Amino acid dipepetide frequency for Sulfolobus filamentous virus 1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.0AlaAla: 0.0 ± 0.0
0.422AlaCys: 0.422 ± 0.182
2.192AlaAsp: 2.192 ± 0.496
2.192AlaGlu: 2.192 ± 0.463
3.373AlaPhe: 3.373 ± 0.735
1.939AlaGly: 1.939 ± 0.378
0.59AlaHis: 0.59 ± 0.209
4.806AlaIle: 4.806 ± 0.661
3.71AlaLys: 3.71 ± 0.461
5.312AlaLeu: 5.312 ± 0.657
1.349AlaMet: 1.349 ± 0.341
2.698AlaAsn: 2.698 ± 0.502
1.012AlaPro: 1.012 ± 0.293
1.181AlaGln: 1.181 ± 0.283
1.939AlaArg: 1.939 ± 0.53
2.783AlaSer: 2.783 ± 0.658
2.951AlaThr: 2.951 ± 0.5
2.783AlaVal: 2.783 ± 0.475
0.084AlaTrp: 0.084 ± 0.076
3.542AlaTyr: 3.542 ± 0.499
0.0AlaXaa: 0.0 ± 0.0
Cys
0.337CysAla: 0.337 ± 0.195
0.253CysCys: 0.253 ± 0.184
0.59CysAsp: 0.59 ± 0.218
0.59CysGlu: 0.59 ± 0.201
0.59CysPhe: 0.59 ± 0.19
0.843CysGly: 0.843 ± 0.309
0.253CysHis: 0.253 ± 0.134
0.675CysIle: 0.675 ± 0.281
1.012CysLys: 1.012 ± 0.28
1.096CysLeu: 1.096 ± 0.242
0.253CysMet: 0.253 ± 0.139
0.759CysAsn: 0.759 ± 0.216
0.422CysPro: 0.422 ± 0.147
0.253CysGln: 0.253 ± 0.15
0.169CysArg: 0.169 ± 0.112
0.843CysSer: 0.843 ± 0.267
1.096CysThr: 1.096 ± 0.273
1.096CysVal: 1.096 ± 0.345
0.0CysTrp: 0.0 ± 0.0
0.928CysTyr: 0.928 ± 0.271
0.0CysXaa: 0.0 ± 0.0
Asp
1.771AspAla: 1.771 ± 0.335
0.337AspCys: 0.337 ± 0.151
2.698AspAsp: 2.698 ± 0.479
3.626AspGlu: 3.626 ± 0.56
2.698AspPhe: 2.698 ± 0.45
1.349AspGly: 1.349 ± 0.331
0.59AspHis: 0.59 ± 0.225
6.83AspIle: 6.83 ± 0.914
3.795AspLys: 3.795 ± 0.576
4.385AspLeu: 4.385 ± 0.532
1.181AspMet: 1.181 ± 0.253
2.445AspAsn: 2.445 ± 0.423
1.602AspPro: 1.602 ± 0.334
1.181AspGln: 1.181 ± 0.336
1.602AspArg: 1.602 ± 0.344
2.445AspSer: 2.445 ± 0.391
2.867AspThr: 2.867 ± 0.514
4.216AspVal: 4.216 ± 0.598
0.59AspTrp: 0.59 ± 0.215
2.867AspTyr: 2.867 ± 0.572
0.0AspXaa: 0.0 ± 0.0
Glu
3.204GluAla: 3.204 ± 0.598
0.422GluCys: 0.422 ± 0.162
3.036GluAsp: 3.036 ± 0.534
4.216GluGlu: 4.216 ± 0.834
2.53GluPhe: 2.53 ± 0.481
2.783GluGly: 2.783 ± 0.607
0.59GluHis: 0.59 ± 0.242
6.409GluIle: 6.409 ± 0.889
5.65GluLys: 5.65 ± 0.808
5.903GluLeu: 5.903 ± 0.808
1.265GluMet: 1.265 ± 0.337
4.132GluAsn: 4.132 ± 0.596
1.434GluPro: 1.434 ± 0.367
1.939GluGln: 1.939 ± 0.542
3.12GluArg: 3.12 ± 0.74
1.855GluSer: 1.855 ± 0.427
2.867GluThr: 2.867 ± 0.553
2.951GluVal: 2.951 ± 0.562
0.59GluTrp: 0.59 ± 0.214
3.289GluTyr: 3.289 ± 0.516
0.0GluXaa: 0.0 ± 0.0
Phe
2.867PheAla: 2.867 ± 0.518
0.506PheCys: 0.506 ± 0.209
3.289PheAsp: 3.289 ± 0.497
2.614PheGlu: 2.614 ± 0.49
1.939PhePhe: 1.939 ± 0.444
1.939PheGly: 1.939 ± 0.402
0.843PheHis: 0.843 ± 0.302
3.626PheIle: 3.626 ± 0.554
3.795PheLys: 3.795 ± 0.602
4.301PheLeu: 4.301 ± 0.636
1.602PheMet: 1.602 ± 0.39
4.301PheAsn: 4.301 ± 0.573
0.928PhePro: 0.928 ± 0.263
2.108PheGln: 2.108 ± 0.394
1.686PheArg: 1.686 ± 0.406
2.53PheSer: 2.53 ± 0.583
3.204PheThr: 3.204 ± 0.61
3.542PheVal: 3.542 ± 0.439
0.337PheTrp: 0.337 ± 0.165
3.036PheTyr: 3.036 ± 0.596
0.0PheXaa: 0.0 ± 0.0
Gly
1.771GlyAla: 1.771 ± 0.384
0.422GlyCys: 0.422 ± 0.23
2.277GlyAsp: 2.277 ± 0.328
2.783GlyGlu: 2.783 ± 0.612
3.036GlyPhe: 3.036 ± 0.407
2.614GlyGly: 2.614 ± 0.727
0.59GlyHis: 0.59 ± 0.233
5.059GlyIle: 5.059 ± 0.752
4.385GlyLys: 4.385 ± 0.681
4.554GlyLeu: 4.554 ± 0.499
1.265GlyMet: 1.265 ± 0.332
2.783GlyAsn: 2.783 ± 0.454
0.169GlyPro: 0.169 ± 0.1
1.518GlyGln: 1.518 ± 0.379
1.771GlyArg: 1.771 ± 0.381
3.71GlySer: 3.71 ± 0.56
2.867GlyThr: 2.867 ± 0.693
3.204GlyVal: 3.204 ± 0.649
0.675GlyTrp: 0.675 ± 0.24
3.289GlyTyr: 3.289 ± 0.475
0.0GlyXaa: 0.0 ± 0.0
His
1.012HisAla: 1.012 ± 0.324
0.253HisCys: 0.253 ± 0.143
0.506HisAsp: 0.506 ± 0.209
0.843HisGlu: 0.843 ± 0.351
1.012HisPhe: 1.012 ± 0.29
0.506HisGly: 0.506 ± 0.165
0.337HisHis: 0.337 ± 0.152
1.686HisIle: 1.686 ± 0.3
0.843HisLys: 0.843 ± 0.298
1.012HisLeu: 1.012 ± 0.302
0.337HisMet: 0.337 ± 0.154
1.096HisAsn: 1.096 ± 0.285
0.084HisPro: 0.084 ± 0.072
0.337HisGln: 0.337 ± 0.204
0.253HisArg: 0.253 ± 0.132
0.422HisSer: 0.422 ± 0.203
0.675HisThr: 0.675 ± 0.286
1.265HisVal: 1.265 ± 0.367
0.084HisTrp: 0.084 ± 0.082
1.096HisTyr: 1.096 ± 0.3
0.0HisXaa: 0.0 ± 0.0
Ile
6.156IleAla: 6.156 ± 0.621
1.096IleCys: 1.096 ± 0.355
4.806IleAsp: 4.806 ± 0.542
5.228IleGlu: 5.228 ± 0.858
4.469IlePhe: 4.469 ± 0.681
3.626IleGly: 3.626 ± 0.577
1.686IleHis: 1.686 ± 0.339
8.685IleIle: 8.685 ± 0.861
6.071IleLys: 6.071 ± 0.87
6.746IleLeu: 6.746 ± 0.901
2.53IleMet: 2.53 ± 0.453
6.409IleAsn: 6.409 ± 0.843
3.963IlePro: 3.963 ± 0.468
2.867IleGln: 2.867 ± 0.419
2.951IleArg: 2.951 ± 0.519
5.818IleSer: 5.818 ± 0.625
8.095IleThr: 8.095 ± 0.931
7.083IleVal: 7.083 ± 0.976
0.506IleTrp: 0.506 ± 0.195
4.469IleTyr: 4.469 ± 0.606
0.0IleXaa: 0.0 ± 0.0
Lys
2.867LysAla: 2.867 ± 0.449
0.843LysCys: 0.843 ± 0.296
3.289LysAsp: 3.289 ± 0.525
4.806LysGlu: 4.806 ± 0.903
3.12LysPhe: 3.12 ± 0.49
3.204LysGly: 3.204 ± 0.506
1.181LysHis: 1.181 ± 0.286
5.565LysIle: 5.565 ± 0.963
6.24LysLys: 6.24 ± 1.051
7.168LysLeu: 7.168 ± 0.857
2.445LysMet: 2.445 ± 0.46
5.228LysAsn: 5.228 ± 0.901
2.53LysPro: 2.53 ± 0.49
2.024LysGln: 2.024 ± 0.263
3.373LysArg: 3.373 ± 0.517
3.542LysSer: 3.542 ± 0.701
4.216LysThr: 4.216 ± 0.563
6.662LysVal: 6.662 ± 1.012
0.675LysTrp: 0.675 ± 0.204
4.132LysTyr: 4.132 ± 0.588
0.0LysXaa: 0.0 ± 0.0
Leu
4.385LeuAla: 4.385 ± 0.522
1.434LeuCys: 1.434 ± 0.418
4.554LeuAsp: 4.554 ± 0.615
4.554LeuGlu: 4.554 ± 0.528
4.638LeuPhe: 4.638 ± 0.571
4.891LeuGly: 4.891 ± 0.749
1.349LeuHis: 1.349 ± 0.298
8.179LeuIle: 8.179 ± 0.676
7.083LeuLys: 7.083 ± 0.732
8.348LeuLeu: 8.348 ± 0.862
2.277LeuMet: 2.277 ± 0.407
7.336LeuAsn: 7.336 ± 0.675
3.71LeuPro: 3.71 ± 0.591
3.963LeuGln: 3.963 ± 0.623
4.301LeuArg: 4.301 ± 0.625
6.409LeuSer: 6.409 ± 0.719
5.481LeuThr: 5.481 ± 0.574
5.987LeuVal: 5.987 ± 0.753
0.759LeuTrp: 0.759 ± 0.24
5.228LeuTyr: 5.228 ± 0.768
0.0LeuXaa: 0.0 ± 0.0
Met
1.181MetAla: 1.181 ± 0.354
0.59MetCys: 0.59 ± 0.191
1.265MetAsp: 1.265 ± 0.33
1.012MetGlu: 1.012 ± 0.28
0.928MetPhe: 0.928 ± 0.246
1.265MetGly: 1.265 ± 0.297
0.0MetHis: 0.0 ± 0.0
2.698MetIle: 2.698 ± 0.465
3.036MetLys: 3.036 ± 0.515
1.855MetLeu: 1.855 ± 0.398
0.506MetMet: 0.506 ± 0.228
0.843MetAsn: 0.843 ± 0.313
0.843MetPro: 0.843 ± 0.261
1.096MetGln: 1.096 ± 0.309
0.928MetArg: 0.928 ± 0.295
1.771MetSer: 1.771 ± 0.343
1.012MetThr: 1.012 ± 0.279
1.434MetVal: 1.434 ± 0.337
0.337MetTrp: 0.337 ± 0.168
1.434MetTyr: 1.434 ± 0.333
0.0MetXaa: 0.0 ± 0.0
Asn
3.036AsnAla: 3.036 ± 0.541
0.506AsnCys: 0.506 ± 0.239
2.192AsnAsp: 2.192 ± 0.394
4.975AsnGlu: 4.975 ± 0.948
4.216AsnPhe: 4.216 ± 0.711
3.542AsnGly: 3.542 ± 0.613
0.759AsnHis: 0.759 ± 0.218
5.312AsnIle: 5.312 ± 0.691
2.614AsnLys: 2.614 ± 0.57
5.312AsnLeu: 5.312 ± 0.672
1.939AsnMet: 1.939 ± 0.442
3.542AsnAsn: 3.542 ± 0.564
2.783AsnPro: 2.783 ± 0.578
2.277AsnGln: 2.277 ± 0.492
2.024AsnArg: 2.024 ± 0.428
3.457AsnSer: 3.457 ± 0.562
5.059AsnThr: 5.059 ± 0.723
5.734AsnVal: 5.734 ± 0.8
0.253AsnTrp: 0.253 ± 0.132
3.373AsnTyr: 3.373 ± 0.513
0.0AsnXaa: 0.0 ± 0.0
Pro
1.771ProAla: 1.771 ± 0.332
0.506ProCys: 0.506 ± 0.233
1.181ProAsp: 1.181 ± 0.329
1.686ProGlu: 1.686 ± 0.399
1.855ProPhe: 1.855 ± 0.3
1.686ProGly: 1.686 ± 0.44
0.337ProHis: 0.337 ± 0.164
2.867ProIle: 2.867 ± 0.622
1.771ProLys: 1.771 ± 0.471
3.373ProLeu: 3.373 ± 0.594
0.59ProMet: 0.59 ± 0.198
1.518ProAsn: 1.518 ± 0.319
2.783ProPro: 2.783 ± 0.913
1.602ProGln: 1.602 ± 0.325
0.59ProArg: 0.59 ± 0.187
3.036ProSer: 3.036 ± 0.469
2.024ProThr: 2.024 ± 0.395
2.783ProVal: 2.783 ± 0.457
0.169ProTrp: 0.169 ± 0.124
2.024ProTyr: 2.024 ± 0.374
0.0ProXaa: 0.0 ± 0.0
Gln
2.277GlnAla: 2.277 ± 0.566
0.506GlnCys: 0.506 ± 0.212
1.434GlnAsp: 1.434 ± 0.371
1.855GlnGlu: 1.855 ± 0.366
1.602GlnPhe: 1.602 ± 0.381
1.434GlnGly: 1.434 ± 0.355
0.084GlnHis: 0.084 ± 0.087
3.879GlnIle: 3.879 ± 0.715
1.686GlnLys: 1.686 ± 0.401
3.963GlnLeu: 3.963 ± 0.633
0.337GlnMet: 0.337 ± 0.144
2.783GlnAsn: 2.783 ± 0.496
1.012GlnPro: 1.012 ± 0.25
1.686GlnGln: 1.686 ± 0.428
1.265GlnArg: 1.265 ± 0.337
2.698GlnSer: 2.698 ± 0.581
1.686GlnThr: 1.686 ± 0.376
2.951GlnVal: 2.951 ± 0.466
0.337GlnTrp: 0.337 ± 0.171
2.108GlnTyr: 2.108 ± 0.441
0.0GlnXaa: 0.0 ± 0.0
Arg
1.518ArgAla: 1.518 ± 0.332
0.253ArgCys: 0.253 ± 0.133
1.939ArgAsp: 1.939 ± 0.486
2.951ArgGlu: 2.951 ± 0.389
1.602ArgPhe: 1.602 ± 0.411
2.277ArgGly: 2.277 ± 0.469
0.337ArgHis: 0.337 ± 0.169
3.963ArgIle: 3.963 ± 0.489
3.542ArgLys: 3.542 ± 0.559
5.059ArgLeu: 5.059 ± 0.566
0.843ArgMet: 0.843 ± 0.258
1.434ArgAsn: 1.434 ± 0.265
0.928ArgPro: 0.928 ± 0.227
0.675ArgGln: 0.675 ± 0.232
1.686ArgArg: 1.686 ± 0.371
1.518ArgSer: 1.518 ± 0.286
2.192ArgThr: 2.192 ± 0.418
3.036ArgVal: 3.036 ± 0.519
0.084ArgTrp: 0.084 ± 0.082
2.614ArgTyr: 2.614 ± 0.534
0.0ArgXaa: 0.0 ± 0.0
Ser
2.783SerAla: 2.783 ± 0.446
0.506SerCys: 0.506 ± 0.195
3.289SerAsp: 3.289 ± 0.593
3.626SerGlu: 3.626 ± 0.778
3.204SerPhe: 3.204 ± 0.506
3.373SerGly: 3.373 ± 0.667
0.759SerHis: 0.759 ± 0.33
4.132SerIle: 4.132 ± 0.579
3.036SerLys: 3.036 ± 0.45
5.65SerLeu: 5.65 ± 0.82
1.181SerMet: 1.181 ± 0.313
3.036SerAsn: 3.036 ± 0.438
2.783SerPro: 2.783 ± 0.563
3.204SerGln: 3.204 ± 0.701
2.783SerArg: 2.783 ± 0.524
4.385SerSer: 4.385 ± 0.824
4.638SerThr: 4.638 ± 0.672
4.132SerVal: 4.132 ± 0.62
0.422SerTrp: 0.422 ± 0.216
2.783SerTyr: 2.783 ± 0.352
0.0SerXaa: 0.0 ± 0.0
Thr
2.783ThrAla: 2.783 ± 0.6
1.265ThrCys: 1.265 ± 0.306
3.12ThrAsp: 3.12 ± 0.462
3.036ThrGlu: 3.036 ± 0.483
3.289ThrPhe: 3.289 ± 0.507
3.795ThrGly: 3.795 ± 0.612
0.843ThrHis: 0.843 ± 0.239
6.577ThrIle: 6.577 ± 0.824
3.289ThrLys: 3.289 ± 0.595
7.589ThrLeu: 7.589 ± 0.895
1.012ThrMet: 1.012 ± 0.288
3.626ThrAsn: 3.626 ± 0.649
3.373ThrPro: 3.373 ± 0.472
2.53ThrGln: 2.53 ± 0.523
2.867ThrArg: 2.867 ± 0.472
4.048ThrSer: 4.048 ± 0.658
6.324ThrThr: 6.324 ± 1.737
4.722ThrVal: 4.722 ± 0.609
0.843ThrTrp: 0.843 ± 0.279
3.373ThrTyr: 3.373 ± 0.67
0.0ThrXaa: 0.0 ± 0.0
Val
2.445ValAla: 2.445 ± 0.467
1.012ValCys: 1.012 ± 0.318
4.301ValAsp: 4.301 ± 0.542
4.048ValGlu: 4.048 ± 0.422
2.192ValPhe: 2.192 ± 0.47
3.71ValGly: 3.71 ± 0.439
1.012ValHis: 1.012 ± 0.365
6.24ValIle: 6.24 ± 0.793
6.999ValLys: 6.999 ± 0.867
6.83ValLeu: 6.83 ± 0.739
1.265ValMet: 1.265 ± 0.354
5.059ValAsn: 5.059 ± 0.702
2.867ValPro: 2.867 ± 0.498
2.867ValGln: 2.867 ± 0.547
2.445ValArg: 2.445 ± 0.448
4.554ValSer: 4.554 ± 0.531
5.987ValThr: 5.987 ± 0.698
4.722ValVal: 4.722 ± 0.74
0.59ValTrp: 0.59 ± 0.233
4.975ValTyr: 4.975 ± 0.711
0.0ValXaa: 0.0 ± 0.0
Trp
0.506TrpAla: 0.506 ± 0.172
0.169TrpCys: 0.169 ± 0.117
0.337TrpAsp: 0.337 ± 0.151
0.422TrpGlu: 0.422 ± 0.161
0.422TrpPhe: 0.422 ± 0.201
0.506TrpGly: 0.506 ± 0.195
0.169TrpHis: 0.169 ± 0.113
0.422TrpIle: 0.422 ± 0.212
0.506TrpLys: 0.506 ± 0.165
1.349TrpLeu: 1.349 ± 0.342
0.253TrpMet: 0.253 ± 0.131
0.253TrpAsn: 0.253 ± 0.171
0.0TrpPro: 0.0 ± 0.0
0.169TrpGln: 0.169 ± 0.098
0.422TrpArg: 0.422 ± 0.154
0.422TrpSer: 0.422 ± 0.175
0.59TrpThr: 0.59 ± 0.197
0.337TrpVal: 0.337 ± 0.169
0.169TrpTrp: 0.169 ± 0.121
0.337TrpTyr: 0.337 ± 0.154
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.192TyrAla: 2.192 ± 0.368
0.759TyrCys: 0.759 ± 0.233
2.783TyrAsp: 2.783 ± 0.515
3.12TyrGlu: 3.12 ± 0.482
2.277TyrPhe: 2.277 ± 0.484
3.457TyrGly: 3.457 ± 0.691
1.349TyrHis: 1.349 ± 0.329
5.734TyrIle: 5.734 ± 0.602
4.048TyrLys: 4.048 ± 0.504
5.059TyrLeu: 5.059 ± 0.615
1.518TyrMet: 1.518 ± 0.334
3.626TyrAsn: 3.626 ± 0.44
0.928TyrPro: 0.928 ± 0.284
2.108TyrGln: 2.108 ± 0.476
2.277TyrArg: 2.277 ± 0.38
3.457TyrSer: 3.457 ± 0.617
4.469TyrThr: 4.469 ± 0.575
5.481TyrVal: 5.481 ± 0.673
0.253TyrTrp: 0.253 ± 0.167
3.289TyrTyr: 3.289 ± 0.528
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 65 proteins (11860 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski