Amino acid dipepetide frequency for Profundibacter amoris

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.739AlaAla: 13.739 ± 0.154	1.037AlaCys: 1.037 ± 0.037	6.741AlaAsp: 6.741 ± 0.085	6.968AlaGlu: 6.968 ± 0.112	4.018AlaPhe: 4.018 ± 0.081	9.67AlaGly: 9.67 ± 0.106	2.036AlaHis: 2.036 ± 0.046	6.103AlaIle: 6.103 ± 0.09	5.013AlaLys: 5.013 ± 0.076	12.251AlaLeu: 12.251 ± 0.141	3.607AlaMet: 3.607 ± 0.059	3.029AlaAsn: 3.029 ± 0.059	4.945AlaPro: 4.945 ± 0.073	4.037AlaGln: 4.037 ± 0.063	7.049AlaArg: 7.049 ± 0.08	5.058AlaSer: 5.058 ± 0.085	5.662AlaThr: 5.662 ± 0.083	7.636AlaVal: 7.636 ± 0.081	1.225AlaTrp: 1.225 ± 0.041	2.718AlaTyr: 2.718 ± 0.058	0.0AlaXaa: 0.0 ± 0.0
Cys	0.938CysAla: 0.938 ± 0.033	0.1CysCys: 0.1 ± 0.011	0.611CysAsp: 0.611 ± 0.024	0.508CysGlu: 0.508 ± 0.023	0.343CysPhe: 0.343 ± 0.018	0.964CysGly: 0.964 ± 0.033	0.294CysHis: 0.294 ± 0.018	0.443CysIle: 0.443 ± 0.019	0.313CysLys: 0.313 ± 0.017	0.755CysLeu: 0.755 ± 0.029	0.173CysMet: 0.173 ± 0.014	0.301CysAsn: 0.301 ± 0.018	0.514CysPro: 0.514 ± 0.025	0.247CysGln: 0.247 ± 0.015	0.498CysArg: 0.498 ± 0.026	0.465CysSer: 0.465 ± 0.026	0.478CysThr: 0.478 ± 0.024	0.601CysVal: 0.601 ± 0.029	0.11CysTrp: 0.11 ± 0.01	0.232CysTyr: 0.232 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	6.817AspAla: 6.817 ± 0.081	0.529AspCys: 0.529 ± 0.022	3.529AspAsp: 3.529 ± 0.071	3.775AspGlu: 3.775 ± 0.069	2.339AspPhe: 2.339 ± 0.044	5.614AspGly: 5.614 ± 0.083	1.289AspHis: 1.289 ± 0.033	3.595AspIle: 3.595 ± 0.064	2.348AspLys: 2.348 ± 0.055	6.154AspLeu: 6.154 ± 0.087	1.946AspMet: 1.946 ± 0.05	1.644AspAsn: 1.644 ± 0.042	3.272AspPro: 3.272 ± 0.061	1.844AspGln: 1.844 ± 0.041	3.596AspArg: 3.596 ± 0.058	2.413AspSer: 2.413 ± 0.054	3.196AspThr: 3.196 ± 0.062	4.455AspVal: 4.455 ± 0.072	1.129AspTrp: 1.129 ± 0.034	1.651AspTyr: 1.651 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	6.599GluAla: 6.599 ± 0.101	0.414GluCys: 0.414 ± 0.022	3.131GluAsp: 3.131 ± 0.058	3.454GluGlu: 3.454 ± 0.078	2.127GluPhe: 2.127 ± 0.045	4.543GluGly: 4.543 ± 0.082	1.138GluHis: 1.138 ± 0.03	3.927GluIle: 3.927 ± 0.057	2.722GluLys: 2.722 ± 0.063	5.254GluLeu: 5.254 ± 0.089	2.053GluMet: 2.053 ± 0.048	2.174GluAsn: 2.174 ± 0.045	2.32GluPro: 2.32 ± 0.049	2.263GluGln: 2.263 ± 0.044	3.73GluArg: 3.73 ± 0.061	2.299GluSer: 2.299 ± 0.047	3.788GluThr: 3.788 ± 0.056	4.285GluVal: 4.285 ± 0.064	0.783GluTrp: 0.783 ± 0.025	1.341GluTyr: 1.341 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	4.287PheAla: 4.287 ± 0.077	0.4PheCys: 0.4 ± 0.02	2.863PheAsp: 2.863 ± 0.051	2.25PheGlu: 2.25 ± 0.05	1.571PhePhe: 1.571 ± 0.047	3.82PheGly: 3.82 ± 0.06	0.776PheHis: 0.776 ± 0.028	2.114PheIle: 2.114 ± 0.051	1.243PheLys: 1.243 ± 0.036	3.511PheLeu: 3.511 ± 0.066	0.966PheMet: 0.966 ± 0.03	1.198PheAsn: 1.198 ± 0.032	1.562PhePro: 1.562 ± 0.039	1.093PheGln: 1.093 ± 0.03	2.013PheArg: 2.013 ± 0.045	2.306PheSer: 2.306 ± 0.048	2.308PheThr: 2.308 ± 0.052	2.709PheVal: 2.709 ± 0.052	0.628PheTrp: 0.628 ± 0.024	1.066PheTyr: 1.066 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	8.833GlyAla: 8.833 ± 0.104	0.878GlyCys: 0.878 ± 0.03	4.83GlyAsp: 4.83 ± 0.093	4.735GlyGlu: 4.735 ± 0.06	3.814GlyPhe: 3.814 ± 0.066	7.152GlyGly: 7.152 ± 0.131	1.828GlyHis: 1.828 ± 0.043	4.632GlyIle: 4.632 ± 0.06	4.131GlyLys: 4.131 ± 0.069	8.459GlyLeu: 8.459 ± 0.105	2.89GlyMet: 2.89 ± 0.051	2.577GlyAsn: 2.577 ± 0.052	3.229GlyPro: 3.229 ± 0.056	3.148GlyGln: 3.148 ± 0.054	4.871GlyArg: 4.871 ± 0.071	3.944GlySer: 3.944 ± 0.071	4.322GlyThr: 4.322 ± 0.066	6.484GlyVal: 6.484 ± 0.075	1.424GlyTrp: 1.424 ± 0.039	2.498GlyTyr: 2.498 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	2.0HisAla: 2.0 ± 0.042	0.243HisCys: 0.243 ± 0.016	1.209HisAsp: 1.209 ± 0.034	1.011HisGlu: 1.011 ± 0.037	0.859HisPhe: 0.859 ± 0.03	1.773HisGly: 1.773 ± 0.042	0.518HisHis: 0.518 ± 0.025	1.214HisIle: 1.214 ± 0.033	0.687HisLys: 0.687 ± 0.024	1.96HisLeu: 1.96 ± 0.042	0.651HisMet: 0.651 ± 0.025	0.596HisAsn: 0.596 ± 0.026	1.317HisPro: 1.317 ± 0.036	0.606HisGln: 0.606 ± 0.024	1.23HisArg: 1.23 ± 0.037	0.987HisSer: 0.987 ± 0.037	0.891HisThr: 0.891 ± 0.027	1.365HisVal: 1.365 ± 0.037	0.38HisTrp: 0.38 ± 0.021	0.552HisTyr: 0.552 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	7.09IleAla: 7.09 ± 0.077	0.624IleCys: 0.624 ± 0.025	3.765IleAsp: 3.765 ± 0.065	3.7IleGlu: 3.7 ± 0.061	1.939IlePhe: 1.939 ± 0.049	5.069IleGly: 5.069 ± 0.071	1.038IleHis: 1.038 ± 0.03	3.048IleIle: 3.048 ± 0.058	2.14IleLys: 2.14 ± 0.051	5.222IleLeu: 5.222 ± 0.082	1.32IleMet: 1.32 ± 0.034	1.866IleAsn: 1.866 ± 0.041	2.703IlePro: 2.703 ± 0.053	1.327IleGln: 1.327 ± 0.039	3.42IleArg: 3.42 ± 0.058	3.387IleSer: 3.387 ± 0.057	3.439IleThr: 3.439 ± 0.057	3.704IleVal: 3.704 ± 0.057	0.804IleTrp: 0.804 ± 0.031	1.367IleTyr: 1.367 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	4.77LysAla: 4.77 ± 0.078	0.279LysCys: 0.279 ± 0.017	2.403LysAsp: 2.403 ± 0.051	2.143LysGlu: 2.143 ± 0.045	1.219LysPhe: 1.219 ± 0.036	3.612LysGly: 3.612 ± 0.066	0.796LysHis: 0.796 ± 0.03	2.36LysIle: 2.36 ± 0.052	1.781LysLys: 1.781 ± 0.055	3.723LysLeu: 3.723 ± 0.061	1.251LysMet: 1.251 ± 0.034	1.211LysAsn: 1.211 ± 0.034	2.431LysPro: 2.431 ± 0.057	1.354LysGln: 1.354 ± 0.038	2.963LysArg: 2.963 ± 0.059	2.447LysSer: 2.447 ± 0.043	2.641LysThr: 2.641 ± 0.048	2.808LysVal: 2.808 ± 0.06	0.541LysTrp: 0.541 ± 0.024	0.956LysTyr: 0.956 ± 0.029	0.0LysXaa: 0.0 ± 0.0
Leu	11.498LeuAla: 11.498 ± 0.141	0.798LeuCys: 0.798 ± 0.028	5.825LeuAsp: 5.825 ± 0.075	5.51LeuGlu: 5.51 ± 0.083	3.804LeuPhe: 3.804 ± 0.076	8.063LeuGly: 8.063 ± 0.102	1.861LeuHis: 1.861 ± 0.04	5.421LeuIle: 5.421 ± 0.089	4.215LeuLys: 4.215 ± 0.064	9.094LeuLeu: 9.094 ± 0.131	2.832LeuMet: 2.832 ± 0.049	3.04LeuAsn: 3.04 ± 0.056	5.196LeuPro: 5.196 ± 0.073	3.114LeuGln: 3.114 ± 0.064	6.076LeuArg: 6.076 ± 0.077	5.982LeuSer: 5.982 ± 0.08	5.837LeuThr: 5.837 ± 0.073	6.712LeuVal: 6.712 ± 0.095	1.219LeuTrp: 1.219 ± 0.035	2.046LeuTyr: 2.046 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	3.551MetAla: 3.551 ± 0.067	0.224MetCys: 0.224 ± 0.015	1.592MetAsp: 1.592 ± 0.041	1.434MetGlu: 1.434 ± 0.04	0.989MetPhe: 0.989 ± 0.032	2.492MetGly: 2.492 ± 0.047	0.489MetHis: 0.489 ± 0.021	1.685MetIle: 1.685 ± 0.042	1.339MetLys: 1.339 ± 0.034	2.828MetLeu: 2.828 ± 0.056	0.9MetMet: 0.9 ± 0.033	1.024MetAsn: 1.024 ± 0.031	1.611MetPro: 1.611 ± 0.041	1.197MetGln: 1.197 ± 0.033	1.903MetArg: 1.903 ± 0.049	1.806MetSer: 1.806 ± 0.043	1.957MetThr: 1.957 ± 0.047	2.108MetVal: 2.108 ± 0.049	0.306MetTrp: 0.306 ± 0.016	0.433MetTyr: 0.433 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.431AsnAla: 3.431 ± 0.06	0.298AsnCys: 0.298 ± 0.018	1.74AsnAsp: 1.74 ± 0.053	1.519AsnGlu: 1.519 ± 0.041	1.102AsnPhe: 1.102 ± 0.031	2.809AsnGly: 2.809 ± 0.055	0.625AsnHis: 0.625 ± 0.025	1.765AsnIle: 1.765 ± 0.033	1.083AsnLys: 1.083 ± 0.036	2.949AsnLeu: 2.949 ± 0.053	0.858AsnMet: 0.858 ± 0.028	0.956AsnAsn: 0.956 ± 0.035	2.18AsnPro: 2.18 ± 0.05	0.854AsnGln: 0.854 ± 0.03	1.932AsnArg: 1.932 ± 0.043	1.493AsnSer: 1.493 ± 0.044	1.701AsnThr: 1.701 ± 0.045	2.004AsnVal: 2.004 ± 0.043	0.525AsnTrp: 0.525 ± 0.025	0.778AsnTyr: 0.778 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	5.417ProAla: 5.417 ± 0.073	0.349ProCys: 0.349 ± 0.019	4.226ProAsp: 4.226 ± 0.075	3.927ProGlu: 3.927 ± 0.073	1.981ProPhe: 1.981 ± 0.045	3.127ProGly: 3.127 ± 0.056	1.022ProHis: 1.022 ± 0.033	2.25ProIle: 2.25 ± 0.054	2.171ProLys: 2.171 ± 0.045	4.522ProLeu: 4.522 ± 0.082	1.361ProMet: 1.361 ± 0.032	1.45ProAsn: 1.45 ± 0.036	2.149ProPro: 2.149 ± 0.051	1.663ProGln: 1.663 ± 0.04	2.322ProArg: 2.322 ± 0.046	2.256ProSer: 2.256 ± 0.046	2.381ProThr: 2.381 ± 0.049	4.236ProVal: 4.236 ± 0.066	0.591ProTrp: 0.591 ± 0.021	1.285ProTyr: 1.285 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	4.15GlnAla: 4.15 ± 0.069	0.226GlnCys: 0.226 ± 0.016	1.793GlnAsp: 1.793 ± 0.039	1.737GlnGlu: 1.737 ± 0.045	1.17GlnPhe: 1.17 ± 0.034	2.602GlnGly: 2.602 ± 0.046	0.623GlnHis: 0.623 ± 0.027	2.19GlnIle: 2.19 ± 0.051	1.432GlnLys: 1.432 ± 0.034	2.686GlnLeu: 2.686 ± 0.051	1.152GlnMet: 1.152 ± 0.036	1.081GlnAsn: 1.081 ± 0.031	1.515GlnPro: 1.515 ± 0.043	1.175GlnGln: 1.175 ± 0.035	2.042GlnArg: 2.042 ± 0.051	1.8GlnSer: 1.8 ± 0.042	1.9GlnThr: 1.9 ± 0.048	2.453GlnVal: 2.453 ± 0.051	0.409GlnTrp: 0.409 ± 0.02	0.65GlnTyr: 0.65 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	6.41ArgAla: 6.41 ± 0.088	0.483ArgCys: 0.483 ± 0.018	3.745ArgAsp: 3.745 ± 0.067	3.569ArgGlu: 3.569 ± 0.06	2.537ArgPhe: 2.537 ± 0.051	4.136ArgGly: 4.136 ± 0.065	1.379ArgHis: 1.379 ± 0.04	3.835ArgIle: 3.835 ± 0.056	2.939ArgLys: 2.939 ± 0.05	6.563ArgLeu: 6.563 ± 0.092	1.925ArgMet: 1.925 ± 0.042	1.91ArgAsn: 1.91 ± 0.051	2.673ArgPro: 2.673 ± 0.052	2.148ArgGln: 2.148 ± 0.047	4.146ArgArg: 4.146 ± 0.074	2.781ArgSer: 2.781 ± 0.055	2.704ArgThr: 2.704 ± 0.05	4.265ArgVal: 4.265 ± 0.062	0.826ArgTrp: 0.826 ± 0.031	1.58ArgTyr: 1.58 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	5.141SerAla: 5.141 ± 0.073	0.486SerCys: 0.486 ± 0.025	3.26SerAsp: 3.26 ± 0.06	2.878SerGlu: 2.878 ± 0.056	2.243SerPhe: 2.243 ± 0.051	5.257SerGly: 5.257 ± 0.072	1.054SerHis: 1.054 ± 0.031	2.788SerIle: 2.788 ± 0.053	1.985SerLys: 1.985 ± 0.046	4.852SerLeu: 4.852 ± 0.071	1.406SerMet: 1.406 ± 0.035	1.594SerAsn: 1.594 ± 0.04	2.495SerPro: 2.495 ± 0.055	1.568SerGln: 1.568 ± 0.047	3.049SerArg: 3.049 ± 0.059	2.426SerSer: 2.426 ± 0.047	2.577SerThr: 2.577 ± 0.054	3.66SerVal: 3.66 ± 0.06	0.615SerTrp: 0.615 ± 0.026	1.36SerTyr: 1.36 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	5.949ThrAla: 5.949 ± 0.091	0.478ThrCys: 0.478 ± 0.025	3.248ThrAsp: 3.248 ± 0.055	2.764ThrGlu: 2.764 ± 0.056	1.967ThrPhe: 1.967 ± 0.044	5.425ThrGly: 5.425 ± 0.076	1.165ThrHis: 1.165 ± 0.031	3.028ThrIle: 3.028 ± 0.052	1.907ThrLys: 1.907 ± 0.044	5.992ThrLeu: 5.992 ± 0.079	1.373ThrMet: 1.373 ± 0.038	1.466ThrAsn: 1.466 ± 0.043	3.539ThrPro: 3.539 ± 0.06	1.57ThrGln: 1.57 ± 0.038	3.296ThrArg: 3.296 ± 0.063	2.728ThrSer: 2.728 ± 0.054	2.971ThrThr: 2.971 ± 0.061	4.163ThrVal: 4.163 ± 0.067	0.67ThrTrp: 0.67 ± 0.025	1.454ThrTyr: 1.454 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	8.153ValAla: 8.153 ± 0.096	0.638ValCys: 0.638 ± 0.025	4.185ValAsp: 4.185 ± 0.061	4.444ValGlu: 4.444 ± 0.066	2.991ValPhe: 2.991 ± 0.052	5.235ValGly: 5.235 ± 0.076	1.235ValHis: 1.235 ± 0.035	4.585ValIle: 4.585 ± 0.067	2.859ValLys: 2.859 ± 0.056	7.313ValLeu: 7.313 ± 0.09	2.191ValMet: 2.191 ± 0.051	2.231ValAsn: 2.231 ± 0.054	3.25ValPro: 3.25 ± 0.064	2.172ValGln: 2.172 ± 0.051	3.886ValArg: 3.886 ± 0.064	3.995ValSer: 3.995 ± 0.059	4.404ValThr: 4.404 ± 0.059	5.913ValVal: 5.913 ± 0.083	0.948ValTrp: 0.948 ± 0.036	1.572ValTyr: 1.572 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	1.256TrpAla: 1.256 ± 0.042	0.147TrpCys: 0.147 ± 0.012	0.79TrpAsp: 0.79 ± 0.029	0.685TrpGlu: 0.685 ± 0.025	0.605TrpPhe: 0.605 ± 0.026	1.013TrpGly: 1.013 ± 0.033	0.323TrpHis: 0.323 ± 0.017	0.73TrpIle: 0.73 ± 0.027	0.551TrpLys: 0.551 ± 0.022	1.585TrpLeu: 1.585 ± 0.045	0.415TrpMet: 0.415 ± 0.022	0.441TrpAsn: 0.441 ± 0.02	0.634TrpPro: 0.634 ± 0.025	0.604TrpGln: 0.604 ± 0.025	0.985TrpArg: 0.985 ± 0.036	0.713TrpSer: 0.713 ± 0.028	0.696TrpThr: 0.696 ± 0.029	1.021TrpVal: 1.021 ± 0.031	0.212TrpTrp: 0.212 ± 0.014	0.33TrpTyr: 0.33 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.513TyrAla: 2.513 ± 0.056	0.259TyrCys: 0.259 ± 0.016	1.649TyrAsp: 1.649 ± 0.049	1.335TyrGlu: 1.335 ± 0.037	1.064TyrPhe: 1.064 ± 0.033	2.304TyrGly: 2.304 ± 0.051	0.558TyrHis: 0.558 ± 0.024	1.258TyrIle: 1.258 ± 0.033	0.829TyrLys: 0.829 ± 0.03	2.473TyrLeu: 2.473 ± 0.051	0.596TyrMet: 0.596 ± 0.023	0.815TyrAsn: 0.815 ± 0.028	1.151TyrPro: 1.151 ± 0.033	0.8TyrGln: 0.8 ± 0.029	1.55TyrArg: 1.55 ± 0.035	1.407TyrSer: 1.407 ± 0.038	1.302TyrThr: 1.302 ± 0.037	1.618TyrVal: 1.618 ± 0.036	0.388TyrTrp: 0.388 ± 0.02	0.729TyrTyr: 0.729 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3454 proteins (1063791 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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