Amino acid dipepetide frequency for Mucilaginibacter gossypii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.967AlaAla: 6.967 ± 0.078
0.667AlaCys: 0.667 ± 0.02
4.872AlaAsp: 4.872 ± 0.053
4.322AlaGlu: 4.322 ± 0.05
3.646AlaPhe: 3.646 ± 0.042
6.131AlaGly: 6.131 ± 0.056
1.303AlaHis: 1.303 ± 0.028
5.656AlaIle: 5.656 ± 0.068
4.745AlaLys: 4.745 ± 0.053
7.081AlaLeu: 7.081 ± 0.068
1.822AlaMet: 1.822 ± 0.031
3.903AlaAsn: 3.903 ± 0.047
2.536AlaPro: 2.536 ± 0.04
3.061AlaGln: 3.061 ± 0.043
2.698AlaArg: 2.698 ± 0.034
4.549AlaSer: 4.549 ± 0.051
4.206AlaThr: 4.206 ± 0.051
5.151AlaVal: 5.151 ± 0.053
0.864AlaTrp: 0.864 ± 0.021
3.017AlaTyr: 3.017 ± 0.042
0.0AlaXaa: 0.0 ± 0.0
Cys
0.522CysAla: 0.522 ± 0.017
0.143CysCys: 0.143 ± 0.01
0.381CysAsp: 0.381 ± 0.015
0.34CysGlu: 0.34 ± 0.013
0.463CysPhe: 0.463 ± 0.015
0.62CysGly: 0.62 ± 0.018
0.182CysHis: 0.182 ± 0.01
0.622CysIle: 0.622 ± 0.019
0.49CysLys: 0.49 ± 0.016
0.794CysLeu: 0.794 ± 0.02
0.187CysMet: 0.187 ± 0.01
0.39CysAsn: 0.39 ± 0.015
0.339CysPro: 0.339 ± 0.015
0.231CysGln: 0.231 ± 0.01
0.342CysArg: 0.342 ± 0.013
0.552CysSer: 0.552 ± 0.015
0.433CysThr: 0.433 ± 0.014
0.435CysVal: 0.435 ± 0.016
0.094CysTrp: 0.094 ± 0.006
0.335CysTyr: 0.335 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
4.142AspAla: 4.142 ± 0.049
0.409AspCys: 0.409 ± 0.014
2.801AspAsp: 2.801 ± 0.041
3.417AspGlu: 3.417 ± 0.044
3.011AspPhe: 3.011 ± 0.043
3.99AspGly: 3.99 ± 0.063
1.15AspHis: 1.15 ± 0.023
3.958AspIle: 3.958 ± 0.049
3.998AspLys: 3.998 ± 0.045
4.883AspLeu: 4.883 ± 0.047
1.201AspMet: 1.201 ± 0.026
2.905AspAsn: 2.905 ± 0.043
2.203AspPro: 2.203 ± 0.032
1.876AspGln: 1.876 ± 0.03
2.066AspArg: 2.066 ± 0.03
2.918AspSer: 2.918 ± 0.043
2.793AspThr: 2.793 ± 0.035
3.476AspVal: 3.476 ± 0.04
0.792AspTrp: 0.792 ± 0.021
2.524AspTyr: 2.524 ± 0.039
0.0AspXaa: 0.0 ± 0.0
Glu
4.188GluAla: 4.188 ± 0.054
0.319GluCys: 0.319 ± 0.013
2.522GluAsp: 2.522 ± 0.041
2.965GluGlu: 2.965 ± 0.047
2.242GluPhe: 2.242 ± 0.035
3.201GluGly: 3.201 ± 0.042
1.121GluHis: 1.121 ± 0.027
3.941GluIle: 3.941 ± 0.055
4.145GluLys: 4.145 ± 0.05
5.47GluLeu: 5.47 ± 0.056
1.336GluMet: 1.336 ± 0.03
2.916GluAsn: 2.916 ± 0.04
1.696GluPro: 1.696 ± 0.032
2.465GluGln: 2.465 ± 0.039
2.41GluArg: 2.41 ± 0.036
2.566GluSer: 2.566 ± 0.035
2.8GluThr: 2.8 ± 0.034
3.502GluVal: 3.502 ± 0.04
0.614GluTrp: 0.614 ± 0.016
1.977GluTyr: 1.977 ± 0.029
0.0GluXaa: 0.0 ± 0.0
Phe
3.484PheAla: 3.484 ± 0.049
0.462PheCys: 0.462 ± 0.016
2.96PheAsp: 2.96 ± 0.037
2.588PheGlu: 2.588 ± 0.037
2.465PhePhe: 2.465 ± 0.038
3.389PheGly: 3.389 ± 0.042
0.862PheHis: 0.862 ± 0.022
3.631PheIle: 3.631 ± 0.05
3.497PheLys: 3.497 ± 0.041
4.15PheLeu: 4.15 ± 0.048
1.108PheMet: 1.108 ± 0.025
3.128PheAsn: 3.128 ± 0.044
1.763PhePro: 1.763 ± 0.028
1.274PheGln: 1.274 ± 0.026
1.829PheArg: 1.829 ± 0.03
3.508PheSer: 3.508 ± 0.048
3.254PheThr: 3.254 ± 0.045
2.762PheVal: 2.762 ± 0.038
0.603PheTrp: 0.603 ± 0.018
2.23PheTyr: 2.23 ± 0.032
0.0PheXaa: 0.0 ± 0.0
Gly
4.787GlyAla: 4.787 ± 0.058
0.615GlyCys: 0.615 ± 0.017
3.607GlyAsp: 3.607 ± 0.05
3.205GlyGlu: 3.205 ± 0.047
3.719GlyPhe: 3.719 ± 0.046
5.039GlyGly: 5.039 ± 0.066
1.351GlyHis: 1.351 ± 0.025
5.468GlyIle: 5.468 ± 0.055
5.298GlyLys: 5.298 ± 0.051
6.466GlyLeu: 6.466 ± 0.059
1.645GlyMet: 1.645 ± 0.029
3.88GlyAsn: 3.88 ± 0.047
1.797GlyPro: 1.797 ± 0.034
2.295GlyGln: 2.295 ± 0.036
2.686GlyArg: 2.686 ± 0.035
4.512GlySer: 4.512 ± 0.055
4.286GlyThr: 4.286 ± 0.061
4.425GlyVal: 4.425 ± 0.051
1.041GlyTrp: 1.041 ± 0.027
3.264GlyTyr: 3.264 ± 0.047
0.0GlyXaa: 0.0 ± 0.0
His
1.172HisAla: 1.172 ± 0.023
0.186HisCys: 0.186 ± 0.01
1.058HisAsp: 1.058 ± 0.023
1.064HisGlu: 1.064 ± 0.024
1.168HisPhe: 1.168 ± 0.023
1.191HisGly: 1.191 ± 0.031
0.573HisHis: 0.573 ± 0.018
1.46HisIle: 1.46 ± 0.026
1.064HisLys: 1.064 ± 0.024
1.962HisLeu: 1.962 ± 0.029
0.4HisMet: 0.4 ± 0.014
1.012HisAsn: 1.012 ± 0.022
1.066HisPro: 1.066 ± 0.024
0.784HisGln: 0.784 ± 0.021
0.795HisArg: 0.795 ± 0.02
1.1HisSer: 1.1 ± 0.025
1.062HisThr: 1.062 ± 0.022
1.083HisVal: 1.083 ± 0.022
0.285HisTrp: 0.285 ± 0.012
0.934HisTyr: 0.934 ± 0.021
0.0HisXaa: 0.0 ± 0.0
Ile
6.042IleAla: 6.042 ± 0.055
0.721IleCys: 0.721 ± 0.02
4.259IleAsp: 4.259 ± 0.052
3.888IleGlu: 3.888 ± 0.046
3.063IlePhe: 3.063 ± 0.043
4.838IleGly: 4.838 ± 0.049
1.288IleHis: 1.288 ± 0.022
5.172IleIle: 5.172 ± 0.063
5.18IleLys: 5.18 ± 0.058
5.945IleLeu: 5.945 ± 0.062
1.427IleMet: 1.427 ± 0.024
4.565IleAsn: 4.565 ± 0.057
2.999IlePro: 2.999 ± 0.042
2.186IleGln: 2.186 ± 0.033
2.914IleArg: 2.914 ± 0.037
5.107IleSer: 5.107 ± 0.05
4.74IleThr: 4.74 ± 0.047
4.217IleVal: 4.217 ± 0.053
0.747IleTrp: 0.747 ± 0.02
2.684IleTyr: 2.684 ± 0.038
0.0IleXaa: 0.0 ± 0.0
Lys
5.541LysAla: 5.541 ± 0.056
0.314LysCys: 0.314 ± 0.013
3.925LysAsp: 3.925 ± 0.048
3.947LysGlu: 3.947 ± 0.043
2.65LysPhe: 2.65 ± 0.033
4.546LysGly: 4.546 ± 0.049
1.388LysHis: 1.388 ± 0.028
4.765LysIle: 4.765 ± 0.054
5.264LysLys: 5.264 ± 0.059
6.486LysLeu: 6.486 ± 0.054
1.761LysMet: 1.761 ± 0.035
4.118LysAsn: 4.118 ± 0.047
3.04LysPro: 3.04 ± 0.043
3.079LysGln: 3.079 ± 0.044
2.694LysArg: 2.694 ± 0.038
3.841LysSer: 3.841 ± 0.043
4.315LysThr: 4.315 ± 0.046
4.431LysVal: 4.431 ± 0.047
0.806LysTrp: 0.806 ± 0.023
2.879LysTyr: 2.879 ± 0.038
0.0LysXaa: 0.0 ± 0.0
Leu
6.963LeuAla: 6.963 ± 0.071
0.817LeuCys: 0.817 ± 0.022
4.532LeuAsp: 4.532 ± 0.051
4.298LeuGlu: 4.298 ± 0.056
4.641LeuPhe: 4.641 ± 0.057
5.724LeuGly: 5.724 ± 0.054
1.701LeuHis: 1.701 ± 0.029
6.567LeuIle: 6.567 ± 0.07
7.386LeuLys: 7.386 ± 0.061
9.499LeuLeu: 9.499 ± 0.095
2.148LeuMet: 2.148 ± 0.034
5.808LeuAsn: 5.808 ± 0.057
4.277LeuPro: 4.277 ± 0.043
3.611LeuGln: 3.611 ± 0.049
3.473LeuArg: 3.473 ± 0.045
6.755LeuSer: 6.755 ± 0.063
5.655LeuThr: 5.655 ± 0.053
5.553LeuVal: 5.553 ± 0.053
0.988LeuTrp: 0.988 ± 0.023
3.477LeuTyr: 3.477 ± 0.042
0.0LeuXaa: 0.0 ± 0.0
Met
1.91MetAla: 1.91 ± 0.031
0.151MetCys: 0.151 ± 0.009
1.149MetAsp: 1.149 ± 0.028
1.283MetGlu: 1.283 ± 0.026
0.882MetPhe: 0.882 ± 0.021
1.487MetGly: 1.487 ± 0.028
0.469MetHis: 0.469 ± 0.016
1.545MetIle: 1.545 ± 0.026
1.942MetLys: 1.942 ± 0.034
2.193MetLeu: 2.193 ± 0.037
0.59MetMet: 0.59 ± 0.02
1.202MetAsn: 1.202 ± 0.023
1.12MetPro: 1.12 ± 0.026
0.963MetGln: 0.963 ± 0.024
0.927MetArg: 0.927 ± 0.021
1.311MetSer: 1.311 ± 0.025
1.081MetThr: 1.081 ± 0.023
1.483MetVal: 1.483 ± 0.029
0.187MetTrp: 0.187 ± 0.008
0.667MetTyr: 0.667 ± 0.017
0.0MetXaa: 0.0 ± 0.0
Asn
4.156AsnAla: 4.156 ± 0.045
0.419AsnCys: 0.419 ± 0.017
2.998AsnAsp: 2.998 ± 0.046
2.928AsnGlu: 2.928 ± 0.041
2.694AsnPhe: 2.694 ± 0.039
4.3AsnGly: 4.3 ± 0.055
1.091AsnHis: 1.091 ± 0.028
4.221AsnIle: 4.221 ± 0.046
3.775AsnLys: 3.775 ± 0.043
4.938AsnLeu: 4.938 ± 0.046
1.21AsnMet: 1.21 ± 0.024
3.623AsnAsn: 3.623 ± 0.055
2.719AsnPro: 2.719 ± 0.037
2.167AsnGln: 2.167 ± 0.03
2.309AsnArg: 2.309 ± 0.037
3.306AsnSer: 3.306 ± 0.043
3.32AsnThr: 3.32 ± 0.044
3.246AsnVal: 3.246 ± 0.038
0.808AsnTrp: 0.808 ± 0.02
2.828AsnTyr: 2.828 ± 0.045
0.0AsnXaa: 0.0 ± 0.0
Pro
3.649ProAla: 3.649 ± 0.048
0.222ProCys: 0.222 ± 0.011
2.762ProAsp: 2.762 ± 0.043
2.722ProGlu: 2.722 ± 0.031
1.973ProPhe: 1.973 ± 0.034
3.167ProGly: 3.167 ± 0.041
0.721ProHis: 0.721 ± 0.018
2.325ProIle: 2.325 ± 0.036
2.2ProLys: 2.2 ± 0.034
3.461ProLeu: 3.461 ± 0.04
0.788ProMet: 0.788 ± 0.02
1.982ProAsn: 1.982 ± 0.033
1.22ProPro: 1.22 ± 0.034
1.523ProGln: 1.523 ± 0.031
1.145ProArg: 1.145 ± 0.023
2.16ProSer: 2.16 ± 0.036
1.989ProThr: 1.989 ± 0.035
3.606ProVal: 3.606 ± 0.044
0.45ProTrp: 0.45 ± 0.015
1.632ProTyr: 1.632 ± 0.032
0.0ProXaa: 0.0 ± 0.0
Gln
2.781GlnAla: 2.781 ± 0.04
0.2GlnCys: 0.2 ± 0.011
1.626GlnAsp: 1.626 ± 0.031
1.801GlnGlu: 1.801 ± 0.034
1.658GlnPhe: 1.658 ± 0.027
2.111GlnGly: 2.111 ± 0.037
0.83GlnHis: 0.83 ± 0.021
2.456GlnIle: 2.456 ± 0.028
2.713GlnLys: 2.713 ± 0.038
3.996GlnLeu: 3.996 ± 0.042
0.948GlnMet: 0.948 ± 0.025
2.135GlnAsn: 2.135 ± 0.032
1.605GlnPro: 1.605 ± 0.03
2.2GlnGln: 2.2 ± 0.07
1.54GlnArg: 1.54 ± 0.034
2.271GlnSer: 2.271 ± 0.038
2.204GlnThr: 2.204 ± 0.035
2.499GlnVal: 2.499 ± 0.035
0.499GlnTrp: 0.499 ± 0.015
1.629GlnTyr: 1.629 ± 0.033
0.0GlnXaa: 0.0 ± 0.0
Arg
2.512ArgAla: 2.512 ± 0.034
0.246ArgCys: 0.246 ± 0.012
2.063ArgAsp: 2.063 ± 0.032
2.223ArgGlu: 2.223 ± 0.042
2.136ArgPhe: 2.136 ± 0.035
2.224ArgGly: 2.224 ± 0.036
0.77ArgHis: 0.77 ± 0.019
2.906ArgIle: 2.906 ± 0.041
2.752ArgLys: 2.752 ± 0.04
3.908ArgLeu: 3.908 ± 0.045
1.005ArgMet: 1.005 ± 0.022
2.184ArgAsn: 2.184 ± 0.036
1.428ArgPro: 1.428 ± 0.033
1.568ArgGln: 1.568 ± 0.035
1.613ArgArg: 1.613 ± 0.03
2.267ArgSer: 2.267 ± 0.036
1.997ArgThr: 1.997 ± 0.03
2.491ArgVal: 2.491 ± 0.037
0.516ArgTrp: 0.516 ± 0.014
1.879ArgTyr: 1.879 ± 0.03
0.0ArgXaa: 0.0 ± 0.0
Ser
4.976SerAla: 4.976 ± 0.056
0.557SerCys: 0.557 ± 0.019
3.006SerAsp: 3.006 ± 0.034
2.8SerGlu: 2.8 ± 0.036
3.53SerPhe: 3.53 ± 0.045
4.898SerGly: 4.898 ± 0.062
1.151SerHis: 1.151 ± 0.025
4.484SerIle: 4.484 ± 0.046
3.917SerLys: 3.917 ± 0.042
5.979SerLeu: 5.979 ± 0.062
1.288SerMet: 1.288 ± 0.025
3.164SerAsn: 3.164 ± 0.048
2.513SerPro: 2.513 ± 0.039
2.029SerGln: 2.029 ± 0.036
2.397SerArg: 2.397 ± 0.033
4.07SerSer: 4.07 ± 0.059
3.473SerThr: 3.473 ± 0.052
4.239SerVal: 4.239 ± 0.049
0.755SerTrp: 0.755 ± 0.018
2.764SerTyr: 2.764 ± 0.035
0.0SerXaa: 0.0 ± 0.0
Thr
4.926ThrAla: 4.926 ± 0.057
0.424ThrCys: 0.424 ± 0.016
3.616ThrAsp: 3.616 ± 0.042
2.935ThrGlu: 2.935 ± 0.041
2.774ThrPhe: 2.774 ± 0.041
5.136ThrGly: 5.136 ± 0.056
1.039ThrHis: 1.039 ± 0.023
4.332ThrIle: 4.332 ± 0.048
3.082ThrLys: 3.082 ± 0.041
5.361ThrLeu: 5.361 ± 0.052
1.055ThrMet: 1.055 ± 0.025
2.965ThrAsn: 2.965 ± 0.043
2.636ThrPro: 2.636 ± 0.043
1.937ThrGln: 1.937 ± 0.03
2.06ThrArg: 2.06 ± 0.028
3.433ThrSer: 3.433 ± 0.049
3.545ThrThr: 3.545 ± 0.05
4.054ThrVal: 4.054 ± 0.048
0.692ThrTrp: 0.692 ± 0.018
2.466ThrTyr: 2.466 ± 0.034
0.0ThrXaa: 0.0 ± 0.0
Val
4.671ValAla: 4.671 ± 0.052
0.546ValCys: 0.546 ± 0.018
3.357ValAsp: 3.357 ± 0.039
3.102ValGlu: 3.102 ± 0.041
3.219ValPhe: 3.219 ± 0.04
3.642ValGly: 3.642 ± 0.047
1.114ValHis: 1.114 ± 0.024
5.011ValIle: 5.011 ± 0.051
4.75ValLys: 4.75 ± 0.049
6.07ValLeu: 6.07 ± 0.057
1.505ValMet: 1.505 ± 0.027
3.848ValAsn: 3.848 ± 0.049
2.54ValPro: 2.54 ± 0.043
2.071ValGln: 2.071 ± 0.034
2.3ValArg: 2.3 ± 0.036
4.381ValSer: 4.381 ± 0.055
4.091ValThr: 4.091 ± 0.043
4.198ValVal: 4.198 ± 0.056
0.7ValTrp: 0.7 ± 0.019
2.69ValTyr: 2.69 ± 0.035
0.0ValXaa: 0.0 ± 0.0
Trp
0.853TrpAla: 0.853 ± 0.024
0.114TrpCys: 0.114 ± 0.008
0.708TrpAsp: 0.708 ± 0.019
0.628TrpGlu: 0.628 ± 0.018
0.645TrpPhe: 0.645 ± 0.02
0.877TrpGly: 0.877 ± 0.02
0.312TrpHis: 0.312 ± 0.014
0.791TrpIle: 0.791 ± 0.02
0.813TrpLys: 0.813 ± 0.022
1.269TrpLeu: 1.269 ± 0.028
0.339TrpMet: 0.339 ± 0.014
0.681TrpAsn: 0.681 ± 0.018
0.421TrpPro: 0.421 ± 0.015
0.59TrpGln: 0.59 ± 0.019
0.512TrpArg: 0.512 ± 0.018
0.638TrpSer: 0.638 ± 0.018
0.632TrpThr: 0.632 ± 0.017
0.716TrpVal: 0.716 ± 0.017
0.226TrpTrp: 0.226 ± 0.013
0.474TrpTyr: 0.474 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.956TyrAla: 2.956 ± 0.039
0.363TyrCys: 0.363 ± 0.013
2.311TyrAsp: 2.311 ± 0.037
1.939TyrGlu: 1.939 ± 0.033
2.368TyrPhe: 2.368 ± 0.037
2.875TyrGly: 2.875 ± 0.04
1.004TyrHis: 1.004 ± 0.023
2.672TyrIle: 2.672 ± 0.037
2.781TyrLys: 2.781 ± 0.04
3.963TyrLeu: 3.963 ± 0.049
0.781TyrMet: 0.781 ± 0.021
2.646TyrAsn: 2.646 ± 0.043
1.777TyrPro: 1.777 ± 0.03
1.79TyrGln: 1.79 ± 0.03
1.98TyrArg: 1.98 ± 0.035
2.744TyrSer: 2.744 ± 0.039
2.591TyrThr: 2.591 ± 0.045
2.238TyrVal: 2.238 ± 0.032
0.573TyrTrp: 0.573 ± 0.017
2.075TyrTyr: 2.075 ± 0.036
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6105 proteins (2079586 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski