Amino acid dipepetide frequency for Streptococcus phage Javan493

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.796AlaAla: 4.796 ± 1.144
0.421AlaCys: 0.421 ± 0.219
4.207AlaAsp: 4.207 ± 0.617
5.049AlaGlu: 5.049 ± 0.997
1.43AlaPhe: 1.43 ± 0.35
4.291AlaGly: 4.291 ± 0.897
0.673AlaHis: 0.673 ± 0.182
5.385AlaIle: 5.385 ± 0.505
6.227AlaLys: 6.227 ± 0.882
6.563AlaLeu: 6.563 ± 1.132
2.02AlaMet: 2.02 ± 0.353
3.534AlaAsn: 3.534 ± 0.595
1.515AlaPro: 1.515 ± 0.347
3.45AlaGln: 3.45 ± 0.707
2.777AlaArg: 2.777 ± 0.386
5.133AlaSer: 5.133 ± 0.889
4.46AlaThr: 4.46 ± 0.86
4.965AlaVal: 4.965 ± 0.771
0.673AlaTrp: 0.673 ± 0.209
2.02AlaTyr: 2.02 ± 0.359
0.0AlaXaa: 0.0 ± 0.0
Cys
0.252CysAla: 0.252 ± 0.149
0.084CysCys: 0.084 ± 0.076
0.337CysAsp: 0.337 ± 0.196
0.841CysGlu: 0.841 ± 0.292
0.421CysPhe: 0.421 ± 0.205
1.01CysGly: 1.01 ± 0.33
0.084CysHis: 0.084 ± 0.077
0.168CysIle: 0.168 ± 0.115
0.168CysLys: 0.168 ± 0.116
0.421CysLeu: 0.421 ± 0.173
0.168CysMet: 0.168 ± 0.122
0.168CysAsn: 0.168 ± 0.112
0.084CysPro: 0.084 ± 0.087
0.252CysGln: 0.252 ± 0.157
0.337CysArg: 0.337 ± 0.147
0.168CysSer: 0.168 ± 0.097
0.252CysThr: 0.252 ± 0.142
0.421CysVal: 0.421 ± 0.253
0.168CysTrp: 0.168 ± 0.114
0.168CysTyr: 0.168 ± 0.109
0.0CysXaa: 0.0 ± 0.0
Asp
3.618AspAla: 3.618 ± 0.47
0.589AspCys: 0.589 ± 0.217
4.544AspAsp: 4.544 ± 0.548
5.722AspGlu: 5.722 ± 0.865
3.113AspPhe: 3.113 ± 0.462
5.049AspGly: 5.049 ± 0.704
0.589AspHis: 0.589 ± 0.199
4.123AspIle: 4.123 ± 0.729
6.227AspLys: 6.227 ± 0.587
7.237AspLeu: 7.237 ± 0.717
1.851AspMet: 1.851 ± 0.359
4.46AspAsn: 4.46 ± 0.514
1.515AspPro: 1.515 ± 0.379
0.926AspGln: 0.926 ± 0.288
2.188AspArg: 2.188 ± 0.341
3.871AspSer: 3.871 ± 0.584
3.702AspThr: 3.702 ± 0.511
4.291AspVal: 4.291 ± 0.56
0.757AspTrp: 0.757 ± 0.252
2.777AspTyr: 2.777 ± 0.52
0.0AspXaa: 0.0 ± 0.0
Glu
5.217GluAla: 5.217 ± 0.777
0.505GluCys: 0.505 ± 0.23
4.123GluAsp: 4.123 ± 0.768
5.89GluGlu: 5.89 ± 0.765
3.113GluPhe: 3.113 ± 0.442
2.524GluGly: 2.524 ± 0.4
1.178GluHis: 1.178 ± 0.393
6.648GluIle: 6.648 ± 0.804
6.311GluLys: 6.311 ± 0.704
7.573GluLeu: 7.573 ± 0.7
2.02GluMet: 2.02 ± 0.405
2.777GluAsn: 2.777 ± 0.49
1.767GluPro: 1.767 ± 0.304
3.534GluGln: 3.534 ± 0.45
3.198GluArg: 3.198 ± 0.667
4.376GluSer: 4.376 ± 0.624
4.544GluThr: 4.544 ± 0.695
5.217GluVal: 5.217 ± 0.855
1.01GluTrp: 1.01 ± 0.264
2.693GluTyr: 2.693 ± 0.451
0.0GluXaa: 0.0 ± 0.0
Phe
3.029PheAla: 3.029 ± 0.471
0.252PheCys: 0.252 ± 0.16
3.198PheAsp: 3.198 ± 0.615
3.113PheGlu: 3.113 ± 0.539
0.926PhePhe: 0.926 ± 0.38
3.029PheGly: 3.029 ± 0.518
0.168PheHis: 0.168 ± 0.099
2.272PheIle: 2.272 ± 0.531
3.871PheLys: 3.871 ± 0.598
2.44PheLeu: 2.44 ± 0.54
1.094PheMet: 1.094 ± 0.265
2.44PheAsn: 2.44 ± 0.492
0.841PhePro: 0.841 ± 0.254
0.926PheGln: 0.926 ± 0.224
1.851PheArg: 1.851 ± 0.475
3.029PheSer: 3.029 ± 0.516
2.356PheThr: 2.356 ± 0.487
2.02PheVal: 2.02 ± 0.387
0.505PheTrp: 0.505 ± 0.208
1.43PheTyr: 1.43 ± 0.369
0.0PheXaa: 0.0 ± 0.0
Gly
3.534GlyAla: 3.534 ± 0.649
0.589GlyCys: 0.589 ± 0.22
4.207GlyAsp: 4.207 ± 0.655
3.702GlyGlu: 3.702 ± 0.557
2.356GlyPhe: 2.356 ± 0.451
4.796GlyGly: 4.796 ± 0.742
0.841GlyHis: 0.841 ± 0.226
4.712GlyIle: 4.712 ± 0.607
5.974GlyLys: 5.974 ± 0.708
5.217GlyLeu: 5.217 ± 0.894
1.935GlyMet: 1.935 ± 0.445
4.039GlyAsn: 4.039 ± 0.559
0.841GlyPro: 0.841 ± 0.314
2.693GlyGln: 2.693 ± 0.414
2.777GlyArg: 2.777 ± 0.456
3.366GlySer: 3.366 ± 0.549
3.282GlyThr: 3.282 ± 0.589
5.049GlyVal: 5.049 ± 0.43
1.262GlyTrp: 1.262 ± 0.414
3.702GlyTyr: 3.702 ± 0.733
0.0GlyXaa: 0.0 ± 0.0
His
0.926HisAla: 0.926 ± 0.359
0.084HisCys: 0.084 ± 0.078
0.926HisAsp: 0.926 ± 0.417
1.178HisGlu: 1.178 ± 0.287
0.589HisPhe: 0.589 ± 0.224
0.757HisGly: 0.757 ± 0.248
0.0HisHis: 0.0 ± 0.0
0.926HisIle: 0.926 ± 0.301
0.673HisLys: 0.673 ± 0.245
0.841HisLeu: 0.841 ± 0.271
0.168HisMet: 0.168 ± 0.118
0.757HisAsn: 0.757 ± 0.199
0.421HisPro: 0.421 ± 0.163
0.505HisGln: 0.505 ± 0.194
0.589HisArg: 0.589 ± 0.172
0.589HisSer: 0.589 ± 0.269
0.926HisThr: 0.926 ± 0.343
0.841HisVal: 0.841 ± 0.209
0.337HisTrp: 0.337 ± 0.159
0.757HisTyr: 0.757 ± 0.303
0.0HisXaa: 0.0 ± 0.0
Ile
4.376IleAla: 4.376 ± 0.601
0.337IleCys: 0.337 ± 0.172
5.974IleAsp: 5.974 ± 1.029
6.227IleGlu: 6.227 ± 0.703
2.02IlePhe: 2.02 ± 0.423
3.787IleGly: 3.787 ± 0.702
1.01IleHis: 1.01 ± 0.223
4.376IleIle: 4.376 ± 0.688
7.742IleLys: 7.742 ± 0.834
6.227IleLeu: 6.227 ± 0.852
1.094IleMet: 1.094 ± 0.27
5.049IleAsn: 5.049 ± 0.77
1.515IlePro: 1.515 ± 0.375
1.851IleGln: 1.851 ± 0.387
2.524IleArg: 2.524 ± 0.445
4.46IleSer: 4.46 ± 0.741
5.301IleThr: 5.301 ± 0.706
3.618IleVal: 3.618 ± 0.461
0.673IleTrp: 0.673 ± 0.27
2.945IleTyr: 2.945 ± 0.486
0.0IleXaa: 0.0 ± 0.0
Lys
6.732LysAla: 6.732 ± 0.99
0.421LysCys: 0.421 ± 0.187
6.059LysAsp: 6.059 ± 0.948
7.237LysGlu: 7.237 ± 0.819
2.945LysPhe: 2.945 ± 0.489
4.796LysGly: 4.796 ± 0.798
1.515LysHis: 1.515 ± 0.331
7.742LysIle: 7.742 ± 1.078
8.751LysLys: 8.751 ± 0.981
6.816LysLeu: 6.816 ± 0.885
2.104LysMet: 2.104 ± 0.345
5.385LysAsn: 5.385 ± 0.682
2.777LysPro: 2.777 ± 0.517
4.376LysGln: 4.376 ± 0.525
3.029LysArg: 3.029 ± 0.629
4.628LysSer: 4.628 ± 0.609
5.638LysThr: 5.638 ± 0.81
5.385LysVal: 5.385 ± 0.604
0.589LysTrp: 0.589 ± 0.173
3.366LysTyr: 3.366 ± 0.535
0.0LysXaa: 0.0 ± 0.0
Leu
6.395LeuAla: 6.395 ± 0.964
0.421LeuCys: 0.421 ± 0.191
6.9LeuAsp: 6.9 ± 0.649
7.489LeuGlu: 7.489 ± 0.94
3.45LeuPhe: 3.45 ± 0.602
5.806LeuGly: 5.806 ± 0.83
0.673LeuHis: 0.673 ± 0.286
6.059LeuIle: 6.059 ± 0.984
8.583LeuLys: 8.583 ± 1.01
6.816LeuLeu: 6.816 ± 0.723
1.683LeuMet: 1.683 ± 0.37
5.385LeuAsn: 5.385 ± 0.653
2.356LeuPro: 2.356 ± 0.387
3.534LeuGln: 3.534 ± 0.655
3.955LeuArg: 3.955 ± 0.515
5.133LeuSer: 5.133 ± 0.747
5.133LeuThr: 5.133 ± 0.643
4.796LeuVal: 4.796 ± 0.537
0.337LeuTrp: 0.337 ± 0.173
2.524LeuTyr: 2.524 ± 0.414
0.0LeuXaa: 0.0 ± 0.0
Met
1.935MetAla: 1.935 ± 0.418
0.0MetCys: 0.0 ± 0.0
1.346MetAsp: 1.346 ± 0.399
1.262MetGlu: 1.262 ± 0.321
1.094MetPhe: 1.094 ± 0.306
1.262MetGly: 1.262 ± 0.276
0.252MetHis: 0.252 ± 0.162
2.104MetIle: 2.104 ± 0.481
1.683MetLys: 1.683 ± 0.314
2.02MetLeu: 2.02 ± 0.437
0.421MetMet: 0.421 ± 0.196
1.094MetAsn: 1.094 ± 0.276
0.841MetPro: 0.841 ± 0.22
0.926MetGln: 0.926 ± 0.242
1.599MetArg: 1.599 ± 0.353
2.104MetSer: 2.104 ± 0.444
2.188MetThr: 2.188 ± 0.498
1.094MetVal: 1.094 ± 0.383
0.084MetTrp: 0.084 ± 0.093
0.589MetTyr: 0.589 ± 0.247
0.0MetXaa: 0.0 ± 0.0
Asn
3.45AsnAla: 3.45 ± 0.67
0.0AsnCys: 0.0 ± 0.0
3.45AsnAsp: 3.45 ± 0.48
3.534AsnGlu: 3.534 ± 0.529
2.524AsnPhe: 2.524 ± 0.415
4.544AsnGly: 4.544 ± 0.693
0.589AsnHis: 0.589 ± 0.257
3.702AsnIle: 3.702 ± 0.682
4.712AsnLys: 4.712 ± 0.67
5.385AsnLeu: 5.385 ± 0.57
1.599AsnMet: 1.599 ± 0.357
3.113AsnAsn: 3.113 ± 0.562
2.44AsnPro: 2.44 ± 0.456
2.693AsnGln: 2.693 ± 0.559
2.188AsnArg: 2.188 ± 0.459
3.534AsnSer: 3.534 ± 0.597
2.777AsnThr: 2.777 ± 0.476
3.366AsnVal: 3.366 ± 0.425
0.757AsnTrp: 0.757 ± 0.26
2.104AsnTyr: 2.104 ± 0.492
0.0AsnXaa: 0.0 ± 0.0
Pro
1.515ProAla: 1.515 ± 0.473
0.168ProCys: 0.168 ± 0.116
1.935ProAsp: 1.935 ± 0.36
1.851ProGlu: 1.851 ± 0.456
1.515ProPhe: 1.515 ± 0.34
0.589ProGly: 0.589 ± 0.243
0.589ProHis: 0.589 ± 0.208
1.767ProIle: 1.767 ± 0.332
2.861ProLys: 2.861 ± 0.536
2.609ProLeu: 2.609 ± 0.576
0.421ProMet: 0.421 ± 0.219
1.515ProAsn: 1.515 ± 0.472
0.589ProPro: 0.589 ± 0.18
1.01ProGln: 1.01 ± 0.283
0.841ProArg: 0.841 ± 0.273
1.43ProSer: 1.43 ± 0.355
2.02ProThr: 2.02 ± 0.388
1.262ProVal: 1.262 ± 0.366
0.084ProTrp: 0.084 ± 0.087
1.599ProTyr: 1.599 ± 0.482
0.0ProXaa: 0.0 ± 0.0
Gln
2.524GlnAla: 2.524 ± 0.455
0.337GlnCys: 0.337 ± 0.203
1.767GlnAsp: 1.767 ± 0.322
3.282GlnGlu: 3.282 ± 0.557
2.02GlnPhe: 2.02 ± 0.374
2.104GlnGly: 2.104 ± 0.38
0.421GlnHis: 0.421 ± 0.187
3.198GlnIle: 3.198 ± 0.483
3.534GlnLys: 3.534 ± 0.564
4.712GlnLeu: 4.712 ± 0.798
1.515GlnMet: 1.515 ± 0.393
2.609GlnAsn: 2.609 ± 0.527
0.421GlnPro: 0.421 ± 0.2
1.515GlnGln: 1.515 ± 0.55
1.599GlnArg: 1.599 ± 0.396
3.198GlnSer: 3.198 ± 0.535
2.188GlnThr: 2.188 ± 0.445
1.094GlnVal: 1.094 ± 0.29
0.589GlnTrp: 0.589 ± 0.251
1.262GlnTyr: 1.262 ± 0.318
0.0GlnXaa: 0.0 ± 0.0
Arg
3.198ArgAla: 3.198 ± 0.505
0.421ArgCys: 0.421 ± 0.202
2.609ArgAsp: 2.609 ± 0.547
2.861ArgGlu: 2.861 ± 0.431
1.262ArgPhe: 1.262 ± 0.286
3.029ArgGly: 3.029 ± 0.524
0.673ArgHis: 0.673 ± 0.285
3.029ArgIle: 3.029 ± 0.403
3.198ArgLys: 3.198 ± 0.587
3.702ArgLeu: 3.702 ± 0.527
0.505ArgMet: 0.505 ± 0.201
2.44ArgAsn: 2.44 ± 0.441
0.589ArgPro: 0.589 ± 0.246
2.272ArgGln: 2.272 ± 0.377
2.02ArgArg: 2.02 ± 0.489
1.767ArgSer: 1.767 ± 0.352
2.524ArgThr: 2.524 ± 0.476
2.188ArgVal: 2.188 ± 0.476
0.421ArgTrp: 0.421 ± 0.19
1.767ArgTyr: 1.767 ± 0.397
0.0ArgXaa: 0.0 ± 0.0
Ser
4.796SerAla: 4.796 ± 0.987
0.084SerCys: 0.084 ± 0.093
4.628SerAsp: 4.628 ± 0.599
4.039SerGlu: 4.039 ± 0.502
2.945SerPhe: 2.945 ± 0.546
4.965SerGly: 4.965 ± 0.745
1.262SerHis: 1.262 ± 0.372
4.291SerIle: 4.291 ± 0.631
4.965SerLys: 4.965 ± 0.659
3.955SerLeu: 3.955 ± 0.627
1.43SerMet: 1.43 ± 0.328
3.366SerAsn: 3.366 ± 0.504
1.683SerPro: 1.683 ± 0.43
3.113SerGln: 3.113 ± 0.536
2.188SerArg: 2.188 ± 0.413
3.702SerSer: 3.702 ± 0.699
2.524SerThr: 2.524 ± 0.575
3.534SerVal: 3.534 ± 0.536
0.926SerTrp: 0.926 ± 0.333
2.861SerTyr: 2.861 ± 0.563
0.0SerXaa: 0.0 ± 0.0
Thr
5.89ThrAla: 5.89 ± 1.071
0.168ThrCys: 0.168 ± 0.109
3.45ThrAsp: 3.45 ± 0.519
2.777ThrGlu: 2.777 ± 0.511
2.609ThrPhe: 2.609 ± 0.456
5.638ThrGly: 5.638 ± 0.631
0.841ThrHis: 0.841 ± 0.291
3.871ThrIle: 3.871 ± 0.498
4.544ThrLys: 4.544 ± 0.462
4.965ThrLeu: 4.965 ± 0.497
1.262ThrMet: 1.262 ± 0.399
2.861ThrAsn: 2.861 ± 0.44
2.693ThrPro: 2.693 ± 0.416
2.356ThrGln: 2.356 ± 0.507
2.104ThrArg: 2.104 ± 0.327
4.123ThrSer: 4.123 ± 0.649
4.207ThrThr: 4.207 ± 0.475
3.787ThrVal: 3.787 ± 0.558
0.757ThrTrp: 0.757 ± 0.164
1.683ThrTyr: 1.683 ± 0.385
0.0ThrXaa: 0.0 ± 0.0
Val
4.039ValAla: 4.039 ± 0.974
0.337ValCys: 0.337 ± 0.215
3.702ValAsp: 3.702 ± 0.589
5.133ValGlu: 5.133 ± 0.687
2.356ValPhe: 2.356 ± 0.487
4.376ValGly: 4.376 ± 0.547
0.841ValHis: 0.841 ± 0.335
3.534ValIle: 3.534 ± 0.542
5.638ValLys: 5.638 ± 0.792
5.89ValLeu: 5.89 ± 0.764
1.515ValMet: 1.515 ± 0.336
3.618ValAsn: 3.618 ± 0.574
1.599ValPro: 1.599 ± 0.253
1.094ValGln: 1.094 ± 0.31
2.272ValArg: 2.272 ± 0.397
3.955ValSer: 3.955 ± 0.565
4.039ValThr: 4.039 ± 0.524
3.955ValVal: 3.955 ± 0.5
0.252ValTrp: 0.252 ± 0.144
1.683ValTyr: 1.683 ± 0.384
0.0ValXaa: 0.0 ± 0.0
Trp
0.421TrpAla: 0.421 ± 0.164
0.084TrpCys: 0.084 ± 0.072
0.841TrpAsp: 0.841 ± 0.259
0.421TrpGlu: 0.421 ± 0.212
0.589TrpPhe: 0.589 ± 0.211
0.757TrpGly: 0.757 ± 0.285
0.168TrpHis: 0.168 ± 0.114
1.094TrpIle: 1.094 ± 0.28
1.178TrpLys: 1.178 ± 0.254
0.926TrpLeu: 0.926 ± 0.316
0.084TrpMet: 0.084 ± 0.076
0.337TrpAsn: 0.337 ± 0.147
0.337TrpPro: 0.337 ± 0.161
0.421TrpGln: 0.421 ± 0.18
0.505TrpArg: 0.505 ± 0.24
0.757TrpSer: 0.757 ± 0.195
0.589TrpThr: 0.589 ± 0.204
0.589TrpVal: 0.589 ± 0.203
0.0TrpTrp: 0.0 ± 0.0
0.589TrpTyr: 0.589 ± 0.195
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.945TyrAla: 2.945 ± 0.479
0.673TyrCys: 0.673 ± 0.244
2.945TyrAsp: 2.945 ± 0.545
2.609TyrGlu: 2.609 ± 0.519
1.515TyrPhe: 1.515 ± 0.362
1.767TyrGly: 1.767 ± 0.404
0.421TyrHis: 0.421 ± 0.176
2.104TyrIle: 2.104 ± 0.609
3.45TyrLys: 3.45 ± 0.569
3.113TyrLeu: 3.113 ± 0.475
0.926TyrMet: 0.926 ± 0.245
1.515TyrAsn: 1.515 ± 0.447
1.346TyrPro: 1.346 ± 0.433
2.44TyrGln: 2.44 ± 0.553
1.935TyrArg: 1.935 ± 0.352
2.02TyrSer: 2.02 ± 0.416
1.935TyrThr: 1.935 ± 0.458
2.356TyrVal: 2.356 ± 0.414
0.505TyrTrp: 0.505 ± 0.159
2.02TyrTyr: 2.02 ± 0.34
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 59 proteins (11885 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski