Amino acid dipepetide frequency for Wallemia ichthyophaga

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.737AlaAla: 6.737 ± 0.075	0.774AlaCys: 0.774 ± 0.02	3.933AlaAsp: 3.933 ± 0.046	4.122AlaGlu: 4.122 ± 0.057	2.967AlaPhe: 2.967 ± 0.045	4.509AlaGly: 4.509 ± 0.057	2.16AlaHis: 2.16 ± 0.035	4.29AlaIle: 4.29 ± 0.053	4.01AlaLys: 4.01 ± 0.051	7.426AlaLeu: 7.426 ± 0.07	1.608AlaMet: 1.608 ± 0.027	3.247AlaAsn: 3.247 ± 0.044	3.685AlaPro: 3.685 ± 0.059	3.626AlaGln: 3.626 ± 0.048	3.934AlaArg: 3.934 ± 0.048	6.304AlaSer: 6.304 ± 0.058	4.38AlaThr: 4.38 ± 0.054	4.617AlaVal: 4.617 ± 0.054	0.776AlaTrp: 0.776 ± 0.019	2.135AlaTyr: 2.135 ± 0.033	0.0AlaXaa: 0.0 ± 0.0
Cys	0.796CysAla: 0.796 ± 0.02	0.201CysCys: 0.201 ± 0.011	0.623CysAsp: 0.623 ± 0.016	0.539CysGlu: 0.539 ± 0.015	0.452CysPhe: 0.452 ± 0.014	0.766CysGly: 0.766 ± 0.021	0.266CysHis: 0.266 ± 0.012	0.631CysIle: 0.631 ± 0.018	0.514CysLys: 0.514 ± 0.017	1.106CysLeu: 1.106 ± 0.023	0.217CysMet: 0.217 ± 0.009	0.436CysAsn: 0.436 ± 0.016	0.467CysPro: 0.467 ± 0.016	0.351CysGln: 0.351 ± 0.015	0.539CysArg: 0.539 ± 0.016	0.804CysSer: 0.804 ± 0.02	0.634CysThr: 0.634 ± 0.018	0.757CysVal: 0.757 ± 0.019	0.151CysTrp: 0.151 ± 0.008	0.335CysTyr: 0.335 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	4.744AspAla: 4.744 ± 0.05	0.579AspCys: 0.579 ± 0.016	5.15AspAsp: 5.15 ± 0.073	5.044AspGlu: 5.044 ± 0.064	2.212AspPhe: 2.212 ± 0.034	3.874AspGly: 3.874 ± 0.047	1.282AspHis: 1.282 ± 0.024	3.625AspIle: 3.625 ± 0.044	3.691AspLys: 3.691 ± 0.047	5.213AspLeu: 5.213 ± 0.051	1.306AspMet: 1.306 ± 0.026	2.893AspAsn: 2.893 ± 0.04	2.443AspPro: 2.443 ± 0.036	2.137AspGln: 2.137 ± 0.035	2.815AspArg: 2.815 ± 0.04	4.991AspSer: 4.991 ± 0.048	3.284AspThr: 3.284 ± 0.039	4.129AspVal: 4.129 ± 0.04	0.724AspTrp: 0.724 ± 0.018	1.841AspTyr: 1.841 ± 0.029	0.0AspXaa: 0.0 ± 0.0
Glu	4.381GluAla: 4.381 ± 0.056	0.692GluCys: 0.692 ± 0.017	4.307GluAsp: 4.307 ± 0.053	5.334GluGlu: 5.334 ± 0.081	1.916GluPhe: 1.916 ± 0.033	3.302GluGly: 3.302 ± 0.041	1.627GluHis: 1.627 ± 0.031	3.309GluIle: 3.309 ± 0.045	4.216GluLys: 4.216 ± 0.055	5.368GluLeu: 5.368 ± 0.058	1.618GluMet: 1.618 ± 0.032	2.975GluAsn: 2.975 ± 0.035	2.045GluPro: 2.045 ± 0.033	2.854GluGln: 2.854 ± 0.044	3.89GluArg: 3.89 ± 0.056	4.856GluSer: 4.856 ± 0.054	2.874GluThr: 2.874 ± 0.037	3.071GluVal: 3.071 ± 0.035	0.756GluTrp: 0.756 ± 0.019	1.863GluTyr: 1.863 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	2.692PheAla: 2.692 ± 0.036	0.45PheCys: 0.45 ± 0.015	2.683PheAsp: 2.683 ± 0.041	2.261PheGlu: 2.261 ± 0.035	1.432PhePhe: 1.432 ± 0.029	2.618PheGly: 2.618 ± 0.053	0.821PheHis: 0.821 ± 0.019	2.145PheIle: 2.145 ± 0.037	2.153PheLys: 2.153 ± 0.033	3.024PheLeu: 3.024 ± 0.044	0.676PheMet: 0.676 ± 0.018	2.113PheAsn: 2.113 ± 0.034	1.495PhePro: 1.495 ± 0.025	1.182PheGln: 1.182 ± 0.026	1.545PheArg: 1.545 ± 0.027	3.034PheSer: 3.034 ± 0.037	2.156PheThr: 2.156 ± 0.034	2.302PheVal: 2.302 ± 0.035	0.45PheTrp: 0.45 ± 0.014	1.139PheTyr: 1.139 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	4.266GlyAla: 4.266 ± 0.057	0.76GlyCys: 0.76 ± 0.02	3.538GlyAsp: 3.538 ± 0.054	3.581GlyGlu: 3.581 ± 0.044	2.37GlyPhe: 2.37 ± 0.046	4.936GlyGly: 4.936 ± 0.077	1.386GlyHis: 1.386 ± 0.027	3.124GlyIle: 3.124 ± 0.043	3.391GlyLys: 3.391 ± 0.043	5.34GlyLeu: 5.34 ± 0.062	1.403GlyMet: 1.403 ± 0.031	2.391GlyAsn: 2.391 ± 0.036	1.916GlyPro: 1.916 ± 0.033	2.087GlyGln: 2.087 ± 0.037	3.127GlyArg: 3.127 ± 0.039	4.866GlySer: 4.866 ± 0.048	2.995GlyThr: 2.995 ± 0.036	4.49GlyVal: 4.49 ± 0.051	0.868GlyTrp: 0.868 ± 0.023	1.881GlyTyr: 1.881 ± 0.032	0.0GlyXaa: 0.0 ± 0.0
His	2.023HisAla: 2.023 ± 0.034	0.296HisCys: 0.296 ± 0.014	1.512HisAsp: 1.512 ± 0.027	1.339HisGlu: 1.339 ± 0.027	0.971HisPhe: 0.971 ± 0.021	1.338HisGly: 1.338 ± 0.029	0.964HisHis: 0.964 ± 0.03	1.438HisIle: 1.438 ± 0.027	1.458HisLys: 1.458 ± 0.025	2.751HisLeu: 2.751 ± 0.039	0.464HisMet: 0.464 ± 0.015	1.279HisAsn: 1.279 ± 0.021	1.769HisPro: 1.769 ± 0.039	1.152HisGln: 1.152 ± 0.023	1.355HisArg: 1.355 ± 0.026	2.871HisSer: 2.871 ± 0.049	1.908HisThr: 1.908 ± 0.035	1.511HisVal: 1.511 ± 0.027	0.272HisTrp: 0.272 ± 0.011	0.763HisTyr: 0.763 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	4.126IleAla: 4.126 ± 0.052	0.624IleCys: 0.624 ± 0.018	3.755IleAsp: 3.755 ± 0.044	3.395IleGlu: 3.395 ± 0.051	1.925IlePhe: 1.925 ± 0.035	3.21IleGly: 3.21 ± 0.042	1.477IleHis: 1.477 ± 0.026	2.816IleIle: 2.816 ± 0.042	3.12IleLys: 3.12 ± 0.043	4.796IleLeu: 4.796 ± 0.051	0.973IleMet: 0.973 ± 0.023	2.756IleAsn: 2.756 ± 0.034	3.161IlePro: 3.161 ± 0.035	2.177IleGln: 2.177 ± 0.031	2.748IleArg: 2.748 ± 0.037	4.577IleSer: 4.577 ± 0.058	2.989IleThr: 2.989 ± 0.039	3.101IleVal: 3.101 ± 0.045	0.594IleTrp: 0.594 ± 0.019	1.578IleTyr: 1.578 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	4.354LysAla: 4.354 ± 0.052	0.543LysCys: 0.543 ± 0.015	3.447LysAsp: 3.447 ± 0.043	4.095LysGlu: 4.095 ± 0.056	1.825LysPhe: 1.825 ± 0.029	2.983LysGly: 2.983 ± 0.04	1.633LysHis: 1.633 ± 0.03	2.694LysIle: 2.694 ± 0.037	4.225LysLys: 4.225 ± 0.064	5.366LysLeu: 5.366 ± 0.058	1.335LysMet: 1.335 ± 0.025	2.411LysAsn: 2.411 ± 0.036	3.062LysPro: 3.062 ± 0.043	2.835LysGln: 2.835 ± 0.036	3.784LysArg: 3.784 ± 0.052	5.074LysSer: 5.074 ± 0.058	3.027LysThr: 3.027 ± 0.038	3.214LysVal: 3.214 ± 0.041	0.618LysTrp: 0.618 ± 0.018	1.627LysTyr: 1.627 ± 0.034	0.0LysXaa: 0.0 ± 0.0
Leu	7.12LeuAla: 7.12 ± 0.061	1.095LeuCys: 1.095 ± 0.023	5.836LeuAsp: 5.836 ± 0.059	5.469LeuGlu: 5.469 ± 0.06	3.437LeuPhe: 3.437 ± 0.044	5.169LeuGly: 5.169 ± 0.047	2.518LeuHis: 2.518 ± 0.035	4.971LeuIle: 4.971 ± 0.056	5.263LeuLys: 5.263 ± 0.063	8.638LeuLeu: 8.638 ± 0.093	1.672LeuMet: 1.672 ± 0.027	4.8LeuAsn: 4.8 ± 0.05	4.926LeuPro: 4.926 ± 0.054	3.895LeuGln: 3.895 ± 0.045	5.118LeuArg: 5.118 ± 0.052	8.621LeuSer: 8.621 ± 0.074	5.096LeuThr: 5.096 ± 0.05	5.235LeuVal: 5.235 ± 0.053	0.906LeuTrp: 0.906 ± 0.02	2.455LeuTyr: 2.455 ± 0.035	0.0LeuXaa: 0.0 ± 0.0
Met	1.637MetAla: 1.637 ± 0.026	0.188MetCys: 0.188 ± 0.009	1.294MetAsp: 1.294 ± 0.024	1.245MetGlu: 1.245 ± 0.024	0.69MetPhe: 0.69 ± 0.017	1.234MetGly: 1.234 ± 0.022	0.548MetHis: 0.548 ± 0.016	1.043MetIle: 1.043 ± 0.023	1.121MetLys: 1.121 ± 0.026	1.825MetLeu: 1.825 ± 0.031	0.536MetMet: 0.536 ± 0.019	0.95MetAsn: 0.95 ± 0.022	1.014MetPro: 1.014 ± 0.025	0.927MetGln: 0.927 ± 0.022	1.263MetArg: 1.263 ± 0.023	2.143MetSer: 2.143 ± 0.028	1.135MetThr: 1.135 ± 0.022	1.097MetVal: 1.097 ± 0.022	0.186MetTrp: 0.186 ± 0.01	0.5MetTyr: 0.5 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.562AsnAla: 3.562 ± 0.041	0.435AsnCys: 0.435 ± 0.012	3.128AsnAsp: 3.128 ± 0.044	2.975AsnGlu: 2.975 ± 0.043	1.516AsnPhe: 1.516 ± 0.029	2.771AsnGly: 2.771 ± 0.038	1.283AsnHis: 1.283 ± 0.027	2.589AsnIle: 2.589 ± 0.035	2.963AsnLys: 2.963 ± 0.043	4.213AsnLeu: 4.213 ± 0.048	0.944AsnMet: 0.944 ± 0.02	2.551AsnAsn: 2.551 ± 0.042	2.488AsnPro: 2.488 ± 0.034	2.088AsnGln: 2.088 ± 0.034	2.15AsnArg: 2.15 ± 0.03	4.122AsnSer: 4.122 ± 0.054	3.155AsnThr: 3.155 ± 0.039	2.907AsnVal: 2.907 ± 0.038	0.557AsnTrp: 0.557 ± 0.018	1.386AsnTyr: 1.386 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	3.834ProAla: 3.834 ± 0.056	0.329ProCys: 0.329 ± 0.014	2.459ProAsp: 2.459 ± 0.035	2.735ProGlu: 2.735 ± 0.039	1.914ProPhe: 1.914 ± 0.033	2.426ProGly: 2.426 ± 0.041	1.536ProHis: 1.536 ± 0.027	2.667ProIle: 2.667 ± 0.038	2.571ProLys: 2.571 ± 0.039	4.419ProLeu: 4.419 ± 0.044	0.824ProMet: 0.824 ± 0.02	2.322ProAsn: 2.322 ± 0.034	4.528ProPro: 4.528 ± 0.079	2.638ProGln: 2.638 ± 0.046	2.408ProArg: 2.408 ± 0.032	5.649ProSer: 5.649 ± 0.062	3.628ProThr: 3.628 ± 0.047	2.731ProVal: 2.731 ± 0.039	0.46ProTrp: 0.46 ± 0.014	1.41ProTyr: 1.41 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	3.208GlnAla: 3.208 ± 0.043	0.383GlnCys: 0.383 ± 0.015	2.365GlnAsp: 2.365 ± 0.032	2.289GlnGlu: 2.289 ± 0.039	1.515GlnPhe: 1.515 ± 0.024	2.085GlnGly: 2.085 ± 0.04	1.397GlnHis: 1.397 ± 0.03	2.235GlnIle: 2.235 ± 0.034	2.215GlnLys: 2.215 ± 0.034	4.534GlnLeu: 4.534 ± 0.053	0.975GlnMet: 0.975 ± 0.021	1.822GlnAsn: 1.822 ± 0.034	2.908GlnPro: 2.908 ± 0.048	3.221GlnGln: 3.221 ± 0.078	2.65GlnArg: 2.65 ± 0.035	4.331GlnSer: 4.331 ± 0.055	2.385GlnThr: 2.385 ± 0.036	2.532GlnVal: 2.532 ± 0.038	0.446GlnTrp: 0.446 ± 0.013	1.133GlnTyr: 1.133 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	3.683ArgAla: 3.683 ± 0.043	0.628ArgCys: 0.628 ± 0.019	3.083ArgAsp: 3.083 ± 0.044	3.423ArgGlu: 3.423 ± 0.046	1.916ArgPhe: 1.916 ± 0.031	3.025ArgGly: 3.025 ± 0.044	1.384ArgHis: 1.384 ± 0.024	2.84ArgIle: 2.84 ± 0.034	3.539ArgLys: 3.539 ± 0.043	4.976ArgLeu: 4.976 ± 0.052	1.238ArgMet: 1.238 ± 0.025	2.423ArgAsn: 2.423 ± 0.03	2.329ArgPro: 2.329 ± 0.038	2.506ArgGln: 2.506 ± 0.034	4.082ArgArg: 4.082 ± 0.058	4.631ArgSer: 4.631 ± 0.054	2.661ArgThr: 2.661 ± 0.041	3.263ArgVal: 3.263 ± 0.042	0.653ArgTrp: 0.653 ± 0.017	1.606ArgTyr: 1.606 ± 0.028	0.0ArgXaa: 0.0 ± 0.0
Ser	6.363SerAla: 6.363 ± 0.067	0.768SerCys: 0.768 ± 0.023	5.06SerAsp: 5.06 ± 0.057	4.518SerGlu: 4.518 ± 0.053	3.308SerPhe: 3.308 ± 0.044	5.11SerGly: 5.11 ± 0.056	2.571SerHis: 2.571 ± 0.039	4.997SerIle: 4.997 ± 0.049	5.0SerLys: 5.0 ± 0.053	8.179SerLeu: 8.179 ± 0.062	1.63SerMet: 1.63 ± 0.027	4.865SerAsn: 4.865 ± 0.056	4.72SerPro: 4.72 ± 0.062	4.054SerGln: 4.054 ± 0.05	4.46SerArg: 4.46 ± 0.049	9.334SerSer: 9.334 ± 0.107	6.266SerThr: 6.266 ± 0.065	4.963SerVal: 4.963 ± 0.038	0.865SerTrp: 0.865 ± 0.022	2.292SerTyr: 2.292 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	4.274ThrAla: 4.274 ± 0.05	0.589ThrCys: 0.589 ± 0.018	2.798ThrAsp: 2.798 ± 0.037	2.695ThrGlu: 2.695 ± 0.04	2.138ThrPhe: 2.138 ± 0.032	3.205ThrGly: 3.205 ± 0.048	2.023ThrHis: 2.023 ± 0.037	3.075ThrIle: 3.075 ± 0.038	2.911ThrLys: 2.911 ± 0.043	5.865ThrLeu: 5.865 ± 0.051	0.988ThrMet: 0.988 ± 0.021	2.74ThrAsn: 2.74 ± 0.03	4.265ThrPro: 4.265 ± 0.057	2.913ThrGln: 2.913 ± 0.043	2.913ThrArg: 2.913 ± 0.038	5.291ThrSer: 5.291 ± 0.055	3.701ThrThr: 3.701 ± 0.056	3.092ThrVal: 3.092 ± 0.04	0.544ThrTrp: 0.544 ± 0.018	1.563ThrTyr: 1.563 ± 0.026	0.0ThrXaa: 0.0 ± 0.0
Val	4.518ValAla: 4.518 ± 0.05	0.74ValCys: 0.74 ± 0.016	4.452ValAsp: 4.452 ± 0.046	4.005ValGlu: 4.005 ± 0.045	2.283ValPhe: 2.283 ± 0.038	3.833ValGly: 3.833 ± 0.053	1.559ValHis: 1.559 ± 0.026	3.167ValIle: 3.167 ± 0.044	3.485ValLys: 3.485 ± 0.042	5.322ValLeu: 5.322 ± 0.056	1.28ValMet: 1.28 ± 0.029	2.76ValAsn: 2.76 ± 0.037	2.578ValPro: 2.578 ± 0.03	2.415ValGln: 2.415 ± 0.037	2.991ValArg: 2.991 ± 0.037	4.508ValSer: 4.508 ± 0.052	2.836ValThr: 2.836 ± 0.041	4.085ValVal: 4.085 ± 0.048	0.685ValTrp: 0.685 ± 0.019	1.804ValTyr: 1.804 ± 0.028	0.0ValXaa: 0.0 ± 0.0
Trp	0.688TrpAla: 0.688 ± 0.019	0.162TrpCys: 0.162 ± 0.008	0.693TrpAsp: 0.693 ± 0.02	0.6TrpGlu: 0.6 ± 0.016	0.452TrpPhe: 0.452 ± 0.015	0.616TrpGly: 0.616 ± 0.019	0.271TrpHis: 0.271 ± 0.013	0.656TrpIle: 0.656 ± 0.016	0.67TrpLys: 0.67 ± 0.018	1.099TrpLeu: 1.099 ± 0.02	0.288TrpMet: 0.288 ± 0.011	0.578TrpAsn: 0.578 ± 0.016	0.393TrpPro: 0.393 ± 0.013	0.447TrpGln: 0.447 ± 0.013	0.666TrpArg: 0.666 ± 0.018	1.005TrpSer: 1.005 ± 0.023	0.622TrpThr: 0.622 ± 0.019	0.606TrpVal: 0.606 ± 0.018	0.18TrpTrp: 0.18 ± 0.01	0.329TrpTyr: 0.329 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.235TyrAla: 2.235 ± 0.031	0.347TyrCys: 0.347 ± 0.013	1.863TyrAsp: 1.863 ± 0.028	1.591TyrGlu: 1.591 ± 0.028	1.133TyrPhe: 1.133 ± 0.025	1.707TyrGly: 1.707 ± 0.031	0.725TyrHis: 0.725 ± 0.02	1.587TyrIle: 1.587 ± 0.029	1.634TyrLys: 1.634 ± 0.027	2.781TyrLeu: 2.781 ± 0.039	0.598TyrMet: 0.598 ± 0.016	1.473TyrAsn: 1.473 ± 0.03	1.295TyrPro: 1.295 ± 0.027	1.125TyrGln: 1.125 ± 0.022	1.452TyrArg: 1.452 ± 0.028	2.309TyrSer: 2.309 ± 0.033	1.849TyrThr: 1.849 ± 0.031	1.603TyrVal: 1.603 ± 0.027	0.329TyrTrp: 0.329 ± 0.013	0.903TyrTyr: 0.903 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4149 proteins (2250108 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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