Amino acid dipepetide frequency for Candidatus Kinetoplastibacterium crithidii TCC036E

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.006AlaAla: 4.006 ± 0.163
0.781AlaCys: 0.781 ± 0.053
2.735AlaAsp: 2.735 ± 0.117
2.902AlaGlu: 2.902 ± 0.122
2.289AlaPhe: 2.289 ± 0.113
3.593AlaGly: 3.593 ± 0.159
1.128AlaHis: 1.128 ± 0.064
5.989AlaIle: 5.989 ± 0.174
3.957AlaLys: 3.957 ± 0.133
5.715AlaLeu: 5.715 ± 0.173
1.512AlaMet: 1.512 ± 0.081
3.242AlaAsn: 3.242 ± 0.122
1.631AlaPro: 1.631 ± 0.082
1.664AlaGln: 1.664 ± 0.091
2.992AlaArg: 2.992 ± 0.104
4.456AlaSer: 4.456 ± 0.133
2.506AlaThr: 2.506 ± 0.106
3.654AlaVal: 3.654 ± 0.144
0.58AlaTrp: 0.58 ± 0.049
1.7AlaTyr: 1.7 ± 0.078
0.0AlaXaa: 0.0 ± 0.0
Cys
0.605CysAla: 0.605 ± 0.05
0.114CysCys: 0.114 ± 0.025
0.74CysAsp: 0.74 ± 0.054
0.576CysGlu: 0.576 ± 0.047
0.74CysPhe: 0.74 ± 0.059
0.907CysGly: 0.907 ± 0.062
0.27CysHis: 0.27 ± 0.034
1.14CysIle: 1.14 ± 0.069
0.793CysLys: 0.793 ± 0.058
1.271CysLeu: 1.271 ± 0.076
0.245CysMet: 0.245 ± 0.03
0.818CysAsn: 0.818 ± 0.055
0.45CysPro: 0.45 ± 0.041
0.347CysGln: 0.347 ± 0.039
0.388CysArg: 0.388 ± 0.041
0.912CysSer: 0.912 ± 0.058
0.511CysThr: 0.511 ± 0.051
0.654CysVal: 0.654 ± 0.055
0.11CysTrp: 0.11 ± 0.026
0.47CysTyr: 0.47 ± 0.042
0.0CysXaa: 0.0 ± 0.0
Asp
2.874AspAla: 2.874 ± 0.098
0.719AspCys: 0.719 ± 0.053
2.645AspAsp: 2.645 ± 0.123
2.976AspGlu: 2.976 ± 0.118
3.013AspPhe: 3.013 ± 0.129
3.054AspGly: 3.054 ± 0.105
1.055AspHis: 1.055 ± 0.064
6.295AspIle: 6.295 ± 0.167
3.74AspLys: 3.74 ± 0.119
5.768AspLeu: 5.768 ± 0.155
1.194AspMet: 1.194 ± 0.059
3.397AspAsn: 3.397 ± 0.111
1.917AspPro: 1.917 ± 0.086
1.418AspGln: 1.418 ± 0.074
2.387AspArg: 2.387 ± 0.092
4.333AspSer: 4.333 ± 0.172
2.044AspThr: 2.044 ± 0.084
3.585AspVal: 3.585 ± 0.112
0.56AspTrp: 0.56 ± 0.054
2.191AspTyr: 2.191 ± 0.101
0.0AspXaa: 0.0 ± 0.0
Glu
3.409GluAla: 3.409 ± 0.122
0.593GluCys: 0.593 ± 0.061
2.694GluAsp: 2.694 ± 0.11
3.769GluGlu: 3.769 ± 0.129
2.444GluPhe: 2.444 ± 0.104
2.677GluGly: 2.677 ± 0.102
1.165GluHis: 1.165 ± 0.067
6.88GluIle: 6.88 ± 0.205
5.012GluLys: 5.012 ± 0.16
5.772GluLeu: 5.772 ± 0.153
1.402GluMet: 1.402 ± 0.081
4.059GluAsn: 4.059 ± 0.137
1.467GluPro: 1.467 ± 0.083
1.974GluGln: 1.974 ± 0.093
2.416GluArg: 2.416 ± 0.102
4.247GluSer: 4.247 ± 0.121
2.547GluThr: 2.547 ± 0.1
3.184GluVal: 3.184 ± 0.12
0.564GluTrp: 0.564 ± 0.049
2.056GluTyr: 2.056 ± 0.085
0.0GluXaa: 0.0 ± 0.0
Phe
2.547PheAla: 2.547 ± 0.1
0.715PheCys: 0.715 ± 0.053
3.131PheAsp: 3.131 ± 0.119
2.534PheGlu: 2.534 ± 0.101
2.42PhePhe: 2.42 ± 0.106
2.845PheGly: 2.845 ± 0.115
0.883PheHis: 0.883 ± 0.054
4.37PheIle: 4.37 ± 0.164
2.698PheLys: 2.698 ± 0.099
4.676PheLeu: 4.676 ± 0.149
0.903PheMet: 0.903 ± 0.066
2.608PheAsn: 2.608 ± 0.1
1.484PhePro: 1.484 ± 0.082
1.128PheGln: 1.128 ± 0.077
1.606PheArg: 1.606 ± 0.08
4.276PheSer: 4.276 ± 0.154
1.66PheThr: 1.66 ± 0.085
2.551PheVal: 2.551 ± 0.108
0.454PheTrp: 0.454 ± 0.054
1.676PheTyr: 1.676 ± 0.093
0.0PheXaa: 0.0 ± 0.0
Gly
3.638GlyAla: 3.638 ± 0.14
0.777GlyCys: 0.777 ± 0.06
2.886GlyAsp: 2.886 ± 0.115
3.217GlyGlu: 3.217 ± 0.111
3.123GlyPhe: 3.123 ± 0.126
3.998GlyGly: 3.998 ± 0.166
1.398GlyHis: 1.398 ± 0.084
6.258GlyIle: 6.258 ± 0.173
4.321GlyLys: 4.321 ± 0.147
5.85GlyLeu: 5.85 ± 0.146
1.553GlyMet: 1.553 ± 0.098
2.763GlyAsn: 2.763 ± 0.118
1.619GlyPro: 1.619 ± 0.084
1.672GlyGln: 1.672 ± 0.092
2.874GlyArg: 2.874 ± 0.126
4.566GlySer: 4.566 ± 0.142
2.87GlyThr: 2.87 ± 0.105
4.398GlyVal: 4.398 ± 0.175
0.613GlyTrp: 0.613 ± 0.052
2.109GlyTyr: 2.109 ± 0.103
0.0GlyXaa: 0.0 ± 0.0
His
1.202HisAla: 1.202 ± 0.074
0.29HisCys: 0.29 ± 0.034
1.063HisAsp: 1.063 ± 0.07
0.924HisGlu: 0.924 ± 0.055
0.773HisPhe: 0.773 ± 0.063
1.504HisGly: 1.504 ± 0.081
0.441HisHis: 0.441 ± 0.043
1.827HisIle: 1.827 ± 0.091
1.443HisLys: 1.443 ± 0.078
1.974HisLeu: 1.974 ± 0.092
0.401HisMet: 0.401 ± 0.038
1.455HisAsn: 1.455 ± 0.082
1.018HisPro: 1.018 ± 0.072
0.601HisGln: 0.601 ± 0.05
0.846HisArg: 0.846 ± 0.062
1.349HisSer: 1.349 ± 0.073
0.699HisThr: 0.699 ± 0.058
1.083HisVal: 1.083 ± 0.065
0.172HisTrp: 0.172 ± 0.026
0.74HisTyr: 0.74 ± 0.055
0.0HisXaa: 0.0 ± 0.0
Ile
6.107IleAla: 6.107 ± 0.181
1.214IleCys: 1.214 ± 0.081
6.814IleAsp: 6.814 ± 0.175
6.79IleGlu: 6.79 ± 0.155
4.108IlePhe: 4.108 ± 0.157
6.442IleGly: 6.442 ± 0.191
1.762IleHis: 1.762 ± 0.082
8.895IleIle: 8.895 ± 0.22
7.603IleLys: 7.603 ± 0.187
9.091IleLeu: 9.091 ± 0.216
2.216IleMet: 2.216 ± 0.085
7.047IleAsn: 7.047 ± 0.214
3.597IlePro: 3.597 ± 0.118
2.477IleGln: 2.477 ± 0.109
3.896IleArg: 3.896 ± 0.107
8.899IleSer: 8.899 ± 0.182
4.693IleThr: 4.693 ± 0.142
5.837IleVal: 5.837 ± 0.14
0.785IleTrp: 0.785 ± 0.057
2.902IleTyr: 2.902 ± 0.123
0.0IleXaa: 0.0 ± 0.0
Lys
3.544LysAla: 3.544 ± 0.12
0.552LysCys: 0.552 ± 0.052
3.896LysAsp: 3.896 ± 0.128
4.93LysGlu: 4.93 ± 0.153
2.796LysPhe: 2.796 ± 0.107
3.27LysGly: 3.27 ± 0.128
1.512LysHis: 1.512 ± 0.083
8.245LysIle: 8.245 ± 0.216
6.532LysLys: 6.532 ± 0.203
6.683LysLeu: 6.683 ± 0.167
1.7LysMet: 1.7 ± 0.09
6.475LysAsn: 6.475 ± 0.207
2.154LysPro: 2.154 ± 0.099
2.444LysGln: 2.444 ± 0.099
2.8LysArg: 2.8 ± 0.106
5.379LysSer: 5.379 ± 0.155
3.961LysThr: 3.961 ± 0.125
3.605LysVal: 3.605 ± 0.14
0.728LysTrp: 0.728 ± 0.059
2.8LysTyr: 2.8 ± 0.125
0.0LysXaa: 0.0 ± 0.0
Leu
5.711LeuAla: 5.711 ± 0.166
0.965LeuCys: 0.965 ± 0.069
5.952LeuAsp: 5.952 ± 0.178
6.258LeuGlu: 6.258 ± 0.165
4.3LeuPhe: 4.3 ± 0.182
5.915LeuGly: 5.915 ± 0.163
2.003LeuHis: 2.003 ± 0.1
8.49LeuIle: 8.49 ± 0.187
7.117LeuLys: 7.117 ± 0.185
9.708LeuLeu: 9.708 ± 0.26
2.216LeuMet: 2.216 ± 0.074
5.686LeuAsn: 5.686 ± 0.159
3.659LeuPro: 3.659 ± 0.132
2.988LeuGln: 2.988 ± 0.117
4.464LeuArg: 4.464 ± 0.148
8.997LeuSer: 8.997 ± 0.206
4.308LeuThr: 4.308 ± 0.14
5.743LeuVal: 5.743 ± 0.166
0.801LeuTrp: 0.801 ± 0.063
2.861LeuTyr: 2.861 ± 0.113
0.0LeuXaa: 0.0 ± 0.0
Met
1.492MetAla: 1.492 ± 0.082
0.168MetCys: 0.168 ± 0.026
1.022MetAsp: 1.022 ± 0.069
1.226MetGlu: 1.226 ± 0.068
0.891MetPhe: 0.891 ± 0.054
1.39MetGly: 1.39 ± 0.077
0.499MetHis: 0.499 ± 0.042
1.868MetIle: 1.868 ± 0.088
1.602MetLys: 1.602 ± 0.081
2.379MetLeu: 2.379 ± 0.098
0.548MetMet: 0.548 ± 0.052
1.467MetAsn: 1.467 ± 0.089
1.153MetPro: 1.153 ± 0.07
0.83MetGln: 0.83 ± 0.06
1.12MetArg: 1.12 ± 0.072
1.954MetSer: 1.954 ± 0.102
1.206MetThr: 1.206 ± 0.073
1.218MetVal: 1.218 ± 0.069
0.098MetTrp: 0.098 ± 0.018
0.495MetTyr: 0.495 ± 0.042
0.0MetXaa: 0.0 ± 0.0
Asn
3.017AsnAla: 3.017 ± 0.117
0.895AsnCys: 0.895 ± 0.065
3.303AsnAsp: 3.303 ± 0.114
3.197AsnGlu: 3.197 ± 0.118
2.931AsnPhe: 2.931 ± 0.12
3.601AsnGly: 3.601 ± 0.124
1.288AsnHis: 1.288 ± 0.085
7.987AsnIle: 7.987 ± 0.241
5.514AsnLys: 5.514 ± 0.179
6.091AsnLeu: 6.091 ± 0.187
1.423AsnMet: 1.423 ± 0.07
5.837AsnAsn: 5.837 ± 0.2
2.236AsnPro: 2.236 ± 0.104
1.725AsnGln: 1.725 ± 0.086
2.502AsnArg: 2.502 ± 0.091
5.016AsnSer: 5.016 ± 0.148
2.657AsnThr: 2.657 ± 0.126
3.242AsnVal: 3.242 ± 0.133
0.683AsnTrp: 0.683 ± 0.053
2.342AsnTyr: 2.342 ± 0.108
0.0AsnXaa: 0.0 ± 0.0
Pro
1.721ProAla: 1.721 ± 0.076
0.356ProCys: 0.356 ± 0.033
2.167ProAsp: 2.167 ± 0.103
2.346ProGlu: 2.346 ± 0.096
1.557ProPhe: 1.557 ± 0.076
2.305ProGly: 2.305 ± 0.101
0.711ProHis: 0.711 ± 0.045
3.237ProIle: 3.237 ± 0.128
2.216ProLys: 2.216 ± 0.089
2.927ProLeu: 2.927 ± 0.097
0.724ProMet: 0.724 ± 0.059
1.88ProAsn: 1.88 ± 0.093
0.773ProPro: 0.773 ± 0.056
0.822ProGln: 0.822 ± 0.057
1.169ProArg: 1.169 ± 0.072
2.473ProSer: 2.473 ± 0.116
1.672ProThr: 1.672 ± 0.086
2.314ProVal: 2.314 ± 0.098
0.368ProTrp: 0.368 ± 0.039
1.263ProTyr: 1.263 ± 0.076
0.0ProXaa: 0.0 ± 0.0
Gln
1.905GlnAla: 1.905 ± 0.089
0.278GlnCys: 0.278 ± 0.033
1.48GlnAsp: 1.48 ± 0.069
1.942GlnGlu: 1.942 ± 0.099
1.124GlnPhe: 1.124 ± 0.067
1.439GlnGly: 1.439 ± 0.072
0.605GlnHis: 0.605 ± 0.052
3.021GlnIle: 3.021 ± 0.114
2.4GlnLys: 2.4 ± 0.119
2.624GlnLeu: 2.624 ± 0.103
0.752GlnMet: 0.752 ± 0.056
1.737GlnAsn: 1.737 ± 0.082
0.752GlnPro: 0.752 ± 0.058
0.932GlnGln: 0.932 ± 0.058
1.312GlnArg: 1.312 ± 0.096
1.86GlnSer: 1.86 ± 0.082
1.292GlnThr: 1.292 ± 0.067
1.786GlnVal: 1.786 ± 0.092
0.343GlnTrp: 0.343 ± 0.04
0.981GlnTyr: 0.981 ± 0.069
0.0GlnXaa: 0.0 ± 0.0
Arg
2.346ArgAla: 2.346 ± 0.117
0.429ArgCys: 0.429 ± 0.041
2.256ArgAsp: 2.256 ± 0.099
2.567ArgGlu: 2.567 ± 0.101
1.991ArgPhe: 1.991 ± 0.083
2.424ArgGly: 2.424 ± 0.104
0.846ArgHis: 0.846 ± 0.057
4.153ArgIle: 4.153 ± 0.138
3.066ArgLys: 3.066 ± 0.112
4.235ArgLeu: 4.235 ± 0.151
0.993ArgMet: 0.993 ± 0.072
2.547ArgAsn: 2.547 ± 0.106
1.427ArgPro: 1.427 ± 0.083
1.288ArgGln: 1.288 ± 0.068
2.011ArgArg: 2.011 ± 0.091
3.237ArgSer: 3.237 ± 0.108
1.954ArgThr: 1.954 ± 0.096
2.698ArgVal: 2.698 ± 0.12
0.388ArgTrp: 0.388 ± 0.034
1.639ArgTyr: 1.639 ± 0.078
0.0ArgXaa: 0.0 ± 0.0
Ser
3.986SerAla: 3.986 ± 0.145
1.124SerCys: 1.124 ± 0.066
4.133SerAsp: 4.133 ± 0.136
4.443SerGlu: 4.443 ± 0.135
4.161SerPhe: 4.161 ± 0.129
5.245SerGly: 5.245 ± 0.133
1.402SerHis: 1.402 ± 0.067
8.188SerIle: 8.188 ± 0.203
5.989SerLys: 5.989 ± 0.156
8.605SerLeu: 8.605 ± 0.201
1.668SerMet: 1.668 ± 0.083
5.486SerAsn: 5.486 ± 0.145
2.326SerPro: 2.326 ± 0.101
2.162SerGln: 2.162 ± 0.103
3.466SerArg: 3.466 ± 0.117
6.544SerSer: 6.544 ± 0.173
3.148SerThr: 3.148 ± 0.107
4.402SerVal: 4.402 ± 0.138
0.867SerTrp: 0.867 ± 0.053
2.718SerTyr: 2.718 ± 0.113
0.0SerXaa: 0.0 ± 0.0
Thr
2.633ThrAla: 2.633 ± 0.135
0.568ThrCys: 0.568 ± 0.05
2.24ThrAsp: 2.24 ± 0.1
2.289ThrGlu: 2.289 ± 0.086
1.688ThrPhe: 1.688 ± 0.079
3.205ThrGly: 3.205 ± 0.119
0.883ThrHis: 0.883 ± 0.071
4.717ThrIle: 4.717 ± 0.156
3.078ThrLys: 3.078 ± 0.11
4.071ThrLeu: 4.071 ± 0.128
0.961ThrMet: 0.961 ± 0.065
2.915ThrAsn: 2.915 ± 0.106
1.803ThrPro: 1.803 ± 0.09
1.263ThrGln: 1.263 ± 0.072
1.884ThrArg: 1.884 ± 0.089
3.237ThrSer: 3.237 ± 0.11
2.252ThrThr: 2.252 ± 0.102
2.845ThrVal: 2.845 ± 0.112
0.425ThrTrp: 0.425 ± 0.039
1.206ThrTyr: 1.206 ± 0.071
0.0ThrXaa: 0.0 ± 0.0
Val
3.842ValAla: 3.842 ± 0.152
0.809ValCys: 0.809 ± 0.055
3.761ValAsp: 3.761 ± 0.138
3.197ValGlu: 3.197 ± 0.106
2.727ValPhe: 2.727 ± 0.119
3.949ValGly: 3.949 ± 0.16
1.128ValHis: 1.128 ± 0.067
5.645ValIle: 5.645 ± 0.146
3.609ValLys: 3.609 ± 0.138
6.201ValLeu: 6.201 ± 0.18
1.308ValMet: 1.308 ± 0.067
3.119ValAsn: 3.119 ± 0.113
2.13ValPro: 2.13 ± 0.096
1.574ValGln: 1.574 ± 0.079
2.498ValArg: 2.498 ± 0.119
4.983ValSer: 4.983 ± 0.144
2.559ValThr: 2.559 ± 0.118
4.394ValVal: 4.394 ± 0.179
0.47ValTrp: 0.47 ± 0.044
1.676ValTyr: 1.676 ± 0.077
0.0ValXaa: 0.0 ± 0.0
Trp
0.466TrpAla: 0.466 ± 0.045
0.184TrpCys: 0.184 ± 0.028
0.47TrpAsp: 0.47 ± 0.044
0.511TrpGlu: 0.511 ± 0.043
0.466TrpPhe: 0.466 ± 0.051
0.421TrpGly: 0.421 ± 0.045
0.208TrpHis: 0.208 ± 0.033
0.973TrpIle: 0.973 ± 0.069
0.707TrpLys: 0.707 ± 0.05
1.185TrpLeu: 1.185 ± 0.067
0.27TrpMet: 0.27 ± 0.034
0.617TrpAsn: 0.617 ± 0.05
0.352TrpPro: 0.352 ± 0.038
0.356TrpGln: 0.356 ± 0.036
0.425TrpArg: 0.425 ± 0.044
0.568TrpSer: 0.568 ± 0.052
0.339TrpThr: 0.339 ± 0.039
0.56TrpVal: 0.56 ± 0.051
0.086TrpTrp: 0.086 ± 0.019
0.282TrpTyr: 0.282 ± 0.037
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.983TyrAla: 1.983 ± 0.074
0.531TyrCys: 0.531 ± 0.044
1.778TyrAsp: 1.778 ± 0.085
1.737TyrGlu: 1.737 ± 0.085
1.623TyrPhe: 1.623 ± 0.086
2.322TyrGly: 2.322 ± 0.103
0.617TyrHis: 0.617 ± 0.053
2.996TyrIle: 2.996 ± 0.112
2.612TyrLys: 2.612 ± 0.111
3.315TyrLeu: 3.315 ± 0.126
0.634TyrMet: 0.634 ± 0.059
2.33TyrAsn: 2.33 ± 0.109
1.055TyrPro: 1.055 ± 0.064
0.899TyrGln: 0.899 ± 0.061
1.439TyrArg: 1.439 ± 0.077
2.776TyrSer: 2.776 ± 0.103
1.288TyrThr: 1.288 ± 0.075
1.823TyrVal: 1.823 ± 0.082
0.352TyrTrp: 0.352 ± 0.037
1.075TyrTyr: 1.075 ± 0.073
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 728 proteins (244635 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski