Amino acid dipepetide frequency for Streptococcus satellite phage Javan248

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.305AlaAla: 7.305 ± 2.932
0.522AlaCys: 0.522 ± 0.387
3.913AlaAsp: 3.913 ± 1.699
4.957AlaGlu: 4.957 ± 0.963
6.522AlaPhe: 6.522 ± 1.766
7.044AlaGly: 7.044 ± 3.134
0.0AlaHis: 0.0 ± 0.0
7.827AlaIle: 7.827 ± 1.769
6.783AlaLys: 6.783 ± 1.298
9.653AlaLeu: 9.653 ± 4.068
3.392AlaMet: 3.392 ± 1.214
3.913AlaAsn: 3.913 ± 1.102
0.522AlaPro: 0.522 ± 0.288
3.913AlaGln: 3.913 ± 1.791
3.392AlaArg: 3.392 ± 0.804
5.479AlaSer: 5.479 ± 2.33
4.696AlaThr: 4.696 ± 1.895
7.305AlaVal: 7.305 ± 3.676
0.261AlaTrp: 0.261 ± 0.337
2.87AlaTyr: 2.87 ± 0.927
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
0.522CysAsp: 0.522 ± 0.453
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
0.261CysGly: 0.261 ± 0.301
0.0CysHis: 0.0 ± 0.0
0.261CysIle: 0.261 ± 0.301
0.522CysLys: 0.522 ± 0.411
0.0CysLeu: 0.0 ± 0.0
0.261CysMet: 0.261 ± 0.27
0.261CysAsn: 0.261 ± 0.309
0.522CysPro: 0.522 ± 0.39
0.0CysGln: 0.0 ± 0.0
0.522CysArg: 0.522 ± 0.415
0.0CysSer: 0.0 ± 0.0
0.261CysThr: 0.261 ± 0.27
0.261CysVal: 0.261 ± 0.307
0.0CysTrp: 0.0 ± 0.0
0.261CysTyr: 0.261 ± 0.27
0.0CysXaa: 0.0 ± 0.0
Asp
5.218AspAla: 5.218 ± 1.329
0.261AspCys: 0.261 ± 0.301
3.652AspAsp: 3.652 ± 1.486
2.87AspGlu: 2.87 ± 0.936
3.652AspPhe: 3.652 ± 1.818
4.435AspGly: 4.435 ± 1.231
0.522AspHis: 0.522 ± 0.276
4.696AspIle: 4.696 ± 2.139
7.566AspLys: 7.566 ± 2.009
5.74AspLeu: 5.74 ± 1.142
1.826AspMet: 1.826 ± 0.642
2.87AspAsn: 2.87 ± 0.98
1.044AspPro: 1.044 ± 0.5
1.044AspGln: 1.044 ± 0.596
0.783AspArg: 0.783 ± 0.352
2.87AspSer: 2.87 ± 1.503
1.826AspThr: 1.826 ± 0.496
3.652AspVal: 3.652 ± 0.974
0.0AspTrp: 0.0 ± 0.0
2.87AspTyr: 2.87 ± 1.135
0.0AspXaa: 0.0 ± 0.0
Glu
1.826GluAla: 1.826 ± 0.543
0.261GluCys: 0.261 ± 0.27
3.392GluAsp: 3.392 ± 1.234
3.131GluGlu: 3.131 ± 1.505
2.087GluPhe: 2.087 ± 1.533
2.348GluGly: 2.348 ± 1.049
1.304GluHis: 1.304 ± 0.799
4.174GluIle: 4.174 ± 1.418
6.001GluLys: 6.001 ± 1.482
8.349GluLeu: 8.349 ± 2.691
1.044GluMet: 1.044 ± 0.751
3.392GluAsn: 3.392 ± 1.629
0.261GluPro: 0.261 ± 0.27
2.609GluGln: 2.609 ± 1.09
4.435GluArg: 4.435 ± 1.512
3.652GluSer: 3.652 ± 1.339
2.87GluThr: 2.87 ± 0.605
3.392GluVal: 3.392 ± 0.941
1.304GluTrp: 1.304 ± 0.875
1.304GluTyr: 1.304 ± 0.573
0.0GluXaa: 0.0 ± 0.0
Phe
4.435PheAla: 4.435 ± 1.176
0.0PheCys: 0.0 ± 0.0
4.435PheAsp: 4.435 ± 1.188
2.609PheGlu: 2.609 ± 1.381
2.087PhePhe: 2.087 ± 1.211
3.913PheGly: 3.913 ± 1.145
0.783PheHis: 0.783 ± 0.498
3.392PheIle: 3.392 ± 1.16
2.87PheLys: 2.87 ± 1.174
4.435PheLeu: 4.435 ± 1.773
0.522PheMet: 0.522 ± 0.335
1.826PheAsn: 1.826 ± 0.582
0.261PhePro: 0.261 ± 0.168
1.044PheGln: 1.044 ± 0.444
1.826PheArg: 1.826 ± 0.641
4.174PheSer: 4.174 ± 0.895
2.087PheThr: 2.087 ± 0.652
1.044PheVal: 1.044 ± 0.653
0.261PheTrp: 0.261 ± 0.301
0.522PheTyr: 0.522 ± 0.57
0.0PheXaa: 0.0 ± 0.0
Gly
8.088GlyAla: 8.088 ± 3.741
0.261GlyCys: 0.261 ± 0.309
2.609GlyAsp: 2.609 ± 0.756
2.087GlyGlu: 2.087 ± 0.693
2.609GlyPhe: 2.609 ± 1.253
2.87GlyGly: 2.87 ± 0.861
0.522GlyHis: 0.522 ± 0.3
7.566GlyIle: 7.566 ± 2.257
4.957GlyLys: 4.957 ± 1.324
7.827GlyLeu: 7.827 ± 2.592
2.87GlyMet: 2.87 ± 0.934
2.609GlyAsn: 2.609 ± 1.217
0.261GlyPro: 0.261 ± 0.168
2.87GlyGln: 2.87 ± 0.645
0.783GlyArg: 0.783 ± 0.375
3.392GlySer: 3.392 ± 1.556
2.87GlyThr: 2.87 ± 1.005
5.74GlyVal: 5.74 ± 1.942
0.522GlyTrp: 0.522 ± 0.295
2.087GlyTyr: 2.087 ± 1.129
0.0GlyXaa: 0.0 ± 0.0
His
0.261HisAla: 0.261 ± 0.168
0.261HisCys: 0.261 ± 0.313
0.783HisAsp: 0.783 ± 0.641
0.783HisGlu: 0.783 ± 0.453
0.261HisPhe: 0.261 ± 0.309
0.783HisGly: 0.783 ± 0.502
0.0HisHis: 0.0 ± 0.0
1.044HisIle: 1.044 ± 0.431
1.044HisLys: 1.044 ± 0.768
0.522HisLeu: 0.522 ± 0.409
0.0HisMet: 0.0 ± 0.0
1.044HisAsn: 1.044 ± 0.598
0.261HisPro: 0.261 ± 0.168
0.783HisGln: 0.783 ± 0.608
0.261HisArg: 0.261 ± 0.295
0.783HisSer: 0.783 ± 0.392
0.783HisThr: 0.783 ± 0.928
0.261HisVal: 0.261 ± 0.337
0.261HisTrp: 0.261 ± 0.313
0.261HisTyr: 0.261 ± 0.285
0.0HisXaa: 0.0 ± 0.0
Ile
5.74IleAla: 5.74 ± 2.012
0.522IleCys: 0.522 ± 0.469
6.522IleAsp: 6.522 ± 2.201
4.435IleGlu: 4.435 ± 0.818
2.087IlePhe: 2.087 ± 0.702
5.479IleGly: 5.479 ± 1.757
0.783IleHis: 0.783 ± 0.403
5.218IleIle: 5.218 ± 1.273
5.74IleLys: 5.74 ± 1.478
6.001IleLeu: 6.001 ± 1.34
1.044IleMet: 1.044 ± 0.49
6.261IleAsn: 6.261 ± 1.779
2.609IlePro: 2.609 ± 1.039
3.131IleGln: 3.131 ± 0.746
2.87IleArg: 2.87 ± 1.118
6.522IleSer: 6.522 ± 1.479
3.913IleThr: 3.913 ± 1.011
3.913IleVal: 3.913 ± 0.765
0.0IleTrp: 0.0 ± 0.0
2.348IleTyr: 2.348 ± 1.143
0.0IleXaa: 0.0 ± 0.0
Lys
8.349LysAla: 8.349 ± 1.596
0.261LysCys: 0.261 ± 0.301
3.652LysAsp: 3.652 ± 1.094
4.435LysGlu: 4.435 ± 1.093
2.609LysPhe: 2.609 ± 0.819
3.392LysGly: 3.392 ± 0.956
0.783LysHis: 0.783 ± 0.57
5.74LysIle: 5.74 ± 1.927
9.392LysLys: 9.392 ± 2.755
8.609LysLeu: 8.609 ± 2.085
1.044LysMet: 1.044 ± 0.668
6.261LysAsn: 6.261 ± 1.317
1.565LysPro: 1.565 ± 0.853
4.435LysGln: 4.435 ± 1.497
4.696LysArg: 4.696 ± 1.897
4.957LysSer: 4.957 ± 1.457
5.479LysThr: 5.479 ± 0.925
3.913LysVal: 3.913 ± 1.275
1.304LysTrp: 1.304 ± 0.802
3.913LysTyr: 3.913 ± 2.002
0.0LysXaa: 0.0 ± 0.0
Leu
11.218LeuAla: 11.218 ± 2.145
0.522LeuCys: 0.522 ± 0.382
7.566LeuAsp: 7.566 ± 1.716
7.044LeuGlu: 7.044 ± 2.619
3.392LeuPhe: 3.392 ± 1.327
5.74LeuGly: 5.74 ± 2.154
1.044LeuHis: 1.044 ± 0.739
6.261LeuIle: 6.261 ± 1.397
8.609LeuLys: 8.609 ± 1.331
9.653LeuLeu: 9.653 ± 2.529
3.392LeuMet: 3.392 ± 0.745
4.957LeuAsn: 4.957 ± 1.194
2.087LeuPro: 2.087 ± 0.624
2.348LeuGln: 2.348 ± 0.881
2.087LeuArg: 2.087 ± 0.926
6.261LeuSer: 6.261 ± 1.582
6.261LeuThr: 6.261 ± 0.662
5.479LeuVal: 5.479 ± 1.192
0.783LeuTrp: 0.783 ± 0.584
4.435LeuTyr: 4.435 ± 1.187
0.0LeuXaa: 0.0 ± 0.0
Met
3.652MetAla: 3.652 ± 1.169
0.0MetCys: 0.0 ± 0.0
0.783MetAsp: 0.783 ± 0.473
2.087MetGlu: 2.087 ± 0.755
1.304MetPhe: 1.304 ± 0.592
2.609MetGly: 2.609 ± 1.03
0.261MetHis: 0.261 ± 0.285
2.087MetIle: 2.087 ± 0.71
1.565MetLys: 1.565 ± 0.693
3.131MetLeu: 3.131 ± 0.964
1.044MetMet: 1.044 ± 0.497
2.348MetAsn: 2.348 ± 0.62
0.783MetPro: 0.783 ± 0.471
1.565MetGln: 1.565 ± 1.005
0.783MetArg: 0.783 ± 0.403
2.609MetSer: 2.609 ± 0.915
2.348MetThr: 2.348 ± 0.744
1.044MetVal: 1.044 ± 0.498
0.0MetTrp: 0.0 ± 0.0
0.522MetTyr: 0.522 ± 0.465
0.0MetXaa: 0.0 ± 0.0
Asn
4.957AsnAla: 4.957 ± 1.355
0.261AsnCys: 0.261 ± 0.337
2.348AsnAsp: 2.348 ± 0.854
4.174AsnGlu: 4.174 ± 1.385
0.783AsnPhe: 0.783 ± 0.454
4.174AsnGly: 4.174 ± 1.002
0.783AsnHis: 0.783 ± 0.494
4.435AsnIle: 4.435 ± 1.345
5.218AsnLys: 5.218 ± 1.908
3.652AsnLeu: 3.652 ± 0.989
1.826AsnMet: 1.826 ± 0.666
2.609AsnAsn: 2.609 ± 0.984
2.087AsnPro: 2.087 ± 0.926
2.609AsnGln: 2.609 ± 1.381
2.087AsnArg: 2.087 ± 0.798
4.435AsnSer: 4.435 ± 1.255
3.131AsnThr: 3.131 ± 1.085
3.131AsnVal: 3.131 ± 1.017
1.044AsnTrp: 1.044 ± 0.721
2.087AsnTyr: 2.087 ± 1.144
0.0AsnXaa: 0.0 ± 0.0
Pro
1.565ProAla: 1.565 ± 0.631
0.0ProCys: 0.0 ± 0.0
0.522ProAsp: 0.522 ± 0.406
0.261ProGlu: 0.261 ± 0.337
1.304ProPhe: 1.304 ± 0.512
1.304ProGly: 1.304 ± 0.623
0.261ProHis: 0.261 ± 0.168
1.565ProIle: 1.565 ± 0.647
2.087ProLys: 2.087 ± 0.795
2.087ProLeu: 2.087 ± 0.908
0.261ProMet: 0.261 ± 0.285
1.044ProAsn: 1.044 ± 0.471
0.261ProPro: 0.261 ± 0.27
0.261ProGln: 0.261 ± 0.285
0.261ProArg: 0.261 ± 0.309
1.304ProSer: 1.304 ± 0.57
2.348ProThr: 2.348 ± 0.734
1.826ProVal: 1.826 ± 0.734
0.261ProTrp: 0.261 ± 0.285
0.522ProTyr: 0.522 ± 0.402
0.0ProXaa: 0.0 ± 0.0
Gln
5.218GlnAla: 5.218 ± 1.571
0.0GlnCys: 0.0 ± 0.0
1.565GlnAsp: 1.565 ± 0.666
2.609GlnGlu: 2.609 ± 1.385
1.826GlnPhe: 1.826 ± 0.607
3.131GlnGly: 3.131 ± 1.815
0.0GlnHis: 0.0 ± 0.0
3.652GlnIle: 3.652 ± 0.789
3.392GlnLys: 3.392 ± 1.53
3.652GlnLeu: 3.652 ± 0.843
1.044GlnMet: 1.044 ± 0.511
1.565GlnAsn: 1.565 ± 0.789
1.044GlnPro: 1.044 ± 0.638
2.87GlnGln: 2.87 ± 1.078
1.565GlnArg: 1.565 ± 0.815
4.174GlnSer: 4.174 ± 1.185
2.87GlnThr: 2.87 ± 0.987
2.348GlnVal: 2.348 ± 0.73
0.261GlnTrp: 0.261 ± 0.168
2.348GlnTyr: 2.348 ± 1.123
0.0GlnXaa: 0.0 ± 0.0
Arg
2.609ArgAla: 2.609 ± 0.605
0.0ArgCys: 0.0 ± 0.0
1.826ArgAsp: 1.826 ± 0.525
3.913ArgGlu: 3.913 ± 1.655
0.522ArgPhe: 0.522 ± 0.335
1.826ArgGly: 1.826 ± 0.821
0.522ArgHis: 0.522 ± 0.41
3.131ArgIle: 3.131 ± 1.173
4.435ArgLys: 4.435 ± 1.396
2.87ArgLeu: 2.87 ± 0.854
1.044ArgMet: 1.044 ± 0.611
1.304ArgAsn: 1.304 ± 0.602
0.522ArgPro: 0.522 ± 0.325
2.087ArgGln: 2.087 ± 0.786
0.783ArgArg: 0.783 ± 0.618
2.087ArgSer: 2.087 ± 0.776
2.087ArgThr: 2.087 ± 1.088
2.348ArgVal: 2.348 ± 0.892
0.522ArgTrp: 0.522 ± 0.409
1.044ArgTyr: 1.044 ± 0.434
0.0ArgXaa: 0.0 ± 0.0
Ser
4.435SerAla: 4.435 ± 2.635
0.261SerCys: 0.261 ± 0.301
4.174SerAsp: 4.174 ± 0.826
3.392SerGlu: 3.392 ± 1.62
2.87SerPhe: 2.87 ± 0.743
3.652SerGly: 3.652 ± 1.146
1.044SerHis: 1.044 ± 0.512
4.174SerIle: 4.174 ± 1.118
4.174SerLys: 4.174 ± 0.743
7.305SerLeu: 7.305 ± 1.566
3.652SerMet: 3.652 ± 0.786
4.174SerAsn: 4.174 ± 1.078
1.826SerPro: 1.826 ± 1.008
3.652SerGln: 3.652 ± 1.015
2.87SerArg: 2.87 ± 0.514
3.652SerSer: 3.652 ± 1.189
4.435SerThr: 4.435 ± 1.398
5.479SerVal: 5.479 ± 1.484
0.783SerTrp: 0.783 ± 0.375
1.304SerTyr: 1.304 ± 0.718
0.0SerXaa: 0.0 ± 0.0
Thr
6.261ThrAla: 6.261 ± 2.793
0.0ThrCys: 0.0 ± 0.0
2.609ThrAsp: 2.609 ± 0.995
3.131ThrGlu: 3.131 ± 1.392
3.131ThrPhe: 3.131 ± 1.367
4.174ThrGly: 4.174 ± 1.149
0.522ThrHis: 0.522 ± 0.409
4.174ThrIle: 4.174 ± 1.004
2.609ThrLys: 2.609 ± 1.0
5.479ThrLeu: 5.479 ± 0.934
3.652ThrMet: 3.652 ± 0.85
2.087ThrAsn: 2.087 ± 0.929
1.304ThrPro: 1.304 ± 0.508
2.87ThrGln: 2.87 ± 1.52
1.826ThrArg: 1.826 ± 0.631
2.609ThrSer: 2.609 ± 0.856
2.87ThrThr: 2.87 ± 1.415
4.696ThrVal: 4.696 ± 1.234
0.0ThrTrp: 0.0 ± 0.0
2.609ThrTyr: 2.609 ± 1.135
0.0ThrXaa: 0.0 ± 0.0
Val
5.479ValAla: 5.479 ± 2.274
0.261ValCys: 0.261 ± 0.27
3.913ValAsp: 3.913 ± 0.986
2.87ValGlu: 2.87 ± 0.912
2.609ValPhe: 2.609 ± 1.119
4.696ValGly: 4.696 ± 2.016
0.522ValHis: 0.522 ± 0.448
3.913ValIle: 3.913 ± 0.861
4.435ValLys: 4.435 ± 1.581
3.652ValLeu: 3.652 ± 0.954
1.826ValMet: 1.826 ± 0.648
3.652ValAsn: 3.652 ± 0.879
1.565ValPro: 1.565 ± 0.681
3.913ValGln: 3.913 ± 0.9
1.826ValArg: 1.826 ± 0.797
5.218ValSer: 5.218 ± 0.679
4.696ValThr: 4.696 ± 0.914
4.174ValVal: 4.174 ± 1.302
0.261ValTrp: 0.261 ± 0.309
2.348ValTyr: 2.348 ± 1.041
0.0ValXaa: 0.0 ± 0.0
Trp
1.565TrpAla: 1.565 ± 0.54
0.0TrpCys: 0.0 ± 0.0
0.261TrpAsp: 0.261 ± 0.309
0.261TrpGlu: 0.261 ± 0.337
0.522TrpPhe: 0.522 ± 0.297
0.0TrpGly: 0.0 ± 0.0
0.261TrpHis: 0.261 ± 0.309
0.783TrpIle: 0.783 ± 0.408
0.522TrpLys: 0.522 ± 0.288
1.044TrpLeu: 1.044 ± 0.629
0.261TrpMet: 0.261 ± 0.336
0.261TrpAsn: 0.261 ± 0.337
0.261TrpPro: 0.261 ± 0.285
0.783TrpGln: 0.783 ± 0.459
0.261TrpArg: 0.261 ± 0.301
0.261TrpSer: 0.261 ± 0.309
0.0TrpThr: 0.0 ± 0.0
0.522TrpVal: 0.522 ± 0.354
0.261TrpTrp: 0.261 ± 0.309
0.261TrpTyr: 0.261 ± 0.295
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.087TyrAla: 2.087 ± 1.316
0.261TyrCys: 0.261 ± 0.27
2.348TyrAsp: 2.348 ± 1.058
2.087TyrGlu: 2.087 ± 0.977
2.348TyrPhe: 2.348 ± 1.254
1.565TyrGly: 1.565 ± 0.791
0.522TyrHis: 0.522 ± 0.43
1.304TyrIle: 1.304 ± 0.525
2.87TyrLys: 2.87 ± 1.351
5.479TyrLeu: 5.479 ± 2.129
0.261TyrMet: 0.261 ± 0.359
3.392TyrAsn: 3.392 ± 1.32
0.261TyrPro: 0.261 ± 0.285
2.348TyrGln: 2.348 ± 0.884
1.565TyrArg: 1.565 ± 0.984
2.87TyrSer: 2.87 ± 1.301
0.783TyrThr: 0.783 ± 0.356
1.304TyrVal: 1.304 ± 0.767
0.261TyrTrp: 0.261 ± 0.309
1.565TyrTyr: 1.565 ± 0.793
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 17 proteins (3834 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski