Amino acid dipepetide frequency for Pacificibacter maritimus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.346AlaAla: 13.346 ± 0.169	1.06AlaCys: 1.06 ± 0.033	6.731AlaAsp: 6.731 ± 0.1	6.644AlaGlu: 6.644 ± 0.104	4.137AlaPhe: 4.137 ± 0.076	9.031AlaGly: 9.031 ± 0.107	2.101AlaHis: 2.101 ± 0.056	6.002AlaIle: 6.002 ± 0.08	5.094AlaLys: 5.094 ± 0.091	12.41AlaLeu: 12.41 ± 0.149	3.589AlaMet: 3.589 ± 0.066	2.975AlaAsn: 2.975 ± 0.065	5.152AlaPro: 5.152 ± 0.089	5.211AlaGln: 5.211 ± 0.082	6.679AlaArg: 6.679 ± 0.097	5.838AlaSer: 5.838 ± 0.081	5.972AlaThr: 5.972 ± 0.076	7.344AlaVal: 7.344 ± 0.099	1.254AlaTrp: 1.254 ± 0.036	2.616AlaTyr: 2.616 ± 0.058	0.0AlaXaa: 0.0 ± 0.0
Cys	1.166CysAla: 1.166 ± 0.037	0.12CysCys: 0.12 ± 0.012	0.721CysAsp: 0.721 ± 0.027	0.495CysGlu: 0.495 ± 0.026	0.395CysPhe: 0.395 ± 0.022	0.903CysGly: 0.903 ± 0.034	0.259CysHis: 0.259 ± 0.017	0.472CysIle: 0.472 ± 0.021	0.255CysLys: 0.255 ± 0.016	0.876CysLeu: 0.876 ± 0.032	0.186CysMet: 0.186 ± 0.015	0.231CysAsn: 0.231 ± 0.015	0.455CysPro: 0.455 ± 0.026	0.27CysGln: 0.27 ± 0.015	0.42CysArg: 0.42 ± 0.023	0.467CysSer: 0.467 ± 0.021	0.474CysThr: 0.474 ± 0.025	0.734CysVal: 0.734 ± 0.033	0.087CysTrp: 0.087 ± 0.009	0.189CysTyr: 0.189 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	7.3AspAla: 7.3 ± 0.104	0.532AspCys: 0.532 ± 0.024	3.953AspAsp: 3.953 ± 0.103	3.705AspGlu: 3.705 ± 0.072	2.669AspPhe: 2.669 ± 0.055	5.209AspGly: 5.209 ± 0.099	1.539AspHis: 1.539 ± 0.046	3.912AspIle: 3.912 ± 0.068	2.151AspLys: 2.151 ± 0.053	6.769AspLeu: 6.769 ± 0.095	1.951AspMet: 1.951 ± 0.052	1.55AspAsn: 1.55 ± 0.045	3.353AspPro: 3.353 ± 0.056	2.354AspGln: 2.354 ± 0.051	3.551AspArg: 3.551 ± 0.069	2.452AspSer: 2.452 ± 0.055	3.621AspThr: 3.621 ± 0.084	4.718AspVal: 4.718 ± 0.071	1.074AspTrp: 1.074 ± 0.037	1.646AspTyr: 1.646 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	6.976GluAla: 6.976 ± 0.102	0.349GluCys: 0.349 ± 0.02	3.365GluAsp: 3.365 ± 0.061	2.907GluGlu: 2.907 ± 0.067	2.064GluPhe: 2.064 ± 0.048	4.154GluGly: 4.154 ± 0.074	1.138GluHis: 1.138 ± 0.038	3.787GluIle: 3.787 ± 0.062	2.726GluLys: 2.726 ± 0.065	5.087GluLeu: 5.087 ± 0.083	1.771GluMet: 1.771 ± 0.049	2.294GluAsn: 2.294 ± 0.059	1.98GluPro: 1.98 ± 0.051	2.002GluGln: 2.002 ± 0.051	3.562GluArg: 3.562 ± 0.07	2.363GluSer: 2.363 ± 0.059	4.022GluThr: 4.022 ± 0.073	4.079GluVal: 4.079 ± 0.069	0.635GluTrp: 0.635 ± 0.029	1.075GluTyr: 1.075 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	4.359PheAla: 4.359 ± 0.081	0.44PheCys: 0.44 ± 0.02	3.193PheAsp: 3.193 ± 0.055	2.581PheGlu: 2.581 ± 0.056	1.542PhePhe: 1.542 ± 0.048	3.924PheGly: 3.924 ± 0.067	0.819PheHis: 0.819 ± 0.032	2.04PheIle: 2.04 ± 0.056	1.389PheLys: 1.389 ± 0.041	3.374PheLeu: 3.374 ± 0.068	1.007PheMet: 1.007 ± 0.034	1.235PheAsn: 1.235 ± 0.037	1.54PhePro: 1.54 ± 0.041	1.136PheGln: 1.136 ± 0.037	1.709PheArg: 1.709 ± 0.037	2.572PheSer: 2.572 ± 0.061	2.24PheThr: 2.24 ± 0.048	2.868PheVal: 2.868 ± 0.066	0.536PheTrp: 0.536 ± 0.029	0.964PheTyr: 0.964 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	8.878GlyAla: 8.878 ± 0.121	0.85GlyCys: 0.85 ± 0.032	4.669GlyAsp: 4.669 ± 0.086	4.278GlyGlu: 4.278 ± 0.081	3.584GlyPhe: 3.584 ± 0.07	6.581GlyGly: 6.581 ± 0.13	1.644GlyHis: 1.644 ± 0.045	4.627GlyIle: 4.627 ± 0.08	3.54GlyLys: 3.54 ± 0.069	8.388GlyLeu: 8.388 ± 0.101	2.304GlyMet: 2.304 ± 0.049	2.189GlyAsn: 2.189 ± 0.071	3.066GlyPro: 3.066 ± 0.059	3.007GlyGln: 3.007 ± 0.063	4.594GlyArg: 4.594 ± 0.082	4.289GlySer: 4.289 ± 0.074	4.634GlyThr: 4.634 ± 0.077	6.078GlyVal: 6.078 ± 0.087	1.185GlyTrp: 1.185 ± 0.036	2.287GlyTyr: 2.287 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	2.136HisAla: 2.136 ± 0.052	0.215HisCys: 0.215 ± 0.014	1.333HisAsp: 1.333 ± 0.042	1.08HisGlu: 1.08 ± 0.034	0.87HisPhe: 0.87 ± 0.033	1.715HisGly: 1.715 ± 0.048	0.571HisHis: 0.571 ± 0.031	1.168HisIle: 1.168 ± 0.04	0.775HisLys: 0.775 ± 0.028	1.971HisLeu: 1.971 ± 0.049	0.577HisMet: 0.577 ± 0.025	0.552HisAsn: 0.552 ± 0.025	1.226HisPro: 1.226 ± 0.04	0.616HisGln: 0.616 ± 0.027	1.117HisArg: 1.117 ± 0.04	1.061HisSer: 1.061 ± 0.034	0.919HisThr: 0.919 ± 0.033	1.452HisVal: 1.452 ± 0.041	0.321HisTrp: 0.321 ± 0.021	0.507HisTyr: 0.507 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	7.127IleAla: 7.127 ± 0.091	0.74IleCys: 0.74 ± 0.029	4.094IleAsp: 4.094 ± 0.073	3.977IleGlu: 3.977 ± 0.071	2.097IlePhe: 2.097 ± 0.049	5.096IleGly: 5.096 ± 0.079	1.013IleHis: 1.013 ± 0.033	2.86IleIle: 2.86 ± 0.068	2.181IleLys: 2.181 ± 0.045	5.367IleLeu: 5.367 ± 0.099	1.314IleMet: 1.314 ± 0.039	1.741IleAsn: 1.741 ± 0.045	2.359IlePro: 2.359 ± 0.048	1.512IleGln: 1.512 ± 0.044	2.765IleArg: 2.765 ± 0.055	3.706IleSer: 3.706 ± 0.071	3.503IleThr: 3.503 ± 0.071	4.205IleVal: 4.205 ± 0.076	0.775IleTrp: 0.775 ± 0.033	1.296IleTyr: 1.296 ± 0.038	0.0IleXaa: 0.0 ± 0.0
Lys	4.813LysAla: 4.813 ± 0.087	0.236LysCys: 0.236 ± 0.018	2.699LysAsp: 2.699 ± 0.058	1.87LysGlu: 1.87 ± 0.044	1.308LysPhe: 1.308 ± 0.04	3.129LysGly: 3.129 ± 0.072	0.874LysHis: 0.874 ± 0.038	2.518LysIle: 2.518 ± 0.06	1.75LysLys: 1.75 ± 0.051	3.734LysLeu: 3.734 ± 0.071	1.213LysMet: 1.213 ± 0.035	1.323LysAsn: 1.323 ± 0.042	2.082LysPro: 2.082 ± 0.054	1.257LysGln: 1.257 ± 0.041	2.697LysArg: 2.697 ± 0.057	2.839LysSer: 2.839 ± 0.066	2.67LysThr: 2.67 ± 0.055	2.77LysVal: 2.77 ± 0.061	0.463LysTrp: 0.463 ± 0.021	0.855LysTyr: 0.855 ± 0.032	0.0LysXaa: 0.0 ± 0.0
Leu	11.036LeuAla: 11.036 ± 0.12	1.061LeuCys: 1.061 ± 0.03	6.08LeuAsp: 6.08 ± 0.09	5.382LeuGlu: 5.382 ± 0.083	3.644LeuPhe: 3.644 ± 0.068	8.094LeuGly: 8.094 ± 0.108	1.738LeuHis: 1.738 ± 0.042	5.693LeuIle: 5.693 ± 0.093	4.134LeuLys: 4.134 ± 0.087	8.351LeuLeu: 8.351 ± 0.129	2.693LeuMet: 2.693 ± 0.058	3.072LeuAsn: 3.072 ± 0.064	4.964LeuPro: 4.964 ± 0.074	2.98LeuGln: 2.98 ± 0.057	6.013LeuArg: 6.013 ± 0.083	7.166LeuSer: 7.166 ± 0.09	5.93LeuThr: 5.93 ± 0.073	6.385LeuVal: 6.385 ± 0.096	1.213LeuTrp: 1.213 ± 0.04	1.959LeuTyr: 1.959 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	3.163MetAla: 3.163 ± 0.066	0.207MetCys: 0.207 ± 0.016	1.513MetAsp: 1.513 ± 0.034	1.229MetGlu: 1.229 ± 0.038	0.933MetPhe: 0.933 ± 0.032	2.309MetGly: 2.309 ± 0.053	0.48MetHis: 0.48 ± 0.025	1.741MetIle: 1.741 ± 0.045	1.297MetLys: 1.297 ± 0.038	2.563MetLeu: 2.563 ± 0.055	0.815MetMet: 0.815 ± 0.031	0.957MetAsn: 0.957 ± 0.031	1.569MetPro: 1.569 ± 0.039	1.099MetGln: 1.099 ± 0.036	1.849MetArg: 1.849 ± 0.044	2.026MetSer: 2.026 ± 0.045	2.348MetThr: 2.348 ± 0.048	1.823MetVal: 1.823 ± 0.043	0.227MetTrp: 0.227 ± 0.017	0.37MetTyr: 0.37 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	3.567AsnAla: 3.567 ± 0.066	0.293AsnCys: 0.293 ± 0.018	1.931AsnAsp: 1.931 ± 0.064	1.502AsnGlu: 1.502 ± 0.044	1.201AsnPhe: 1.201 ± 0.039	2.678AsnGly: 2.678 ± 0.074	0.573AsnHis: 0.573 ± 0.026	1.778AsnIle: 1.778 ± 0.039	1.024AsnLys: 1.024 ± 0.035	2.94AsnLeu: 2.94 ± 0.056	0.857AsnMet: 0.857 ± 0.031	0.844AsnAsn: 0.844 ± 0.03	1.861AsnPro: 1.861 ± 0.049	0.849AsnGln: 0.849 ± 0.032	1.642AsnArg: 1.642 ± 0.045	1.608AsnSer: 1.608 ± 0.044	1.741AsnThr: 1.741 ± 0.039	2.245AsnVal: 2.245 ± 0.049	0.462AsnTrp: 0.462 ± 0.022	0.721AsnTyr: 0.721 ± 0.031	0.0AsnXaa: 0.0 ± 0.0
Pro	4.789ProAla: 4.789 ± 0.094	0.354ProCys: 0.354 ± 0.021	3.416ProAsp: 3.416 ± 0.06	3.443ProGlu: 3.443 ± 0.079	1.91ProPhe: 1.91 ± 0.046	2.462ProGly: 2.462 ± 0.06	1.057ProHis: 1.057 ± 0.036	2.536ProIle: 2.536 ± 0.057	2.288ProLys: 2.288 ± 0.057	4.281ProLeu: 4.281 ± 0.072	1.314ProMet: 1.314 ± 0.038	1.775ProAsn: 1.775 ± 0.046	1.648ProPro: 1.648 ± 0.045	1.778ProGln: 1.778 ± 0.047	2.353ProArg: 2.353 ± 0.06	2.775ProSer: 2.775 ± 0.059	2.497ProThr: 2.497 ± 0.053	3.765ProVal: 3.765 ± 0.064	0.596ProTrp: 0.596 ± 0.026	1.136ProTyr: 1.136 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	4.187GlnAla: 4.187 ± 0.077	0.239GlnCys: 0.239 ± 0.016	2.244GlnAsp: 2.244 ± 0.055	1.602GlnGlu: 1.602 ± 0.044	1.299GlnPhe: 1.299 ± 0.039	2.753GlnGly: 2.753 ± 0.067	0.646GlnHis: 0.646 ± 0.027	2.422GlnIle: 2.422 ± 0.048	1.441GlnLys: 1.441 ± 0.033	3.011GlnLeu: 3.011 ± 0.056	1.185GlnMet: 1.185 ± 0.03	1.258GlnAsn: 1.258 ± 0.039	1.441GlnPro: 1.441 ± 0.043	1.139GlnGln: 1.139 ± 0.036	2.047GlnArg: 2.047 ± 0.05	2.411GlnSer: 2.411 ± 0.054	2.192GlnThr: 2.192 ± 0.053	2.602GlnVal: 2.602 ± 0.059	0.376GlnTrp: 0.376 ± 0.023	0.657GlnTyr: 0.657 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	6.228ArgAla: 6.228 ± 0.094	0.399ArgCys: 0.399 ± 0.019	3.784ArgAsp: 3.784 ± 0.065	3.093ArgGlu: 3.093 ± 0.065	2.38ArgPhe: 2.38 ± 0.058	3.881ArgGly: 3.881 ± 0.069	1.255ArgHis: 1.255 ± 0.04	3.38ArgIle: 3.38 ± 0.064	2.566ArgLys: 2.566 ± 0.054	6.01ArgLeu: 6.01 ± 0.09	1.692ArgMet: 1.692 ± 0.045	1.741ArgAsn: 1.741 ± 0.044	2.473ArgPro: 2.473 ± 0.054	1.954ArgGln: 1.954 ± 0.048	3.511ArgArg: 3.511 ± 0.083	3.225ArgSer: 3.225 ± 0.063	2.624ArgThr: 2.624 ± 0.059	4.034ArgVal: 4.034 ± 0.077	0.66ArgTrp: 0.66 ± 0.031	1.371ArgTyr: 1.371 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	6.208SerAla: 6.208 ± 0.092	0.505SerCys: 0.505 ± 0.024	3.743SerAsp: 3.743 ± 0.061	3.269SerGlu: 3.269 ± 0.061	2.552SerPhe: 2.552 ± 0.057	5.531SerGly: 5.531 ± 0.093	1.223SerHis: 1.223 ± 0.034	3.244SerIle: 3.244 ± 0.067	2.299SerLys: 2.299 ± 0.052	5.686SerLeu: 5.686 ± 0.081	1.608SerMet: 1.608 ± 0.036	1.792SerAsn: 1.792 ± 0.045	2.471SerPro: 2.471 ± 0.055	2.174SerGln: 2.174 ± 0.052	3.002SerArg: 3.002 ± 0.063	3.281SerSer: 3.281 ± 0.068	3.095SerThr: 3.095 ± 0.069	4.323SerVal: 4.323 ± 0.066	0.678SerTrp: 0.678 ± 0.033	1.589SerTyr: 1.589 ± 0.046	0.0SerXaa: 0.0 ± 0.0
Thr	6.286ThrAla: 6.286 ± 0.097	0.555ThrCys: 0.555 ± 0.023	3.667ThrAsp: 3.667 ± 0.073	3.027ThrGlu: 3.027 ± 0.063	2.274ThrPhe: 2.274 ± 0.059	5.137ThrGly: 5.137 ± 0.078	1.184ThrHis: 1.184 ± 0.038	3.08ThrIle: 3.08 ± 0.066	2.03ThrLys: 2.03 ± 0.042	6.228ThrLeu: 6.228 ± 0.094	1.402ThrMet: 1.402 ± 0.045	1.576ThrAsn: 1.576 ± 0.038	3.596ThrPro: 3.596 ± 0.068	2.233ThrGln: 2.233 ± 0.044	3.035ThrArg: 3.035 ± 0.062	3.421ThrSer: 3.421 ± 0.073	3.096ThrThr: 3.096 ± 0.066	4.485ThrVal: 4.485 ± 0.089	0.681ThrTrp: 0.681 ± 0.028	1.412ThrTyr: 1.412 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	7.839ValAla: 7.839 ± 0.105	0.651ValCys: 0.651 ± 0.032	4.418ValAsp: 4.418 ± 0.072	4.354ValGlu: 4.354 ± 0.064	3.102ValPhe: 3.102 ± 0.063	5.073ValGly: 5.073 ± 0.086	1.273ValHis: 1.273 ± 0.038	4.572ValIle: 4.572 ± 0.075	2.833ValLys: 2.833 ± 0.054	7.007ValLeu: 7.007 ± 0.102	2.123ValMet: 2.123 ± 0.044	2.128ValAsn: 2.128 ± 0.049	3.276ValPro: 3.276 ± 0.063	2.301ValGln: 2.301 ± 0.052	3.557ValArg: 3.557 ± 0.059	4.728ValSer: 4.728 ± 0.076	4.821ValThr: 4.821 ± 0.079	5.549ValVal: 5.549 ± 0.099	0.802ValTrp: 0.802 ± 0.032	1.49ValTyr: 1.49 ± 0.039	0.001ValXaa: 0.001 ± 0.001
Trp	1.282TrpAla: 1.282 ± 0.04	0.129TrpCys: 0.129 ± 0.012	0.77TrpAsp: 0.77 ± 0.032	0.553TrpGlu: 0.553 ± 0.026	0.512TrpPhe: 0.512 ± 0.024	0.941TrpGly: 0.941 ± 0.034	0.298TrpHis: 0.298 ± 0.017	0.734TrpIle: 0.734 ± 0.028	0.494TrpLys: 0.494 ± 0.023	1.357TrpLeu: 1.357 ± 0.049	0.369TrpMet: 0.369 ± 0.022	0.394TrpAsn: 0.394 ± 0.019	0.61TrpPro: 0.61 ± 0.03	0.517TrpGln: 0.517 ± 0.023	0.841TrpArg: 0.841 ± 0.032	0.738TrpSer: 0.738 ± 0.03	0.723TrpThr: 0.723 ± 0.027	0.84TrpVal: 0.84 ± 0.032	0.198TrpTrp: 0.198 ± 0.015	0.275TrpTyr: 0.275 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.5TyrAla: 2.5 ± 0.057	0.242TyrCys: 0.242 ± 0.015	1.683TyrAsp: 1.683 ± 0.05	1.344TyrGlu: 1.344 ± 0.038	0.993TyrPhe: 0.993 ± 0.031	2.071TyrGly: 2.071 ± 0.051	0.496TyrHis: 0.496 ± 0.025	1.161TyrIle: 1.161 ± 0.039	0.833TyrLys: 0.833 ± 0.03	2.18TyrLeu: 2.18 ± 0.051	0.547TyrMet: 0.547 ± 0.026	0.691TyrAsn: 0.691 ± 0.027	1.052TyrPro: 1.052 ± 0.036	0.769TyrGln: 0.769 ± 0.034	1.315TyrArg: 1.315 ± 0.039	1.308TyrSer: 1.308 ± 0.036	1.285TyrThr: 1.285 ± 0.042	1.596TyrVal: 1.596 ± 0.046	0.35TyrTrp: 0.35 ± 0.019	0.566TyrTyr: 0.566 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.001XaaThr: 0.001 ± 0.001	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.002XaaXaa: 0.002 ± 0.002

Statistics based on 2932 proteins (919199 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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