Amino acid dipepetide frequency for halophilic archaeon J07HX5

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.172AlaAla: 16.172 ± 0.284	0.866AlaCys: 0.866 ± 0.046	9.639AlaAsp: 9.639 ± 0.147	7.917AlaGlu: 7.917 ± 0.155	3.541AlaPhe: 3.541 ± 0.079	10.687AlaGly: 10.687 ± 0.173	2.031AlaHis: 2.031 ± 0.07	4.601AlaIle: 4.601 ± 0.09	1.574AlaLys: 1.574 ± 0.067	9.72AlaLeu: 9.72 ± 0.154	1.846AlaMet: 1.846 ± 0.061	2.634AlaAsn: 2.634 ± 0.086	4.438AlaPro: 4.438 ± 0.105	2.796AlaGln: 2.796 ± 0.09	6.452AlaArg: 6.452 ± 0.123	5.627AlaSer: 5.627 ± 0.112	8.421AlaThr: 8.421 ± 0.136	12.411AlaVal: 12.411 ± 0.168	1.111AlaTrp: 1.111 ± 0.051	2.629AlaTyr: 2.629 ± 0.071	0.037AlaXaa: 0.037 ± 0.008
Cys	0.786CysAla: 0.786 ± 0.048	0.185CysCys: 0.185 ± 0.024	0.663CysAsp: 0.663 ± 0.037	0.603CysGlu: 0.603 ± 0.041	0.183CysPhe: 0.183 ± 0.019	0.909CysGly: 0.909 ± 0.049	0.257CysHis: 0.257 ± 0.023	0.298CysIle: 0.298 ± 0.027	0.128CysLys: 0.128 ± 0.016	0.802CysLeu: 0.802 ± 0.044	0.169CysMet: 0.169 ± 0.018	0.218CysAsn: 0.218 ± 0.024	0.65CysPro: 0.65 ± 0.039	0.307CysGln: 0.307 ± 0.026	0.741CysArg: 0.741 ± 0.043	0.679CysSer: 0.679 ± 0.038	0.477CysThr: 0.477 ± 0.032	0.681CysVal: 0.681 ± 0.045	0.119CysTrp: 0.119 ± 0.016	0.187CysTyr: 0.187 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	8.259AspAla: 8.259 ± 0.153	0.728AspCys: 0.728 ± 0.037	5.864AspAsp: 5.864 ± 0.156	6.15AspGlu: 6.15 ± 0.128	1.179AspPhe: 1.179 ± 0.053	6.864AspGly: 6.864 ± 0.13	1.73AspHis: 1.73 ± 0.06	2.843AspIle: 2.843 ± 0.081	1.115AspLys: 1.115 ± 0.055	5.362AspLeu: 5.362 ± 0.113	1.06AspMet: 1.06 ± 0.051	1.669AspAsn: 1.669 ± 0.061	4.405AspPro: 4.405 ± 0.087	2.969AspGln: 2.969 ± 0.078	7.45AspArg: 7.45 ± 0.137	3.611AspSer: 3.611 ± 0.086	5.288AspThr: 5.288 ± 0.106	5.094AspVal: 5.094 ± 0.1	1.035AspTrp: 1.035 ± 0.046	1.37AspTyr: 1.37 ± 0.05	0.029AspXaa: 0.029 ± 0.007
Glu	7.092GluAla: 7.092 ± 0.134	0.543GluCys: 0.543 ± 0.039	3.623GluAsp: 3.623 ± 0.114	3.981GluGlu: 3.981 ± 0.117	2.469GluPhe: 2.469 ± 0.081	3.625GluGly: 3.625 ± 0.086	1.815GluHis: 1.815 ± 0.067	3.524GluIle: 3.524 ± 0.09	1.36GluLys: 1.36 ± 0.064	8.041GluLeu: 8.041 ± 0.143	1.49GluMet: 1.49 ± 0.061	1.883GluAsn: 1.883 ± 0.073	3.778GluPro: 3.778 ± 0.093	4.037GluGln: 4.037 ± 0.107	6.127GluArg: 6.127 ± 0.139	4.271GluSer: 4.271 ± 0.099	7.662GluThr: 7.662 ± 0.125	4.043GluVal: 4.043 ± 0.115	0.926GluTrp: 0.926 ± 0.046	2.432GluTyr: 2.432 ± 0.072	0.01GluXaa: 0.01 ± 0.005
Phe	3.247PheAla: 3.247 ± 0.085	0.261PheCys: 0.261 ± 0.022	2.664PheAsp: 2.664 ± 0.076	2.72PheGlu: 2.72 ± 0.085	0.874PhePhe: 0.874 ± 0.046	2.699PheGly: 2.699 ± 0.087	0.545PheHis: 0.545 ± 0.034	1.045PheIle: 1.045 ± 0.047	0.467PheLys: 0.467 ± 0.033	2.401PheLeu: 2.401 ± 0.073	0.428PheMet: 0.428 ± 0.03	0.749PheAsn: 0.749 ± 0.036	1.191PhePro: 1.191 ± 0.049	0.794PheGln: 0.794 ± 0.047	1.695PheArg: 1.695 ± 0.062	1.638PheSer: 1.638 ± 0.062	1.829PheThr: 1.829 ± 0.078	2.741PheVal: 2.741 ± 0.076	0.379PheTrp: 0.379 ± 0.027	0.749PheTyr: 0.749 ± 0.041	0.006PheXaa: 0.006 ± 0.003
Gly	8.602GlyAla: 8.602 ± 0.141	0.848GlyCys: 0.848 ± 0.044	5.646GlyAsp: 5.646 ± 0.117	5.712GlyGlu: 5.712 ± 0.122	2.634GlyPhe: 2.634 ± 0.082	6.627GlyGly: 6.627 ± 0.131	1.73GlyHis: 1.73 ± 0.064	3.872GlyIle: 3.872 ± 0.103	1.619GlyLys: 1.619 ± 0.065	7.783GlyLeu: 7.783 ± 0.15	1.418GlyMet: 1.418 ± 0.056	1.683GlyAsn: 1.683 ± 0.064	3.631GlyPro: 3.631 ± 0.088	2.594GlyGln: 2.594 ± 0.072	5.175GlyArg: 5.175 ± 0.114	4.87GlySer: 4.87 ± 0.107	6.018GlyThr: 6.018 ± 0.13	7.74GlyVal: 7.74 ± 0.165	1.074GlyTrp: 1.074 ± 0.05	2.465GlyTyr: 2.465 ± 0.074	0.023GlyXaa: 0.023 ± 0.006
His	2.261HisAla: 2.261 ± 0.072	0.243HisCys: 0.243 ± 0.023	1.784HisAsp: 1.784 ± 0.069	1.681HisGlu: 1.681 ± 0.061	0.385HisPhe: 0.385 ± 0.028	1.938HisGly: 1.938 ± 0.067	0.527HisHis: 0.527 ± 0.035	0.776HisIle: 0.776 ± 0.043	0.372HisLys: 0.372 ± 0.026	1.451HisLeu: 1.451 ± 0.055	0.292HisMet: 0.292 ± 0.022	0.603HisAsn: 0.603 ± 0.042	1.226HisPro: 1.226 ± 0.049	0.593HisGln: 0.593 ± 0.035	1.44HisArg: 1.44 ± 0.049	1.152HisSer: 1.152 ± 0.049	1.348HisThr: 1.348 ± 0.053	1.502HisVal: 1.502 ± 0.057	0.216HisTrp: 0.216 ± 0.022	0.453HisTyr: 0.453 ± 0.03	0.006HisXaa: 0.006 ± 0.003
Ile	5.096IleAla: 5.096 ± 0.105	0.377IleCys: 0.377 ± 0.028	4.123IleAsp: 4.123 ± 0.109	4.197IleGlu: 4.197 ± 0.122	0.848IlePhe: 0.848 ± 0.047	4.024IleGly: 4.024 ± 0.102	0.782IleHis: 0.782 ± 0.041	1.632IleIle: 1.632 ± 0.061	0.903IleLys: 0.903 ± 0.049	2.531IleLeu: 2.531 ± 0.079	0.529IleMet: 0.529 ± 0.036	1.183IleAsn: 1.183 ± 0.057	1.78IlePro: 1.78 ± 0.062	1.175IleGln: 1.175 ± 0.055	2.306IleArg: 2.306 ± 0.071	2.101IleSer: 2.101 ± 0.066	2.802IleThr: 2.802 ± 0.078	3.648IleVal: 3.648 ± 0.097	0.311IleTrp: 0.311 ± 0.025	0.819IleTyr: 0.819 ± 0.042	0.01IleXaa: 0.01 ± 0.004
Lys	1.543LysAla: 1.543 ± 0.062	0.136LysCys: 0.136 ± 0.018	0.874LysAsp: 0.874 ± 0.047	0.979LysGlu: 0.979 ± 0.052	0.411LysPhe: 0.411 ± 0.033	1.0LysGly: 1.0 ± 0.047	0.469LysHis: 0.469 ± 0.031	0.905LysIle: 0.905 ± 0.045	0.488LysLys: 0.488 ± 0.036	1.771LysLeu: 1.771 ± 0.062	0.335LysMet: 0.335 ± 0.027	0.537LysAsn: 0.537 ± 0.036	0.971LysPro: 0.971 ± 0.042	1.181LysGln: 1.181 ± 0.054	1.634LysArg: 1.634 ± 0.07	1.088LysSer: 1.088 ± 0.053	1.697LysThr: 1.697 ± 0.064	0.811LysVal: 0.811 ± 0.044	0.142LysTrp: 0.142 ± 0.017	0.477LysTyr: 0.477 ± 0.03	0.004LysXaa: 0.004 ± 0.003
Leu	11.228LeuAla: 11.228 ± 0.186	0.825LeuCys: 0.825 ± 0.045	6.111LeuAsp: 6.111 ± 0.111	6.345LeuGlu: 6.345 ± 0.141	3.045LeuPhe: 3.045 ± 0.074	7.246LeuGly: 7.246 ± 0.148	1.416LeuHis: 1.416 ± 0.056	3.415LeuIle: 3.415 ± 0.086	1.584LeuLys: 1.584 ± 0.053	8.189LeuLeu: 8.189 ± 0.155	1.218LeuMet: 1.218 ± 0.053	2.121LeuAsn: 2.121 ± 0.061	4.339LeuPro: 4.339 ± 0.095	2.453LeuGln: 2.453 ± 0.075	5.845LeuArg: 5.845 ± 0.1	6.039LeuSer: 6.039 ± 0.122	6.253LeuThr: 6.253 ± 0.126	7.732LeuVal: 7.732 ± 0.137	0.802LeuTrp: 0.802 ± 0.041	2.068LeuTyr: 2.068 ± 0.064	0.019LeuXaa: 0.019 ± 0.006
Met	1.64MetAla: 1.64 ± 0.058	0.185MetCys: 0.185 ± 0.019	0.918MetAsp: 0.918 ± 0.041	0.831MetGlu: 0.831 ± 0.042	0.438MetPhe: 0.438 ± 0.03	1.125MetGly: 1.125 ± 0.052	0.29MetHis: 0.29 ± 0.022	0.757MetIle: 0.757 ± 0.041	0.321MetLys: 0.321 ± 0.027	1.619MetLeu: 1.619 ± 0.059	0.276MetMet: 0.276 ± 0.027	0.547MetAsn: 0.547 ± 0.032	0.856MetPro: 0.856 ± 0.045	0.539MetGln: 0.539 ± 0.034	0.994MetArg: 0.994 ± 0.046	1.592MetSer: 1.592 ± 0.053	1.685MetThr: 1.685 ± 0.055	1.012MetVal: 1.012 ± 0.049	0.148MetTrp: 0.148 ± 0.019	0.36MetTyr: 0.36 ± 0.028	0.004MetXaa: 0.004 ± 0.003
Asn	2.845AsnAla: 2.845 ± 0.071	0.245AsnCys: 0.245 ± 0.024	1.611AsnAsp: 1.611 ± 0.055	1.765AsnGlu: 1.765 ± 0.067	0.605AsnPhe: 0.605 ± 0.04	2.121AsnGly: 2.121 ± 0.071	0.549AsnHis: 0.549 ± 0.032	1.039AsnIle: 1.039 ± 0.046	0.673AsnLys: 0.673 ± 0.038	1.792AsnLeu: 1.792 ± 0.059	0.457AsnMet: 0.457 ± 0.035	0.953AsnAsn: 0.953 ± 0.052	1.43AsnPro: 1.43 ± 0.052	0.87AsnGln: 0.87 ± 0.043	1.827AsnArg: 1.827 ± 0.059	1.292AsnSer: 1.292 ± 0.047	1.739AsnThr: 1.739 ± 0.074	1.981AsnVal: 1.981 ± 0.065	0.313AsnTrp: 0.313 ± 0.026	0.625AsnTyr: 0.625 ± 0.037	0.004AsnXaa: 0.004 ± 0.003
Pro	6.304ProAla: 6.304 ± 0.132	0.339ProCys: 0.339 ± 0.025	4.483ProAsp: 4.483 ± 0.114	3.932ProGlu: 3.932 ± 0.092	1.35ProPhe: 1.35 ± 0.05	4.187ProGly: 4.187 ± 0.104	0.813ProHis: 0.813 ± 0.045	1.753ProIle: 1.753 ± 0.057	0.708ProLys: 0.708 ± 0.038	3.452ProLeu: 3.452 ± 0.094	0.817ProMet: 0.817 ± 0.046	1.082ProAsn: 1.082 ± 0.045	2.475ProPro: 2.475 ± 0.071	1.226ProGln: 1.226 ± 0.051	2.531ProArg: 2.531 ± 0.07	2.839ProSer: 2.839 ± 0.078	4.078ProThr: 4.078 ± 0.094	4.812ProVal: 4.812 ± 0.089	0.502ProTrp: 0.502 ± 0.029	1.08ProTyr: 1.08 ± 0.051	0.029ProXaa: 0.029 ± 0.007
Gln	3.856GlnAla: 3.856 ± 0.091	0.27GlnCys: 0.27 ± 0.024	1.496GlnAsp: 1.496 ± 0.057	1.792GlnGlu: 1.792 ± 0.068	1.422GlnPhe: 1.422 ± 0.059	1.671GlnGly: 1.671 ± 0.065	0.706GlnHis: 0.706 ± 0.039	1.615GlnIle: 1.615 ± 0.061	0.593GlnLys: 0.593 ± 0.033	3.631GlnLeu: 3.631 ± 0.096	0.634GlnMet: 0.634 ± 0.04	0.821GlnAsn: 0.821 ± 0.041	1.755GlnPro: 1.755 ± 0.055	1.683GlnGln: 1.683 ± 0.075	2.597GlnArg: 2.597 ± 0.089	2.352GlnSer: 2.352 ± 0.076	3.169GlnThr: 3.169 ± 0.082	2.202GlnVal: 2.202 ± 0.06	0.358GlnTrp: 0.358 ± 0.03	1.123GlnTyr: 1.123 ± 0.045	0.012GlnXaa: 0.012 ± 0.005
Arg	7.055ArgAla: 7.055 ± 0.139	0.7ArgCys: 0.7 ± 0.042	4.465ArgAsp: 4.465 ± 0.113	5.514ArgGlu: 5.514 ± 0.131	1.961ArgPhe: 1.961 ± 0.065	4.59ArgGly: 4.59 ± 0.105	1.485ArgHis: 1.485 ± 0.057	2.88ArgIle: 2.88 ± 0.084	1.232ArgLys: 1.232 ± 0.05	7.349ArgLeu: 7.349 ± 0.127	1.226ArgMet: 1.226 ± 0.049	1.498ArgAsn: 1.498 ± 0.054	3.059ArgPro: 3.059 ± 0.082	2.722ArgGln: 2.722 ± 0.087	5.751ArgArg: 5.751 ± 0.154	4.364ArgSer: 4.364 ± 0.101	4.339ArgThr: 4.339 ± 0.099	5.539ArgVal: 5.539 ± 0.122	0.827ArgTrp: 0.827 ± 0.041	1.852ArgTyr: 1.852 ± 0.064	0.033ArgXaa: 0.033 ± 0.009
Ser	5.784SerAla: 5.784 ± 0.112	0.541SerCys: 0.541 ± 0.037	3.889SerAsp: 3.889 ± 0.086	3.957SerGlu: 3.957 ± 0.086	1.944SerPhe: 1.944 ± 0.063	5.253SerGly: 5.253 ± 0.112	1.09SerHis: 1.09 ± 0.052	2.226SerIle: 2.226 ± 0.062	1.321SerLys: 1.321 ± 0.056	5.1SerLeu: 5.1 ± 0.107	1.105SerMet: 1.105 ± 0.05	1.479SerAsn: 1.479 ± 0.06	2.856SerPro: 2.856 ± 0.082	1.924SerGln: 1.924 ± 0.065	3.644SerArg: 3.644 ± 0.092	3.444SerSer: 3.444 ± 0.104	3.969SerThr: 3.969 ± 0.101	5.734SerVal: 5.734 ± 0.119	0.693SerTrp: 0.693 ± 0.04	1.607SerTyr: 1.607 ± 0.065	0.035SerXaa: 0.035 ± 0.009
Thr	9.761ThrAla: 9.761 ± 0.161	0.411ThrCys: 0.411 ± 0.031	6.81ThrAsp: 6.81 ± 0.124	5.24ThrGlu: 5.24 ± 0.113	1.848ThrPhe: 1.848 ± 0.056	6.806ThrGly: 6.806 ± 0.123	1.545ThrHis: 1.545 ± 0.058	3.218ThrIle: 3.218 ± 0.083	1.072ThrLys: 1.072 ± 0.051	6.045ThrLeu: 6.045 ± 0.114	1.076ThrMet: 1.076 ± 0.048	1.979ThrAsn: 1.979 ± 0.068	4.088ThrPro: 4.088 ± 0.099	2.29ThrGln: 2.29 ± 0.084	4.004ThrArg: 4.004 ± 0.096	3.29ThrSer: 3.29 ± 0.081	5.786ThrThr: 5.786 ± 0.119	8.604ThrVal: 8.604 ± 0.143	0.558ThrTrp: 0.558 ± 0.037	1.451ThrTyr: 1.451 ± 0.054	0.035ThrXaa: 0.035 ± 0.008
Val	10.045ValAla: 10.045 ± 0.168	0.903ValCys: 0.903 ± 0.042	6.541ValAsp: 6.541 ± 0.12	6.722ValGlu: 6.722 ± 0.127	2.769ValPhe: 2.769 ± 0.077	7.732ValGly: 7.732 ± 0.143	1.65ValHis: 1.65 ± 0.058	3.555ValIle: 3.555 ± 0.085	1.175ValLys: 1.175 ± 0.059	7.656ValLeu: 7.656 ± 0.169	1.224ValMet: 1.224 ± 0.048	1.992ValAsn: 1.992 ± 0.074	4.208ValPro: 4.208 ± 0.105	2.261ValGln: 2.261 ± 0.073	5.45ValArg: 5.45 ± 0.114	5.405ValSer: 5.405 ± 0.117	6.886ValThr: 6.886 ± 0.128	8.67ValVal: 8.67 ± 0.162	0.792ValTrp: 0.792 ± 0.04	2.062ValTyr: 2.062 ± 0.064	0.016ValXaa: 0.016 ± 0.006
Trp	1.002TrpAla: 1.002 ± 0.048	0.138TrpCys: 0.138 ± 0.017	0.595TrpAsp: 0.595 ± 0.034	0.634TrpGlu: 0.634 ± 0.04	0.395TrpPhe: 0.395 ± 0.03	0.786TrpGly: 0.786 ± 0.039	0.224TrpHis: 0.224 ± 0.02	0.411TrpIle: 0.411 ± 0.029	0.265TrpLys: 0.265 ± 0.024	1.21TrpLeu: 1.21 ± 0.06	0.181TrpMet: 0.181 ± 0.018	0.335TrpAsn: 0.335 ± 0.025	0.449TrpPro: 0.449 ± 0.031	0.428TrpGln: 0.428 ± 0.029	0.885TrpArg: 0.885 ± 0.05	0.669TrpSer: 0.669 ± 0.046	0.774TrpThr: 0.774 ± 0.037	0.854TrpVal: 0.854 ± 0.041	0.146TrpTrp: 0.146 ± 0.018	0.339TrpTyr: 0.339 ± 0.025	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.549TyrAla: 2.549 ± 0.086	0.288TyrCys: 0.288 ± 0.023	2.261TyrAsp: 2.261 ± 0.065	2.053TyrGlu: 2.053 ± 0.071	0.811TyrPhe: 0.811 ± 0.042	1.846TyrGly: 1.846 ± 0.07	0.586TyrHis: 0.586 ± 0.038	0.796TyrIle: 0.796 ± 0.045	0.479TyrLys: 0.479 ± 0.029	2.362TyrLeu: 2.362 ± 0.068	0.352TyrMet: 0.352 ± 0.028	0.765TyrAsn: 0.765 ± 0.043	1.191TyrPro: 1.191 ± 0.049	0.905TyrGln: 0.905 ± 0.043	1.86TyrArg: 1.86 ± 0.059	1.234TyrSer: 1.234 ± 0.055	1.671TyrThr: 1.671 ± 0.059	1.881TyrVal: 1.881 ± 0.059	0.263TyrTrp: 0.263 ± 0.023	0.7TyrTyr: 0.7 ± 0.04	0.004TyrXaa: 0.004 ± 0.003
Xaa	0.023XaaAla: 0.023 ± 0.007	0.01XaaCys: 0.01 ± 0.004	0.014XaaAsp: 0.014 ± 0.006	0.008XaaGlu: 0.008 ± 0.004	0.012XaaPhe: 0.012 ± 0.005	0.027XaaGly: 0.027 ± 0.008	0.006XaaHis: 0.006 ± 0.004	0.012XaaIle: 0.012 ± 0.005	0.006XaaLys: 0.006 ± 0.004	0.025XaaLeu: 0.025 ± 0.006	0.006XaaMet: 0.006 ± 0.004	0.006XaaAsn: 0.006 ± 0.003	0.016XaaPro: 0.016 ± 0.005	0.008XaaGln: 0.008 ± 0.004	0.035XaaArg: 0.035 ± 0.009	0.037XaaSer: 0.037 ± 0.008	0.027XaaThr: 0.027 ± 0.008	0.023XaaVal: 0.023 ± 0.007	0.004XaaTrp: 0.004 ± 0.003	0.01XaaTyr: 0.01 ± 0.005	1.957XaaXaa: 1.957 ± 0.163

Statistics based on 2128 proteins (486033 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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