Amino acid dipepetide frequency for Micromonospora nigra

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	23.667AlaAla: 23.667 ± 0.18	1.033AlaCys: 1.033 ± 0.028	9.489AlaAsp: 9.489 ± 0.098	8.417AlaGlu: 8.417 ± 0.073	3.186AlaPhe: 3.186 ± 0.05	15.142AlaGly: 15.142 ± 0.119	2.739AlaHis: 2.739 ± 0.043	3.412AlaIle: 3.412 ± 0.052	1.99AlaLys: 1.99 ± 0.048	14.588AlaLeu: 14.588 ± 0.126	2.323AlaMet: 2.323 ± 0.037	2.024AlaAsn: 2.024 ± 0.042	7.336AlaPro: 7.336 ± 0.082	3.739AlaGln: 3.739 ± 0.05	11.022AlaArg: 11.022 ± 0.096	5.333AlaSer: 5.333 ± 0.061	8.54AlaThr: 8.54 ± 0.08	13.617AlaVal: 13.617 ± 0.117	1.943AlaTrp: 1.943 ± 0.034	2.819AlaTyr: 2.819 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	1.011CysAla: 1.011 ± 0.026	0.093CysCys: 0.093 ± 0.007	0.542CysAsp: 0.542 ± 0.019	0.337CysGlu: 0.337 ± 0.014	0.205CysPhe: 0.205 ± 0.011	0.92CysGly: 0.92 ± 0.024	0.206CysHis: 0.206 ± 0.012	0.127CysIle: 0.127 ± 0.009	0.093CysLys: 0.093 ± 0.007	0.731CysLeu: 0.731 ± 0.02	0.093CysMet: 0.093 ± 0.007	0.143CysAsn: 0.143 ± 0.01	0.518CysPro: 0.518 ± 0.019	0.19CysGln: 0.19 ± 0.011	0.716CysArg: 0.716 ± 0.02	0.388CysSer: 0.388 ± 0.015	0.455CysThr: 0.455 ± 0.016	0.634CysVal: 0.634 ± 0.017	0.136CysTrp: 0.136 ± 0.01	0.156CysTyr: 0.156 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	8.094AspAla: 8.094 ± 0.08	0.43AspCys: 0.43 ± 0.017	4.058AspAsp: 4.058 ± 0.055	3.79AspGlu: 3.79 ± 0.054	1.405AspPhe: 1.405 ± 0.029	6.495AspGly: 6.495 ± 0.077	1.423AspHis: 1.423 ± 0.029	1.508AspIle: 1.508 ± 0.032	0.793AspLys: 0.793 ± 0.025	7.077AspLeu: 7.077 ± 0.07	0.713AspMet: 0.713 ± 0.02	0.901AspAsn: 0.901 ± 0.028	5.283AspPro: 5.283 ± 0.06	1.681AspGln: 1.681 ± 0.029	6.017AspArg: 6.017 ± 0.067	2.222AspSer: 2.222 ± 0.038	3.167AspThr: 3.167 ± 0.048	5.267AspVal: 5.267 ± 0.063	1.06AspTrp: 1.06 ± 0.025	1.05AspTyr: 1.05 ± 0.025	0.0AspXaa: 0.0 ± 0.0
Glu	6.522GluAla: 6.522 ± 0.074	0.357GluCys: 0.357 ± 0.014	2.047GluAsp: 2.047 ± 0.038	2.392GluGlu: 2.392 ± 0.049	1.352GluPhe: 1.352 ± 0.029	3.218GluGly: 3.218 ± 0.05	1.317GluHis: 1.317 ± 0.031	2.019GluIle: 2.019 ± 0.037	0.916GluLys: 0.916 ± 0.028	6.306GluLeu: 6.306 ± 0.067	0.806GluMet: 0.806 ± 0.022	0.776GluAsn: 0.776 ± 0.025	3.481GluPro: 3.481 ± 0.049	2.2GluGln: 2.2 ± 0.042	4.925GluArg: 4.925 ± 0.06	2.074GluSer: 2.074 ± 0.035	2.416GluThr: 2.416 ± 0.037	4.805GluVal: 4.805 ± 0.064	0.693GluTrp: 0.693 ± 0.019	0.988GluTyr: 0.988 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	3.649PheAla: 3.649 ± 0.045	0.239PheCys: 0.239 ± 0.012	1.983PheAsp: 1.983 ± 0.036	1.098PheGlu: 1.098 ± 0.024	0.779PhePhe: 0.779 ± 0.024	2.823PheGly: 2.823 ± 0.042	0.58PheHis: 0.58 ± 0.019	0.57PheIle: 0.57 ± 0.018	0.344PheLys: 0.344 ± 0.015	2.378PheLeu: 2.378 ± 0.039	0.289PheMet: 0.289 ± 0.012	0.486PheAsn: 0.486 ± 0.018	1.288PhePro: 1.288 ± 0.029	0.536PheGln: 0.536 ± 0.018	1.803PheArg: 1.803 ± 0.031	1.244PheSer: 1.244 ± 0.026	1.843PheThr: 1.843 ± 0.035	2.405PheVal: 2.405 ± 0.036	0.429PheTrp: 0.429 ± 0.015	0.55PheTyr: 0.55 ± 0.02	0.0PheXaa: 0.0 ± 0.0
Gly	10.908GlyAla: 10.908 ± 0.088	0.837GlyCys: 0.837 ± 0.024	5.546GlyAsp: 5.546 ± 0.061	4.673GlyGlu: 4.673 ± 0.05	2.678GlyPhe: 2.678 ± 0.04	9.108GlyGly: 9.108 ± 0.103	2.28GlyHis: 2.28 ± 0.044	2.946GlyIle: 2.946 ± 0.051	1.601GlyLys: 1.601 ± 0.034	9.399GlyLeu: 9.399 ± 0.091	1.846GlyMet: 1.846 ± 0.033	1.636GlyAsn: 1.636 ± 0.041	5.587GlyPro: 5.587 ± 0.076	2.883GlyGln: 2.883 ± 0.045	8.688GlyArg: 8.688 ± 0.079	4.757GlySer: 4.757 ± 0.065	6.043GlyThr: 6.043 ± 0.079	8.57GlyVal: 8.57 ± 0.096	2.03GlyTrp: 2.03 ± 0.035	2.332GlyTyr: 2.332 ± 0.039	0.0GlyXaa: 0.0 ± 0.0
His	2.631HisAla: 2.631 ± 0.039	0.188HisCys: 0.188 ± 0.01	1.413HisAsp: 1.413 ± 0.028	1.023HisGlu: 1.023 ± 0.029	0.506HisPhe: 0.506 ± 0.017	2.2HisGly: 2.2 ± 0.041	0.689HisHis: 0.689 ± 0.024	0.495HisIle: 0.495 ± 0.015	0.239HisLys: 0.239 ± 0.012	2.673HisLeu: 2.673 ± 0.042	0.256HisMet: 0.256 ± 0.012	0.341HisAsn: 0.341 ± 0.014	1.874HisPro: 1.874 ± 0.04	0.647HisGln: 0.647 ± 0.021	2.339HisArg: 2.339 ± 0.039	0.937HisSer: 0.937 ± 0.022	1.22HisThr: 1.22 ± 0.029	1.803HisVal: 1.803 ± 0.033	0.341HisTrp: 0.341 ± 0.016	0.412HisTyr: 0.412 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	4.114IleAla: 4.114 ± 0.052	0.274IleCys: 0.274 ± 0.012	2.114IleAsp: 2.114 ± 0.038	1.659IleGlu: 1.659 ± 0.037	0.724IlePhe: 0.724 ± 0.021	3.085IleGly: 3.085 ± 0.036	0.485IleHis: 0.485 ± 0.017	0.798IleIle: 0.798 ± 0.024	0.533IleLys: 0.533 ± 0.018	2.239IleLeu: 2.239 ± 0.044	0.384IleMet: 0.384 ± 0.016	0.647IleAsn: 0.647 ± 0.019	1.491IlePro: 1.491 ± 0.028	0.624IleGln: 0.624 ± 0.02	2.239IleArg: 2.239 ± 0.036	1.564IleSer: 1.564 ± 0.03	1.925IleThr: 1.925 ± 0.033	2.536IleVal: 2.536 ± 0.04	0.356IleTrp: 0.356 ± 0.015	0.501IleTyr: 0.501 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	1.905LysAla: 1.905 ± 0.047	0.093LysCys: 0.093 ± 0.007	0.696LysAsp: 0.696 ± 0.024	0.669LysGlu: 0.669 ± 0.025	0.314LysPhe: 0.314 ± 0.012	1.119LysGly: 1.119 ± 0.029	0.275LysHis: 0.275 ± 0.014	0.659LysIle: 0.659 ± 0.022	0.422LysLys: 0.422 ± 0.021	1.554LysLeu: 1.554 ± 0.033	0.272LysMet: 0.272 ± 0.015	0.286LysAsn: 0.286 ± 0.013	0.978LysPro: 0.978 ± 0.029	0.494LysGln: 0.494 ± 0.018	1.135LysArg: 1.135 ± 0.031	0.77LysSer: 0.77 ± 0.022	0.895LysThr: 0.895 ± 0.025	1.413LysVal: 1.413 ± 0.03	0.193LysTrp: 0.193 ± 0.012	0.295LysTyr: 0.295 ± 0.013	0.0LysXaa: 0.0 ± 0.0
Leu	16.994LeuAla: 16.994 ± 0.142	0.748LeuCys: 0.748 ± 0.021	7.122LeuAsp: 7.122 ± 0.076	3.676LeuGlu: 3.676 ± 0.047	2.526LeuPhe: 2.526 ± 0.04	9.156LeuGly: 9.156 ± 0.085	2.396LeuHis: 2.396 ± 0.044	2.773LeuIle: 2.773 ± 0.044	1.24LeuLys: 1.24 ± 0.029	11.7LeuLeu: 11.7 ± 0.126	1.305LeuMet: 1.305 ± 0.031	1.508LeuAsn: 1.508 ± 0.033	7.019LeuPro: 7.019 ± 0.07	1.708LeuGln: 1.708 ± 0.034	9.597LeuArg: 9.597 ± 0.085	4.556LeuSer: 4.556 ± 0.056	7.295LeuThr: 7.295 ± 0.07	10.372LeuVal: 10.372 ± 0.104	1.316LeuTrp: 1.316 ± 0.029	1.582LeuTyr: 1.582 ± 0.032	0.0LeuXaa: 0.0 ± 0.0
Met	2.041MetAla: 2.041 ± 0.039	0.105MetCys: 0.105 ± 0.008	0.688MetAsp: 0.688 ± 0.017	0.552MetGlu: 0.552 ± 0.018	0.419MetPhe: 0.419 ± 0.015	1.058MetGly: 1.058 ± 0.024	0.273MetHis: 0.273 ± 0.01	0.585MetIle: 0.585 ± 0.019	0.307MetLys: 0.307 ± 0.014	1.629MetLeu: 1.629 ± 0.028	0.241MetMet: 0.241 ± 0.012	0.317MetAsn: 0.317 ± 0.014	1.007MetPro: 1.007 ± 0.024	0.4MetGln: 0.4 ± 0.014	1.359MetArg: 1.359 ± 0.026	1.146MetSer: 1.146 ± 0.025	1.53MetThr: 1.53 ± 0.034	1.28MetVal: 1.28 ± 0.027	0.193MetTrp: 0.193 ± 0.011	0.261MetTyr: 0.261 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.017AsnAla: 2.017 ± 0.036	0.154AsnCys: 0.154 ± 0.01	0.902AsnAsp: 0.902 ± 0.026	0.681AsnGlu: 0.681 ± 0.022	0.469AsnPhe: 0.469 ± 0.017	1.726AsnGly: 1.726 ± 0.039	0.371AsnHis: 0.371 ± 0.015	0.529AsnIle: 0.529 ± 0.016	0.257AsnLys: 0.257 ± 0.015	1.772AsnLeu: 1.772 ± 0.032	0.244AsnMet: 0.244 ± 0.01	0.413AsnAsn: 0.413 ± 0.019	1.424AsnPro: 1.424 ± 0.038	0.536AsnGln: 0.536 ± 0.02	1.406AsnArg: 1.406 ± 0.032	0.853AsnSer: 0.853 ± 0.024	0.978AsnThr: 0.978 ± 0.028	1.331AsnVal: 1.331 ± 0.032	0.299AsnTrp: 0.299 ± 0.012	0.39AsnTyr: 0.39 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	10.655ProAla: 10.655 ± 0.105	0.341ProCys: 0.341 ± 0.014	4.896ProAsp: 4.896 ± 0.056	3.732ProGlu: 3.732 ± 0.05	1.342ProPhe: 1.342 ± 0.027	6.822ProGly: 6.822 ± 0.074	1.36ProHis: 1.36 ± 0.026	1.403ProIle: 1.403 ± 0.031	0.894ProLys: 0.894 ± 0.028	5.328ProLeu: 5.328 ± 0.063	0.941ProMet: 0.941 ± 0.026	0.994ProAsn: 0.994 ± 0.023	4.64ProPro: 4.64 ± 0.084	1.727ProGln: 1.727 ± 0.035	4.275ProArg: 4.275 ± 0.053	2.952ProSer: 2.952 ± 0.046	4.427ProThr: 4.427 ± 0.069	6.375ProVal: 6.375 ± 0.071	0.995ProTrp: 0.995 ± 0.024	1.206ProTyr: 1.206 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	3.735GlnAla: 3.735 ± 0.058	0.152GlnCys: 0.152 ± 0.01	1.093GlnAsp: 1.093 ± 0.026	1.137GlnGlu: 1.137 ± 0.026	0.688GlnPhe: 0.688 ± 0.023	1.948GlnGly: 1.948 ± 0.033	0.599GlnHis: 0.599 ± 0.016	0.959GlnIle: 0.959 ± 0.026	0.373GlnLys: 0.373 ± 0.015	3.138GlnLeu: 3.138 ± 0.042	0.437GlnMet: 0.437 ± 0.016	0.433GlnAsn: 0.433 ± 0.017	1.953GlnPro: 1.953 ± 0.036	1.173GlnGln: 1.173 ± 0.029	2.862GlnArg: 2.862 ± 0.043	1.077GlnSer: 1.077 ± 0.024	1.297GlnThr: 1.297 ± 0.031	2.94GlnVal: 2.94 ± 0.045	0.505GlnTrp: 0.505 ± 0.015	0.482GlnTyr: 0.482 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	10.963ArgAla: 10.963 ± 0.101	0.703ArgCys: 0.703 ± 0.024	4.83ArgAsp: 4.83 ± 0.049	4.343ArgGlu: 4.343 ± 0.051	2.385ArgPhe: 2.385 ± 0.04	6.157ArgGly: 6.157 ± 0.068	2.464ArgHis: 2.464 ± 0.04	3.01ArgIle: 3.01 ± 0.04	1.189ArgLys: 1.189 ± 0.033	9.874ArgLeu: 9.874 ± 0.086	1.826ArgMet: 1.826 ± 0.032	1.448ArgAsn: 1.448 ± 0.029	5.919ArgPro: 5.919 ± 0.08	2.858ArgGln: 2.858 ± 0.04	9.367ArgArg: 9.367 ± 0.099	4.089ArgSer: 4.089 ± 0.043	5.032ArgThr: 5.032 ± 0.054	7.0ArgVal: 7.0 ± 0.061	1.787ArgTrp: 1.787 ± 0.041	1.944ArgTyr: 1.944 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	6.135SerAla: 6.135 ± 0.066	0.385SerCys: 0.385 ± 0.016	2.331SerAsp: 2.331 ± 0.035	1.825SerGlu: 1.825 ± 0.032	1.36SerPhe: 1.36 ± 0.03	5.318SerGly: 5.318 ± 0.065	0.907SerHis: 0.907 ± 0.017	1.337SerIle: 1.337 ± 0.026	0.646SerLys: 0.646 ± 0.021	4.168SerLeu: 4.168 ± 0.056	0.905SerMet: 0.905 ± 0.024	0.844SerAsn: 0.844 ± 0.027	3.09SerPro: 3.09 ± 0.045	1.069SerGln: 1.069 ± 0.028	3.609SerArg: 3.609 ± 0.049	2.366SerSer: 2.366 ± 0.05	3.07SerThr: 3.07 ± 0.045	3.998SerVal: 3.998 ± 0.054	0.867SerTrp: 0.867 ± 0.023	1.151SerTyr: 1.151 ± 0.026	0.0SerXaa: 0.0 ± 0.0
Thr	9.069ThrAla: 9.069 ± 0.084	0.467ThrCys: 0.467 ± 0.016	3.942ThrAsp: 3.942 ± 0.05	2.891ThrGlu: 2.891 ± 0.042	1.547ThrPhe: 1.547 ± 0.029	7.097ThrGly: 7.097 ± 0.064	1.109ThrHis: 1.109 ± 0.025	1.783ThrIle: 1.783 ± 0.036	0.827ThrLys: 0.827 ± 0.025	5.888ThrLeu: 5.888 ± 0.055	0.928ThrMet: 0.928 ± 0.025	1.082ThrAsn: 1.082 ± 0.028	4.464ThrPro: 4.464 ± 0.066	1.247ThrGln: 1.247 ± 0.027	4.424ThrArg: 4.424 ± 0.053	2.957ThrSer: 2.957 ± 0.047	4.065ThrThr: 4.065 ± 0.073	6.65ThrVal: 6.65 ± 0.061	0.961ThrTrp: 0.961 ± 0.023	1.283ThrTyr: 1.283 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	13.575ValAla: 13.575 ± 0.127	0.758ValCys: 0.758 ± 0.024	6.661ValAsp: 6.661 ± 0.069	5.104ValGlu: 5.104 ± 0.063	2.387ValPhe: 2.387 ± 0.046	7.929ValGly: 7.929 ± 0.075	1.898ValHis: 1.898 ± 0.032	2.539ValIle: 2.539 ± 0.039	1.274ValLys: 1.274 ± 0.033	9.969ValLeu: 9.969 ± 0.1	1.162ValMet: 1.162 ± 0.024	1.696ValAsn: 1.696 ± 0.033	5.787ValPro: 5.787 ± 0.055	1.969ValGln: 1.969 ± 0.031	7.781ValArg: 7.781 ± 0.071	4.237ValSer: 4.237 ± 0.056	6.391ValThr: 6.391 ± 0.065	9.693ValVal: 9.693 ± 0.114	1.155ValTrp: 1.155 ± 0.027	1.433ValTyr: 1.433 ± 0.027	0.0ValXaa: 0.0 ± 0.0
Trp	1.763TrpAla: 1.763 ± 0.035	0.172TrpCys: 0.172 ± 0.01	0.74TrpAsp: 0.74 ± 0.021	0.642TrpGlu: 0.642 ± 0.019	0.499TrpPhe: 0.499 ± 0.017	1.02TrpGly: 1.02 ± 0.028	0.427TrpHis: 0.427 ± 0.018	0.491TrpIle: 0.491 ± 0.017	0.243TrpLys: 0.243 ± 0.013	1.99TrpLeu: 1.99 ± 0.033	0.248TrpMet: 0.248 ± 0.011	0.408TrpAsn: 0.408 ± 0.017	0.991TrpPro: 0.991 ± 0.024	0.691TrpGln: 0.691 ± 0.021	1.723TrpArg: 1.723 ± 0.034	1.037TrpSer: 1.037 ± 0.025	1.026TrpThr: 1.026 ± 0.021	1.101TrpVal: 1.101 ± 0.023	0.41TrpTrp: 0.41 ± 0.016	0.385TrpTyr: 0.385 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.911TyrAla: 2.911 ± 0.043	0.162TyrCys: 0.162 ± 0.011	1.342TyrAsp: 1.342 ± 0.029	0.972TyrGlu: 0.972 ± 0.026	0.541TyrPhe: 0.541 ± 0.018	2.005TyrGly: 2.005 ± 0.039	0.428TyrHis: 0.428 ± 0.015	0.348TyrIle: 0.348 ± 0.016	0.257TyrLys: 0.257 ± 0.014	2.188TyrLeu: 2.188 ± 0.037	0.172TyrMet: 0.172 ± 0.01	0.369TyrAsn: 0.369 ± 0.017	1.176TyrPro: 1.176 ± 0.028	0.61TyrGln: 0.61 ± 0.017	1.902TyrArg: 1.902 ± 0.04	0.821TyrSer: 0.821 ± 0.024	1.067TyrThr: 1.067 ± 0.028	1.609TyrVal: 1.609 ± 0.028	0.34TyrTrp: 0.34 ± 0.013	0.388TyrTyr: 0.388 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5321 proteins (1856018 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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