Amino acid dipepetide frequency for Streptococcus phage Javan252

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.858AlaAla: 3.858 ± 0.727
0.628AlaCys: 0.628 ± 0.182
5.562AlaAsp: 5.562 ± 0.674
4.486AlaGlu: 4.486 ± 0.568
2.243AlaPhe: 2.243 ± 0.53
3.768AlaGly: 3.768 ± 0.509
0.359AlaHis: 0.359 ± 0.178
6.1AlaIle: 6.1 ± 0.866
6.459AlaLys: 6.459 ± 0.979
6.639AlaLeu: 6.639 ± 0.607
2.063AlaMet: 2.063 ± 0.455
4.575AlaAsn: 4.575 ± 0.89
1.435AlaPro: 1.435 ± 0.363
4.486AlaGln: 4.486 ± 0.674
1.794AlaArg: 1.794 ± 0.429
4.306AlaSer: 4.306 ± 0.745
3.858AlaThr: 3.858 ± 0.535
5.562AlaVal: 5.562 ± 0.632
0.807AlaTrp: 0.807 ± 0.28
1.884AlaTyr: 1.884 ± 0.416
0.0AlaXaa: 0.0 ± 0.0
Cys
0.09CysAla: 0.09 ± 0.069
0.179CysCys: 0.179 ± 0.186
0.359CysAsp: 0.359 ± 0.203
0.269CysGlu: 0.269 ± 0.158
0.0CysPhe: 0.0 ± 0.0
0.09CysGly: 0.09 ± 0.09
0.179CysHis: 0.179 ± 0.147
0.179CysIle: 0.179 ± 0.143
0.269CysLys: 0.269 ± 0.203
0.538CysLeu: 0.538 ± 0.202
0.0CysMet: 0.0 ± 0.0
0.179CysAsn: 0.179 ± 0.112
0.179CysPro: 0.179 ± 0.105
0.449CysGln: 0.449 ± 0.204
0.359CysArg: 0.359 ± 0.18
0.179CysSer: 0.179 ± 0.133
0.359CysThr: 0.359 ± 0.171
0.359CysVal: 0.359 ± 0.142
0.09CysTrp: 0.09 ± 0.07
0.179CysTyr: 0.179 ± 0.126
0.0CysXaa: 0.0 ± 0.0
Asp
4.216AspAla: 4.216 ± 0.581
0.09AspCys: 0.09 ± 0.084
4.306AspAsp: 4.306 ± 0.562
4.844AspGlu: 4.844 ± 0.733
3.768AspPhe: 3.768 ± 0.445
6.459AspGly: 6.459 ± 0.982
0.538AspHis: 0.538 ± 0.188
4.575AspIle: 4.575 ± 0.654
5.113AspLys: 5.113 ± 0.696
4.934AspLeu: 4.934 ± 0.768
1.435AspMet: 1.435 ± 0.424
4.306AspAsn: 4.306 ± 0.665
1.077AspPro: 1.077 ± 0.319
1.077AspGln: 1.077 ± 0.286
2.422AspArg: 2.422 ± 0.593
4.575AspSer: 4.575 ± 0.664
4.216AspThr: 4.216 ± 0.53
3.947AspVal: 3.947 ± 0.767
1.077AspTrp: 1.077 ± 0.249
2.422AspTyr: 2.422 ± 0.467
0.0AspXaa: 0.0 ± 0.0
Glu
4.486GluAla: 4.486 ± 0.617
0.09GluCys: 0.09 ± 0.07
3.319GluAsp: 3.319 ± 0.452
5.203GluGlu: 5.203 ± 0.945
2.781GluPhe: 2.781 ± 0.583
2.691GluGly: 2.691 ± 0.464
0.628GluHis: 0.628 ± 0.253
5.741GluIle: 5.741 ± 0.683
5.383GluLys: 5.383 ± 0.809
7.267GluLeu: 7.267 ± 0.809
3.23GluMet: 3.23 ± 0.747
3.947GluAsn: 3.947 ± 0.624
1.884GluPro: 1.884 ± 0.36
3.319GluGln: 3.319 ± 0.449
2.96GluArg: 2.96 ± 0.498
3.23GluSer: 3.23 ± 0.562
5.293GluThr: 5.293 ± 0.6
4.127GluVal: 4.127 ± 0.652
0.987GluTrp: 0.987 ± 0.194
2.602GluTyr: 2.602 ± 0.359
0.0GluXaa: 0.0 ± 0.0
Phe
2.781PheAla: 2.781 ± 0.507
0.179PheCys: 0.179 ± 0.129
3.588PheAsp: 3.588 ± 0.447
4.127PheGlu: 4.127 ± 0.564
1.615PhePhe: 1.615 ± 0.369
2.781PheGly: 2.781 ± 0.553
0.269PheHis: 0.269 ± 0.151
1.615PheIle: 1.615 ± 0.367
3.319PheLys: 3.319 ± 0.411
3.14PheLeu: 3.14 ± 0.544
0.269PheMet: 0.269 ± 0.165
3.319PheAsn: 3.319 ± 0.516
1.346PhePro: 1.346 ± 0.348
0.987PheGln: 0.987 ± 0.287
1.077PheArg: 1.077 ± 0.327
2.512PheSer: 2.512 ± 0.473
1.974PheThr: 1.974 ± 0.374
3.588PheVal: 3.588 ± 0.48
0.09PheTrp: 0.09 ± 0.096
1.974PheTyr: 1.974 ± 0.466
0.0PheXaa: 0.0 ± 0.0
Gly
3.678GlyAla: 3.678 ± 0.771
0.0GlyCys: 0.0 ± 0.0
3.858GlyAsp: 3.858 ± 0.684
3.858GlyGlu: 3.858 ± 0.543
2.691GlyPhe: 2.691 ± 0.381
3.768GlyGly: 3.768 ± 0.709
0.628GlyHis: 0.628 ± 0.231
4.037GlyIle: 4.037 ± 0.698
4.934GlyLys: 4.934 ± 0.593
6.639GlyLeu: 6.639 ± 0.617
1.704GlyMet: 1.704 ± 0.346
3.858GlyAsn: 3.858 ± 0.868
0.718GlyPro: 0.718 ± 0.262
2.602GlyGln: 2.602 ± 0.36
3.05GlyArg: 3.05 ± 0.41
3.499GlySer: 3.499 ± 0.88
3.678GlyThr: 3.678 ± 0.509
3.499GlyVal: 3.499 ± 0.655
0.718GlyTrp: 0.718 ± 0.217
3.14GlyTyr: 3.14 ± 0.636
0.0GlyXaa: 0.0 ± 0.0
His
0.628HisAla: 0.628 ± 0.314
0.179HisCys: 0.179 ± 0.127
0.807HisAsp: 0.807 ± 0.222
0.897HisGlu: 0.897 ± 0.242
0.538HisPhe: 0.538 ± 0.2
0.987HisGly: 0.987 ± 0.302
0.09HisHis: 0.09 ± 0.069
0.897HisIle: 0.897 ± 0.348
0.897HisLys: 0.897 ± 0.255
0.897HisLeu: 0.897 ± 0.257
0.359HisMet: 0.359 ± 0.14
0.807HisAsn: 0.807 ± 0.248
0.269HisPro: 0.269 ± 0.163
0.269HisGln: 0.269 ± 0.166
0.718HisArg: 0.718 ± 0.228
0.538HisSer: 0.538 ± 0.212
0.897HisThr: 0.897 ± 0.253
0.538HisVal: 0.538 ± 0.183
0.09HisTrp: 0.09 ± 0.1
0.628HisTyr: 0.628 ± 0.253
0.0HisXaa: 0.0 ± 0.0
Ile
5.113IleAla: 5.113 ± 0.663
0.269IleCys: 0.269 ± 0.219
4.844IleAsp: 4.844 ± 0.47
4.216IleGlu: 4.216 ± 0.729
2.153IlePhe: 2.153 ± 0.53
3.947IleGly: 3.947 ± 0.847
0.807IleHis: 0.807 ± 0.22
5.203IleIle: 5.203 ± 0.821
6.1IleLys: 6.1 ± 0.47
5.024IleLeu: 5.024 ± 0.773
1.077IleMet: 1.077 ± 0.264
4.127IleAsn: 4.127 ± 0.701
2.96IlePro: 2.96 ± 0.528
2.063IleGln: 2.063 ± 0.348
2.243IleArg: 2.243 ± 0.64
6.459IleSer: 6.459 ± 0.903
5.472IleThr: 5.472 ± 0.793
3.409IleVal: 3.409 ± 0.511
0.987IleTrp: 0.987 ± 0.338
2.422IleTyr: 2.422 ± 0.489
0.0IleXaa: 0.0 ± 0.0
Lys
6.28LysAla: 6.28 ± 0.924
0.179LysCys: 0.179 ± 0.129
5.472LysAsp: 5.472 ± 0.723
5.472LysGlu: 5.472 ± 0.927
3.768LysPhe: 3.768 ± 0.666
3.499LysGly: 3.499 ± 0.641
1.884LysHis: 1.884 ± 0.465
6.549LysIle: 6.549 ± 0.688
7.984LysLys: 7.984 ± 1.229
6.908LysLeu: 6.908 ± 0.603
2.153LysMet: 2.153 ± 0.424
6.19LysAsn: 6.19 ± 0.92
1.704LysPro: 1.704 ± 0.491
4.755LysGln: 4.755 ± 0.745
4.127LysArg: 4.127 ± 0.92
5.113LysSer: 5.113 ± 0.696
5.113LysThr: 5.113 ± 0.642
6.1LysVal: 6.1 ± 0.631
0.718LysTrp: 0.718 ± 0.228
3.05LysTyr: 3.05 ± 0.689
0.0LysXaa: 0.0 ± 0.0
Leu
7.267LeuAla: 7.267 ± 0.792
0.269LeuCys: 0.269 ± 0.135
5.472LeuAsp: 5.472 ± 1.014
5.562LeuGlu: 5.562 ± 0.786
2.512LeuPhe: 2.512 ± 0.529
4.486LeuGly: 4.486 ± 0.868
0.807LeuHis: 0.807 ± 0.307
4.844LeuIle: 4.844 ± 0.784
8.433LeuLys: 8.433 ± 0.735
6.011LeuLeu: 6.011 ± 0.587
2.153LeuMet: 2.153 ± 0.574
4.934LeuAsn: 4.934 ± 0.707
2.063LeuPro: 2.063 ± 0.407
3.319LeuGln: 3.319 ± 0.583
2.422LeuArg: 2.422 ± 0.544
7.087LeuSer: 7.087 ± 0.811
6.997LeuThr: 6.997 ± 1.353
4.396LeuVal: 4.396 ± 0.456
0.538LeuTrp: 0.538 ± 0.194
2.691LeuTyr: 2.691 ± 0.449
0.0LeuXaa: 0.0 ± 0.0
Met
2.332MetAla: 2.332 ± 0.599
0.0MetCys: 0.0 ± 0.0
1.346MetAsp: 1.346 ± 0.441
0.897MetGlu: 0.897 ± 0.26
1.256MetPhe: 1.256 ± 0.372
1.435MetGly: 1.435 ± 0.338
0.09MetHis: 0.09 ± 0.113
1.704MetIle: 1.704 ± 0.343
2.691MetLys: 2.691 ± 0.537
1.256MetLeu: 1.256 ± 0.383
0.807MetMet: 0.807 ± 0.279
1.256MetAsn: 1.256 ± 0.314
1.166MetPro: 1.166 ± 0.314
1.256MetGln: 1.256 ± 0.329
1.077MetArg: 1.077 ± 0.331
1.704MetSer: 1.704 ± 0.367
2.243MetThr: 2.243 ± 0.416
1.346MetVal: 1.346 ± 0.395
0.09MetTrp: 0.09 ± 0.115
1.166MetTyr: 1.166 ± 0.376
0.0MetXaa: 0.0 ± 0.0
Asn
5.562AsnAla: 5.562 ± 0.971
0.09AsnCys: 0.09 ± 0.07
3.947AsnAsp: 3.947 ± 0.568
3.409AsnGlu: 3.409 ± 0.613
1.974AsnPhe: 1.974 ± 0.39
5.024AsnGly: 5.024 ± 0.729
0.987AsnHis: 0.987 ± 0.231
3.947AsnIle: 3.947 ± 0.572
6.1AsnLys: 6.1 ± 0.708
4.486AsnLeu: 4.486 ± 0.449
1.256AsnMet: 1.256 ± 0.289
4.216AsnAsn: 4.216 ± 0.848
2.332AsnPro: 2.332 ± 0.54
3.499AsnGln: 3.499 ± 0.58
2.153AsnArg: 2.153 ± 0.42
3.319AsnSer: 3.319 ± 0.456
2.063AsnThr: 2.063 ± 0.394
3.588AsnVal: 3.588 ± 0.437
1.166AsnTrp: 1.166 ± 0.342
2.243AsnTyr: 2.243 ± 0.313
0.0AsnXaa: 0.0 ± 0.0
Pro
1.704ProAla: 1.704 ± 0.318
0.0ProCys: 0.0 ± 0.0
1.166ProAsp: 1.166 ± 0.361
2.153ProGlu: 2.153 ± 0.471
1.435ProPhe: 1.435 ± 0.35
1.077ProGly: 1.077 ± 0.341
0.449ProHis: 0.449 ± 0.202
1.794ProIle: 1.794 ± 0.353
3.409ProLys: 3.409 ± 0.607
2.153ProLeu: 2.153 ± 0.416
0.449ProMet: 0.449 ± 0.201
1.525ProAsn: 1.525 ± 0.365
0.449ProPro: 0.449 ± 0.196
1.166ProGln: 1.166 ± 0.327
0.538ProArg: 0.538 ± 0.227
1.525ProSer: 1.525 ± 0.32
2.512ProThr: 2.512 ± 0.365
1.525ProVal: 1.525 ± 0.371
0.179ProTrp: 0.179 ± 0.099
1.346ProTyr: 1.346 ± 0.327
0.0ProXaa: 0.0 ± 0.0
Gln
4.575GlnAla: 4.575 ± 0.721
0.179GlnCys: 0.179 ± 0.141
1.794GlnAsp: 1.794 ± 0.331
3.23GlnGlu: 3.23 ± 0.557
1.256GlnPhe: 1.256 ± 0.329
2.781GlnGly: 2.781 ± 0.548
0.628GlnHis: 0.628 ± 0.279
3.319GlnIle: 3.319 ± 0.504
3.678GlnLys: 3.678 ± 0.487
3.947GlnLeu: 3.947 ± 0.597
1.256GlnMet: 1.256 ± 0.35
2.602GlnAsn: 2.602 ± 0.481
1.077GlnPro: 1.077 ± 0.28
2.512GlnGln: 2.512 ± 0.462
1.166GlnArg: 1.166 ± 0.331
2.691GlnSer: 2.691 ± 0.615
2.602GlnThr: 2.602 ± 0.514
2.512GlnVal: 2.512 ± 0.442
0.359GlnTrp: 0.359 ± 0.159
1.435GlnTyr: 1.435 ± 0.455
0.0GlnXaa: 0.0 ± 0.0
Arg
1.346ArgAla: 1.346 ± 0.294
0.269ArgCys: 0.269 ± 0.167
2.871ArgAsp: 2.871 ± 0.434
2.871ArgGlu: 2.871 ± 0.716
1.525ArgPhe: 1.525 ± 0.391
1.435ArgGly: 1.435 ± 0.282
0.449ArgHis: 0.449 ± 0.203
1.884ArgIle: 1.884 ± 0.751
2.691ArgLys: 2.691 ± 0.479
4.037ArgLeu: 4.037 ± 0.771
1.166ArgMet: 1.166 ± 0.347
2.243ArgAsn: 2.243 ± 0.405
1.346ArgPro: 1.346 ± 0.359
2.063ArgGln: 2.063 ± 0.545
1.704ArgArg: 1.704 ± 0.335
1.525ArgSer: 1.525 ± 0.294
2.512ArgThr: 2.512 ± 0.507
2.332ArgVal: 2.332 ± 0.341
0.628ArgTrp: 0.628 ± 0.229
2.332ArgTyr: 2.332 ± 0.406
0.0ArgXaa: 0.0 ± 0.0
Ser
3.858SerAla: 3.858 ± 0.77
0.179SerCys: 0.179 ± 0.121
4.127SerAsp: 4.127 ± 0.633
5.383SerGlu: 5.383 ± 0.644
2.871SerPhe: 2.871 ± 0.517
5.113SerGly: 5.113 ± 0.89
0.628SerHis: 0.628 ± 0.25
3.678SerIle: 3.678 ± 0.614
5.383SerLys: 5.383 ± 0.81
5.472SerLeu: 5.472 ± 0.697
1.615SerMet: 1.615 ± 0.439
3.947SerAsn: 3.947 ± 0.675
1.704SerPro: 1.704 ± 0.371
2.512SerGln: 2.512 ± 0.549
2.781SerArg: 2.781 ± 0.443
4.486SerSer: 4.486 ± 0.705
4.396SerThr: 4.396 ± 0.677
3.947SerVal: 3.947 ± 0.585
1.256SerTrp: 1.256 ± 0.28
2.153SerTyr: 2.153 ± 0.452
0.0SerXaa: 0.0 ± 0.0
Thr
5.293ThrAla: 5.293 ± 0.844
0.269ThrCys: 0.269 ± 0.137
4.486ThrAsp: 4.486 ± 0.69
3.858ThrGlu: 3.858 ± 0.504
2.332ThrPhe: 2.332 ± 0.405
4.396ThrGly: 4.396 ± 0.63
0.987ThrHis: 0.987 ± 0.43
4.934ThrIle: 4.934 ± 0.636
4.934ThrLys: 4.934 ± 0.654
5.652ThrLeu: 5.652 ± 0.711
2.063ThrMet: 2.063 ± 0.45
3.23ThrAsn: 3.23 ± 0.8
1.435ThrPro: 1.435 ± 0.378
2.691ThrGln: 2.691 ± 0.504
1.884ThrArg: 1.884 ± 0.357
4.396ThrSer: 4.396 ± 0.633
4.216ThrThr: 4.216 ± 0.72
5.562ThrVal: 5.562 ± 0.886
1.166ThrTrp: 1.166 ± 0.259
2.332ThrTyr: 2.332 ± 0.509
0.0ThrXaa: 0.0 ± 0.0
Val
5.024ValAla: 5.024 ± 0.652
0.538ValCys: 0.538 ± 0.29
5.024ValAsp: 5.024 ± 0.627
5.562ValGlu: 5.562 ± 0.819
2.871ValPhe: 2.871 ± 0.454
3.409ValGly: 3.409 ± 0.697
0.538ValHis: 0.538 ± 0.216
4.216ValIle: 4.216 ± 0.554
5.383ValLys: 5.383 ± 0.698
3.768ValLeu: 3.768 ± 0.641
0.987ValMet: 0.987 ± 0.379
3.947ValAsn: 3.947 ± 0.52
2.332ValPro: 2.332 ± 0.452
2.153ValGln: 2.153 ± 0.52
1.884ValArg: 1.884 ± 0.44
5.024ValSer: 5.024 ± 0.778
4.575ValThr: 4.575 ± 0.653
3.858ValVal: 3.858 ± 0.582
0.628ValTrp: 0.628 ± 0.253
1.794ValTyr: 1.794 ± 0.362
0.0ValXaa: 0.0 ± 0.0
Trp
0.987TrpAla: 0.987 ± 0.321
0.179TrpCys: 0.179 ± 0.114
0.807TrpAsp: 0.807 ± 0.335
0.449TrpGlu: 0.449 ± 0.193
0.449TrpPhe: 0.449 ± 0.158
0.628TrpGly: 0.628 ± 0.266
0.269TrpHis: 0.269 ± 0.139
0.897TrpIle: 0.897 ± 0.293
1.346TrpLys: 1.346 ± 0.264
1.166TrpLeu: 1.166 ± 0.362
0.269TrpMet: 0.269 ± 0.136
0.628TrpAsn: 0.628 ± 0.244
0.0TrpPro: 0.0 ± 0.0
0.718TrpGln: 0.718 ± 0.211
0.628TrpArg: 0.628 ± 0.209
0.807TrpSer: 0.807 ± 0.335
0.718TrpThr: 0.718 ± 0.297
0.807TrpVal: 0.807 ± 0.271
0.269TrpTrp: 0.269 ± 0.2
0.269TrpTyr: 0.269 ± 0.133
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.794TyrAla: 1.794 ± 0.417
0.718TyrCys: 0.718 ± 0.266
2.243TyrAsp: 2.243 ± 0.491
2.422TyrGlu: 2.422 ± 0.567
2.512TyrPhe: 2.512 ± 0.505
2.781TyrGly: 2.781 ± 0.444
0.718TyrHis: 0.718 ± 0.226
2.781TyrIle: 2.781 ± 0.642
2.512TyrLys: 2.512 ± 0.518
2.332TyrLeu: 2.332 ± 0.454
0.718TyrMet: 0.718 ± 0.288
1.525TyrAsn: 1.525 ± 0.28
1.077TyrPro: 1.077 ± 0.284
1.704TyrGln: 1.704 ± 0.295
2.332TyrArg: 2.332 ± 0.353
2.512TyrSer: 2.512 ± 0.605
2.422TyrThr: 2.422 ± 0.589
2.512TyrVal: 2.512 ± 0.41
0.449TyrTrp: 0.449 ± 0.165
1.525TyrTyr: 1.525 ± 0.459
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 54 proteins (11148 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski