Amino acid dipepetide frequency for Wenzhou picorna-like virus 9

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.575AlaAla: 4.575 ± 0.891
0.762AlaCys: 0.762 ± 0.148
4.956AlaAsp: 4.956 ± 0.681
4.194AlaGlu: 4.194 ± 0.035
2.287AlaPhe: 2.287 ± 0.445
7.244AlaGly: 7.244 ± 0.009
1.906AlaHis: 1.906 ± 0.655
4.575AlaIle: 4.575 ± 0.245
3.431AlaLys: 3.431 ± 0.183
4.575AlaLeu: 4.575 ± 0.891
1.906AlaMet: 1.906 ± 0.163
3.431AlaAsn: 3.431 ± 2.087
3.812AlaPro: 3.812 ± 2.445
2.287AlaGln: 2.287 ± 1.013
1.906AlaArg: 1.906 ± 1.223
4.194AlaSer: 4.194 ± 0.603
7.625AlaThr: 7.625 ± 0.349
3.812AlaVal: 3.812 ± 1.528
0.381AlaTrp: 0.381 ± 0.358
3.05AlaTyr: 3.05 ± 0.541
0.0AlaXaa: 0.0 ± 0.0
Cys
1.906CysAla: 1.906 ± 0.087
0.762CysCys: 0.762 ± 0.419
0.381CysAsp: 0.381 ± 0.21
0.0CysGlu: 0.0 ± 0.0
1.906CysPhe: 1.906 ± 0.48
0.0CysGly: 0.0 ± 0.0
0.0CysHis: 0.0 ± 0.0
0.381CysIle: 0.381 ± 0.358
1.525CysLys: 1.525 ± 0.838
0.762CysLeu: 0.762 ± 0.419
0.381CysMet: 0.381 ± 0.21
0.762CysAsn: 0.762 ± 0.419
0.762CysPro: 0.762 ± 0.419
0.381CysGln: 0.381 ± 0.358
0.762CysArg: 0.762 ± 0.716
1.144CysSer: 1.144 ± 0.629
0.762CysThr: 0.762 ± 0.148
1.525CysVal: 1.525 ± 0.838
0.0CysTrp: 0.0 ± 0.0
1.144CysTyr: 1.144 ± 0.629
0.0CysXaa: 0.0 ± 0.0
Asp
4.575AspAla: 4.575 ± 0.891
0.762AspCys: 0.762 ± 0.148
4.575AspAsp: 4.575 ± 0.891
4.575AspGlu: 4.575 ± 0.891
1.525AspPhe: 1.525 ± 0.838
1.906AspGly: 1.906 ± 0.087
0.762AspHis: 0.762 ± 0.148
2.669AspIle: 2.669 ± 0.332
4.194AspLys: 4.194 ± 1.738
5.337AspLeu: 5.337 ± 1.231
2.287AspMet: 2.287 ± 0.122
1.906AspAsn: 1.906 ± 0.087
3.05AspPro: 3.05 ± 1.729
2.669AspGln: 2.669 ± 0.236
1.525AspArg: 1.525 ± 0.271
7.244AspSer: 7.244 ± 0.576
2.669AspThr: 2.669 ± 0.332
3.431AspVal: 3.431 ± 1.519
0.762AspTrp: 0.762 ± 0.419
1.906AspTyr: 1.906 ± 0.087
0.0AspXaa: 0.0 ± 0.0
Glu
3.431GluAla: 3.431 ± 0.751
1.525GluCys: 1.525 ± 0.271
3.05GluAsp: 3.05 ± 0.026
3.431GluGlu: 3.431 ± 0.751
4.194GluPhe: 4.194 ± 0.035
3.05GluGly: 3.05 ± 0.594
1.144GluHis: 1.144 ± 0.061
4.194GluIle: 4.194 ± 0.035
3.812GluLys: 3.812 ± 0.961
6.862GluLeu: 6.862 ± 1.336
1.144GluMet: 1.144 ± 0.979
2.669GluAsn: 2.669 ± 0.236
3.431GluPro: 3.431 ± 0.384
2.669GluGln: 2.669 ± 0.899
3.05GluArg: 3.05 ± 1.109
4.575GluSer: 4.575 ± 1.38
4.194GluThr: 4.194 ± 1.668
2.287GluVal: 2.287 ± 1.257
0.762GluTrp: 0.762 ± 0.419
2.669GluTyr: 2.669 ± 0.236
0.0GluXaa: 0.0 ± 0.0
Phe
1.906PheAla: 1.906 ± 0.655
1.144PheCys: 1.144 ± 0.061
4.575PheAsp: 4.575 ± 0.245
4.194PheGlu: 4.194 ± 0.533
4.575PhePhe: 4.575 ± 2.594
3.05PheGly: 3.05 ± 0.026
1.525PheHis: 1.525 ± 0.865
3.05PheIle: 3.05 ± 1.109
3.431PheLys: 3.431 ± 0.384
4.194PheLeu: 4.194 ± 1.17
0.762PheMet: 0.762 ± 0.419
3.431PheAsn: 3.431 ± 0.384
1.525PhePro: 1.525 ± 0.297
1.906PheGln: 1.906 ± 0.655
2.669PheArg: 2.669 ± 0.332
3.05PheSer: 3.05 ± 0.026
4.194PheThr: 4.194 ± 1.738
2.287PheVal: 2.287 ± 0.122
0.762PheTrp: 0.762 ± 0.148
0.762PheTyr: 0.762 ± 0.148
0.0PheXaa: 0.0 ± 0.0
Gly
4.194GlyAla: 4.194 ± 1.1
0.381GlyCys: 0.381 ± 0.21
1.525GlyAsp: 1.525 ± 0.271
4.575GlyGlu: 4.575 ± 0.891
1.906GlyPhe: 1.906 ± 0.087
2.669GlyGly: 2.669 ± 1.371
0.762GlyHis: 0.762 ± 0.419
3.812GlyIle: 3.812 ± 0.175
4.194GlyLys: 4.194 ± 1.738
5.719GlyLeu: 5.719 ± 0.262
1.144GlyMet: 1.144 ± 0.506
3.431GlyAsn: 3.431 ± 0.183
0.0GlyPro: 0.0 ± 0.0
1.144GlyGln: 1.144 ± 0.506
3.05GlyArg: 3.05 ± 0.541
3.05GlySer: 3.05 ± 0.594
4.194GlyThr: 4.194 ± 0.533
3.812GlyVal: 3.812 ± 0.175
0.381GlyTrp: 0.381 ± 0.358
4.194GlyTyr: 4.194 ± 0.533
0.0GlyXaa: 0.0 ± 0.0
His
1.525HisAla: 1.525 ± 0.865
0.381HisCys: 0.381 ± 0.21
1.144HisAsp: 1.144 ± 0.061
1.525HisGlu: 1.525 ± 0.297
1.144HisPhe: 1.144 ± 0.629
1.144HisGly: 1.144 ± 0.629
0.762HisHis: 0.762 ± 0.419
1.906HisIle: 1.906 ± 0.087
1.525HisLys: 1.525 ± 0.271
0.762HisLeu: 0.762 ± 0.419
0.0HisMet: 0.0 ± 0.0
0.381HisAsn: 0.381 ± 0.21
0.762HisPro: 0.762 ± 0.419
0.381HisGln: 0.381 ± 0.21
1.525HisArg: 1.525 ± 0.865
1.525HisSer: 1.525 ± 0.838
1.906HisThr: 1.906 ± 0.087
2.287HisVal: 2.287 ± 0.445
0.381HisTrp: 0.381 ± 0.21
0.762HisTyr: 0.762 ± 0.148
0.0HisXaa: 0.0 ± 0.0
Ile
8.769IleAla: 8.769 ± 0.288
1.144IleCys: 1.144 ± 0.629
1.906IleAsp: 1.906 ± 0.655
3.431IleGlu: 3.431 ± 0.751
1.525IlePhe: 1.525 ± 0.271
1.525IleGly: 1.525 ± 0.271
1.144IleHis: 1.144 ± 0.506
4.575IleIle: 4.575 ± 1.38
2.287IleLys: 2.287 ± 0.122
7.244IleLeu: 7.244 ± 0.576
1.525IleMet: 1.525 ± 0.838
4.575IleAsn: 4.575 ± 0.245
2.669IlePro: 2.669 ± 0.332
1.144IleGln: 1.144 ± 0.061
4.194IleArg: 4.194 ± 0.533
4.956IleSer: 4.956 ± 1.249
5.337IleThr: 5.337 ± 0.664
4.575IleVal: 4.575 ± 0.245
0.381IleTrp: 0.381 ± 0.21
1.906IleTyr: 1.906 ± 1.048
0.0IleXaa: 0.0 ± 0.0
Lys
1.906LysAla: 1.906 ± 0.655
0.762LysCys: 0.762 ± 0.419
4.956LysAsp: 4.956 ± 1.589
2.287LysGlu: 2.287 ± 0.69
3.431LysPhe: 3.431 ± 0.384
1.906LysGly: 1.906 ± 0.48
1.144LysHis: 1.144 ± 0.629
6.1LysIle: 6.1 ± 0.515
3.812LysLys: 3.812 ± 0.961
3.431LysLeu: 3.431 ± 0.751
0.762LysMet: 0.762 ± 0.419
3.05LysAsn: 3.05 ± 0.541
3.05LysPro: 3.05 ± 0.541
3.431LysGln: 3.431 ± 0.751
3.812LysArg: 3.812 ± 0.175
2.669LysSer: 2.669 ± 0.899
3.812LysThr: 3.812 ± 1.528
3.812LysVal: 3.812 ± 0.393
0.0LysTrp: 0.0 ± 0.0
3.812LysTyr: 3.812 ± 0.393
0.0LysXaa: 0.0 ± 0.0
Leu
7.625LeuAla: 7.625 ± 0.218
1.144LeuCys: 1.144 ± 0.629
3.812LeuAsp: 3.812 ± 1.31
5.337LeuGlu: 5.337 ± 0.096
3.812LeuPhe: 3.812 ± 0.175
3.431LeuGly: 3.431 ± 0.751
4.194LeuHis: 4.194 ± 0.035
4.194LeuIle: 4.194 ± 0.603
5.719LeuLys: 5.719 ± 1.441
8.387LeuLeu: 8.387 ± 0.638
3.05LeuMet: 3.05 ± 0.541
2.287LeuAsn: 2.287 ± 0.445
3.812LeuPro: 3.812 ± 0.175
3.05LeuGln: 3.05 ± 0.541
6.1LeuArg: 6.1 ± 0.052
8.387LeuSer: 8.387 ± 0.07
4.575LeuThr: 4.575 ± 0.891
3.431LeuVal: 3.431 ± 0.183
0.762LeuTrp: 0.762 ± 0.148
2.287LeuTyr: 2.287 ± 0.69
0.0LeuXaa: 0.0 ± 0.0
Met
2.287MetAla: 2.287 ± 0.122
0.762MetCys: 0.762 ± 0.419
1.144MetAsp: 1.144 ± 0.061
1.906MetGlu: 1.906 ± 0.655
0.0MetPhe: 0.0 ± 0.0
1.525MetGly: 1.525 ± 0.865
0.0MetHis: 0.0 ± 0.0
2.287MetIle: 2.287 ± 0.445
0.762MetLys: 0.762 ± 0.716
2.669MetLeu: 2.669 ± 0.236
1.144MetMet: 1.144 ± 0.061
0.762MetAsn: 0.762 ± 0.148
0.381MetPro: 0.381 ± 0.21
0.762MetGln: 0.762 ± 0.419
1.525MetArg: 1.525 ± 0.838
2.287MetSer: 2.287 ± 0.122
1.525MetThr: 1.525 ± 0.271
1.906MetVal: 1.906 ± 0.48
0.381MetTrp: 0.381 ± 0.21
0.381MetTyr: 0.381 ± 0.21
0.0MetXaa: 0.0 ± 0.0
Asn
2.669AsnAla: 2.669 ± 0.803
0.381AsnCys: 0.381 ± 0.21
3.431AsnAsp: 3.431 ± 0.384
1.144AsnGlu: 1.144 ± 0.629
1.525AsnPhe: 1.525 ± 0.271
1.906AsnGly: 1.906 ± 0.087
1.144AsnHis: 1.144 ± 0.629
4.575AsnIle: 4.575 ± 1.38
0.762AsnLys: 0.762 ± 0.419
3.431AsnLeu: 3.431 ± 1.519
0.762AsnMet: 0.762 ± 0.148
2.669AsnAsn: 2.669 ± 1.939
2.669AsnPro: 2.669 ± 1.371
1.906AsnGln: 1.906 ± 0.087
1.906AsnArg: 1.906 ± 1.223
1.906AsnSer: 1.906 ± 0.087
3.812AsnThr: 3.812 ± 0.175
5.719AsnVal: 5.719 ± 0.873
0.0AsnTrp: 0.0 ± 0.0
3.05AsnTyr: 3.05 ± 2.297
0.0AsnXaa: 0.0 ± 0.0
Pro
3.431ProAla: 3.431 ± 1.519
0.381ProCys: 0.381 ± 0.358
2.287ProAsp: 2.287 ± 1.013
1.906ProGlu: 1.906 ± 0.087
4.956ProPhe: 4.956 ± 2.384
3.05ProGly: 3.05 ± 0.594
0.381ProHis: 0.381 ± 0.358
3.05ProIle: 3.05 ± 0.026
3.05ProLys: 3.05 ± 1.677
4.575ProLeu: 4.575 ± 0.323
1.525ProMet: 1.525 ± 0.865
1.525ProAsn: 1.525 ± 0.297
1.906ProPro: 1.906 ± 1.223
1.144ProGln: 1.144 ± 0.506
1.144ProArg: 1.144 ± 0.061
4.575ProSer: 4.575 ± 0.891
3.05ProThr: 3.05 ± 0.594
2.287ProVal: 2.287 ± 1.013
0.381ProTrp: 0.381 ± 0.358
1.525ProTyr: 1.525 ± 0.297
0.0ProXaa: 0.0 ± 0.0
Gln
3.812GlnAla: 3.812 ± 1.877
0.0GlnCys: 0.0 ± 0.0
3.05GlnAsp: 3.05 ± 0.026
3.05GlnGlu: 3.05 ± 0.541
1.144GlnPhe: 1.144 ± 0.061
1.906GlnGly: 1.906 ± 0.087
0.0GlnHis: 0.0 ± 0.0
3.05GlnIle: 3.05 ± 0.026
1.144GlnLys: 1.144 ± 0.629
3.812GlnLeu: 3.812 ± 0.393
1.525GlnMet: 1.525 ± 0.271
0.381GlnAsn: 0.381 ± 0.358
2.287GlnPro: 2.287 ± 1.013
1.144GlnGln: 1.144 ± 0.061
2.669GlnArg: 2.669 ± 0.332
3.431GlnSer: 3.431 ± 0.384
2.669GlnThr: 2.669 ± 0.236
0.762GlnVal: 0.762 ± 0.419
0.0GlnTrp: 0.0 ± 0.0
0.0GlnTyr: 0.0 ± 0.0
0.0GlnXaa: 0.0 ± 0.0
Arg
2.669ArgAla: 2.669 ± 0.332
0.0ArgCys: 0.0 ± 0.0
1.525ArgAsp: 1.525 ± 0.838
3.812ArgGlu: 3.812 ± 0.393
1.906ArgPhe: 1.906 ± 0.48
4.194ArgGly: 4.194 ± 0.603
1.525ArgHis: 1.525 ± 0.865
3.431ArgIle: 3.431 ± 0.384
5.337ArgLys: 5.337 ± 0.096
3.431ArgLeu: 3.431 ± 0.384
1.144ArgMet: 1.144 ± 0.506
0.762ArgAsn: 0.762 ± 0.419
2.669ArgPro: 2.669 ± 0.236
1.144ArgGln: 1.144 ± 0.629
3.05ArgArg: 3.05 ± 1.677
3.812ArgSer: 3.812 ± 0.393
4.575ArgThr: 4.575 ± 0.323
3.812ArgVal: 3.812 ± 1.31
0.381ArgTrp: 0.381 ± 0.358
1.144ArgTyr: 1.144 ± 0.061
0.0ArgXaa: 0.0 ± 0.0
Ser
4.575SerAla: 4.575 ± 0.891
1.144SerCys: 1.144 ± 0.061
4.956SerAsp: 4.956 ± 1.589
5.337SerGlu: 5.337 ± 2.367
5.719SerPhe: 5.719 ± 0.306
6.1SerGly: 6.1 ± 1.188
1.525SerHis: 1.525 ± 0.838
5.719SerIle: 5.719 ± 0.262
2.669SerLys: 2.669 ± 0.803
4.575SerLeu: 4.575 ± 0.812
0.0SerMet: 0.0 ± 0.0
3.05SerAsn: 3.05 ± 0.541
4.194SerPro: 4.194 ± 2.235
5.719SerGln: 5.719 ± 0.83
2.287SerArg: 2.287 ± 0.445
6.1SerSer: 6.1 ± 0.515
3.431SerThr: 3.431 ± 0.952
6.481SerVal: 6.481 ± 0.725
0.762SerTrp: 0.762 ± 0.419
2.287SerTyr: 2.287 ± 0.122
0.0SerXaa: 0.0 ± 0.0
Thr
2.287ThrAla: 2.287 ± 1.013
1.144ThrCys: 1.144 ± 0.061
2.287ThrAsp: 2.287 ± 0.445
4.575ThrGlu: 4.575 ± 1.458
5.337ThrPhe: 5.337 ± 0.664
2.669ThrGly: 2.669 ± 0.236
1.906ThrHis: 1.906 ± 1.048
4.194ThrIle: 4.194 ± 0.603
3.05ThrLys: 3.05 ± 1.109
7.244ThrLeu: 7.244 ± 1.712
1.525ThrMet: 1.525 ± 0.271
2.669ThrAsn: 2.669 ± 0.332
3.812ThrPro: 3.812 ± 2.445
1.906ThrGln: 1.906 ± 0.48
2.669ThrArg: 2.669 ± 0.236
6.1ThrSer: 6.1 ± 0.052
3.431ThrThr: 3.431 ± 0.183
4.194ThrVal: 4.194 ± 1.668
0.381ThrTrp: 0.381 ± 0.21
4.575ThrTyr: 4.575 ± 0.245
0.0ThrXaa: 0.0 ± 0.0
Val
4.575ValAla: 4.575 ± 1.38
0.381ValCys: 0.381 ± 0.21
4.575ValAsp: 4.575 ± 0.245
3.05ValGlu: 3.05 ± 0.026
3.05ValPhe: 3.05 ± 0.026
2.287ValGly: 2.287 ± 0.445
0.381ValHis: 0.381 ± 0.21
3.05ValIle: 3.05 ± 0.026
5.337ValLys: 5.337 ± 0.472
4.575ValLeu: 4.575 ± 0.245
1.144ValMet: 1.144 ± 0.061
3.431ValAsn: 3.431 ± 0.384
3.812ValPro: 3.812 ± 0.175
1.144ValGln: 1.144 ± 1.074
4.956ValArg: 4.956 ± 1.589
6.862ValSer: 6.862 ± 1.904
1.906ValThr: 1.906 ± 0.48
6.1ValVal: 6.1 ± 2.218
1.144ValTrp: 1.144 ± 0.061
2.287ValTyr: 2.287 ± 0.69
0.0ValXaa: 0.0 ± 0.0
Trp
1.144TrpAla: 1.144 ± 0.061
0.762TrpCys: 0.762 ± 0.148
0.381TrpAsp: 0.381 ± 0.21
0.381TrpGlu: 0.381 ± 0.21
0.762TrpPhe: 0.762 ± 0.148
0.381TrpGly: 0.381 ± 0.21
0.762TrpHis: 0.762 ± 0.419
0.0TrpIle: 0.0 ± 0.0
0.0TrpLys: 0.0 ± 0.0
0.762TrpLeu: 0.762 ± 0.148
0.381TrpMet: 0.381 ± 0.21
0.381TrpAsn: 0.381 ± 0.358
0.0TrpPro: 0.0 ± 0.0
0.381TrpGln: 0.381 ± 0.358
0.0TrpArg: 0.0 ± 0.0
0.0TrpSer: 0.0 ± 0.0
0.762TrpThr: 0.762 ± 0.419
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.762TrpTyr: 0.762 ± 0.148
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.05TyrAla: 3.05 ± 0.541
1.525TyrCys: 1.525 ± 0.838
3.812TyrAsp: 3.812 ± 0.742
3.812TyrGlu: 3.812 ± 0.961
2.287TyrPhe: 2.287 ± 0.69
4.194TyrGly: 4.194 ± 1.1
0.762TyrHis: 0.762 ± 0.419
0.0TyrIle: 0.0 ± 0.0
1.906TyrLys: 1.906 ± 0.48
3.05TyrLeu: 3.05 ± 0.026
1.906TyrMet: 1.906 ± 0.087
3.812TyrAsn: 3.812 ± 1.877
1.525TyrPro: 1.525 ± 0.838
1.525TyrGln: 1.525 ± 0.271
1.525TyrArg: 1.525 ± 0.271
0.762TyrSer: 0.762 ± 0.148
1.525TyrThr: 1.525 ± 0.297
1.525TyrVal: 1.525 ± 0.297
0.0TyrTrp: 0.0 ± 0.0
1.144TyrTyr: 1.144 ± 0.061
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (2624 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski