Amino acid dipepetide frequency for Legionella tucsonensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.113AlaAla: 6.113 ± 0.101	1.049AlaCys: 1.049 ± 0.035	3.195AlaAsp: 3.195 ± 0.061	4.115AlaGlu: 4.115 ± 0.074	3.122AlaPhe: 3.122 ± 0.068	4.752AlaGly: 4.752 ± 0.086	1.824AlaHis: 1.824 ± 0.048	5.818AlaIle: 5.818 ± 0.085	4.808AlaLys: 4.808 ± 0.071	9.0AlaLeu: 9.0 ± 0.121	1.966AlaMet: 1.966 ± 0.05	3.311AlaAsn: 3.311 ± 0.069	2.479AlaPro: 2.479 ± 0.05	3.53AlaGln: 3.53 ± 0.067	3.075AlaArg: 3.075 ± 0.062	4.535AlaSer: 4.535 ± 0.07	3.718AlaThr: 3.718 ± 0.063	4.744AlaVal: 4.744 ± 0.077	0.741AlaTrp: 0.741 ± 0.03	2.594AlaTyr: 2.594 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	0.812CysAla: 0.812 ± 0.029	0.212CysCys: 0.212 ± 0.015	0.567CysAsp: 0.567 ± 0.027	0.594CysGlu: 0.594 ± 0.026	0.699CysPhe: 0.699 ± 0.029	0.856CysGly: 0.856 ± 0.031	0.322CysHis: 0.322 ± 0.019	0.884CysIle: 0.884 ± 0.03	0.616CysLys: 0.616 ± 0.028	1.274CysLeu: 1.274 ± 0.036	0.279CysMet: 0.279 ± 0.016	0.499CysAsn: 0.499 ± 0.026	0.475CysPro: 0.475 ± 0.022	0.518CysGln: 0.518 ± 0.022	0.492CysArg: 0.492 ± 0.024	0.812CysSer: 0.812 ± 0.028	0.611CysThr: 0.611 ± 0.025	0.693CysVal: 0.693 ± 0.027	0.154CysTrp: 0.154 ± 0.011	0.495CysTyr: 0.495 ± 0.023	0.0CysXaa: 0.0 ± 0.0
Asp	3.439AspAla: 3.439 ± 0.062	0.575AspCys: 0.575 ± 0.025	2.203AspAsp: 2.203 ± 0.054	3.461AspGlu: 3.461 ± 0.071	2.526AspPhe: 2.526 ± 0.058	2.505AspGly: 2.505 ± 0.056	0.988AspHis: 0.988 ± 0.029	3.411AspIle: 3.411 ± 0.068	3.345AspLys: 3.345 ± 0.063	5.251AspLeu: 5.251 ± 0.082	1.022AspMet: 1.022 ± 0.034	2.177AspAsn: 2.177 ± 0.039	2.005AspPro: 2.005 ± 0.053	1.55AspGln: 1.55 ± 0.04	1.822AspArg: 1.822 ± 0.043	2.838AspSer: 2.838 ± 0.061	2.303AspThr: 2.303 ± 0.052	3.021AspVal: 3.021 ± 0.058	0.661AspTrp: 0.661 ± 0.025	2.013AspTyr: 2.013 ± 0.047	0.001AspXaa: 0.001 ± 0.001
Glu	4.196GluAla: 4.196 ± 0.067	0.587GluCys: 0.587 ± 0.024	2.589GluAsp: 2.589 ± 0.057	4.453GluGlu: 4.453 ± 0.096	2.546GluPhe: 2.546 ± 0.057	2.997GluGly: 2.997 ± 0.056	1.788GluHis: 1.788 ± 0.052	4.609GluIle: 4.609 ± 0.076	4.905GluLys: 4.905 ± 0.084	6.87GluLeu: 6.87 ± 0.111	1.533GluMet: 1.533 ± 0.044	3.082GluAsn: 3.082 ± 0.059	1.778GluPro: 1.778 ± 0.043	3.583GluGln: 3.583 ± 0.077	2.935GluArg: 2.935 ± 0.072	3.385GluSer: 3.385 ± 0.057	2.969GluThr: 2.969 ± 0.061	3.501GluVal: 3.501 ± 0.063	0.62GluTrp: 0.62 ± 0.025	1.973GluTyr: 1.973 ± 0.052	0.0GluXaa: 0.0 ± 0.0
Phe	3.527PheAla: 3.527 ± 0.063	0.662PheCys: 0.662 ± 0.027	2.446PheAsp: 2.446 ± 0.058	2.213PheGlu: 2.213 ± 0.051	2.677PhePhe: 2.677 ± 0.065	2.605PheGly: 2.605 ± 0.059	1.076PheHis: 1.076 ± 0.037	3.843PheIle: 3.843 ± 0.072	2.617PheLys: 2.617 ± 0.063	4.904PheLeu: 4.904 ± 0.084	1.012PheMet: 1.012 ± 0.035	2.442PheAsn: 2.442 ± 0.055	1.795PhePro: 1.795 ± 0.046	1.548PheGln: 1.548 ± 0.038	1.528PheArg: 1.528 ± 0.041	3.66PheSer: 3.66 ± 0.072	2.558PheThr: 2.558 ± 0.053	2.526PheVal: 2.526 ± 0.055	0.576PheTrp: 0.576 ± 0.025	1.807PheTyr: 1.807 ± 0.042	0.0PheXaa: 0.0 ± 0.0
Gly	4.301GlyAla: 4.301 ± 0.091	0.791GlyCys: 0.791 ± 0.033	2.64GlyAsp: 2.64 ± 0.056	3.153GlyGlu: 3.153 ± 0.065	3.115GlyPhe: 3.115 ± 0.075	3.993GlyGly: 3.993 ± 0.088	1.472GlyHis: 1.472 ± 0.044	5.039GlyIle: 5.039 ± 0.077	3.819GlyLys: 3.819 ± 0.06	6.391GlyLeu: 6.391 ± 0.086	1.7GlyMet: 1.7 ± 0.046	2.402GlyAsn: 2.402 ± 0.052	1.653GlyPro: 1.653 ± 0.043	2.199GlyGln: 2.199 ± 0.057	2.45GlyArg: 2.45 ± 0.058	3.68GlySer: 3.68 ± 0.077	3.033GlyThr: 3.033 ± 0.059	4.213GlyVal: 4.213 ± 0.078	0.837GlyTrp: 0.837 ± 0.032	2.49GlyTyr: 2.49 ± 0.059	0.001GlyXaa: 0.001 ± 0.001
His	1.917HisAla: 1.917 ± 0.05	0.385HisCys: 0.385 ± 0.021	1.169HisAsp: 1.169 ± 0.035	1.564HisGlu: 1.564 ± 0.045	1.351HisPhe: 1.351 ± 0.036	1.625HisGly: 1.625 ± 0.047	0.925HisHis: 0.925 ± 0.035	1.691HisIle: 1.691 ± 0.041	1.182HisLys: 1.182 ± 0.034	2.866HisLeu: 2.866 ± 0.056	0.535HisMet: 0.535 ± 0.023	1.062HisAsn: 1.062 ± 0.032	1.308HisPro: 1.308 ± 0.04	1.368HisGln: 1.368 ± 0.039	1.075HisArg: 1.075 ± 0.038	1.626HisSer: 1.626 ± 0.041	1.195HisThr: 1.195 ± 0.037	1.408HisVal: 1.408 ± 0.042	0.39HisTrp: 0.39 ± 0.019	1.142HisTyr: 1.142 ± 0.036	0.0HisXaa: 0.0 ± 0.0
Ile	6.351IleAla: 6.351 ± 0.079	0.902IleCys: 0.902 ± 0.029	4.24IleAsp: 4.24 ± 0.064	4.871IleGlu: 4.871 ± 0.077	2.924IlePhe: 2.924 ± 0.076	4.641IleGly: 4.641 ± 0.092	1.895IleHis: 1.895 ± 0.043	5.662IleIle: 5.662 ± 0.094	5.089IleLys: 5.089 ± 0.087	7.391IleLeu: 7.391 ± 0.094	1.57IleMet: 1.57 ± 0.038	4.239IleAsn: 4.239 ± 0.073	3.523IlePro: 3.523 ± 0.068	2.979IleGln: 2.979 ± 0.06	3.008IleArg: 3.008 ± 0.05	5.209IleSer: 5.209 ± 0.074	4.26IleThr: 4.26 ± 0.071	4.084IleVal: 4.084 ± 0.071	0.662IleTrp: 0.662 ± 0.027	2.37IleTyr: 2.37 ± 0.047	0.0IleXaa: 0.0 ± 0.0
Lys	4.533LysAla: 4.533 ± 0.076	0.414LysCys: 0.414 ± 0.025	2.992LysAsp: 2.992 ± 0.076	5.011LysGlu: 5.011 ± 0.101	1.887LysPhe: 1.887 ± 0.05	3.226LysGly: 3.226 ± 0.063	1.521LysHis: 1.521 ± 0.043	5.152LysIle: 5.152 ± 0.076	5.64LysLys: 5.64 ± 0.096	6.257LysLeu: 6.257 ± 0.092	1.605LysMet: 1.605 ± 0.039	4.017LysAsn: 4.017 ± 0.079	2.786LysPro: 2.786 ± 0.056	3.322LysGln: 3.322 ± 0.066	2.839LysArg: 2.839 ± 0.052	3.895LysSer: 3.895 ± 0.074	3.662LysThr: 3.662 ± 0.06	3.384LysVal: 3.384 ± 0.061	0.602LysTrp: 0.602 ± 0.026	1.856LysTyr: 1.856 ± 0.052	0.0LysXaa: 0.0 ± 0.0
Leu	8.762LeuAla: 8.762 ± 0.118	1.365LeuCys: 1.365 ± 0.035	5.133LeuAsp: 5.133 ± 0.081	6.047LeuGlu: 6.047 ± 0.099	5.412LeuPhe: 5.412 ± 0.085	6.552LeuGly: 6.552 ± 0.108	2.692LeuHis: 2.692 ± 0.064	8.583LeuIle: 8.583 ± 0.119	6.943LeuLys: 6.943 ± 0.091	11.852LeuLeu: 11.852 ± 0.163	2.646LeuMet: 2.646 ± 0.053	5.596LeuAsn: 5.596 ± 0.084	4.893LeuPro: 4.893 ± 0.072	4.468LeuGln: 4.468 ± 0.078	4.401LeuArg: 4.401 ± 0.076	8.218LeuSer: 8.218 ± 0.109	6.045LeuThr: 6.045 ± 0.072	5.984LeuVal: 5.984 ± 0.085	1.034LeuTrp: 1.034 ± 0.036	3.242LeuTyr: 3.242 ± 0.068	0.0LeuXaa: 0.0 ± 0.0
Met	1.941MetAla: 1.941 ± 0.047	0.185MetCys: 0.185 ± 0.014	1.166MetAsp: 1.166 ± 0.036	1.328MetGlu: 1.328 ± 0.036	0.8MetPhe: 0.8 ± 0.031	1.492MetGly: 1.492 ± 0.04	0.659MetHis: 0.659 ± 0.026	1.679MetIle: 1.679 ± 0.039	1.602MetLys: 1.602 ± 0.047	2.539MetLeu: 2.539 ± 0.055	0.706MetMet: 0.706 ± 0.028	1.283MetAsn: 1.283 ± 0.04	1.122MetPro: 1.122 ± 0.038	1.158MetGln: 1.158 ± 0.034	1.176MetArg: 1.176 ± 0.035	1.693MetSer: 1.693 ± 0.043	1.355MetThr: 1.355 ± 0.041	1.404MetVal: 1.404 ± 0.04	0.161MetTrp: 0.161 ± 0.014	0.57MetTyr: 0.57 ± 0.027	0.0MetXaa: 0.0 ± 0.0
Asn	3.351AsnAla: 3.351 ± 0.063	0.55AsnCys: 0.55 ± 0.027	2.224AsnAsp: 2.224 ± 0.046	3.08AsnGlu: 3.08 ± 0.052	2.031AsnPhe: 2.031 ± 0.044	2.511AsnGly: 2.511 ± 0.067	1.386AsnHis: 1.386 ± 0.043	3.393AsnIle: 3.393 ± 0.055	3.355AsnLys: 3.355 ± 0.06	4.963AsnLeu: 4.963 ± 0.074	1.041AsnMet: 1.041 ± 0.034	2.646AsnAsn: 2.646 ± 0.066	2.687AsnPro: 2.687 ± 0.053	2.715AsnGln: 2.715 ± 0.056	1.993AsnArg: 1.993 ± 0.046	3.155AsnSer: 3.155 ± 0.064	2.694AsnThr: 2.694 ± 0.058	2.425AsnVal: 2.425 ± 0.056	0.636AsnTrp: 0.636 ± 0.027	2.005AsnTyr: 2.005 ± 0.049	0.0AsnXaa: 0.0 ± 0.0
Pro	2.716ProAla: 2.716 ± 0.055	0.417ProCys: 0.417 ± 0.022	2.201ProAsp: 2.201 ± 0.049	3.191ProGlu: 3.191 ± 0.064	1.99ProPhe: 1.99 ± 0.05	2.562ProGly: 2.562 ± 0.056	0.996ProHis: 0.996 ± 0.034	2.904ProIle: 2.904 ± 0.062	2.434ProLys: 2.434 ± 0.046	4.338ProLeu: 4.338 ± 0.067	0.933ProMet: 0.933 ± 0.035	1.917ProAsn: 1.917 ± 0.045	1.526ProPro: 1.526 ± 0.045	1.858ProGln: 1.858 ± 0.04	1.36ProArg: 1.36 ± 0.034	2.577ProSer: 2.577 ± 0.05	2.119ProThr: 2.119 ± 0.049	2.954ProVal: 2.954 ± 0.066	0.45ProTrp: 0.45 ± 0.022	1.454ProTyr: 1.454 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	3.525GlnAla: 3.525 ± 0.077	0.513GlnCys: 0.513 ± 0.026	1.813GlnAsp: 1.813 ± 0.036	2.832GlnGlu: 2.832 ± 0.058	2.118GlnPhe: 2.118 ± 0.05	2.539GlnGly: 2.539 ± 0.056	1.238GlnHis: 1.238 ± 0.04	3.45GlnIle: 3.45 ± 0.062	3.135GlnLys: 3.135 ± 0.069	5.318GlnLeu: 5.318 ± 0.085	1.056GlnMet: 1.056 ± 0.035	2.186GlnAsn: 2.186 ± 0.053	1.51GlnPro: 1.51 ± 0.038	2.672GlnGln: 2.672 ± 0.071	1.959GlnArg: 1.959 ± 0.049	2.754GlnSer: 2.754 ± 0.062	2.242GlnThr: 2.242 ± 0.051	2.544GlnVal: 2.544 ± 0.053	0.587GlnTrp: 0.587 ± 0.027	1.472GlnTyr: 1.472 ± 0.039	0.0GlnXaa: 0.0 ± 0.0
Arg	2.974ArgAla: 2.974 ± 0.054	0.465ArgCys: 0.465 ± 0.024	2.039ArgAsp: 2.039 ± 0.043	2.666ArgGlu: 2.666 ± 0.065	2.137ArgPhe: 2.137 ± 0.056	2.246ArgGly: 2.246 ± 0.051	1.098ArgHis: 1.098 ± 0.034	3.172ArgIle: 3.172 ± 0.06	2.626ArgLys: 2.626 ± 0.055	4.687ArgLeu: 4.687 ± 0.076	1.008ArgMet: 1.008 ± 0.032	1.881ArgAsn: 1.881 ± 0.045	1.397ArgPro: 1.397 ± 0.035	1.776ArgGln: 1.776 ± 0.044	1.873ArgArg: 1.873 ± 0.05	2.366ArgSer: 2.366 ± 0.055	1.955ArgThr: 1.955 ± 0.045	2.614ArgVal: 2.614 ± 0.055	0.546ArgTrp: 0.546 ± 0.024	1.668ArgTyr: 1.668 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	4.429SerAla: 4.429 ± 0.073	0.797SerCys: 0.797 ± 0.035	2.895SerAsp: 2.895 ± 0.061	3.589SerGlu: 3.589 ± 0.067	3.211SerPhe: 3.211 ± 0.065	4.351SerGly: 4.351 ± 0.074	1.659SerHis: 1.659 ± 0.037	4.942SerIle: 4.942 ± 0.084	3.824SerLys: 3.824 ± 0.067	7.733SerLeu: 7.733 ± 0.122	1.754SerMet: 1.754 ± 0.042	2.945SerAsn: 2.945 ± 0.06	2.767SerPro: 2.767 ± 0.064	2.897SerGln: 2.897 ± 0.063	2.62SerArg: 2.62 ± 0.053	4.731SerSer: 4.731 ± 0.099	3.498SerThr: 3.498 ± 0.064	3.711SerVal: 3.711 ± 0.056	0.833SerTrp: 0.833 ± 0.032	2.329SerTyr: 2.329 ± 0.06	0.0SerXaa: 0.0 ± 0.0
Thr	3.975ThrAla: 3.975 ± 0.077	0.587ThrCys: 0.587 ± 0.026	2.347ThrAsp: 2.347 ± 0.046	2.901ThrGlu: 2.901 ± 0.058	2.115ThrPhe: 2.115 ± 0.047	3.53ThrGly: 3.53 ± 0.066	1.524ThrHis: 1.524 ± 0.041	3.87ThrIle: 3.87 ± 0.073	2.758ThrLys: 2.758 ± 0.051	6.331ThrLeu: 6.331 ± 0.097	1.129ThrMet: 1.129 ± 0.036	2.248ThrAsn: 2.248 ± 0.047	2.779ThrPro: 2.779 ± 0.054	2.559ThrGln: 2.559 ± 0.053	2.145ThrArg: 2.145 ± 0.048	3.287ThrSer: 3.287 ± 0.062	2.941ThrThr: 2.941 ± 0.069	3.381ThrVal: 3.381 ± 0.058	0.536ThrTrp: 0.536 ± 0.022	1.789ThrTyr: 1.789 ± 0.045	0.0ThrXaa: 0.0 ± 0.0
Val	4.53ValAla: 4.53 ± 0.077	0.752ValCys: 0.752 ± 0.03	3.125ValAsp: 3.125 ± 0.062	3.314ValGlu: 3.314 ± 0.063	2.839ValPhe: 2.839 ± 0.057	3.601ValGly: 3.601 ± 0.076	1.428ValHis: 1.428 ± 0.046	4.766ValIle: 4.766 ± 0.075	3.392ValLys: 3.392 ± 0.061	6.333ValLeu: 6.333 ± 0.081	1.568ValMet: 1.568 ± 0.042	2.942ValAsn: 2.942 ± 0.059	2.341ValPro: 2.341 ± 0.045	2.063ValGln: 2.063 ± 0.05	2.32ValArg: 2.32 ± 0.054	4.06ValSer: 4.06 ± 0.076	3.3ValThr: 3.3 ± 0.053	4.065ValVal: 4.065 ± 0.092	0.561ValTrp: 0.561 ± 0.028	1.864ValTyr: 1.864 ± 0.043	0.001ValXaa: 0.001 ± 0.001
Trp	0.642TrpAla: 0.642 ± 0.024	0.13TrpCys: 0.13 ± 0.012	0.493TrpAsp: 0.493 ± 0.022	0.574TrpGlu: 0.574 ± 0.024	0.614TrpPhe: 0.614 ± 0.028	0.727TrpGly: 0.727 ± 0.028	0.346TrpHis: 0.346 ± 0.02	0.83TrpIle: 0.83 ± 0.027	0.575TrpLys: 0.575 ± 0.027	1.421TrpLeu: 1.421 ± 0.044	0.305TrpMet: 0.305 ± 0.02	0.515TrpAsn: 0.515 ± 0.024	0.435TrpPro: 0.435 ± 0.021	0.665TrpGln: 0.665 ± 0.027	0.538TrpArg: 0.538 ± 0.023	0.73TrpSer: 0.73 ± 0.033	0.484TrpThr: 0.484 ± 0.025	0.719TrpVal: 0.719 ± 0.026	0.177TrpTrp: 0.177 ± 0.014	0.37TrpTyr: 0.37 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.457TyrAla: 2.457 ± 0.049	0.525TyrCys: 0.525 ± 0.022	1.641TyrAsp: 1.641 ± 0.045	1.942TyrGlu: 1.942 ± 0.047	1.909TyrPhe: 1.909 ± 0.054	2.061TyrGly: 2.061 ± 0.05	0.944TyrHis: 0.944 ± 0.033	2.172TyrIle: 2.172 ± 0.051	1.934TyrLys: 1.934 ± 0.051	4.149TyrLeu: 4.149 ± 0.075	0.651TyrMet: 0.651 ± 0.025	1.451TyrAsn: 1.451 ± 0.043	1.639TyrPro: 1.639 ± 0.046	2.036TyrGln: 2.036 ± 0.041	1.586TyrArg: 1.586 ± 0.042	2.304TyrSer: 2.304 ± 0.054	1.788TyrThr: 1.788 ± 0.044	1.791TyrVal: 1.791 ± 0.045	0.523TyrTrp: 0.523 ± 0.026	1.473TyrTyr: 1.473 ± 0.048	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.001XaaCys: 0.001 ± 0.001	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.009XaaXaa: 0.009 ± 0.007

Statistics based on 2936 proteins (972462 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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