Amino acid dipepetide frequency for Simian virus 40 (SV40)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.82AlaAla: 7.82 ± 3.665
0.46AlaCys: 0.46 ± 0.327
4.14AlaAsp: 4.14 ± 0.825
1.84AlaGlu: 1.84 ± 0.583
2.3AlaPhe: 2.3 ± 0.878
1.84AlaGly: 1.84 ± 0.661
1.38AlaHis: 1.38 ± 0.663
4.6AlaIle: 4.6 ± 1.913
2.3AlaLys: 2.3 ± 0.987
5.06AlaLeu: 5.06 ± 1.468
2.3AlaMet: 2.3 ± 0.761
4.14AlaAsn: 4.14 ± 1.643
5.52AlaPro: 5.52 ± 2.115
3.68AlaGln: 3.68 ± 0.886
3.22AlaArg: 3.22 ± 1.136
2.76AlaSer: 2.76 ± 1.554
4.6AlaThr: 4.6 ± 1.228
4.6AlaVal: 4.6 ± 1.467
1.84AlaTrp: 1.84 ± 0.746
3.68AlaTyr: 3.68 ± 0.897
0.0AlaXaa: 0.0 ± 0.0
Cys
0.46CysAla: 0.46 ± 0.665
0.0CysCys: 0.0 ± 0.0
0.92CysAsp: 0.92 ± 0.625
0.92CysGlu: 0.92 ± 0.991
2.3CysPhe: 2.3 ± 1.212
1.38CysGly: 1.38 ± 0.871
0.0CysHis: 0.0 ± 0.0
0.92CysIle: 0.92 ± 0.625
2.76CysLys: 2.76 ± 1.177
2.3CysLeu: 2.3 ± 1.335
0.46CysMet: 0.46 ± 0.327
0.0CysAsn: 0.0 ± 0.0
0.46CysPro: 0.46 ± 0.463
0.46CysGln: 0.46 ± 0.327
0.46CysArg: 0.46 ± 0.327
0.92CysSer: 0.92 ± 0.543
0.46CysThr: 0.46 ± 0.327
0.0CysVal: 0.0 ± 0.0
0.46CysTrp: 0.46 ± 0.463
0.92CysTyr: 0.92 ± 0.777
0.0CysXaa: 0.0 ± 0.0
Asp
1.84AspAla: 1.84 ± 1.211
0.92AspCys: 0.92 ± 1.33
4.14AspAsp: 4.14 ± 1.268
6.44AspGlu: 6.44 ± 1.357
3.22AspPhe: 3.22 ± 1.48
4.6AspGly: 4.6 ± 0.715
1.38AspHis: 1.38 ± 0.434
3.68AspIle: 3.68 ± 0.848
4.6AspLys: 4.6 ± 1.507
5.52AspLeu: 5.52 ± 1.412
0.46AspMet: 0.46 ± 0.463
2.3AspAsn: 2.3 ± 0.657
3.22AspPro: 3.22 ± 0.589
0.46AspGln: 0.46 ± 0.327
0.92AspArg: 0.92 ± 0.653
8.28AspSer: 8.28 ± 1.625
1.38AspThr: 1.38 ± 0.662
0.92AspVal: 0.92 ± 0.653
0.92AspTrp: 0.92 ± 0.424
2.76AspTyr: 2.76 ± 1.145
0.0AspXaa: 0.0 ± 0.0
Glu
8.28GluAla: 8.28 ± 3.188
1.38GluCys: 1.38 ± 1.093
6.44GluAsp: 6.44 ± 0.872
8.74GluGlu: 8.74 ± 2.093
5.06GluPhe: 5.06 ± 0.827
2.76GluGly: 2.76 ± 1.554
0.92GluHis: 0.92 ± 0.468
1.38GluIle: 1.38 ± 0.602
6.44GluLys: 6.44 ± 1.31
3.68GluLeu: 3.68 ± 0.771
1.38GluMet: 1.38 ± 0.756
3.22GluAsn: 3.22 ± 1.369
1.38GluPro: 1.38 ± 0.871
2.76GluGln: 2.76 ± 1.188
5.06GluArg: 5.06 ± 1.293
3.22GluSer: 3.22 ± 1.403
2.76GluThr: 2.76 ± 1.161
2.76GluVal: 2.76 ± 1.815
1.84GluTrp: 1.84 ± 1.03
1.38GluTyr: 1.38 ± 0.98
0.0GluXaa: 0.0 ± 0.0
Phe
2.76PheAla: 2.76 ± 0.727
1.38PheCys: 1.38 ± 0.749
0.46PheAsp: 0.46 ± 0.665
2.76PheGlu: 2.76 ± 0.909
1.38PhePhe: 1.38 ± 0.434
4.6PheGly: 4.6 ± 1.138
1.84PheHis: 1.84 ± 0.743
1.84PheIle: 1.84 ± 0.794
1.38PheLys: 1.38 ± 0.661
5.06PheLeu: 5.06 ± 1.404
0.0PheMet: 0.0 ± 0.0
3.22PheAsn: 3.22 ± 1.169
1.84PhePro: 1.84 ± 0.674
0.92PheGln: 0.92 ± 0.653
0.92PheArg: 0.92 ± 0.625
2.76PheSer: 2.76 ± 1.316
1.84PheThr: 1.84 ± 1.315
2.3PheVal: 2.3 ± 1.395
2.3PheTrp: 2.3 ± 0.724
0.0PheTyr: 0.0 ± 0.0
0.0PheXaa: 0.0 ± 0.0
Gly
3.22GlyAla: 3.22 ± 1.337
0.0GlyCys: 0.0 ± 0.0
2.3GlyAsp: 2.3 ± 0.651
4.14GlyGlu: 4.14 ± 0.87
2.76GlyPhe: 2.76 ± 0.808
7.36GlyGly: 7.36 ± 1.173
1.84GlyHis: 1.84 ± 0.794
2.76GlyIle: 2.76 ± 1.54
1.84GlyLys: 1.84 ± 0.724
7.82GlyLeu: 7.82 ± 1.934
1.38GlyMet: 1.38 ± 0.434
2.3GlyAsn: 2.3 ± 1.045
3.22GlyPro: 3.22 ± 1.136
1.84GlyGln: 1.84 ± 0.969
0.0GlyArg: 0.0 ± 0.0
5.52GlySer: 5.52 ± 1.132
4.6GlyThr: 4.6 ± 1.013
7.36GlyVal: 7.36 ± 1.593
0.0GlyTrp: 0.0 ± 0.0
0.46GlyTyr: 0.46 ± 0.374
0.0GlyXaa: 0.0 ± 0.0
His
0.46HisAla: 0.46 ± 0.327
0.92HisCys: 0.92 ± 0.653
0.92HisAsp: 0.92 ± 0.653
1.84HisGlu: 1.84 ± 0.715
0.46HisPhe: 0.46 ± 0.463
0.0HisGly: 0.0 ± 0.0
0.0HisHis: 0.0 ± 0.0
0.92HisIle: 0.92 ± 0.468
2.3HisLys: 2.3 ± 1.034
0.46HisLeu: 0.46 ± 0.327
0.0HisMet: 0.0 ± 0.0
1.38HisAsn: 1.38 ± 0.98
1.38HisPro: 1.38 ± 0.663
1.84HisGln: 1.84 ± 0.743
0.92HisArg: 0.92 ± 0.653
2.3HisSer: 2.3 ± 0.638
1.38HisThr: 1.38 ± 0.923
0.0HisVal: 0.0 ± 0.0
0.92HisTrp: 0.92 ± 0.644
0.92HisTyr: 0.92 ± 0.653
0.0HisXaa: 0.0 ± 0.0
Ile
2.3IleAla: 2.3 ± 1.44
2.3IleCys: 2.3 ± 0.886
3.68IleAsp: 3.68 ± 0.86
3.22IleGlu: 3.22 ± 0.708
0.92IlePhe: 0.92 ± 0.653
2.3IleGly: 2.3 ± 0.845
0.0IleHis: 0.0 ± 0.0
0.92IleIle: 0.92 ± 0.625
0.92IleLys: 0.92 ± 0.468
1.84IleLeu: 1.84 ± 0.449
0.92IleMet: 0.92 ± 0.653
2.76IleAsn: 2.76 ± 0.653
4.6IlePro: 4.6 ± 0.847
3.68IleGln: 3.68 ± 0.993
1.38IleArg: 1.38 ± 0.625
3.68IleSer: 3.68 ± 1.351
0.92IleThr: 0.92 ± 0.926
0.92IleVal: 0.92 ± 0.653
0.46IleTrp: 0.46 ± 0.327
0.46IleTyr: 0.46 ± 0.327
0.0IleXaa: 0.0 ± 0.0
Lys
6.44LysAla: 6.44 ± 1.141
2.76LysCys: 2.76 ± 1.197
1.84LysAsp: 1.84 ± 0.715
5.06LysGlu: 5.06 ± 1.944
1.84LysPhe: 1.84 ± 0.794
5.98LysGly: 5.98 ± 1.189
1.84LysHis: 1.84 ± 0.964
0.92LysIle: 0.92 ± 0.468
13.339LysLys: 13.339 ± 2.731
3.68LysLeu: 3.68 ± 1.214
5.52LysMet: 5.52 ± 2.516
2.76LysAsn: 2.76 ± 1.403
2.3LysPro: 2.3 ± 1.38
1.84LysGln: 1.84 ± 0.715
6.9LysArg: 6.9 ± 1.078
0.46LysSer: 0.46 ± 0.463
4.6LysThr: 4.6 ± 0.968
3.22LysVal: 3.22 ± 0.936
0.0LysTrp: 0.0 ± 0.0
2.76LysTyr: 2.76 ± 0.893
0.0LysXaa: 0.0 ± 0.0
Leu
3.68LeuAla: 3.68 ± 0.763
2.3LeuCys: 2.3 ± 1.212
5.06LeuAsp: 5.06 ± 1.241
6.9LeuGlu: 6.9 ± 1.163
4.6LeuPhe: 4.6 ± 1.086
4.6LeuGly: 4.6 ± 0.51
1.38LeuHis: 1.38 ± 0.871
2.3LeuIle: 2.3 ± 0.723
5.06LeuLys: 5.06 ± 1.322
14.259LeuLeu: 14.259 ± 2.598
4.6LeuMet: 4.6 ± 1.799
4.14LeuAsn: 4.14 ± 1.387
5.06LeuPro: 5.06 ± 1.339
5.98LeuGln: 5.98 ± 1.137
3.22LeuArg: 3.22 ± 0.744
5.52LeuSer: 5.52 ± 1.109
5.06LeuThr: 5.06 ± 1.156
1.84LeuVal: 1.84 ± 0.715
0.46LeuTrp: 0.46 ± 0.665
5.52LeuTyr: 5.52 ± 1.388
0.0LeuXaa: 0.0 ± 0.0
Met
1.84MetAla: 1.84 ± 0.449
0.46MetCys: 0.46 ± 0.327
3.68MetAsp: 3.68 ± 1.493
2.76MetGlu: 2.76 ± 1.197
0.46MetPhe: 0.46 ± 0.327
1.38MetGly: 1.38 ± 0.434
0.0MetHis: 0.0 ± 0.0
0.92MetIle: 0.92 ± 0.926
2.3MetLys: 2.3 ± 1.195
2.76MetLeu: 2.76 ± 0.566
0.0MetMet: 0.0 ± 0.0
2.3MetAsn: 2.3 ± 0.753
0.92MetPro: 0.92 ± 0.543
0.92MetGln: 0.92 ± 0.653
1.38MetArg: 1.38 ± 0.663
0.92MetSer: 0.92 ± 0.777
0.0MetThr: 0.0 ± 0.0
2.3MetVal: 2.3 ± 1.043
0.92MetTrp: 0.92 ± 0.777
1.38MetTyr: 1.38 ± 0.744
0.0MetXaa: 0.0 ± 0.0
Asn
4.6AsnAla: 4.6 ± 0.939
0.46AsnCys: 0.46 ± 0.665
1.38AsnAsp: 1.38 ± 0.573
2.76AsnGlu: 2.76 ± 1.188
0.92AsnPhe: 0.92 ± 0.468
0.46AsnGly: 0.46 ± 0.463
0.46AsnHis: 0.46 ± 0.327
4.6AsnIle: 4.6 ± 0.518
2.3AsnLys: 2.3 ± 0.789
3.22AsnLeu: 3.22 ± 1.561
0.46AsnMet: 0.46 ± 0.327
0.92AsnAsn: 0.92 ± 0.653
2.3AsnPro: 2.3 ± 1.362
2.3AsnGln: 2.3 ± 0.789
5.98AsnArg: 5.98 ± 1.474
1.84AsnSer: 1.84 ± 0.674
3.22AsnThr: 3.22 ± 1.86
2.76AsnVal: 2.76 ± 0.566
0.92AsnTrp: 0.92 ± 0.644
0.92AsnTyr: 0.92 ± 0.468
0.0AsnXaa: 0.0 ± 0.0
Pro
0.92ProAla: 0.92 ± 0.501
0.46ProCys: 0.46 ± 0.463
5.52ProAsp: 5.52 ± 1.781
2.76ProGlu: 2.76 ± 1.422
0.46ProPhe: 0.46 ± 0.327
5.06ProGly: 5.06 ± 1.062
0.46ProHis: 0.46 ± 0.327
2.3ProIle: 2.3 ± 0.71
5.06ProLys: 5.06 ± 2.236
5.52ProLeu: 5.52 ± 1.461
0.46ProMet: 0.46 ± 0.463
3.22ProAsn: 3.22 ± 1.732
3.68ProPro: 3.68 ± 1.452
2.76ProGln: 2.76 ± 0.824
3.22ProArg: 3.22 ± 1.725
2.76ProSer: 2.76 ± 1.274
3.68ProThr: 3.68 ± 0.984
2.76ProVal: 2.76 ± 1.111
0.0ProTrp: 0.0 ± 0.0
0.92ProTyr: 0.92 ± 0.468
0.0ProXaa: 0.0 ± 0.0
Gln
3.22GlnAla: 3.22 ± 1.081
0.0GlnCys: 0.0 ± 0.0
0.92GlnAsp: 0.92 ± 0.644
1.38GlnGlu: 1.38 ± 0.573
1.38GlnPhe: 1.38 ± 0.662
2.3GlnGly: 2.3 ± 1.32
0.92GlnHis: 0.92 ± 0.543
2.3GlnIle: 2.3 ± 0.789
3.68GlnLys: 3.68 ± 0.669
2.76GlnLeu: 2.76 ± 0.611
1.84GlnMet: 1.84 ± 1.283
0.92GlnAsn: 0.92 ± 0.644
3.22GlnPro: 3.22 ± 0.732
3.22GlnGln: 3.22 ± 0.897
3.68GlnArg: 3.68 ± 1.775
6.9GlnSer: 6.9 ± 2.366
2.76GlnThr: 2.76 ± 1.077
4.6GlnVal: 4.6 ± 1.64
3.22GlnTrp: 3.22 ± 0.81
1.38GlnTyr: 1.38 ± 0.573
0.0GlnXaa: 0.0 ± 0.0
Arg
0.0ArgAla: 0.0 ± 0.0
0.0ArgCys: 0.0 ± 0.0
2.76ArgAsp: 2.76 ± 0.814
3.22ArgGlu: 3.22 ± 0.802
2.3ArgPhe: 2.3 ± 0.864
1.84ArgGly: 1.84 ± 0.794
3.22ArgHis: 3.22 ± 1.235
1.38ArgIle: 1.38 ± 0.661
5.98ArgLys: 5.98 ± 1.934
3.22ArgLeu: 3.22 ± 1.923
1.84ArgMet: 1.84 ± 1.252
1.84ArgAsn: 1.84 ± 0.794
4.14ArgPro: 4.14 ± 1.951
1.84ArgGln: 1.84 ± 1.201
3.68ArgArg: 3.68 ± 1.99
5.98ArgSer: 5.98 ± 1.73
4.14ArgThr: 4.14 ± 0.935
2.76ArgVal: 2.76 ± 0.653
1.38ArgTrp: 1.38 ± 0.923
2.76ArgTyr: 2.76 ± 1.111
0.0ArgXaa: 0.0 ± 0.0
Ser
8.28SerAla: 8.28 ± 2.191
0.46SerCys: 0.46 ± 0.463
2.3SerAsp: 2.3 ± 0.729
3.22SerGlu: 3.22 ± 1.124
4.14SerPhe: 4.14 ± 0.814
4.6SerGly: 4.6 ± 0.779
0.92SerHis: 0.92 ± 0.653
1.84SerIle: 1.84 ± 0.794
1.84SerLys: 1.84 ± 0.963
5.98SerLeu: 5.98 ± 0.779
1.38SerMet: 1.38 ± 1.068
0.92SerAsn: 0.92 ± 0.468
2.76SerPro: 2.76 ± 1.345
8.28SerGln: 8.28 ± 1.833
5.06SerArg: 5.06 ± 1.789
5.52SerSer: 5.52 ± 1.53
2.76SerThr: 2.76 ± 0.922
7.82SerVal: 7.82 ± 1.447
0.92SerTrp: 0.92 ± 0.615
0.92SerTyr: 0.92 ± 0.484
0.0SerXaa: 0.0 ± 0.0
Thr
3.68ThrAla: 3.68 ± 1.065
0.92ThrCys: 0.92 ± 0.468
1.84ThrAsp: 1.84 ± 1.027
5.52ThrGlu: 5.52 ± 1.558
1.84ThrPhe: 1.84 ± 0.674
3.22ThrGly: 3.22 ± 0.975
0.46ThrHis: 0.46 ± 0.463
0.46ThrIle: 0.46 ± 0.327
3.68ThrLys: 3.68 ± 0.669
5.98ThrLeu: 5.98 ± 1.028
2.3ThrMet: 2.3 ± 0.72
1.38ThrAsn: 1.38 ± 0.871
2.3ThrPro: 2.3 ± 1.011
2.76ThrGln: 2.76 ± 1.111
1.84ThrArg: 1.84 ± 0.936
4.6ThrSer: 4.6 ± 2.41
4.14ThrThr: 4.14 ± 0.903
5.52ThrVal: 5.52 ± 2.024
0.92ThrTrp: 0.92 ± 0.644
3.22ThrTyr: 3.22 ± 0.81
0.0ThrXaa: 0.0 ± 0.0
Val
5.06ValAla: 5.06 ± 1.311
0.0ValCys: 0.0 ± 0.0
5.06ValAsp: 5.06 ± 1.72
2.76ValGlu: 2.76 ± 1.2
1.84ValPhe: 1.84 ± 0.909
1.84ValGly: 1.84 ± 1.001
1.38ValHis: 1.38 ± 0.573
3.68ValIle: 3.68 ± 1.232
4.6ValLys: 4.6 ± 1.408
5.98ValLeu: 5.98 ± 2.245
0.0ValMet: 0.0 ± 0.0
2.3ValAsn: 2.3 ± 0.891
1.84ValPro: 1.84 ± 1.315
4.14ValGln: 4.14 ± 2.14
2.3ValArg: 2.3 ± 1.137
2.76ValSer: 2.76 ± 0.992
5.98ValThr: 5.98 ± 1.313
0.92ValVal: 0.92 ± 0.653
0.46ValTrp: 0.46 ± 0.665
1.84ValTyr: 1.84 ± 0.932
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.46TrpCys: 0.46 ± 0.665
1.84TrpAsp: 1.84 ± 0.644
2.76TrpGlu: 2.76 ± 0.71
0.46TrpPhe: 0.46 ± 0.665
2.3TrpGly: 2.3 ± 0.724
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
1.38TrpLys: 1.38 ± 0.661
1.38TrpLeu: 1.38 ± 0.98
1.84TrpMet: 1.84 ± 0.794
0.92TrpAsn: 0.92 ± 0.543
0.46TrpPro: 0.46 ± 0.665
0.0TrpGln: 0.0 ± 0.0
0.92TrpArg: 0.92 ± 0.644
0.0TrpSer: 0.0 ± 0.0
1.38TrpThr: 1.38 ± 0.976
0.92TrpVal: 0.92 ± 0.777
0.92TrpTrp: 0.92 ± 0.543
1.38TrpTyr: 1.38 ± 0.573
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.22TyrAla: 3.22 ± 1.099
0.92TyrCys: 0.92 ± 1.33
2.76TyrAsp: 2.76 ± 1.314
1.84TyrGlu: 1.84 ± 0.869
0.92TyrPhe: 0.92 ± 0.926
2.3TyrGly: 2.3 ± 0.807
0.92TyrHis: 0.92 ± 0.653
0.46TyrIle: 0.46 ± 0.463
2.3TyrLys: 2.3 ± 0.943
5.06TyrLeu: 5.06 ± 1.281
0.0TyrMet: 0.0 ± 0.0
1.84TyrAsn: 1.84 ± 0.674
1.38TyrPro: 1.38 ± 1.388
0.92TyrGln: 0.92 ± 0.424
3.22TyrArg: 3.22 ± 1.193
3.68TyrSer: 3.68 ± 0.934
0.92TyrThr: 0.92 ± 0.468
0.46TyrVal: 0.46 ± 0.463
0.46TyrTrp: 0.46 ± 0.327
1.84TyrTyr: 1.84 ± 1.289
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 9 proteins (2175 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski