± 0.052	0.106MetCys: 0.106 ± 0.011	1.759MetAsp: 1.759 ± 0.046	2.259MetGlu: 2.259 ± 0.048	1.053MetPhe: 1.053 ± 0.034	1.917MetGly: 1.917 ± 0.042	0.476MetHis: 0.476 ± 0.023	1.891MetIle: 1.891 ± 0.046	2.422MetLys: 2.422 ± 0.045	2.574MetLeu: 2.574 ± 0.052	0.913MetMet: 0.913 ± 0.037	1.392MetAsn: 1.392 ± 0.035	1.184MetPro: 1.184 ± 0.031	1.075MetGln: 1.075 ± 0.03	1.245MetArg: 1.245 ± 0.037	1.646MetSer: 1.646 ± 0.042	1.866MetThr: 1.866 ± 0.049	1.795MetVal: 1.795 ± 0.042	0.203MetTrp: 0.203 ± 0.013	0.729MetTyr: 0.729 ± 0.029	0.0MetXaa: 0.0 ± 0.0
Asn	2.834AsnAla: 2.834 ± 0.06	0.249AsnCys: 0.249 ± 0.017	1.909AsnAsp: 1.909 ± 0.041	2.899AsnGlu: 2.899 ± 0.057	1.48AsnPhe: 1.48 ± 0.043	2.882AsnGly: 2.882 ± 0.062	0.736AsnHis: 0.736 ± 0.029	2.406AsnIle: 2.406 ± 0.054	1.785AsnLys: 1.785 ± 0.037	3.161AsnLeu: 3.161 ± 0.058	1.059AsnMet: 1.059 ± 0.034	1.25AsnAsn: 1.25 ± 0.042	1.924AsnPro: 1.924 ± 0.047	1.322AsnGln: 1.322 ± 0.036	1.917AsnArg: 1.917 ± 0.043	1.994AsnSer: 1.994 ± 0.049	1.798AsnThr: 1.798 ± 0.039	2.431AsnVal: 2.431 ± 0.047	0.434AsnTrp: 0.434 ± 0.02	1.227AsnTyr: 1.227 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	3.206ProAla: 3.206 ± 0.066	0.164ProCys: 0.164 ± 0.012	2.363ProAsp: 2.363 ± 0.049	3.827ProGlu: 3.827 ± 0.071	2.014ProPhe: 2.014 ± 0.046	2.54ProGly: 2.54 ± 0.047	0.869ProHis: 0.869 ± 0.03	2.534ProIle: 2.534 ± 0.054	2.095ProLys: 2.095 ± 0.043	3.744ProLeu: 3.744 ± 0.068	0.942ProMet: 0.942 ± 0.033	1.465ProAsn: 1.465 ± 0.039	1.06ProPro: 1.06 ± 0.031	1.229ProGln: 1.229 ± 0.035	1.211ProArg: 1.211 ± 0.037	2.182ProSer: 2.182 ± 0.043	1.758ProThr: 1.758 ± 0.042	3.317ProVal: 3.317 ± 0.058	0.354ProTrp: 0.354 ± 0.017	1.324ProTyr: 1.324 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	3.758GlnAla: 3.758 ± 0.072	0.147GlnCys: 0.147 ± 0.013	1.855GlnAsp: 1.855 ± 0.041	3.156GlnGlu: 3.156 ± 0.059	1.53GlnPhe: 1.53 ± 0.043	2.382GlnGly: 2.382 ± 0.052	0.815GlnHis: 0.815 ± 0.026	2.131GlnIle: 2.131 ± 0.043	2.17GlnLys: 2.17 ± 0.054	4.398GlnLeu: 4.398 ± 0.07	1.186GlnMet: 1.186 ± 0.033	1.342GlnAsn: 1.342 ± 0.04	1.394GlnPro: 1.394 ± 0.035	2.315GlnGln: 2.315 ± 0.051	1.695GlnArg: 1.695 ± 0.043	2.148GlnSer: 2.148 ± 0.044	1.929GlnThr: 1.929 ± 0.048	2.626GlnVal: 2.626 ± 0.052	0.428GlnTrp: 0.428 ± 0.024	1.203GlnTyr: 1.203 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	3.046ArgAla: 3.046 ± 0.058	0.211ArgCys: 0.211 ± 0.015	2.318ArgAsp: 2.318 ± 0.051	3.643ArgGlu: 3.643 ± 0.064	2.268ArgPhe: 2.268 ± 0.048	2.573ArgGly: 2.573 ± 0.052	1.024ArgHis: 1.024 ± 0.036	3.273ArgIle: 3.273 ± 0.055	2.953ArgLys: 2.953 ± 0.06	4.619ArgLeu: 4.619 ± 0.075	1.479ArgMet: 1.479 ± 0.037	1.741ArgAsn: 1.741 ± 0.043	1.459ArgPro: 1.459 ± 0.031	1.803ArgGln: 1.803 ± 0.05	2.046ArgArg: 2.046 ± 0.053	2.538ArgSer: 2.538 ± 0.048	2.273ArgThr: 2.273 ± 0.052	2.827ArgVal: 2.827 ± 0.061	0.418ArgTrp: 0.418 ± 0.021	1.662ArgTyr: 1.662 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	4.765SerAla: 4.765 ± 0.064	0.319SerCys: 0.319 ± 0.018	2.965SerAsp: 2.965 ± 0.054	4.071SerGlu: 4.071 ± 0.073	3.01SerPhe: 3.01 ± 0.058	5.125SerGly: 5.125 ± 0.071	1.195SerHis: 1.195 ± 0.038	4.24SerIle: 4.24 ± 0.069	2.951SerLys: 2.951 ± 0.054	5.831SerLeu: 5.831 ± 0.077	1.775SerMet: 1.775 ± 0.045	1.999SerAsn: 1.999 ± 0.042	2.179SerPro: 2.179 ± 0.053	1.877SerGln: 1.877 ± 0.051	2.524SerArg: 2.524 ± 0.053	3.562SerSer: 3.562 ± 0.072	3.035SerThr: 3.035 ± 0.058	4.251SerVal: 4.251 ± 0.068	0.677SerTrp: 0.677 ± 0.03	2.158SerTyr: 2.158 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	5.052ThrAla: 5.052 ± 0.071	0.266ThrCys: 0.266 ± 0.016	3.0ThrAsp: 3.0 ± 0.051	4.17ThrGlu: 4.17 ± 0.075	2.221ThrPhe: 2.221 ± 0.046	4.637ThrGly: 4.637 ± 0.062	1.102ThrHis: 1.102 ± 0.032	3.953ThrIle: 3.953 ± 0.061	2.681ThrLys: 2.681 ± 0.053	5.074ThrLeu: 5.074 ± 0.069	1.349ThrMet: 1.349 ± 0.038	1.818ThrAsn: 1.818 ± 0.047	2.342ThrPro: 2.342 ± 0.052	1.601ThrGln: 1.601 ± 0.041	1.909ThrArg: 1.909 ± 0.047	2.945ThrSer: 2.945 ± 0.06	2.629ThrThr: 2.629 ± 0.059	4.45ThrVal: 4.45 ± 0.068	0.499ThrTrp: 0.499 ± 0.023	1.673ThrTyr: 1.673 ± 0.046	0.0ThrXaa: 0.0 ± 0.0
Val	5.752ValAla: 5.752 ± 0.092	0.444ValCys: 0.444 ± 0.024	3.913ValAsp: 3.913 ± 0.072	5.383ValGlu: 5.383 ± 0.086	3.32ValPhe: 3.32 ± 0.067	4.626ValGly: 4.626 ± 0.076	1.432ValHis: 1.432 ± 0.039	5.209ValIle: 5.209 ± 0.07	3.892ValLys: 3.892 ± 0.066	7.482ValLeu: 7.482 ± 0.097	2.076ValMet: 2.076 ± 0.051	2.625ValAsn: 2.625 ± 0.05	2.949ValPro: 2.949 ± 0.053	2.342ValGln: 2.342 ± 0.044	3.029ValArg: 3.029 ± 0.054	4.571ValSer: 4.571 ± 0.071	4.195ValThr: 4.195 ± 0.069	5.029ValVal: 5.029 ± 0.075	0.651ValTrp: 0.651 ± 0.028	2.189ValTyr: 2.189 ± 0.053	0.0ValXaa: 0.0 ± 0.0
Trp	0.724TrpAla: 0.724 ± 0.025	0.054TrpCys: 0.054 ± 0.007	0.492TrpAsp: 0.492 ± 0.023	0.63TrpGlu: 0.63 ± 0.028	0.535TrpPhe: 0.535 ± 0.026	0.712TrpGly: 0.712 ± 0.027	0.216TrpHis: 0.216 ± 0.015	0.795TrpIle: 0.795 ± 0.031	0.601TrpLys: 0.601 ± 0.026	1.272TrpLeu: 1.272 ± 0.041	0.378TrpMet: 0.378 ± 0.021	0.502TrpAsn: 0.502 ± 0.024	0.303TrpPro: 0.303 ± 0.019	0.505TrpGln: 0.505 ± 0.023	0.478TrpArg: 0.478 ± 0.025	0.607TrpSer: 0.607 ± 0.023	0.577TrpThr: 0.577 ± 0.029	0.695TrpVal: 0.695 ± 0.026	0.153TrpTrp: 0.153 ± 0.012	0.295TrpTyr: 0.295 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.551TyrAla: 2.551 ± 0.061	0.221TyrCys: 0.221 ± 0.015	1.878TyrAsp: 1.878 ± 0.047	2.578TyrGlu: 2.578 ± 0.053	1.619TyrPhe: 1.619 ± 0.044	2.517TyrGly: 2.517 ± 0.055	0.694TyrHis: 0.694 ± 0.027	2.09TyrIle: 2.09 ± 0.051	1.489TyrLys: 1.489 ± 0.041	3.212TyrLeu: 3.212 ± 0.06	0.798TyrMet: 0.798 ± 0.026	1.061TyrAsn: 1.061 ± 0.036	1.386TyrPro: 1.386 ± 0.036	1.168TyrGln: 1.168 ± 0.034	1.698TyrArg: 1.698 ± 0.042	1.907TyrSer: 1.907 ± 0.046	1.723TyrThr: 1.723 ± 0.041	2.038TyrVal: 2.038 ± 0.043	0.378TyrTrp: 0.378 ± 0.023	1.19TyrTyr: 1.19 ± 0.037	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3386 proteins (996273 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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