Amino acid dipepetide frequency for Primorskyibacter sedentarius

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.355AlaAla: 15.355 ± 0.164	1.123AlaCys: 1.123 ± 0.028	6.869AlaAsp: 6.869 ± 0.076	8.085AlaGlu: 8.085 ± 0.095	4.237AlaPhe: 4.237 ± 0.062	9.982AlaGly: 9.982 ± 0.094	2.305AlaHis: 2.305 ± 0.049	5.846AlaIle: 5.846 ± 0.072	3.797AlaLys: 3.797 ± 0.057	13.151AlaLeu: 13.151 ± 0.121	3.738AlaMet: 3.738 ± 0.054	2.838AlaAsn: 2.838 ± 0.054	5.512AlaPro: 5.512 ± 0.074	4.417AlaGln: 4.417 ± 0.065	8.201AlaArg: 8.201 ± 0.104	5.9AlaSer: 5.9 ± 0.071	5.905AlaThr: 5.905 ± 0.06	7.847AlaVal: 7.847 ± 0.083	1.368AlaTrp: 1.368 ± 0.033	2.437AlaTyr: 2.437 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	1.093CysAla: 1.093 ± 0.024	0.116CysCys: 0.116 ± 0.009	0.628CysAsp: 0.628 ± 0.022	0.496CysGlu: 0.496 ± 0.021	0.354CysPhe: 0.354 ± 0.015	0.966CysGly: 0.966 ± 0.026	0.283CysHis: 0.283 ± 0.014	0.451CysIle: 0.451 ± 0.019	0.242CysLys: 0.242 ± 0.015	0.869CysLeu: 0.869 ± 0.025	0.187CysMet: 0.187 ± 0.011	0.239CysAsn: 0.239 ± 0.013	0.499CysPro: 0.499 ± 0.019	0.258CysGln: 0.258 ± 0.014	0.586CysArg: 0.586 ± 0.019	0.483CysSer: 0.483 ± 0.018	0.453CysThr: 0.453 ± 0.018	0.628CysVal: 0.628 ± 0.023	0.136CysTrp: 0.136 ± 0.01	0.219CysTyr: 0.219 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.381AspAla: 7.381 ± 0.073	0.525AspCys: 0.525 ± 0.018	3.554AspAsp: 3.554 ± 0.073	3.613AspGlu: 3.613 ± 0.055	2.394AspPhe: 2.394 ± 0.044	5.798AspGly: 5.798 ± 0.092	1.356AspHis: 1.356 ± 0.032	3.23AspIle: 3.23 ± 0.053	1.721AspLys: 1.721 ± 0.041	6.396AspLeu: 6.396 ± 0.066	1.649AspMet: 1.649 ± 0.034	1.354AspAsn: 1.354 ± 0.039	3.712AspPro: 3.712 ± 0.054	1.833AspGln: 1.833 ± 0.035	4.267AspArg: 4.267 ± 0.062	2.344AspSer: 2.344 ± 0.049	3.181AspThr: 3.181 ± 0.068	4.429AspVal: 4.429 ± 0.069	1.229AspTrp: 1.229 ± 0.031	1.582AspTyr: 1.582 ± 0.031	0.0AspXaa: 0.0 ± 0.0
Glu	7.869GluAla: 7.869 ± 0.095	0.389GluCys: 0.389 ± 0.019	3.54GluAsp: 3.54 ± 0.052	3.643GluGlu: 3.643 ± 0.067	1.891GluPhe: 1.891 ± 0.036	4.734GluGly: 4.734 ± 0.061	1.16GluHis: 1.16 ± 0.03	3.72GluIle: 3.72 ± 0.055	2.174GluLys: 2.174 ± 0.04	5.344GluLeu: 5.344 ± 0.07	1.898GluMet: 1.898 ± 0.036	1.829GluAsn: 1.829 ± 0.039	2.485GluPro: 2.485 ± 0.047	1.967GluGln: 1.967 ± 0.044	4.018GluArg: 4.018 ± 0.055	2.202GluSer: 2.202 ± 0.041	3.786GluThr: 3.786 ± 0.055	4.328GluVal: 4.328 ± 0.064	0.756GluTrp: 0.756 ± 0.025	1.094GluTyr: 1.094 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	4.43PheAla: 4.43 ± 0.054	0.43PheCys: 0.43 ± 0.019	2.948PheAsp: 2.948 ± 0.049	2.294PheGlu: 2.294 ± 0.036	1.493PhePhe: 1.493 ± 0.032	3.766PheGly: 3.766 ± 0.062	0.771PheHis: 0.771 ± 0.024	1.742PheIle: 1.742 ± 0.038	0.933PheLys: 0.933 ± 0.025	3.488PheLeu: 3.488 ± 0.058	0.902PheMet: 0.902 ± 0.029	1.062PheAsn: 1.062 ± 0.027	1.604PhePro: 1.604 ± 0.033	1.064PheGln: 1.064 ± 0.027	2.235PheArg: 2.235 ± 0.039	2.241PheSer: 2.241 ± 0.033	2.078PheThr: 2.078 ± 0.04	2.859PheVal: 2.859 ± 0.055	0.567PheTrp: 0.567 ± 0.021	0.967PheTyr: 0.967 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	9.566GlyAla: 9.566 ± 0.104	0.903GlyCys: 0.903 ± 0.025	4.834GlyAsp: 4.834 ± 0.08	4.634GlyGlu: 4.634 ± 0.06	3.732GlyPhe: 3.732 ± 0.063	7.53GlyGly: 7.53 ± 0.105	1.935GlyHis: 1.935 ± 0.036	4.586GlyIle: 4.586 ± 0.063	3.176GlyLys: 3.176 ± 0.049	9.09GlyLeu: 9.09 ± 0.103	2.554GlyMet: 2.554 ± 0.044	2.398GlyAsn: 2.398 ± 0.068	3.566GlyPro: 3.566 ± 0.053	3.266GlyGln: 3.266 ± 0.052	5.489GlyArg: 5.489 ± 0.066	4.458GlySer: 4.458 ± 0.075	4.882GlyThr: 4.882 ± 0.071	6.251GlyVal: 6.251 ± 0.064	1.517GlyTrp: 1.517 ± 0.035	2.368GlyTyr: 2.368 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	2.293HisAla: 2.293 ± 0.046	0.25HisCys: 0.25 ± 0.015	1.314HisAsp: 1.314 ± 0.033	1.059HisGlu: 1.059 ± 0.026	0.859HisPhe: 0.859 ± 0.025	1.921HisGly: 1.921 ± 0.041	0.562HisHis: 0.562 ± 0.022	0.988HisIle: 0.988 ± 0.027	0.568HisLys: 0.568 ± 0.02	2.137HisLeu: 2.137 ± 0.037	0.559HisMet: 0.559 ± 0.019	0.468HisAsn: 0.468 ± 0.018	1.382HisPro: 1.382 ± 0.032	0.585HisGln: 0.585 ± 0.02	1.322HisArg: 1.322 ± 0.029	0.994HisSer: 0.994 ± 0.029	0.805HisThr: 0.805 ± 0.026	1.598HisVal: 1.598 ± 0.03	0.329HisTrp: 0.329 ± 0.015	0.545HisTyr: 0.545 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	6.977IleAla: 6.977 ± 0.074	0.651IleCys: 0.651 ± 0.022	3.536IleAsp: 3.536 ± 0.053	3.437IleGlu: 3.437 ± 0.05	1.891IlePhe: 1.891 ± 0.037	4.877IleGly: 4.877 ± 0.059	0.911IleHis: 0.911 ± 0.025	2.409IleIle: 2.409 ± 0.053	1.4IleLys: 1.4 ± 0.029	4.937IleLeu: 4.937 ± 0.061	1.093IleMet: 1.093 ± 0.027	1.411IleAsn: 1.411 ± 0.031	2.435IlePro: 2.435 ± 0.042	1.271IleGln: 1.271 ± 0.026	3.277IleArg: 3.277 ± 0.045	3.252IleSer: 3.252 ± 0.048	2.902IleThr: 2.902 ± 0.048	3.877IleVal: 3.877 ± 0.048	0.76IleTrp: 0.76 ± 0.021	1.23IleTyr: 1.23 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	3.878LysAla: 3.878 ± 0.052	0.206LysCys: 0.206 ± 0.013	1.772LysAsp: 1.772 ± 0.04	1.631LysGlu: 1.631 ± 0.035	0.957LysPhe: 0.957 ± 0.026	2.7LysGly: 2.7 ± 0.053	0.653LysHis: 0.653 ± 0.021	1.642LysIle: 1.642 ± 0.033	1.182LysLys: 1.182 ± 0.034	3.155LysLeu: 3.155 ± 0.055	0.892LysMet: 0.892 ± 0.024	0.813LysAsn: 0.813 ± 0.027	1.805LysPro: 1.805 ± 0.042	0.968LysGln: 0.968 ± 0.028	2.248LysArg: 2.248 ± 0.042	1.853LysSer: 1.853 ± 0.04	2.002LysThr: 2.002 ± 0.04	2.372LysVal: 2.372 ± 0.049	0.423LysTrp: 0.423 ± 0.016	0.614LysTyr: 0.614 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	12.207LeuAla: 12.207 ± 0.125	1.019LeuCys: 1.019 ± 0.027	6.168LeuAsp: 6.168 ± 0.073	5.472LeuGlu: 5.472 ± 0.072	3.535LeuPhe: 3.535 ± 0.058	8.455LeuGly: 8.455 ± 0.09	1.897LeuHis: 1.897 ± 0.035	5.299LeuIle: 5.299 ± 0.063	3.152LeuLys: 3.152 ± 0.051	9.142LeuLeu: 9.142 ± 0.112	2.623LeuMet: 2.623 ± 0.041	2.837LeuAsn: 2.837 ± 0.041	5.6LeuPro: 5.6 ± 0.062	2.806LeuGln: 2.806 ± 0.042	7.131LeuArg: 7.131 ± 0.081	6.989LeuSer: 6.989 ± 0.066	6.084LeuThr: 6.084 ± 0.068	6.82LeuVal: 6.82 ± 0.076	1.275LeuTrp: 1.275 ± 0.033	1.979LeuTyr: 1.979 ± 0.035	0.0LeuXaa: 0.0 ± 0.0
Met	3.365MetAla: 3.365 ± 0.051	0.189MetCys: 0.189 ± 0.012	1.325MetAsp: 1.325 ± 0.029	1.315MetGlu: 1.315 ± 0.032	0.841MetPhe: 0.841 ± 0.025	2.191MetGly: 2.191 ± 0.045	0.497MetHis: 0.497 ± 0.017	1.596MetIle: 1.596 ± 0.036	1.103MetLys: 1.103 ± 0.029	2.666MetLeu: 2.666 ± 0.041	0.788MetMet: 0.788 ± 0.026	0.853MetAsn: 0.853 ± 0.023	1.531MetPro: 1.531 ± 0.032	0.997MetGln: 0.997 ± 0.025	1.906MetArg: 1.906 ± 0.037	1.83MetSer: 1.83 ± 0.04	2.173MetThr: 2.173 ± 0.038	1.845MetVal: 1.845 ± 0.038	0.268MetTrp: 0.268 ± 0.014	0.368MetTyr: 0.368 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.256AsnAla: 3.256 ± 0.046	0.276AsnCys: 0.276 ± 0.017	1.699AsnAsp: 1.699 ± 0.047	1.262AsnGlu: 1.262 ± 0.031	1.011AsnPhe: 1.011 ± 0.031	2.58AsnGly: 2.58 ± 0.058	0.538AsnHis: 0.538 ± 0.018	1.434AsnIle: 1.434 ± 0.031	0.734AsnLys: 0.734 ± 0.025	2.678AsnLeu: 2.678 ± 0.046	0.736AsnMet: 0.736 ± 0.023	0.725AsnAsn: 0.725 ± 0.029	1.872AsnPro: 1.872 ± 0.042	0.764AsnGln: 0.764 ± 0.022	1.797AsnArg: 1.797 ± 0.038	1.319AsnSer: 1.319 ± 0.033	1.405AsnThr: 1.405 ± 0.034	1.872AsnVal: 1.872 ± 0.04	0.472AsnTrp: 0.472 ± 0.018	0.699AsnTyr: 0.699 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	5.354ProAla: 5.354 ± 0.059	0.365ProCys: 0.365 ± 0.019	4.09ProAsp: 4.09 ± 0.053	4.145ProGlu: 4.145 ± 0.051	1.919ProPhe: 1.919 ± 0.034	4.396ProGly: 4.396 ± 0.06	1.013ProHis: 1.013 ± 0.027	2.288ProIle: 2.288 ± 0.044	1.66ProLys: 1.66 ± 0.032	4.58ProLeu: 4.58 ± 0.059	1.297ProMet: 1.297 ± 0.032	1.335ProAsn: 1.335 ± 0.029	2.225ProPro: 2.225 ± 0.043	1.65ProGln: 1.65 ± 0.031	2.764ProArg: 2.764 ± 0.045	2.641ProSer: 2.641 ± 0.041	2.49ProThr: 2.49 ± 0.048	4.238ProVal: 4.238 ± 0.052	0.688ProTrp: 0.688 ± 0.024	1.181ProTyr: 1.181 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	3.919GlnAla: 3.919 ± 0.057	0.225GlnCys: 0.225 ± 0.012	1.823GlnAsp: 1.823 ± 0.039	1.628GlnGlu: 1.628 ± 0.034	1.173GlnPhe: 1.173 ± 0.03	2.643GlnGly: 2.643 ± 0.053	0.658GlnHis: 0.658 ± 0.02	2.073GlnIle: 2.073 ± 0.035	1.067GlnLys: 1.067 ± 0.031	2.944GlnLeu: 2.944 ± 0.047	1.087GlnMet: 1.087 ± 0.028	0.936GlnAsn: 0.936 ± 0.029	1.67GlnPro: 1.67 ± 0.031	1.139GlnGln: 1.139 ± 0.031	2.215GlnArg: 2.215 ± 0.044	1.953GlnSer: 1.953 ± 0.037	1.938GlnThr: 1.938 ± 0.039	2.291GlnVal: 2.291 ± 0.037	0.386GlnTrp: 0.386 ± 0.016	0.607GlnTyr: 0.607 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	7.438ArgAla: 7.438 ± 0.083	0.509ArgCys: 0.509 ± 0.018	4.221ArgAsp: 4.221 ± 0.058	3.666ArgGlu: 3.666 ± 0.054	2.711ArgPhe: 2.711 ± 0.045	4.533ArgGly: 4.533 ± 0.059	1.561ArgHis: 1.561 ± 0.035	3.889ArgIle: 3.889 ± 0.053	2.452ArgLys: 2.452 ± 0.042	7.037ArgLeu: 7.037 ± 0.077	1.957ArgMet: 1.957 ± 0.034	1.961ArgAsn: 1.961 ± 0.041	3.217ArgPro: 3.217 ± 0.045	2.429ArgGln: 2.429 ± 0.043	4.788ArgArg: 4.788 ± 0.082	3.435ArgSer: 3.435 ± 0.047	3.01ArgThr: 3.01 ± 0.049	4.512ArgVal: 4.512 ± 0.065	0.936ArgTrp: 0.936 ± 0.027	1.59ArgTyr: 1.59 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	5.988SerAla: 5.988 ± 0.068	0.444SerCys: 0.444 ± 0.017	3.457SerAsp: 3.457 ± 0.064	3.029SerGlu: 3.029 ± 0.048	2.395SerPhe: 2.395 ± 0.044	5.622SerGly: 5.622 ± 0.077	1.187SerHis: 1.187 ± 0.029	2.631SerIle: 2.631 ± 0.045	1.634SerLys: 1.634 ± 0.033	5.255SerLeu: 5.255 ± 0.068	1.404SerMet: 1.404 ± 0.031	1.516SerAsn: 1.516 ± 0.04	2.578SerPro: 2.578 ± 0.043	1.746SerGln: 1.746 ± 0.032	3.384SerArg: 3.384 ± 0.048	2.852SerSer: 2.852 ± 0.053	2.668SerThr: 2.668 ± 0.042	4.022SerVal: 4.022 ± 0.059	0.762SerTrp: 0.762 ± 0.02	1.43SerTyr: 1.43 ± 0.032	0.001SerXaa: 0.001 ± 0.001
Thr	6.093ThrAla: 6.093 ± 0.069	0.516ThrCys: 0.516 ± 0.023	3.253ThrAsp: 3.253 ± 0.061	3.033ThrGlu: 3.033 ± 0.047	2.02ThrPhe: 2.02 ± 0.041	5.535ThrGly: 5.535 ± 0.066	1.08ThrHis: 1.08 ± 0.029	2.78ThrIle: 2.78 ± 0.047	1.545ThrLys: 1.545 ± 0.03	6.135ThrLeu: 6.135 ± 0.077	1.3ThrMet: 1.3 ± 0.03	1.414ThrAsn: 1.414 ± 0.033	3.371ThrPro: 3.371 ± 0.046	1.726ThrGln: 1.726 ± 0.035	3.547ThrArg: 3.547 ± 0.05	2.897ThrSer: 2.897 ± 0.045	2.896ThrThr: 2.896 ± 0.048	4.315ThrVal: 4.315 ± 0.058	0.683ThrTrp: 0.683 ± 0.022	1.302ThrTyr: 1.302 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	8.62ValAla: 8.62 ± 0.076	0.656ValCys: 0.656 ± 0.02	4.133ValAsp: 4.133 ± 0.058	4.424ValGlu: 4.424 ± 0.061	2.949ValPhe: 2.949 ± 0.052	5.376ValGly: 5.376 ± 0.061	1.309ValHis: 1.309 ± 0.032	4.251ValIle: 4.251 ± 0.068	2.115ValLys: 2.115 ± 0.045	7.411ValLeu: 7.411 ± 0.072	2.085ValMet: 2.085 ± 0.042	2.049ValAsn: 2.049 ± 0.041	3.49ValPro: 3.49 ± 0.046	2.125ValGln: 2.125 ± 0.033	4.066ValArg: 4.066 ± 0.055	4.323ValSer: 4.323 ± 0.062	4.824ValThr: 4.824 ± 0.07	5.58ValVal: 5.58 ± 0.08	0.925ValTrp: 0.925 ± 0.028	1.454ValTyr: 1.454 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.336TrpAla: 1.336 ± 0.033	0.139TrpCys: 0.139 ± 0.01	0.772TrpAsp: 0.772 ± 0.021	0.64TrpGlu: 0.64 ± 0.022	0.564TrpPhe: 0.564 ± 0.019	1.013TrpGly: 1.013 ± 0.027	0.351TrpHis: 0.351 ± 0.012	0.706TrpIle: 0.706 ± 0.024	0.494TrpLys: 0.494 ± 0.021	1.736TrpLeu: 1.736 ± 0.038	0.416TrpMet: 0.416 ± 0.015	0.436TrpAsn: 0.436 ± 0.016	0.671TrpPro: 0.671 ± 0.021	0.645TrpGln: 0.645 ± 0.026	1.084TrpArg: 1.084 ± 0.023	0.82TrpSer: 0.82 ± 0.026	0.804TrpThr: 0.804 ± 0.025	0.932TrpVal: 0.932 ± 0.026	0.244TrpTrp: 0.244 ± 0.015	0.285TrpTyr: 0.285 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.496TyrAla: 2.496 ± 0.046	0.256TyrCys: 0.256 ± 0.012	1.61TyrAsp: 1.61 ± 0.04	1.321TyrGlu: 1.321 ± 0.031	0.947TyrPhe: 0.947 ± 0.027	2.116TyrGly: 2.116 ± 0.045	0.51TyrHis: 0.51 ± 0.021	0.971TyrIle: 0.971 ± 0.024	0.614TyrLys: 0.614 ± 0.023	2.34TyrLeu: 2.34 ± 0.04	0.482TyrMet: 0.482 ± 0.015	0.658TyrAsn: 0.658 ± 0.02	1.095TyrPro: 1.095 ± 0.025	0.718TyrGln: 0.718 ± 0.023	1.527TyrArg: 1.527 ± 0.034	1.218TyrSer: 1.218 ± 0.03	1.157TyrThr: 1.157 ± 0.031	1.55TyrVal: 1.55 ± 0.031	0.364TyrTrp: 0.364 ± 0.014	0.615TyrTyr: 0.615 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.001XaaHis: 0.001 ± 0.001	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.001XaaXaa: 0.001 ± 0.001

Statistics based on 4734 proteins (1499026 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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