Amino acid dipepetide frequency for Pseudomonas fulva (strain 12-X)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.99AlaAla: 13.99 ± 0.201	1.217AlaCys: 1.217 ± 0.031	6.132AlaAsp: 6.132 ± 0.079	7.362AlaGlu: 7.362 ± 0.086	3.918AlaPhe: 3.918 ± 0.054	9.314AlaGly: 9.314 ± 0.113	2.205AlaHis: 2.205 ± 0.043	5.345AlaIle: 5.345 ± 0.062	3.789AlaLys: 3.789 ± 0.065	14.484AlaLeu: 14.484 ± 0.289	2.961AlaMet: 2.961 ± 0.05	3.015AlaAsn: 3.015 ± 0.056	4.892AlaPro: 4.892 ± 0.08	5.433AlaGln: 5.433 ± 0.186	7.482AlaArg: 7.482 ± 0.086	6.413AlaSer: 6.413 ± 0.073	4.89AlaThr: 4.89 ± 0.081	7.737AlaVal: 7.737 ± 0.082	1.632AlaTrp: 1.632 ± 0.041	2.557AlaTyr: 2.557 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	1.093CysAla: 1.093 ± 0.026	0.136CysCys: 0.136 ± 0.011	0.52CysAsp: 0.52 ± 0.018	0.544CysGlu: 0.544 ± 0.023	0.313CysPhe: 0.313 ± 0.016	0.923CysGly: 0.923 ± 0.026	0.252CysHis: 0.252 ± 0.015	0.447CysIle: 0.447 ± 0.018	0.236CysLys: 0.236 ± 0.014	1.098CysLeu: 1.098 ± 0.026	0.199CysMet: 0.199 ± 0.012	0.238CysAsn: 0.238 ± 0.014	0.46CysPro: 0.46 ± 0.018	0.407CysGln: 0.407 ± 0.017	0.622CysArg: 0.622 ± 0.024	0.62CysSer: 0.62 ± 0.021	0.44CysThr: 0.44 ± 0.019	0.677CysVal: 0.677 ± 0.022	0.139CysTrp: 0.139 ± 0.009	0.246CysTyr: 0.246 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	6.167AspAla: 6.167 ± 0.084	0.509AspCys: 0.509 ± 0.021	2.983AspAsp: 2.983 ± 0.05	3.736AspGlu: 3.736 ± 0.057	2.025AspPhe: 2.025 ± 0.041	4.632AspGly: 4.632 ± 0.065	1.084AspHis: 1.084 ± 0.029	2.626AspIle: 2.626 ± 0.054	1.911AspLys: 1.911 ± 0.042	5.858AspLeu: 5.858 ± 0.075	1.196AspMet: 1.196 ± 0.03	1.532AspAsn: 1.532 ± 0.037	2.678AspPro: 2.678 ± 0.047	2.041AspGln: 2.041 ± 0.045	3.077AspArg: 3.077 ± 0.048	2.928AspSer: 2.928 ± 0.047	2.415AspThr: 2.415 ± 0.067	3.636AspVal: 3.636 ± 0.047	0.972AspTrp: 0.972 ± 0.029	1.692AspTyr: 1.692 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	6.785GluAla: 6.785 ± 0.076	0.419GluCys: 0.419 ± 0.017	2.491GluAsp: 2.491 ± 0.046	3.201GluGlu: 3.201 ± 0.058	1.74GluPhe: 1.74 ± 0.038	4.011GluGly: 4.011 ± 0.056	1.655GluHis: 1.655 ± 0.035	2.72GluIle: 2.72 ± 0.047	2.012GluLys: 2.012 ± 0.045	7.301GluLeu: 7.301 ± 0.079	1.284GluMet: 1.284 ± 0.032	1.503GluAsn: 1.503 ± 0.035	2.744GluPro: 2.744 ± 0.046	4.084GluGln: 4.084 ± 0.071	5.273GluArg: 5.273 ± 0.076	2.657GluSer: 2.657 ± 0.045	2.5GluThr: 2.5 ± 0.049	4.344GluVal: 4.344 ± 0.066	0.708GluTrp: 0.708 ± 0.022	1.159GluTyr: 1.159 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	4.177PheAla: 4.177 ± 0.061	0.445PheCys: 0.445 ± 0.019	2.378PheAsp: 2.378 ± 0.044	2.145PheGlu: 2.145 ± 0.042	1.405PhePhe: 1.405 ± 0.041	3.181PheGly: 3.181 ± 0.053	0.697PheHis: 0.697 ± 0.021	1.797PheIle: 1.797 ± 0.04	1.184PheLys: 1.184 ± 0.032	3.232PheLeu: 3.232 ± 0.052	0.815PheMet: 0.815 ± 0.026	1.23PheAsn: 1.23 ± 0.03	1.32PhePro: 1.32 ± 0.033	1.158PheGln: 1.158 ± 0.027	1.816PheArg: 1.816 ± 0.036	2.493PheSer: 2.493 ± 0.048	1.936PheThr: 1.936 ± 0.047	2.561PheVal: 2.561 ± 0.048	0.549PheTrp: 0.549 ± 0.022	0.994PheTyr: 0.994 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	7.695GlyAla: 7.695 ± 0.095	0.923GlyCys: 0.923 ± 0.031	4.029GlyAsp: 4.029 ± 0.055	5.181GlyGlu: 5.181 ± 0.067	3.177GlyPhe: 3.177 ± 0.055	6.191GlyGly: 6.191 ± 0.089	1.822GlyHis: 1.822 ± 0.04	4.239GlyIle: 4.239 ± 0.057	3.36GlyLys: 3.36 ± 0.055	9.467GlyLeu: 9.467 ± 0.103	2.249GlyMet: 2.249 ± 0.044	2.475GlyAsn: 2.475 ± 0.06	2.516GlyPro: 2.516 ± 0.044	3.623GlyGln: 3.623 ± 0.046	4.977GlyArg: 4.977 ± 0.068	4.664GlySer: 4.664 ± 0.067	3.827GlyThr: 3.827 ± 0.107	6.071GlyVal: 6.071 ± 0.069	1.317GlyTrp: 1.317 ± 0.033	2.413GlyTyr: 2.413 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	2.301HisAla: 2.301 ± 0.041	0.306HisCys: 0.306 ± 0.015	1.203HisAsp: 1.203 ± 0.036	1.244HisGlu: 1.244 ± 0.031	0.933HisPhe: 0.933 ± 0.026	1.971HisGly: 1.971 ± 0.039	0.574HisHis: 0.574 ± 0.022	0.969HisIle: 0.969 ± 0.026	0.622HisLys: 0.622 ± 0.021	2.598HisLeu: 2.598 ± 0.05	0.488HisMet: 0.488 ± 0.019	0.609HisAsn: 0.609 ± 0.023	1.339HisPro: 1.339 ± 0.033	0.905HisGln: 0.905 ± 0.028	1.293HisArg: 1.293 ± 0.034	1.19HisSer: 1.19 ± 0.029	0.911HisThr: 0.911 ± 0.024	1.33HisVal: 1.33 ± 0.03	0.432HisTrp: 0.432 ± 0.018	0.669HisTyr: 0.669 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	6.146IleAla: 6.146 ± 0.072	0.498IleCys: 0.498 ± 0.018	3.365IleAsp: 3.365 ± 0.045	3.352IleGlu: 3.352 ± 0.057	1.415IlePhe: 1.415 ± 0.034	4.685IleGly: 4.685 ± 0.074	0.946IleHis: 0.946 ± 0.028	2.035IleIle: 2.035 ± 0.04	1.594IleLys: 1.594 ± 0.039	4.121IleLeu: 4.121 ± 0.062	0.838IleMet: 0.838 ± 0.028	1.612IleAsn: 1.612 ± 0.037	2.119IlePro: 2.119 ± 0.041	1.574IleGln: 1.574 ± 0.042	2.913IleArg: 2.913 ± 0.05	2.913IleSer: 2.913 ± 0.046	2.601IleThr: 2.601 ± 0.049	3.328IleVal: 3.328 ± 0.06	0.503IleTrp: 0.503 ± 0.022	1.075IleTyr: 1.075 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	4.055LysAla: 4.055 ± 0.064	0.154LysCys: 0.154 ± 0.012	1.675LysAsp: 1.675 ± 0.037	1.588LysGlu: 1.588 ± 0.037	0.809LysPhe: 0.809 ± 0.026	2.503LysGly: 2.503 ± 0.047	0.688LysHis: 0.688 ± 0.024	1.459LysIle: 1.459 ± 0.039	1.253LysLys: 1.253 ± 0.039	3.736LysLeu: 3.736 ± 0.053	0.655LysMet: 0.655 ± 0.026	0.91LysAsn: 0.91 ± 0.024	2.074LysPro: 2.074 ± 0.05	1.586LysGln: 1.586 ± 0.035	2.432LysArg: 2.432 ± 0.042	1.75LysSer: 1.75 ± 0.04	1.689LysThr: 1.689 ± 0.039	2.634LysVal: 2.634 ± 0.048	0.338LysTrp: 0.338 ± 0.015	0.632LysTyr: 0.632 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	14.647LeuAla: 14.647 ± 0.125	1.244LeuCys: 1.244 ± 0.033	6.918LeuAsp: 6.918 ± 0.082	6.439LeuGlu: 6.439 ± 0.078	4.215LeuPhe: 4.215 ± 0.063	9.39LeuGly: 9.39 ± 0.094	2.461LeuHis: 2.461 ± 0.047	5.689LeuIle: 5.689 ± 0.065	4.062LeuLys: 4.062 ± 0.057	14.049LeuLeu: 14.049 ± 0.157	2.542LeuMet: 2.542 ± 0.048	3.432LeuAsn: 3.432 ± 0.057	6.413LeuPro: 6.413 ± 0.077	5.185LeuGln: 5.185 ± 0.077	7.539LeuArg: 7.539 ± 0.103	7.31LeuSer: 7.31 ± 0.133	5.791LeuThr: 5.791 ± 0.184	8.051LeuVal: 8.051 ± 0.087	1.384LeuTrp: 1.384 ± 0.035	2.542LeuTyr: 2.542 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	2.74MetAla: 2.74 ± 0.048	0.161MetCys: 0.161 ± 0.01	1.001MetAsp: 1.001 ± 0.029	0.946MetGlu: 0.946 ± 0.026	0.665MetPhe: 0.665 ± 0.024	1.617MetGly: 1.617 ± 0.042	0.483MetHis: 0.483 ± 0.017	1.125MetIle: 1.125 ± 0.034	0.838MetLys: 0.838 ± 0.023	2.768MetLeu: 2.768 ± 0.047	0.518MetMet: 0.518 ± 0.023	0.839MetAsn: 0.839 ± 0.023	1.379MetPro: 1.379 ± 0.03	1.153MetGln: 1.153 ± 0.031	1.546MetArg: 1.546 ± 0.034	1.774MetSer: 1.774 ± 0.035	1.41MetThr: 1.41 ± 0.037	1.495MetVal: 1.495 ± 0.034	0.179MetTrp: 0.179 ± 0.01	0.352MetTyr: 0.352 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.199AsnAla: 3.199 ± 0.068	0.282AsnCys: 0.282 ± 0.015	1.559AsnAsp: 1.559 ± 0.044	1.406AsnGlu: 1.406 ± 0.036	1.035AsnPhe: 1.035 ± 0.027	2.602AsnGly: 2.602 ± 0.068	0.589AsnHis: 0.589 ± 0.02	1.331AsnIle: 1.331 ± 0.035	0.875AsnLys: 0.875 ± 0.028	3.515AsnLeu: 3.515 ± 0.056	0.618AsnMet: 0.618 ± 0.02	0.875AsnAsn: 0.875 ± 0.03	1.885AsnPro: 1.885 ± 0.041	1.229AsnGln: 1.229 ± 0.033	1.881AsnArg: 1.881 ± 0.037	1.489AsnSer: 1.489 ± 0.033	1.364AsnThr: 1.364 ± 0.036	1.855AsnVal: 1.855 ± 0.037	0.438AsnTrp: 0.438 ± 0.018	0.709AsnTyr: 0.709 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	5.906ProAla: 5.906 ± 0.096	0.357ProCys: 0.357 ± 0.017	2.695ProAsp: 2.695 ± 0.046	3.207ProGlu: 3.207 ± 0.052	1.807ProPhe: 1.807 ± 0.036	3.962ProGly: 3.962 ± 0.066	1.053ProHis: 1.053 ± 0.03	2.059ProIle: 2.059 ± 0.04	1.5ProLys: 1.5 ± 0.039	5.643ProLeu: 5.643 ± 0.076	1.179ProMet: 1.179 ± 0.031	1.317ProAsn: 1.317 ± 0.03	1.898ProPro: 1.898 ± 0.049	2.159ProGln: 2.159 ± 0.042	2.652ProArg: 2.652 ± 0.048	2.601ProSer: 2.601 ± 0.049	2.241ProThr: 2.241 ± 0.061	3.758ProVal: 3.758 ± 0.06	0.727ProTrp: 0.727 ± 0.027	1.193ProTyr: 1.193 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	6.167GlnAla: 6.167 ± 0.088	0.322GlnCys: 0.322 ± 0.013	1.832GlnAsp: 1.832 ± 0.038	2.016GlnGlu: 2.016 ± 0.043	1.336GlnPhe: 1.336 ± 0.034	3.444GlnGly: 3.444 ± 0.051	1.138GlnHis: 1.138 ± 0.029	2.167GlnIle: 2.167 ± 0.128	1.191GlnLys: 1.191 ± 0.034	5.615GlnLeu: 5.615 ± 0.093	1.022GlnMet: 1.022 ± 0.028	1.097GlnAsn: 1.097 ± 0.031	2.582GlnPro: 2.582 ± 0.053	2.781GlnGln: 2.781 ± 0.056	3.958GlnArg: 3.958 ± 0.06	2.362GlnSer: 2.362 ± 0.047	1.932GlnThr: 1.932 ± 0.038	3.717GlnVal: 3.717 ± 0.128	0.691GlnTrp: 0.691 ± 0.024	0.936GlnTyr: 0.936 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	6.279ArgAla: 6.279 ± 0.081	0.624ArgCys: 0.624 ± 0.02	3.705ArgAsp: 3.705 ± 0.054	4.511ArgGlu: 4.511 ± 0.068	2.762ArgPhe: 2.762 ± 0.048	4.294ArgGly: 4.294 ± 0.062	1.766ArgHis: 1.766 ± 0.041	3.429ArgIle: 3.429 ± 0.05	2.026ArgLys: 2.026 ± 0.046	8.556ArgLeu: 8.556 ± 0.097	1.66ArgMet: 1.66 ± 0.033	1.954ArgAsn: 1.954 ± 0.042	2.744ArgPro: 2.744 ± 0.044	3.61ArgGln: 3.61 ± 0.063	4.516ArgArg: 4.516 ± 0.064	3.483ArgSer: 3.483 ± 0.048	2.667ArgThr: 2.667 ± 0.045	4.526ArgVal: 4.526 ± 0.06	1.028ArgTrp: 1.028 ± 0.027	2.076ArgTyr: 2.076 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	6.242SerAla: 6.242 ± 0.09	0.491SerCys: 0.491 ± 0.018	2.881SerAsp: 2.881 ± 0.05	3.233SerGlu: 3.233 ± 0.042	2.182SerPhe: 2.182 ± 0.048	5.149SerGly: 5.149 ± 0.069	1.252SerHis: 1.252 ± 0.028	2.701SerIle: 2.701 ± 0.047	1.763SerLys: 1.763 ± 0.041	7.116SerLeu: 7.116 ± 0.085	1.41SerMet: 1.41 ± 0.033	1.752SerAsn: 1.752 ± 0.049	2.598SerPro: 2.598 ± 0.047	2.405SerGln: 2.405 ± 0.047	3.616SerArg: 3.616 ± 0.049	3.402SerSer: 3.402 ± 0.071	2.88SerThr: 2.88 ± 0.085	3.98SerVal: 3.98 ± 0.055	0.791SerTrp: 0.791 ± 0.021	1.391SerTyr: 1.391 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	5.307ThrAla: 5.307 ± 0.192	0.423ThrCys: 0.423 ± 0.019	2.357ThrAsp: 2.357 ± 0.049	2.293ThrGlu: 2.293 ± 0.047	1.738ThrPhe: 1.738 ± 0.039	4.103ThrGly: 4.103 ± 0.06	0.954ThrHis: 0.954 ± 0.029	1.989ThrIle: 1.989 ± 0.067	1.077ThrLys: 1.077 ± 0.027	6.645ThrLeu: 6.645 ± 0.07	0.809ThrMet: 0.809 ± 0.023	1.135ThrAsn: 1.135 ± 0.046	3.077ThrPro: 3.077 ± 0.055	1.914ThrGln: 1.914 ± 0.045	3.044ThrArg: 3.044 ± 0.046	2.656ThrSer: 2.656 ± 0.05	2.481ThrThr: 2.481 ± 0.145	3.454ThrVal: 3.454 ± 0.139	0.689ThrTrp: 0.689 ± 0.021	1.173ThrTyr: 1.173 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	8.193ValAla: 8.193 ± 0.142	0.675ValCys: 0.675 ± 0.022	4.044ValAsp: 4.044 ± 0.068	4.491ValGlu: 4.491 ± 0.063	2.535ValPhe: 2.535 ± 0.049	5.309ValGly: 5.309 ± 0.076	1.375ValHis: 1.375 ± 0.03	3.884ValIle: 3.884 ± 0.059	2.225ValLys: 2.225 ± 0.048	8.257ValLeu: 8.257 ± 0.088	1.749ValMet: 1.749 ± 0.033	2.078ValAsn: 2.078 ± 0.042	3.306ValPro: 3.306 ± 0.054	2.776ValGln: 2.776 ± 0.042	4.483ValArg: 4.483 ± 0.062	4.24ValSer: 4.24 ± 0.051	3.673ValThr: 3.673 ± 0.097	5.554ValVal: 5.554 ± 0.072	0.819ValTrp: 0.819 ± 0.025	1.522ValTyr: 1.522 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	1.208TrpAla: 1.208 ± 0.034	0.15TrpCys: 0.15 ± 0.009	0.589TrpAsp: 0.589 ± 0.021	0.549TrpGlu: 0.549 ± 0.02	0.535TrpPhe: 0.535 ± 0.02	0.893TrpGly: 0.893 ± 0.024	0.38TrpHis: 0.38 ± 0.016	0.669TrpIle: 0.669 ± 0.022	0.396TrpLys: 0.396 ± 0.015	2.208TrpLeu: 2.208 ± 0.053	0.343TrpMet: 0.343 ± 0.016	0.429TrpAsn: 0.429 ± 0.015	0.649TrpPro: 0.649 ± 0.023	0.998TrpGln: 0.998 ± 0.027	1.138TrpArg: 1.138 ± 0.036	0.808TrpSer: 0.808 ± 0.03	0.571TrpThr: 0.571 ± 0.019	0.901TrpVal: 0.901 ± 0.027	0.218TrpTrp: 0.218 ± 0.012	0.314TrpTyr: 0.314 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.469TyrAla: 2.469 ± 0.046	0.272TyrCys: 0.272 ± 0.012	1.344TyrAsp: 1.344 ± 0.036	1.146TyrGlu: 1.146 ± 0.033	0.968TyrPhe: 0.968 ± 0.03	2.042TyrGly: 2.042 ± 0.042	0.513TyrHis: 0.513 ± 0.02	0.951TyrIle: 0.951 ± 0.03	0.707TyrLys: 0.707 ± 0.023	3.035TyrLeu: 3.035 ± 0.052	0.456TyrMet: 0.456 ± 0.018	0.705TyrAsn: 0.705 ± 0.026	1.242TyrPro: 1.242 ± 0.031	1.284TyrGln: 1.284 ± 0.029	1.96TyrArg: 1.96 ± 0.039	1.483TyrSer: 1.483 ± 0.038	1.101TyrThr: 1.101 ± 0.03	1.577TyrVal: 1.577 ± 0.037	0.392TyrTrp: 0.392 ± 0.018	0.676TyrTyr: 0.676 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4459 proteins (1450635 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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