Amino acid dipepetide frequency for Acidianus filamentous virus 9

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.0AlaAla: 0.0 ± 0.0
0.484AlaCys: 0.484 ± 0.242
2.016AlaAsp: 2.016 ± 0.426
2.903AlaGlu: 2.903 ± 0.525
1.371AlaPhe: 1.371 ± 0.263
2.742AlaGly: 2.742 ± 0.512
0.806AlaHis: 0.806 ± 0.24
4.274AlaIle: 4.274 ± 0.508
4.758AlaLys: 4.758 ± 0.646
4.919AlaLeu: 4.919 ± 0.864
1.532AlaMet: 1.532 ± 0.355
2.097AlaAsn: 2.097 ± 0.392
1.048AlaPro: 1.048 ± 0.275
1.693AlaGln: 1.693 ± 0.513
2.016AlaArg: 2.016 ± 0.392
2.177AlaSer: 2.177 ± 0.491
2.177AlaThr: 2.177 ± 0.468
4.032AlaVal: 4.032 ± 0.562
0.564AlaTrp: 0.564 ± 0.203
2.822AlaTyr: 2.822 ± 0.523
0.0AlaXaa: 0.0 ± 0.0
Cys
0.645CysAla: 0.645 ± 0.286
0.242CysCys: 0.242 ± 0.147
1.29CysAsp: 1.29 ± 0.346
1.048CysGlu: 1.048 ± 0.302
0.564CysPhe: 0.564 ± 0.204
1.129CysGly: 1.129 ± 0.331
0.161CysHis: 0.161 ± 0.092
0.887CysIle: 0.887 ± 0.244
0.403CysLys: 0.403 ± 0.155
1.129CysLeu: 1.129 ± 0.385
0.484CysMet: 0.484 ± 0.164
0.968CysAsn: 0.968 ± 0.24
0.645CysPro: 0.645 ± 0.286
0.564CysGln: 0.564 ± 0.198
0.323CysArg: 0.323 ± 0.176
1.613CysSer: 1.613 ± 0.415
1.129CysThr: 1.129 ± 0.328
0.887CysVal: 0.887 ± 0.237
0.161CysTrp: 0.161 ± 0.109
0.968CysTyr: 0.968 ± 0.28
0.0CysXaa: 0.0 ± 0.0
Asp
2.097AspAla: 2.097 ± 0.363
0.564AspCys: 0.564 ± 0.223
2.742AspAsp: 2.742 ± 0.534
3.306AspGlu: 3.306 ± 0.546
2.097AspPhe: 2.097 ± 0.396
2.016AspGly: 2.016 ± 0.345
0.403AspHis: 0.403 ± 0.193
4.596AspIle: 4.596 ± 0.597
4.596AspLys: 4.596 ± 0.804
3.951AspLeu: 3.951 ± 0.546
1.29AspMet: 1.29 ± 0.324
3.064AspAsn: 3.064 ± 0.431
1.774AspPro: 1.774 ± 0.379
0.484AspGln: 0.484 ± 0.176
1.21AspArg: 1.21 ± 0.336
2.742AspSer: 2.742 ± 0.466
1.451AspThr: 1.451 ± 0.349
3.709AspVal: 3.709 ± 0.515
0.403AspTrp: 0.403 ± 0.174
3.709AspTyr: 3.709 ± 0.565
0.0AspXaa: 0.0 ± 0.0
Glu
3.064GluAla: 3.064 ± 0.443
1.613GluCys: 1.613 ± 0.372
3.467GluAsp: 3.467 ± 0.6
7.338GluGlu: 7.338 ± 1.092
2.742GluPhe: 2.742 ± 0.463
3.064GluGly: 3.064 ± 0.45
0.726GluHis: 0.726 ± 0.238
8.79GluIle: 8.79 ± 1.109
7.499GluLys: 7.499 ± 0.943
7.741GluLeu: 7.741 ± 0.803
2.097GluMet: 2.097 ± 0.498
3.79GluAsn: 3.79 ± 0.647
1.693GluPro: 1.693 ± 0.311
1.693GluGln: 1.693 ± 0.414
2.016GluArg: 2.016 ± 0.471
2.822GluSer: 2.822 ± 0.626
3.145GluThr: 3.145 ± 0.53
4.838GluVal: 4.838 ± 0.563
0.806GluTrp: 0.806 ± 0.274
4.435GluTyr: 4.435 ± 0.575
0.0GluXaa: 0.0 ± 0.0
Phe
1.855PheAla: 1.855 ± 0.406
1.048PheCys: 1.048 ± 0.317
2.742PheAsp: 2.742 ± 0.459
2.984PheGlu: 2.984 ± 0.436
1.451PhePhe: 1.451 ± 0.398
1.693PheGly: 1.693 ± 0.357
0.645PheHis: 0.645 ± 0.205
3.871PheIle: 3.871 ± 0.531
3.306PheLys: 3.306 ± 0.662
3.951PheLeu: 3.951 ± 0.653
1.21PheMet: 1.21 ± 0.356
2.742PheAsn: 2.742 ± 0.407
1.693PhePro: 1.693 ± 0.345
2.258PheGln: 2.258 ± 0.407
1.613PheArg: 1.613 ± 0.412
3.709PheSer: 3.709 ± 0.542
3.387PheThr: 3.387 ± 0.573
2.742PheVal: 2.742 ± 0.407
0.242PheTrp: 0.242 ± 0.139
2.742PheTyr: 2.742 ± 0.421
0.0PheXaa: 0.0 ± 0.0
Gly
1.935GlyAla: 1.935 ± 0.385
0.726GlyCys: 0.726 ± 0.323
3.226GlyAsp: 3.226 ± 0.512
4.758GlyGlu: 4.758 ± 0.689
2.742GlyPhe: 2.742 ± 0.581
2.177GlyGly: 2.177 ± 0.508
0.645GlyHis: 0.645 ± 0.226
5.161GlyIle: 5.161 ± 0.656
4.758GlyLys: 4.758 ± 0.634
3.629GlyLeu: 3.629 ± 0.524
1.29GlyMet: 1.29 ± 0.385
2.822GlyAsn: 2.822 ± 0.446
0.0GlyPro: 0.0 ± 0.0
1.774GlyGln: 1.774 ± 0.495
2.419GlyArg: 2.419 ± 0.718
2.742GlySer: 2.742 ± 0.715
3.387GlyThr: 3.387 ± 0.725
3.467GlyVal: 3.467 ± 0.493
0.806GlyTrp: 0.806 ± 0.227
3.306GlyTyr: 3.306 ± 0.423
0.0GlyXaa: 0.0 ± 0.0
His
0.645HisAla: 0.645 ± 0.164
0.484HisCys: 0.484 ± 0.235
0.806HisAsp: 0.806 ± 0.303
0.887HisGlu: 0.887 ± 0.281
0.484HisPhe: 0.484 ± 0.166
0.484HisGly: 0.484 ± 0.191
0.484HisHis: 0.484 ± 0.209
1.693HisIle: 1.693 ± 0.371
0.806HisLys: 0.806 ± 0.246
0.564HisLeu: 0.564 ± 0.225
0.323HisMet: 0.323 ± 0.15
0.887HisAsn: 0.887 ± 0.325
0.726HisPro: 0.726 ± 0.217
0.323HisGln: 0.323 ± 0.156
0.403HisArg: 0.403 ± 0.159
0.968HisSer: 0.968 ± 0.243
0.806HisThr: 0.806 ± 0.216
1.048HisVal: 1.048 ± 0.302
0.081HisTrp: 0.081 ± 0.073
0.806HisTyr: 0.806 ± 0.211
0.0HisXaa: 0.0 ± 0.0
Ile
5.08IleAla: 5.08 ± 0.655
0.968IleCys: 0.968 ± 0.338
4.677IleAsp: 4.677 ± 0.649
6.693IleGlu: 6.693 ± 0.846
4.113IlePhe: 4.113 ± 0.506
3.306IleGly: 3.306 ± 0.621
1.532IleHis: 1.532 ± 0.365
8.87IleIle: 8.87 ± 1.199
7.822IleLys: 7.822 ± 1.053
7.499IleLeu: 7.499 ± 0.891
2.016IleMet: 2.016 ± 0.426
5.242IleAsn: 5.242 ± 0.744
4.354IlePro: 4.354 ± 0.702
2.903IleGln: 2.903 ± 0.524
4.274IleArg: 4.274 ± 0.662
6.29IleSer: 6.29 ± 0.739
6.37IleThr: 6.37 ± 0.787
6.532IleVal: 6.532 ± 0.792
1.29IleTrp: 1.29 ± 0.351
5.161IleTyr: 5.161 ± 0.782
0.0IleXaa: 0.0 ± 0.0
Lys
3.306LysAla: 3.306 ± 0.621
0.806LysCys: 0.806 ± 0.254
2.5LysAsp: 2.5 ± 0.45
7.983LysGlu: 7.983 ± 1.033
2.258LysPhe: 2.258 ± 0.583
3.709LysGly: 3.709 ± 0.595
0.887LysHis: 0.887 ± 0.263
7.499LysIle: 7.499 ± 1.228
6.532LysLys: 6.532 ± 1.178
8.225LysLeu: 8.225 ± 1.137
2.984LysMet: 2.984 ± 0.521
4.274LysAsn: 4.274 ± 0.618
2.339LysPro: 2.339 ± 0.437
2.742LysGln: 2.742 ± 0.552
2.742LysArg: 2.742 ± 0.587
4.919LysSer: 4.919 ± 0.693
3.871LysThr: 3.871 ± 0.692
4.919LysVal: 4.919 ± 0.654
0.564LysTrp: 0.564 ± 0.197
5.322LysTyr: 5.322 ± 0.75
0.0LysXaa: 0.0 ± 0.0
Leu
4.758LeuAla: 4.758 ± 0.712
1.613LeuCys: 1.613 ± 0.357
3.145LeuAsp: 3.145 ± 0.576
5.645LeuGlu: 5.645 ± 0.594
3.79LeuPhe: 3.79 ± 0.589
4.274LeuGly: 4.274 ± 0.583
1.371LeuHis: 1.371 ± 0.395
7.499LeuIle: 7.499 ± 0.755
7.499LeuLys: 7.499 ± 0.942
7.58LeuLeu: 7.58 ± 1.097
2.419LeuMet: 2.419 ± 0.517
4.596LeuAsn: 4.596 ± 0.7
3.548LeuPro: 3.548 ± 0.511
3.226LeuGln: 3.226 ± 0.516
3.629LeuArg: 3.629 ± 0.596
6.935LeuSer: 6.935 ± 0.906
4.435LeuThr: 4.435 ± 0.639
5.483LeuVal: 5.483 ± 0.65
0.887LeuTrp: 0.887 ± 0.215
5.0LeuTyr: 5.0 ± 0.697
0.0LeuXaa: 0.0 ± 0.0
Met
1.21MetAla: 1.21 ± 0.406
0.0MetCys: 0.0 ± 0.0
0.806MetAsp: 0.806 ± 0.287
1.29MetGlu: 1.29 ± 0.323
1.129MetPhe: 1.129 ± 0.277
1.129MetGly: 1.129 ± 0.303
0.242MetHis: 0.242 ± 0.156
2.016MetIle: 2.016 ± 0.473
2.742MetLys: 2.742 ± 0.491
2.419MetLeu: 2.419 ± 0.422
0.726MetMet: 0.726 ± 0.25
1.613MetAsn: 1.613 ± 0.344
0.806MetPro: 0.806 ± 0.233
0.806MetGln: 0.806 ± 0.239
1.613MetArg: 1.613 ± 0.348
2.097MetSer: 2.097 ± 0.364
1.451MetThr: 1.451 ± 0.354
1.774MetVal: 1.774 ± 0.403
0.081MetTrp: 0.081 ± 0.074
0.968MetTyr: 0.968 ± 0.242
0.0MetXaa: 0.0 ± 0.0
Asn
2.822AsnAla: 2.822 ± 0.442
0.806AsnCys: 0.806 ± 0.251
2.016AsnAsp: 2.016 ± 0.402
4.435AsnGlu: 4.435 ± 0.619
2.984AsnPhe: 2.984 ± 0.523
3.951AsnGly: 3.951 ± 0.521
0.484AsnHis: 0.484 ± 0.272
5.08AsnIle: 5.08 ± 0.692
4.677AsnLys: 4.677 ± 0.785
4.113AsnLeu: 4.113 ± 0.723
0.645AsnMet: 0.645 ± 0.248
2.984AsnAsn: 2.984 ± 0.537
2.5AsnPro: 2.5 ± 0.368
0.726AsnGln: 0.726 ± 0.234
1.532AsnArg: 1.532 ± 0.348
3.548AsnSer: 3.548 ± 0.564
2.419AsnThr: 2.419 ± 0.548
4.354AsnVal: 4.354 ± 0.633
0.806AsnTrp: 0.806 ± 0.24
2.742AsnTyr: 2.742 ± 0.562
0.0AsnXaa: 0.0 ± 0.0
Pro
2.177ProAla: 2.177 ± 0.43
1.29ProCys: 1.29 ± 0.347
2.097ProAsp: 2.097 ± 0.499
2.097ProGlu: 2.097 ± 0.385
1.613ProPhe: 1.613 ± 0.307
1.935ProGly: 1.935 ± 0.398
0.726ProHis: 0.726 ± 0.282
4.032ProIle: 4.032 ± 0.538
2.016ProLys: 2.016 ± 0.406
2.016ProLeu: 2.016 ± 0.335
0.161ProMet: 0.161 ± 0.096
1.935ProAsn: 1.935 ± 0.412
2.903ProPro: 2.903 ± 0.596
1.29ProGln: 1.29 ± 0.34
0.968ProArg: 0.968 ± 0.242
3.226ProSer: 3.226 ± 0.69
2.822ProThr: 2.822 ± 0.931
2.822ProVal: 2.822 ± 0.504
0.323ProTrp: 0.323 ± 0.16
1.774ProTyr: 1.774 ± 0.351
0.0ProXaa: 0.0 ± 0.0
Gln
1.129GlnAla: 1.129 ± 0.387
0.564GlnCys: 0.564 ± 0.236
0.806GlnAsp: 0.806 ± 0.225
1.613GlnGlu: 1.613 ± 0.398
1.613GlnPhe: 1.613 ± 0.308
1.613GlnGly: 1.613 ± 0.388
0.161GlnHis: 0.161 ± 0.118
3.306GlnIle: 3.306 ± 0.523
2.984GlnLys: 2.984 ± 0.629
4.032GlnLeu: 4.032 ± 0.452
0.403GlnMet: 0.403 ± 0.174
1.693GlnAsn: 1.693 ± 0.479
0.968GlnPro: 0.968 ± 0.357
1.21GlnGln: 1.21 ± 0.359
1.129GlnArg: 1.129 ± 0.312
1.29GlnSer: 1.29 ± 0.384
2.742GlnThr: 2.742 ± 0.652
2.903GlnVal: 2.903 ± 0.804
0.242GlnTrp: 0.242 ± 0.128
1.774GlnTyr: 1.774 ± 0.425
0.0GlnXaa: 0.0 ± 0.0
Arg
1.371ArgAla: 1.371 ± 0.514
0.161ArgCys: 0.161 ± 0.113
1.048ArgAsp: 1.048 ± 0.294
2.661ArgGlu: 2.661 ± 0.557
1.855ArgPhe: 1.855 ± 0.377
2.258ArgGly: 2.258 ± 0.47
0.564ArgHis: 0.564 ± 0.206
2.903ArgIle: 2.903 ± 0.449
3.871ArgLys: 3.871 ± 0.64
2.822ArgLeu: 2.822 ± 0.602
1.371ArgMet: 1.371 ± 0.355
1.613ArgAsn: 1.613 ± 0.475
0.645ArgPro: 0.645 ± 0.274
1.29ArgGln: 1.29 ± 0.406
1.855ArgArg: 1.855 ± 0.434
1.21ArgSer: 1.21 ± 0.27
1.613ArgThr: 1.613 ± 0.346
1.935ArgVal: 1.935 ± 0.375
0.323ArgTrp: 0.323 ± 0.136
2.984ArgTyr: 2.984 ± 0.581
0.0ArgXaa: 0.0 ± 0.0
Ser
2.339SerAla: 2.339 ± 0.442
0.887SerCys: 0.887 ± 0.424
2.984SerAsp: 2.984 ± 0.507
4.596SerGlu: 4.596 ± 0.691
3.226SerPhe: 3.226 ± 0.473
5.725SerGly: 5.725 ± 1.373
1.21SerHis: 1.21 ± 0.312
6.129SerIle: 6.129 ± 0.79
3.306SerLys: 3.306 ± 0.467
5.403SerLeu: 5.403 ± 0.695
1.532SerMet: 1.532 ± 0.382
2.58SerAsn: 2.58 ± 0.437
2.5SerPro: 2.5 ± 0.819
3.064SerGln: 3.064 ± 0.596
1.129SerArg: 1.129 ± 0.37
4.677SerSer: 4.677 ± 1.431
2.984SerThr: 2.984 ± 0.514
5.242SerVal: 5.242 ± 1.096
0.564SerTrp: 0.564 ± 0.212
4.677SerTyr: 4.677 ± 0.726
0.0SerXaa: 0.0 ± 0.0
Thr
3.145ThrAla: 3.145 ± 0.559
0.645ThrCys: 0.645 ± 0.206
2.822ThrAsp: 2.822 ± 0.47
3.629ThrGlu: 3.629 ± 0.521
3.629ThrPhe: 3.629 ± 0.605
3.709ThrGly: 3.709 ± 0.61
0.645ThrHis: 0.645 ± 0.217
5.161ThrIle: 5.161 ± 0.756
2.661ThrLys: 2.661 ± 0.629
4.838ThrLeu: 4.838 ± 0.697
0.806ThrMet: 0.806 ± 0.34
2.5ThrAsn: 2.5 ± 0.422
3.387ThrPro: 3.387 ± 0.587
1.855ThrGln: 1.855 ± 0.651
1.935ThrArg: 1.935 ± 0.444
4.354ThrSer: 4.354 ± 0.982
2.822ThrThr: 2.822 ± 0.666
3.709ThrVal: 3.709 ± 0.684
0.484ThrTrp: 0.484 ± 0.164
4.596ThrTyr: 4.596 ± 0.816
0.0ThrXaa: 0.0 ± 0.0
Val
3.226ValAla: 3.226 ± 0.531
1.371ValCys: 1.371 ± 0.345
2.822ValAsp: 2.822 ± 0.42
4.354ValGlu: 4.354 ± 0.606
3.226ValPhe: 3.226 ± 0.476
2.903ValGly: 2.903 ± 0.404
0.968ValHis: 0.968 ± 0.298
5.806ValIle: 5.806 ± 0.619
4.274ValLys: 4.274 ± 0.58
6.854ValLeu: 6.854 ± 0.707
1.451ValMet: 1.451 ± 0.311
3.709ValAsn: 3.709 ± 0.442
3.951ValPro: 3.951 ± 0.879
1.774ValGln: 1.774 ± 0.321
1.774ValArg: 1.774 ± 0.334
5.483ValSer: 5.483 ± 1.203
6.209ValThr: 6.209 ± 0.915
5.0ValVal: 5.0 ± 0.872
0.323ValTrp: 0.323 ± 0.142
4.919ValTyr: 4.919 ± 0.63
0.0ValXaa: 0.0 ± 0.0
Trp
0.242TrpAla: 0.242 ± 0.131
0.403TrpCys: 0.403 ± 0.148
0.484TrpAsp: 0.484 ± 0.181
0.887TrpGlu: 0.887 ± 0.231
0.323TrpPhe: 0.323 ± 0.155
0.323TrpGly: 0.323 ± 0.149
0.081TrpHis: 0.081 ± 0.082
0.887TrpIle: 0.887 ± 0.259
0.484TrpLys: 0.484 ± 0.171
0.726TrpLeu: 0.726 ± 0.262
0.484TrpMet: 0.484 ± 0.17
0.323TrpAsn: 0.323 ± 0.185
0.0TrpPro: 0.0 ± 0.0
0.403TrpGln: 0.403 ± 0.157
0.484TrpArg: 0.484 ± 0.228
1.048TrpSer: 1.048 ± 0.405
0.323TrpThr: 0.323 ± 0.179
0.968TrpVal: 0.968 ± 0.303
0.242TrpTrp: 0.242 ± 0.155
0.564TrpTyr: 0.564 ± 0.249
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.387TyrAla: 3.387 ± 0.499
0.564TyrCys: 0.564 ± 0.206
3.709TyrAsp: 3.709 ± 0.453
4.354TyrGlu: 4.354 ± 0.651
4.677TyrPhe: 4.677 ± 0.538
3.629TyrGly: 3.629 ± 0.665
0.968TyrHis: 0.968 ± 0.314
6.532TyrIle: 6.532 ± 0.572
3.387TyrLys: 3.387 ± 0.612
4.919TyrLeu: 4.919 ± 0.781
1.613TyrMet: 1.613 ± 0.363
4.193TyrAsn: 4.193 ± 0.813
2.742TyrPro: 2.742 ± 0.561
2.097TyrGln: 2.097 ± 0.459
1.29TyrArg: 1.29 ± 0.389
2.903TyrSer: 2.903 ± 0.588
3.79TyrThr: 3.79 ± 0.5
4.032TyrVal: 4.032 ± 0.584
0.484TyrTrp: 0.484 ± 0.174
3.951TyrTyr: 3.951 ± 0.572
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 73 proteins (12402 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski