Amino acid dipepetide frequency for Dubosiella newyorkensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.281AlaAla: 4.281 ± 0.107	1.188AlaCys: 1.188 ± 0.051	3.109AlaAsp: 3.109 ± 0.089	3.073AlaGlu: 3.073 ± 0.077	3.251AlaPhe: 3.251 ± 0.076	4.118AlaGly: 4.118 ± 0.097	1.403AlaHis: 1.403 ± 0.05	5.897AlaIle: 5.897 ± 0.111	5.592AlaLys: 5.592 ± 0.1	7.943AlaLeu: 7.943 ± 0.134	2.233AlaMet: 2.233 ± 0.068	3.136AlaAsn: 3.136 ± 0.068	1.918AlaPro: 1.918 ± 0.056	2.873AlaGln: 2.873 ± 0.083	2.587AlaArg: 2.587 ± 0.065	4.462AlaSer: 4.462 ± 0.084	2.841AlaThr: 2.841 ± 0.085	3.35AlaVal: 3.35 ± 0.098	0.62AlaTrp: 0.62 ± 0.028	2.837AlaTyr: 2.837 ± 0.068	0.0AlaXaa: 0.0 ± 0.0
Cys	0.976CysAla: 0.976 ± 0.037	0.178CysCys: 0.178 ± 0.016	0.72CysAsp: 0.72 ± 0.038	0.723CysGlu: 0.723 ± 0.038	0.675CysPhe: 0.675 ± 0.033	0.964CysGly: 0.964 ± 0.036	0.307CysHis: 0.307 ± 0.022	0.994CysIle: 0.994 ± 0.042	0.646CysLys: 0.646 ± 0.032	1.268CysLeu: 1.268 ± 0.043	0.431CysMet: 0.431 ± 0.026	0.388CysAsn: 0.388 ± 0.025	0.554CysPro: 0.554 ± 0.029	0.492CysGln: 0.492 ± 0.026	0.437CysArg: 0.437 ± 0.025	0.903CysSer: 0.903 ± 0.041	0.622CysThr: 0.622 ± 0.028	0.84CysVal: 0.84 ± 0.037	0.131CysTrp: 0.131 ± 0.017	0.352CysTyr: 0.352 ± 0.023	0.0CysXaa: 0.0 ± 0.0
Asp	3.752AspAla: 3.752 ± 0.085	0.625AspCys: 0.625 ± 0.036	2.629AspAsp: 2.629 ± 0.068	4.513AspGlu: 4.513 ± 0.092	2.841AspPhe: 2.841 ± 0.072	3.719AspGly: 3.719 ± 0.087	1.58AspHis: 1.58 ± 0.043	3.663AspIle: 3.663 ± 0.076	2.709AspLys: 2.709 ± 0.07	6.649AspLeu: 6.649 ± 0.104	1.453AspMet: 1.453 ± 0.043	1.619AspAsn: 1.619 ± 0.043	3.316AspPro: 3.316 ± 0.083	2.908AspGln: 2.908 ± 0.075	2.579AspArg: 2.579 ± 0.06	3.124AspSer: 3.124 ± 0.079	2.792AspThr: 2.792 ± 0.074	3.674AspVal: 3.674 ± 0.083	0.663AspTrp: 0.663 ± 0.029	2.373AspTyr: 2.373 ± 0.062	0.0AspXaa: 0.0 ± 0.0
Glu	5.559GluAla: 5.559 ± 0.099	0.675GluCys: 0.675 ± 0.033	4.242GluAsp: 4.242 ± 0.089	7.393GluGlu: 7.393 ± 0.136	2.412GluPhe: 2.412 ± 0.062	4.457GluGly: 4.457 ± 0.077	1.662GluHis: 1.662 ± 0.054	5.729GluIle: 5.729 ± 0.099	6.753GluLys: 6.753 ± 0.113	6.065GluLeu: 6.065 ± 0.123	2.372GluMet: 2.372 ± 0.062	4.272GluAsn: 4.272 ± 0.084	1.942GluPro: 1.942 ± 0.059	3.56GluGln: 3.56 ± 0.085	3.106GluArg: 3.106 ± 0.072	3.576GluSer: 3.576 ± 0.074	3.588GluThr: 3.588 ± 0.09	4.311GluVal: 4.311 ± 0.102	0.72GluTrp: 0.72 ± 0.034	2.716GluTyr: 2.716 ± 0.073	0.0GluXaa: 0.0 ± 0.0
Phe	2.926PheAla: 2.926 ± 0.075	0.65PheCys: 0.65 ± 0.029	2.992PheAsp: 2.992 ± 0.072	3.304PheGlu: 3.304 ± 0.086	2.152PhePhe: 2.152 ± 0.072	3.115PheGly: 3.115 ± 0.076	1.043PheHis: 1.043 ± 0.04	2.941PheIle: 2.941 ± 0.072	2.62PheLys: 2.62 ± 0.064	4.672PheLeu: 4.672 ± 0.105	1.263PheMet: 1.263 ± 0.052	1.691PheAsn: 1.691 ± 0.052	1.433PhePro: 1.433 ± 0.043	1.679PheGln: 1.679 ± 0.06	1.444PheArg: 1.444 ± 0.045	3.31PheSer: 3.31 ± 0.073	2.049PheThr: 2.049 ± 0.063	3.109PheVal: 3.109 ± 0.071	0.413PheTrp: 0.413 ± 0.026	1.848PheTyr: 1.848 ± 0.055	0.0PheXaa: 0.0 ± 0.0
Gly	4.183GlyAla: 4.183 ± 0.089	1.012GlyCys: 1.012 ± 0.042	2.87GlyAsp: 2.87 ± 0.072	3.572GlyGlu: 3.572 ± 0.078	3.084GlyPhe: 3.084 ± 0.07	3.831GlyGly: 3.831 ± 0.095	1.209GlyHis: 1.209 ± 0.047	5.722GlyIle: 5.722 ± 0.104	5.038GlyLys: 5.038 ± 0.09	5.761GlyLeu: 5.761 ± 0.102	2.072GlyMet: 2.072 ± 0.067	2.751GlyAsn: 2.751 ± 0.072	1.348GlyPro: 1.348 ± 0.036	1.885GlyGln: 1.885 ± 0.048	2.266GlyArg: 2.266 ± 0.066	3.755GlySer: 3.755 ± 0.081	3.536GlyThr: 3.536 ± 0.097	4.099GlyVal: 4.099 ± 0.085	0.763GlyTrp: 0.763 ± 0.057	2.965GlyTyr: 2.965 ± 0.068	0.0GlyXaa: 0.0 ± 0.0
His	1.315HisAla: 1.315 ± 0.041	0.303HisCys: 0.303 ± 0.022	1.263HisAsp: 1.263 ± 0.046	1.4HisGlu: 1.4 ± 0.052	1.077HisPhe: 1.077 ± 0.042	1.387HisGly: 1.387 ± 0.048	0.58HisHis: 0.58 ± 0.04	1.485HisIle: 1.485 ± 0.047	1.173HisLys: 1.173 ± 0.045	2.016HisLeu: 2.016 ± 0.057	0.444HisMet: 0.444 ± 0.022	0.678HisAsn: 0.678 ± 0.035	1.117HisPro: 1.117 ± 0.043	0.899HisGln: 0.899 ± 0.036	0.845HisArg: 0.845 ± 0.035	1.324HisSer: 1.324 ± 0.049	1.15HisThr: 1.15 ± 0.04	1.283HisVal: 1.283 ± 0.046	0.184HisTrp: 0.184 ± 0.018	0.911HisTyr: 0.911 ± 0.038	0.0HisXaa: 0.0 ± 0.0
Ile	5.717IleAla: 5.717 ± 0.099	1.144IleCys: 1.144 ± 0.043	5.368IleAsp: 5.368 ± 0.091	6.749IleGlu: 6.749 ± 0.105	3.005IlePhe: 3.005 ± 0.092	5.101IleGly: 5.101 ± 0.108	1.796IleHis: 1.796 ± 0.052	4.552IleIle: 4.552 ± 0.108	4.833IleLys: 4.833 ± 0.083	7.958IleLeu: 7.958 ± 0.148	1.837IleMet: 1.837 ± 0.052	2.966IleAsn: 2.966 ± 0.064	3.364IlePro: 3.364 ± 0.071	3.962IleGln: 3.962 ± 0.079	3.093IleArg: 3.093 ± 0.068	4.55IleSer: 4.55 ± 0.086	3.56IleThr: 3.56 ± 0.08	5.875IleVal: 5.875 ± 0.095	0.599IleTrp: 0.599 ± 0.035	2.981IleTyr: 2.981 ± 0.076	0.0IleXaa: 0.0 ± 0.0
Lys	5.3LysAla: 5.3 ± 0.102	0.476LysCys: 0.476 ± 0.026	4.751LysAsp: 4.751 ± 0.088	8.602LysGlu: 8.602 ± 0.141	1.775LysPhe: 1.775 ± 0.051	4.067LysGly: 4.067 ± 0.08	1.296LysHis: 1.296 ± 0.051	5.684LysIle: 5.684 ± 0.09	7.66LysLys: 7.66 ± 0.143	5.36LysLeu: 5.36 ± 0.095	2.182LysMet: 2.182 ± 0.059	3.98LysAsn: 3.98 ± 0.081	2.203LysPro: 2.203 ± 0.063	2.95LysGln: 2.95 ± 0.067	3.395LysArg: 3.395 ± 0.077	3.513LysSer: 3.513 ± 0.08	4.299LysThr: 4.299 ± 0.086	4.097LysVal: 4.097 ± 0.085	0.663LysTrp: 0.663 ± 0.032	2.579LysTyr: 2.579 ± 0.06	0.0LysXaa: 0.0 ± 0.0
Leu	6.598LeuAla: 6.598 ± 0.119	1.396LeuCys: 1.396 ± 0.052	6.124LeuAsp: 6.124 ± 0.107	7.244LeuGlu: 7.244 ± 0.114	4.984LeuPhe: 4.984 ± 0.121	5.644LeuGly: 5.644 ± 0.099	1.995LeuHis: 1.995 ± 0.048	7.366LeuIle: 7.366 ± 0.131	7.398LeuLys: 7.398 ± 0.105	9.421LeuLeu: 9.421 ± 0.192	2.599LeuMet: 2.599 ± 0.056	4.297LeuAsn: 4.297 ± 0.087	3.585LeuPro: 3.585 ± 0.083	3.505LeuGln: 3.505 ± 0.067	3.359LeuArg: 3.359 ± 0.083	7.338LeuSer: 7.338 ± 0.123	3.924LeuThr: 3.924 ± 0.079	5.964LeuVal: 5.964 ± 0.084	0.909LeuTrp: 0.909 ± 0.035	3.808LeuTyr: 3.808 ± 0.088	0.0LeuXaa: 0.0 ± 0.0
Met	2.119MetAla: 2.119 ± 0.056	0.282MetCys: 0.282 ± 0.021	1.836MetAsp: 1.836 ± 0.048	2.331MetGlu: 2.331 ± 0.063	0.944MetPhe: 0.944 ± 0.043	1.545MetGly: 1.545 ± 0.048	0.535MetHis: 0.535 ± 0.03	2.688MetIle: 2.688 ± 0.072	2.715MetLys: 2.715 ± 0.073	2.433MetLeu: 2.433 ± 0.058	0.928MetMet: 0.928 ± 0.042	1.718MetAsn: 1.718 ± 0.051	1.096MetPro: 1.096 ± 0.049	1.007MetGln: 1.007 ± 0.041	1.111MetArg: 1.111 ± 0.034	1.76MetSer: 1.76 ± 0.056	1.167MetThr: 1.167 ± 0.039	1.589MetVal: 1.589 ± 0.049	0.178MetTrp: 0.178 ± 0.016	0.867MetTyr: 0.867 ± 0.04	0.0MetXaa: 0.0 ± 0.0
Asn	3.308AsnAla: 3.308 ± 0.072	0.485AsnCys: 0.485 ± 0.026	2.78AsnAsp: 2.78 ± 0.061	3.501AsnGlu: 3.501 ± 0.084	1.638AsnPhe: 1.638 ± 0.048	3.513AsnGly: 3.513 ± 0.102	0.929AsnHis: 0.929 ± 0.038	3.254AsnIle: 3.254 ± 0.076	3.024AsnLys: 3.024 ± 0.07	3.779AsnLeu: 3.779 ± 0.078	1.322AsnMet: 1.322 ± 0.048	1.836AsnAsn: 1.836 ± 0.059	1.837AsnPro: 1.837 ± 0.053	2.021AsnGln: 2.021 ± 0.058	1.829AsnArg: 1.829 ± 0.056	2.262AsnSer: 2.262 ± 0.063	2.603AsnThr: 2.603 ± 0.075	3.082AsnVal: 3.082 ± 0.056	0.507AsnTrp: 0.507 ± 0.026	1.783AsnTyr: 1.783 ± 0.055	0.0AsnXaa: 0.0 ± 0.0
Pro	2.076ProAla: 2.076 ± 0.065	0.423ProCys: 0.423 ± 0.029	1.982ProAsp: 1.982 ± 0.055	2.695ProGlu: 2.695 ± 0.069	1.81ProPhe: 1.81 ± 0.053	1.872ProGly: 1.872 ± 0.048	0.66ProHis: 0.66 ± 0.03	3.046ProIle: 3.046 ± 0.068	2.454ProLys: 2.454 ± 0.064	3.165ProLeu: 3.165 ± 0.066	0.998ProMet: 0.998 ± 0.035	1.858ProAsn: 1.858 ± 0.053	0.613ProPro: 0.613 ± 0.033	1.244ProGln: 1.244 ± 0.041	1.093ProArg: 1.093 ± 0.044	2.471ProSer: 2.471 ± 0.065	1.751ProThr: 1.751 ± 0.051	2.438ProVal: 2.438 ± 0.075	0.399ProTrp: 0.399 ± 0.024	1.709ProTyr: 1.709 ± 0.049	0.0ProXaa: 0.0 ± 0.0
Gln	3.027GlnAla: 3.027 ± 0.077	0.363GlnCys: 0.363 ± 0.021	2.147GlnAsp: 2.147 ± 0.06	3.856GlnGlu: 3.856 ± 0.095	1.548GlnPhe: 1.548 ± 0.048	2.226GlnGly: 2.226 ± 0.057	0.536GlnHis: 0.536 ± 0.029	3.439GlnIle: 3.439 ± 0.082	3.73GlnLys: 3.73 ± 0.079	3.397GlnLeu: 3.397 ± 0.072	1.168GlnMet: 1.168 ± 0.043	2.088GlnAsn: 2.088 ± 0.062	1.06GlnPro: 1.06 ± 0.044	1.45GlnGln: 1.45 ± 0.051	1.54GlnArg: 1.54 ± 0.05	2.066GlnSer: 2.066 ± 0.057	2.057GlnThr: 2.057 ± 0.059	2.414GlnVal: 2.414 ± 0.056	0.373GlnTrp: 0.373 ± 0.025	1.747GlnTyr: 1.747 ± 0.051	0.0GlnXaa: 0.0 ± 0.0
Arg	2.305ArgAla: 2.305 ± 0.064	0.437ArgCys: 0.437 ± 0.028	1.747ArgAsp: 1.747 ± 0.055	2.567ArgGlu: 2.567 ± 0.067	2.266ArgPhe: 2.266 ± 0.059	1.923ArgGly: 1.923 ± 0.059	0.775ArgHis: 0.775 ± 0.033	3.418ArgIle: 3.418 ± 0.075	3.448ArgLys: 3.448 ± 0.074	3.944ArgLeu: 3.944 ± 0.08	1.351ArgMet: 1.351 ± 0.052	1.923ArgAsn: 1.923 ± 0.064	1.182ArgPro: 1.182 ± 0.038	1.524ArgGln: 1.524 ± 0.053	1.593ArgArg: 1.593 ± 0.057	2.459ArgSer: 2.459 ± 0.065	1.857ArgThr: 1.857 ± 0.057	2.153ArgVal: 2.153 ± 0.061	0.361ArgTrp: 0.361 ± 0.024	1.786ArgTyr: 1.786 ± 0.062	0.0ArgXaa: 0.0 ± 0.0
Ser	3.843SerAla: 3.843 ± 0.086	0.736SerCys: 0.736 ± 0.031	3.176SerAsp: 3.176 ± 0.069	3.421SerGlu: 3.421 ± 0.071	3.224SerPhe: 3.224 ± 0.081	4.005SerGly: 4.005 ± 0.084	1.26SerHis: 1.26 ± 0.039	5.498SerIle: 5.498 ± 0.098	4.4SerLys: 4.4 ± 0.079	6.669SerLeu: 6.669 ± 0.107	1.905SerMet: 1.905 ± 0.061	2.887SerAsn: 2.887 ± 0.074	1.739SerPro: 1.739 ± 0.055	2.426SerGln: 2.426 ± 0.061	2.409SerArg: 2.409 ± 0.063	4.019SerSer: 4.019 ± 0.097	2.771SerThr: 2.771 ± 0.069	3.6SerVal: 3.6 ± 0.073	0.691SerTrp: 0.691 ± 0.034	2.515SerTyr: 2.515 ± 0.059	0.0SerXaa: 0.0 ± 0.0
Thr	2.6ThrAla: 2.6 ± 0.076	0.55ThrCys: 0.55 ± 0.029	2.28ThrAsp: 2.28 ± 0.063	2.272ThrGlu: 2.272 ± 0.065	2.408ThrPhe: 2.408 ± 0.07	3.284ThrGly: 3.284 ± 0.08	0.917ThrHis: 0.917 ± 0.038	5.272ThrIle: 5.272 ± 0.111	3.474ThrLys: 3.474 ± 0.074	5.433ThrLeu: 5.433 ± 0.086	1.409ThrMet: 1.409 ± 0.049	2.331ThrAsn: 2.331 ± 0.072	2.134ThrPro: 2.134 ± 0.063	1.598ThrGln: 1.598 ± 0.05	1.647ThrArg: 1.647 ± 0.047	3.064ThrSer: 3.064 ± 0.076	2.545ThrThr: 2.545 ± 0.079	2.754ThrVal: 2.754 ± 0.064	0.485ThrTrp: 0.485 ± 0.025	2.159ThrTyr: 2.159 ± 0.063	0.0ThrXaa: 0.0 ± 0.0
Val	3.725ValAla: 3.725 ± 0.074	1.001ValCys: 1.001 ± 0.042	3.978ValAsp: 3.978 ± 0.087	4.261ValGlu: 4.261 ± 0.085	3.126ValPhe: 3.126 ± 0.076	3.691ValGly: 3.691 ± 0.083	1.289ValHis: 1.289 ± 0.046	4.41ValIle: 4.41 ± 0.08	3.939ValLys: 3.939 ± 0.086	6.815ValLeu: 6.815 ± 0.102	1.622ValMet: 1.622 ± 0.05	2.617ValAsn: 2.617 ± 0.07	2.326ValPro: 2.326 ± 0.061	2.274ValGln: 2.274 ± 0.064	2.441ValArg: 2.441 ± 0.064	4.12ValSer: 4.12 ± 0.085	2.625ValThr: 2.625 ± 0.082	4.117ValVal: 4.117 ± 0.094	0.647ValTrp: 0.647 ± 0.04	2.533ValTyr: 2.533 ± 0.069	0.0ValXaa: 0.0 ± 0.0
Trp	0.509TrpAla: 0.509 ± 0.033	0.169TrpCys: 0.169 ± 0.017	0.53TrpAsp: 0.53 ± 0.03	0.577TrpGlu: 0.577 ± 0.028	0.444TrpPhe: 0.444 ± 0.025	0.498TrpGly: 0.498 ± 0.032	0.16TrpHis: 0.16 ± 0.017	1.224TrpIle: 1.224 ± 0.046	0.816TrpLys: 0.816 ± 0.035	1.007TrpLeu: 1.007 ± 0.04	0.376TrpMet: 0.376 ± 0.026	0.644TrpAsn: 0.644 ± 0.033	0.259TrpPro: 0.259 ± 0.02	0.336TrpGln: 0.336 ± 0.023	0.339TrpArg: 0.339 ± 0.025	0.513TrpSer: 0.513 ± 0.04	0.47TrpThr: 0.47 ± 0.026	0.516TrpVal: 0.516 ± 0.025	0.116TrpTrp: 0.116 ± 0.015	0.351TrpTyr: 0.351 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.594TyrAla: 2.594 ± 0.07	0.51TyrCys: 0.51 ± 0.032	2.659TyrAsp: 2.659 ± 0.066	3.057TyrGlu: 3.057 ± 0.071	1.991TyrPhe: 1.991 ± 0.062	2.762TyrGly: 2.762 ± 0.072	0.899TyrHis: 0.899 ± 0.038	2.731TyrIle: 2.731 ± 0.064	2.411TyrLys: 2.411 ± 0.063	3.703TyrLeu: 3.703 ± 0.076	0.881TyrMet: 0.881 ± 0.033	1.613TyrAsn: 1.613 ± 0.053	1.73TyrPro: 1.73 ± 0.049	1.641TyrGln: 1.641 ± 0.051	1.903TyrArg: 1.903 ± 0.061	2.603TyrSer: 2.603 ± 0.068	2.409TyrThr: 2.409 ± 0.059	2.29TyrVal: 2.29 ± 0.057	0.432TyrTrp: 0.432 ± 0.026	1.694TyrTyr: 1.694 ± 0.05	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2225 proteins (664121 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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