Amino acid dipepetide frequency for Joostella marina DSM 19592

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.158AlaAla: 4.158 ± 0.092	0.547AlaCys: 0.547 ± 0.025	3.309AlaAsp: 3.309 ± 0.057	4.132AlaGlu: 4.132 ± 0.065	3.203AlaPhe: 3.203 ± 0.06	4.113AlaGly: 4.113 ± 0.073	1.052AlaHis: 1.052 ± 0.033	5.653AlaIle: 5.653 ± 0.077	4.67AlaLys: 4.67 ± 0.074	6.072AlaLeu: 6.072 ± 0.082	1.547AlaMet: 1.547 ± 0.037	3.555AlaAsn: 3.555 ± 0.066	1.976AlaPro: 1.976 ± 0.04	2.266AlaGln: 2.266 ± 0.05	1.923AlaArg: 1.923 ± 0.037	4.458AlaSer: 4.458 ± 0.068	3.834AlaThr: 3.834 ± 0.08	4.01AlaVal: 4.01 ± 0.06	0.62AlaTrp: 0.62 ± 0.023	2.605AlaTyr: 2.605 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	0.385CysAla: 0.385 ± 0.019	0.113CysCys: 0.113 ± 0.01	0.368CysAsp: 0.368 ± 0.021	0.442CysGlu: 0.442 ± 0.022	0.406CysPhe: 0.406 ± 0.021	0.568CysGly: 0.568 ± 0.021	0.158CysHis: 0.158 ± 0.011	0.558CysIle: 0.558 ± 0.023	0.508CysLys: 0.508 ± 0.022	0.584CysLeu: 0.584 ± 0.022	0.124CysMet: 0.124 ± 0.01	0.421CysAsn: 0.421 ± 0.022	0.31CysPro: 0.31 ± 0.019	0.201CysGln: 0.201 ± 0.012	0.177CysArg: 0.177 ± 0.013	0.534CysSer: 0.534 ± 0.025	0.382CysThr: 0.382 ± 0.02	0.378CysVal: 0.378 ± 0.016	0.07CysTrp: 0.07 ± 0.008	0.305CysTyr: 0.305 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	3.656AspAla: 3.656 ± 0.069	0.381AspCys: 0.381 ± 0.019	2.899AspAsp: 2.899 ± 0.068	3.847AspGlu: 3.847 ± 0.06	3.537AspPhe: 3.537 ± 0.053	3.811AspGly: 3.811 ± 0.081	0.769AspHis: 0.769 ± 0.026	4.474AspIle: 4.474 ± 0.068	4.35AspLys: 4.35 ± 0.07	4.921AspLeu: 4.921 ± 0.072	1.099AspMet: 1.099 ± 0.032	3.131AspAsn: 3.131 ± 0.067	1.662AspPro: 1.662 ± 0.048	1.385AspGln: 1.385 ± 0.032	1.767AspArg: 1.767 ± 0.041	3.263AspSer: 3.263 ± 0.059	2.791AspThr: 2.791 ± 0.054	3.478AspVal: 3.478 ± 0.069	0.745AspTrp: 0.745 ± 0.026	2.816AspTyr: 2.816 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	4.708GluAla: 4.708 ± 0.071	0.329GluCys: 0.329 ± 0.017	3.767GluAsp: 3.767 ± 0.058	5.696GluGlu: 5.696 ± 0.086	2.861GluPhe: 2.861 ± 0.055	4.061GluGly: 4.061 ± 0.06	1.148GluHis: 1.148 ± 0.035	5.913GluIle: 5.913 ± 0.076	6.457GluLys: 6.457 ± 0.097	6.228GluLeu: 6.228 ± 0.075	1.625GluMet: 1.625 ± 0.036	5.159GluAsn: 5.159 ± 0.064	1.58GluPro: 1.58 ± 0.033	2.302GluGln: 2.302 ± 0.046	2.591GluArg: 2.591 ± 0.051	3.424GluSer: 3.424 ± 0.052	3.828GluThr: 3.828 ± 0.058	4.926GluVal: 4.926 ± 0.067	0.69GluTrp: 0.69 ± 0.022	2.512GluTyr: 2.512 ± 0.044	0.0GluXaa: 0.0 ± 0.0
Phe	2.793PheAla: 2.793 ± 0.05	0.402PheCys: 0.402 ± 0.019	3.104PheAsp: 3.104 ± 0.051	3.268PheGlu: 3.268 ± 0.052	2.673PhePhe: 2.673 ± 0.053	3.368PheGly: 3.368 ± 0.069	0.809PheHis: 0.809 ± 0.025	4.085PheIle: 4.085 ± 0.071	3.774PheLys: 3.774 ± 0.064	4.767PheLeu: 4.767 ± 0.083	1.074PheMet: 1.074 ± 0.031	3.201PheAsn: 3.201 ± 0.058	1.707PhePro: 1.707 ± 0.048	1.446PheGln: 1.446 ± 0.036	1.504PheArg: 1.504 ± 0.033	3.923PheSer: 3.923 ± 0.061	2.962PheThr: 2.962 ± 0.055	2.898PheVal: 2.898 ± 0.051	0.583PheTrp: 0.583 ± 0.02	2.234PheTyr: 2.234 ± 0.041	0.0PheXaa: 0.0 ± 0.0
Gly	4.242GlyAla: 4.242 ± 0.068	0.545GlyCys: 0.545 ± 0.03	3.364GlyAsp: 3.364 ± 0.069	3.786GlyGlu: 3.786 ± 0.053	3.497GlyPhe: 3.497 ± 0.052	4.436GlyGly: 4.436 ± 0.086	1.1GlyHis: 1.1 ± 0.03	5.533GlyIle: 5.533 ± 0.071	4.913GlyLys: 4.913 ± 0.078	5.431GlyLeu: 5.431 ± 0.072	1.679GlyMet: 1.679 ± 0.039	3.742GlyAsn: 3.742 ± 0.065	1.246GlyPro: 1.246 ± 0.041	1.765GlyGln: 1.765 ± 0.04	2.077GlyArg: 2.077 ± 0.037	3.922GlySer: 3.922 ± 0.065	3.872GlyThr: 3.872 ± 0.083	4.574GlyVal: 4.574 ± 0.072	0.795GlyTrp: 0.795 ± 0.03	3.012GlyTyr: 3.012 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	0.929HisAla: 0.929 ± 0.028	0.172HisCys: 0.172 ± 0.013	0.735HisAsp: 0.735 ± 0.029	0.899HisGlu: 0.899 ± 0.023	1.086HisPhe: 1.086 ± 0.03	1.027HisGly: 1.027 ± 0.032	0.474HisHis: 0.474 ± 0.02	1.404HisIle: 1.404 ± 0.036	1.257HisLys: 1.257 ± 0.037	1.734HisLeu: 1.734 ± 0.041	0.339HisMet: 0.339 ± 0.017	0.947HisAsn: 0.947 ± 0.032	0.877HisPro: 0.877 ± 0.029	0.729HisGln: 0.729 ± 0.026	0.644HisArg: 0.644 ± 0.025	0.993HisSer: 0.993 ± 0.03	0.998HisThr: 0.998 ± 0.03	0.853HisVal: 0.853 ± 0.028	0.219HisTrp: 0.219 ± 0.014	0.819HisTyr: 0.819 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.734IleAla: 5.734 ± 0.084	0.585IleCys: 0.585 ± 0.023	5.003IleAsp: 5.003 ± 0.067	5.893IleGlu: 5.893 ± 0.064	3.581IlePhe: 3.581 ± 0.064	5.086IleGly: 5.086 ± 0.077	1.305IleHis: 1.305 ± 0.037	6.301IleIle: 6.301 ± 0.082	6.199IleLys: 6.199 ± 0.08	7.145IleLeu: 7.145 ± 0.095	1.339IleMet: 1.339 ± 0.035	5.022IleAsn: 5.022 ± 0.068	3.23IlePro: 3.23 ± 0.054	2.495IleGln: 2.495 ± 0.047	2.568IleArg: 2.568 ± 0.046	5.716IleSer: 5.716 ± 0.069	4.84IleThr: 4.84 ± 0.074	4.607IleVal: 4.607 ± 0.067	0.721IleTrp: 0.721 ± 0.027	2.974IleTyr: 2.974 ± 0.049	0.0IleXaa: 0.0 ± 0.0
Lys	5.145LysAla: 5.145 ± 0.078	0.321LysCys: 0.321 ± 0.017	4.573LysAsp: 4.573 ± 0.055	7.13LysGlu: 7.13 ± 0.097	2.91LysPhe: 2.91 ± 0.046	4.636LysGly: 4.636 ± 0.054	1.447LysHis: 1.447 ± 0.03	6.158LysIle: 6.158 ± 0.088	7.296LysLys: 7.296 ± 0.107	6.865LysLeu: 6.865 ± 0.075	2.058LysMet: 2.058 ± 0.042	5.46LysAsn: 5.46 ± 0.074	2.313LysPro: 2.313 ± 0.044	2.814LysGln: 2.814 ± 0.058	2.992LysArg: 2.992 ± 0.056	4.6LysSer: 4.6 ± 0.073	4.671LysThr: 4.671 ± 0.066	4.812LysVal: 4.812 ± 0.063	0.87LysTrp: 0.87 ± 0.028	3.194LysTyr: 3.194 ± 0.056	0.0LysXaa: 0.0 ± 0.0
Leu	5.656LeuAla: 5.656 ± 0.085	0.681LeuCys: 0.681 ± 0.025	4.877LeuAsp: 4.877 ± 0.066	6.257LeuGlu: 6.257 ± 0.08	4.75LeuPhe: 4.75 ± 0.075	5.605LeuGly: 5.605 ± 0.073	1.555LeuHis: 1.555 ± 0.036	7.055LeuIle: 7.055 ± 0.094	8.031LeuLys: 8.031 ± 0.094	8.516LeuLeu: 8.516 ± 0.111	2.084LeuMet: 2.084 ± 0.05	5.759LeuAsn: 5.759 ± 0.076	3.448LeuPro: 3.448 ± 0.056	3.182LeuGln: 3.182 ± 0.058	3.116LeuArg: 3.116 ± 0.053	6.498LeuSer: 6.498 ± 0.079	4.989LeuThr: 4.989 ± 0.07	5.048LeuVal: 5.048 ± 0.067	0.88LeuTrp: 0.88 ± 0.03	3.397LeuTyr: 3.397 ± 0.06	0.0LeuXaa: 0.0 ± 0.0
Met	1.618MetAla: 1.618 ± 0.038	0.126MetCys: 0.126 ± 0.01	1.179MetAsp: 1.179 ± 0.033	1.509MetGlu: 1.509 ± 0.037	0.853MetPhe: 0.853 ± 0.025	1.372MetGly: 1.372 ± 0.036	0.403MetHis: 0.403 ± 0.018	1.525MetIle: 1.525 ± 0.037	2.254MetLys: 2.254 ± 0.044	1.994MetLeu: 1.994 ± 0.042	0.581MetMet: 0.581 ± 0.025	1.268MetAsn: 1.268 ± 0.033	0.858MetPro: 0.858 ± 0.027	0.8MetGln: 0.8 ± 0.028	0.82MetArg: 0.82 ± 0.024	1.377MetSer: 1.377 ± 0.033	1.026MetThr: 1.026 ± 0.028	1.355MetVal: 1.355 ± 0.036	0.176MetTrp: 0.176 ± 0.011	0.73MetTyr: 0.73 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	3.835AsnAla: 3.835 ± 0.055	0.393AsnCys: 0.393 ± 0.019	3.279AsnAsp: 3.279 ± 0.057	4.072AsnGlu: 4.072 ± 0.056	3.146AsnPhe: 3.146 ± 0.059	4.085AsnGly: 4.085 ± 0.081	1.101AsnHis: 1.101 ± 0.031	4.969AsnIle: 4.969 ± 0.068	4.806AsnLys: 4.806 ± 0.071	5.353AsnLeu: 5.353 ± 0.069	1.264AsnMet: 1.264 ± 0.034	4.185AsnAsn: 4.185 ± 0.085	2.826AsnPro: 2.826 ± 0.059	2.208AsnGln: 2.208 ± 0.044	2.206AsnArg: 2.206 ± 0.05	3.963AsnSer: 3.963 ± 0.069	3.827AsnThr: 3.827 ± 0.073	3.469AsnVal: 3.469 ± 0.06	0.796AsnTrp: 0.796 ± 0.027	3.043AsnTyr: 3.043 ± 0.06	0.0AsnXaa: 0.0 ± 0.0
Pro	1.83ProAla: 1.83 ± 0.04	0.188ProCys: 0.188 ± 0.012	1.991ProAsp: 1.991 ± 0.043	2.923ProGlu: 2.923 ± 0.052	1.814ProPhe: 1.814 ± 0.038	1.888ProGly: 1.888 ± 0.045	0.605ProHis: 0.605 ± 0.022	2.714ProIle: 2.714 ± 0.055	2.486ProLys: 2.486 ± 0.051	2.873ProLeu: 2.873 ± 0.051	0.724ProMet: 0.724 ± 0.026	2.195ProAsn: 2.195 ± 0.045	0.818ProPro: 0.818 ± 0.027	1.171ProGln: 1.171 ± 0.031	0.912ProArg: 0.912 ± 0.025	2.26ProSer: 2.26 ± 0.045	2.094ProThr: 2.094 ± 0.051	2.184ProVal: 2.184 ± 0.039	0.365ProTrp: 0.365 ± 0.019	1.43ProTyr: 1.43 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	1.999GlnAla: 1.999 ± 0.042	0.157GlnCys: 0.157 ± 0.01	1.642GlnAsp: 1.642 ± 0.036	2.467GlnGlu: 2.467 ± 0.047	1.597GlnPhe: 1.597 ± 0.037	1.773GlnGly: 1.773 ± 0.036	0.586GlnHis: 0.586 ± 0.023	2.544GlnIle: 2.544 ± 0.045	2.813GlnLys: 2.813 ± 0.06	3.398GlnLeu: 3.398 ± 0.054	0.773GlnMet: 0.773 ± 0.028	2.058GlnAsn: 2.058 ± 0.045	1.087GlnPro: 1.087 ± 0.031	1.473GlnGln: 1.473 ± 0.042	1.197GlnArg: 1.197 ± 0.027	1.866GlnSer: 1.866 ± 0.039	1.911GlnThr: 1.911 ± 0.037	1.888GlnVal: 1.888 ± 0.041	0.375GlnTrp: 0.375 ± 0.018	1.375GlnTyr: 1.375 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	1.999ArgAla: 1.999 ± 0.04	0.19ArgCys: 0.19 ± 0.012	1.711ArgAsp: 1.711 ± 0.037	2.283ArgGlu: 2.283 ± 0.045	1.795ArgPhe: 1.795 ± 0.039	2.005ArgGly: 2.005 ± 0.04	0.592ArgHis: 0.592 ± 0.023	2.881ArgIle: 2.881 ± 0.051	2.816ArgLys: 2.816 ± 0.057	3.18ArgLeu: 3.18 ± 0.049	0.862ArgMet: 0.862 ± 0.027	2.135ArgAsn: 2.135 ± 0.046	1.067ArgPro: 1.067 ± 0.026	1.023ArgGln: 1.023 ± 0.035	1.319ArgArg: 1.319 ± 0.034	1.858ArgSer: 1.858 ± 0.047	1.801ArgThr: 1.801 ± 0.036	2.083ArgVal: 2.083 ± 0.04	0.378ArgTrp: 0.378 ± 0.018	1.613ArgTyr: 1.613 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	3.712SerAla: 3.712 ± 0.063	0.605SerCys: 0.605 ± 0.022	3.223SerAsp: 3.223 ± 0.06	4.392SerGlu: 4.392 ± 0.069	3.804SerPhe: 3.804 ± 0.059	4.358SerGly: 4.358 ± 0.074	1.045SerHis: 1.045 ± 0.028	5.341SerIle: 5.341 ± 0.064	4.929SerLys: 4.929 ± 0.064	6.174SerLeu: 6.174 ± 0.077	1.323SerMet: 1.323 ± 0.036	3.948SerAsn: 3.948 ± 0.065	2.034SerPro: 2.034 ± 0.042	2.046SerGln: 2.046 ± 0.038	2.121SerArg: 2.121 ± 0.04	4.291SerSer: 4.291 ± 0.076	3.473SerThr: 3.473 ± 0.055	4.029SerVal: 4.029 ± 0.064	0.67SerTrp: 0.67 ± 0.023	2.98SerTyr: 2.98 ± 0.051	0.0SerXaa: 0.0 ± 0.0
Thr	3.882ThrAla: 3.882 ± 0.076	0.333ThrCys: 0.333 ± 0.019	3.289ThrAsp: 3.289 ± 0.06	3.611ThrGlu: 3.611 ± 0.054	2.834ThrPhe: 2.834 ± 0.051	3.945ThrGly: 3.945 ± 0.084	1.008ThrHis: 1.008 ± 0.03	4.862ThrIle: 4.862 ± 0.076	3.885ThrLys: 3.885 ± 0.065	5.331ThrLeu: 5.331 ± 0.057	0.973ThrMet: 0.973 ± 0.03	3.403ThrAsn: 3.403 ± 0.082	2.46ThrPro: 2.46 ± 0.056	1.801ThrGln: 1.801 ± 0.044	1.64ThrArg: 1.64 ± 0.041	3.867ThrSer: 3.867 ± 0.064	3.625ThrThr: 3.625 ± 0.08	3.776ThrVal: 3.776 ± 0.075	0.575ThrTrp: 0.575 ± 0.028	2.482ThrTyr: 2.482 ± 0.059	0.0ThrXaa: 0.0 ± 0.0
Val	4.304ValAla: 4.304 ± 0.067	0.508ValCys: 0.508 ± 0.02	3.544ValAsp: 3.544 ± 0.057	3.94ValGlu: 3.94 ± 0.058	3.22ValPhe: 3.22 ± 0.056	3.896ValGly: 3.896 ± 0.063	0.936ValHis: 0.936 ± 0.028	4.723ValIle: 4.723 ± 0.067	4.531ValLys: 4.531 ± 0.072	5.882ValLeu: 5.882 ± 0.075	1.308ValMet: 1.308 ± 0.031	3.645ValAsn: 3.645 ± 0.063	2.126ValPro: 2.126 ± 0.039	1.78ValGln: 1.78 ± 0.042	1.96ValArg: 1.96 ± 0.043	4.377ValSer: 4.377 ± 0.069	3.663ValThr: 3.663 ± 0.086	4.121ValVal: 4.121 ± 0.059	0.607ValTrp: 0.607 ± 0.022	2.404ValTyr: 2.404 ± 0.046	0.0ValXaa: 0.0 ± 0.0
Trp	0.624TrpAla: 0.624 ± 0.024	0.088TrpCys: 0.088 ± 0.008	0.66TrpAsp: 0.66 ± 0.027	0.75TrpGlu: 0.75 ± 0.027	0.571TrpPhe: 0.571 ± 0.022	0.71TrpGly: 0.71 ± 0.027	0.232TrpHis: 0.232 ± 0.014	0.792TrpIle: 0.792 ± 0.023	0.851TrpLys: 0.851 ± 0.029	0.993TrpLeu: 0.993 ± 0.029	0.297TrpMet: 0.297 ± 0.015	0.738TrpAsn: 0.738 ± 0.027	0.269TrpPro: 0.269 ± 0.016	0.412TrpGln: 0.412 ± 0.018	0.408TrpArg: 0.408 ± 0.019	0.635TrpSer: 0.635 ± 0.023	0.521TrpThr: 0.521 ± 0.024	0.654TrpVal: 0.654 ± 0.026	0.173TrpTrp: 0.173 ± 0.012	0.464TrpTyr: 0.464 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.494TyrAla: 2.494 ± 0.044	0.333TyrCys: 0.333 ± 0.015	2.265TyrAsp: 2.265 ± 0.042	2.507TyrGlu: 2.507 ± 0.05	2.436TyrPhe: 2.436 ± 0.044	2.787TyrGly: 2.787 ± 0.055	0.81TyrHis: 0.81 ± 0.026	2.858TyrIle: 2.858 ± 0.047	3.436TyrLys: 3.436 ± 0.057	3.946TyrLeu: 3.946 ± 0.059	0.752TyrMet: 0.752 ± 0.021	2.854TyrAsn: 2.854 ± 0.062	1.574TyrPro: 1.574 ± 0.038	1.678TyrGln: 1.678 ± 0.038	1.647TyrArg: 1.647 ± 0.036	2.673TyrSer: 2.673 ± 0.051	2.473TyrThr: 2.473 ± 0.06	2.333TyrVal: 2.333 ± 0.044	0.535TyrTrp: 0.535 ± 0.023	2.013TyrTyr: 2.013 ± 0.043	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3783 proteins (1268527 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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