Amino acid dipepetide frequency for Halomonas elongata (strain ATCC 33173 / DSM 2581 / NBRC 15536 / NCIMB 2198 / 1H9)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.149AlaAla: 12.149 ± 0.141
1.182AlaCys: 1.182 ± 0.036
6.351AlaAsp: 6.351 ± 0.08
8.142AlaGlu: 8.142 ± 0.107
3.894AlaPhe: 3.894 ± 0.069
9.429AlaGly: 9.429 ± 0.096
2.298AlaHis: 2.298 ± 0.045
5.246AlaIle: 5.246 ± 0.075
2.543AlaLys: 2.543 ± 0.055
13.79AlaLeu: 13.79 ± 0.128
3.453AlaMet: 3.453 ± 0.05
2.533AlaAsn: 2.533 ± 0.05
4.988AlaPro: 4.988 ± 0.059
3.654AlaGln: 3.654 ± 0.057
8.529AlaArg: 8.529 ± 0.101
6.747AlaSer: 6.747 ± 0.079
5.34AlaThr: 5.34 ± 0.07
7.303AlaVal: 7.303 ± 0.083
1.89AlaTrp: 1.89 ± 0.045
2.373AlaTyr: 2.373 ± 0.043
0.0AlaXaa: 0.0 ± 0.0
Cys
0.902CysAla: 0.902 ± 0.028
0.12CysCys: 0.12 ± 0.011
0.583CysAsp: 0.583 ± 0.021
0.53CysGlu: 0.53 ± 0.022
0.329CysPhe: 0.329 ± 0.015
0.901CysGly: 0.901 ± 0.031
0.306CysHis: 0.306 ± 0.018
0.359CysIle: 0.359 ± 0.018
0.178CysLys: 0.178 ± 0.011
1.11CysLeu: 1.11 ± 0.028
0.187CysMet: 0.187 ± 0.013
0.219CysAsn: 0.219 ± 0.012
0.508CysPro: 0.508 ± 0.021
0.354CysGln: 0.354 ± 0.019
0.775CysArg: 0.775 ± 0.023
0.468CysSer: 0.468 ± 0.018
0.344CysThr: 0.344 ± 0.018
0.61CysVal: 0.61 ± 0.027
0.134CysTrp: 0.134 ± 0.01
0.222CysTyr: 0.222 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
7.073AspAla: 7.073 ± 0.088
0.493AspCys: 0.493 ± 0.022
4.409AspAsp: 4.409 ± 0.075
4.661AspGlu: 4.661 ± 0.074
2.193AspPhe: 2.193 ± 0.044
5.151AspGly: 5.151 ± 0.081
1.436AspHis: 1.436 ± 0.037
3.052AspIle: 3.052 ± 0.054
1.562AspLys: 1.562 ± 0.045
5.722AspLeu: 5.722 ± 0.075
1.415AspMet: 1.415 ± 0.035
1.628AspAsn: 1.628 ± 0.036
3.225AspPro: 3.225 ± 0.055
1.965AspGln: 1.965 ± 0.042
3.903AspArg: 3.903 ± 0.054
2.806AspSer: 2.806 ± 0.049
3.183AspThr: 3.183 ± 0.061
4.096AspVal: 4.096 ± 0.065
1.174AspTrp: 1.174 ± 0.033
1.756AspTyr: 1.756 ± 0.043
0.0AspXaa: 0.0 ± 0.0
Glu
8.948GluAla: 8.948 ± 0.114
0.492GluCys: 0.492 ± 0.023
3.351GluAsp: 3.351 ± 0.055
4.081GluGlu: 4.081 ± 0.078
1.665GluPhe: 1.665 ± 0.037
5.238GluGly: 5.238 ± 0.064
1.918GluHis: 1.918 ± 0.046
2.968GluIle: 2.968 ± 0.051
1.7GluLys: 1.7 ± 0.044
7.132GluLeu: 7.132 ± 0.085
1.466GluMet: 1.466 ± 0.038
1.536GluAsn: 1.536 ± 0.039
3.027GluPro: 3.027 ± 0.053
3.006GluGln: 3.006 ± 0.052
6.751GluArg: 6.751 ± 0.089
3.429GluSer: 3.429 ± 0.059
3.549GluThr: 3.549 ± 0.059
4.822GluVal: 4.822 ± 0.074
0.874GluTrp: 0.874 ± 0.028
1.243GluTyr: 1.243 ± 0.035
0.0GluXaa: 0.0 ± 0.0
Phe
3.578PheAla: 3.578 ± 0.059
0.355PheCys: 0.355 ± 0.016
2.547PheAsp: 2.547 ± 0.051
2.182PheGlu: 2.182 ± 0.045
1.271PhePhe: 1.271 ± 0.037
3.215PheGly: 3.215 ± 0.062
0.82PheHis: 0.82 ± 0.027
1.571PheIle: 1.571 ± 0.041
0.828PheLys: 0.828 ± 0.028
3.19PheLeu: 3.19 ± 0.058
0.842PheMet: 0.842 ± 0.029
0.993PheAsn: 0.993 ± 0.031
1.391PhePro: 1.391 ± 0.036
1.118PheGln: 1.118 ± 0.03
2.036PheArg: 2.036 ± 0.049
2.151PheSer: 2.151 ± 0.041
1.87PheThr: 1.87 ± 0.045
2.456PheVal: 2.456 ± 0.048
0.507PheTrp: 0.507 ± 0.022
0.91PheTyr: 0.91 ± 0.031
0.0PheXaa: 0.0 ± 0.0
Gly
7.631GlyAla: 7.631 ± 0.084
0.918GlyCys: 0.918 ± 0.027
4.859GlyAsp: 4.859 ± 0.077
6.097GlyGlu: 6.097 ± 0.071
3.222GlyPhe: 3.222 ± 0.054
6.972GlyGly: 6.972 ± 0.096
2.157GlyHis: 2.157 ± 0.045
4.532GlyIle: 4.532 ± 0.068
2.551GlyLys: 2.551 ± 0.049
9.424GlyLeu: 9.424 ± 0.11
2.534GlyMet: 2.534 ± 0.048
2.137GlyAsn: 2.137 ± 0.051
2.883GlyPro: 2.883 ± 0.049
3.264GlyGln: 3.264 ± 0.061
5.992GlyArg: 5.992 ± 0.073
4.313GlySer: 4.313 ± 0.059
3.88GlyThr: 3.88 ± 0.059
6.463GlyVal: 6.463 ± 0.078
1.477GlyTrp: 1.477 ± 0.037
2.369GlyTyr: 2.369 ± 0.041
0.0GlyXaa: 0.0 ± 0.0
His
2.536HisAla: 2.536 ± 0.055
0.322HisCys: 0.322 ± 0.017
1.774HisAsp: 1.774 ± 0.049
1.504HisGlu: 1.504 ± 0.038
0.959HisPhe: 0.959 ± 0.029
2.309HisGly: 2.309 ± 0.054
0.852HisHis: 0.852 ± 0.03
0.897HisIle: 0.897 ± 0.029
0.478HisLys: 0.478 ± 0.02
2.776HisLeu: 2.776 ± 0.053
0.487HisMet: 0.487 ± 0.019
0.555HisAsn: 0.555 ± 0.022
1.581HisPro: 1.581 ± 0.042
0.877HisGln: 0.877 ± 0.026
1.965HisArg: 1.965 ± 0.043
1.124HisSer: 1.124 ± 0.03
0.975HisThr: 0.975 ± 0.028
1.511HisVal: 1.511 ± 0.037
0.454HisTrp: 0.454 ± 0.019
0.765HisTyr: 0.765 ± 0.023
0.0HisXaa: 0.0 ± 0.0
Ile
5.523IleAla: 5.523 ± 0.076
0.41IleCys: 0.41 ± 0.021
3.52IleAsp: 3.52 ± 0.053
3.545IleGlu: 3.545 ± 0.054
1.462IlePhe: 1.462 ± 0.037
4.42IleGly: 4.42 ± 0.075
1.032IleHis: 1.032 ± 0.031
1.926IleIle: 1.926 ± 0.046
1.233IleLys: 1.233 ± 0.037
3.997IleLeu: 3.997 ± 0.071
0.926IleMet: 0.926 ± 0.03
1.369IleAsn: 1.369 ± 0.033
2.103IlePro: 2.103 ± 0.041
1.411IleGln: 1.411 ± 0.034
2.986IleArg: 2.986 ± 0.051
2.468IleSer: 2.468 ± 0.042
2.434IleThr: 2.434 ± 0.044
3.179IleVal: 3.179 ± 0.057
0.503IleTrp: 0.503 ± 0.02
0.973IleTyr: 0.973 ± 0.03
0.0IleXaa: 0.0 ± 0.0
Lys
2.962LysAla: 2.962 ± 0.053
0.136LysCys: 0.136 ± 0.012
1.218LysAsp: 1.218 ± 0.036
1.393LysGlu: 1.393 ± 0.04
0.571LysPhe: 0.571 ± 0.022
2.045LysGly: 2.045 ± 0.043
0.523LysHis: 0.523 ± 0.023
1.009LysIle: 1.009 ± 0.03
0.814LysLys: 0.814 ± 0.032
2.53LysLeu: 2.53 ± 0.054
0.495LysMet: 0.495 ± 0.022
0.606LysAsn: 0.606 ± 0.024
1.366LysPro: 1.366 ± 0.039
1.033LysGln: 1.033 ± 0.029
2.264LysArg: 2.264 ± 0.051
1.39LysSer: 1.39 ± 0.038
1.314LysThr: 1.314 ± 0.033
1.934LysVal: 1.934 ± 0.044
0.298LysTrp: 0.298 ± 0.016
0.487LysTyr: 0.487 ± 0.022
0.0LysXaa: 0.0 ± 0.0
Leu
14.777LeuAla: 14.777 ± 0.148
1.105LeuCys: 1.105 ± 0.032
7.604LeuAsp: 7.604 ± 0.094
8.016LeuGlu: 8.016 ± 0.095
3.649LeuPhe: 3.649 ± 0.066
9.706LeuGly: 9.706 ± 0.104
2.414LeuHis: 2.414 ± 0.048
5.086LeuIle: 5.086 ± 0.067
2.962LeuLys: 2.962 ± 0.063
11.905LeuLeu: 11.905 ± 0.166
2.823LeuMet: 2.823 ± 0.061
2.749LeuAsn: 2.749 ± 0.045
6.238LeuPro: 6.238 ± 0.083
3.094LeuGln: 3.094 ± 0.051
7.027LeuArg: 7.027 ± 0.089
6.64LeuSer: 6.64 ± 0.095
5.883LeuThr: 5.883 ± 0.073
8.372LeuVal: 8.372 ± 0.103
1.416LeuTrp: 1.416 ± 0.041
2.36LeuTyr: 2.36 ± 0.037
0.0LeuXaa: 0.0 ± 0.0
Met
3.24MetAla: 3.24 ± 0.046
0.176MetCys: 0.176 ± 0.011
1.195MetAsp: 1.195 ± 0.032
1.217MetGlu: 1.217 ± 0.03
0.678MetPhe: 0.678 ± 0.023
1.884MetGly: 1.884 ± 0.042
0.518MetHis: 0.518 ± 0.023
1.234MetIle: 1.234 ± 0.031
0.756MetLys: 0.756 ± 0.026
2.742MetLeu: 2.742 ± 0.054
0.682MetMet: 0.682 ± 0.022
0.749MetAsn: 0.749 ± 0.024
1.554MetPro: 1.554 ± 0.035
0.937MetGln: 0.937 ± 0.026
1.747MetArg: 1.747 ± 0.038
1.795MetSer: 1.795 ± 0.035
1.812MetThr: 1.812 ± 0.035
1.725MetVal: 1.725 ± 0.04
0.194MetTrp: 0.194 ± 0.013
0.319MetTyr: 0.319 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
2.884AsnAla: 2.884 ± 0.055
0.221AsnCys: 0.221 ± 0.013
1.455AsnAsp: 1.455 ± 0.038
1.346AsnGlu: 1.346 ± 0.033
0.826AsnPhe: 0.826 ± 0.03
2.073AsnGly: 2.073 ± 0.043
0.59AsnHis: 0.59 ± 0.022
1.218AsnIle: 1.218 ± 0.035
0.58AsnLys: 0.58 ± 0.023
2.695AsnLeu: 2.695 ± 0.051
0.559AsnMet: 0.559 ± 0.022
0.676AsnAsn: 0.676 ± 0.029
1.603AsnPro: 1.603 ± 0.033
0.874AsnGln: 0.874 ± 0.031
1.739AsnArg: 1.739 ± 0.038
1.083AsnSer: 1.083 ± 0.032
1.208AsnThr: 1.208 ± 0.03
1.776AsnVal: 1.776 ± 0.04
0.35AsnTrp: 0.35 ± 0.016
0.619AsnTyr: 0.619 ± 0.023
0.0AsnXaa: 0.0 ± 0.0
Pro
5.313ProAla: 5.313 ± 0.075
0.344ProCys: 0.344 ± 0.017
3.593ProAsp: 3.593 ± 0.053
4.276ProGlu: 4.276 ± 0.07
1.695ProPhe: 1.695 ± 0.04
4.396ProGly: 4.396 ± 0.06
1.16ProHis: 1.16 ± 0.034
1.903ProIle: 1.903 ± 0.042
1.025ProLys: 1.025 ± 0.034
5.615ProLeu: 5.615 ± 0.077
1.273ProMet: 1.273 ± 0.029
1.16ProAsn: 1.16 ± 0.035
2.231ProPro: 2.231 ± 0.05
1.559ProGln: 1.559 ± 0.04
3.311ProArg: 3.311 ± 0.055
2.895ProSer: 2.895 ± 0.049
2.28ProThr: 2.28 ± 0.044
3.82ProVal: 3.82 ± 0.058
0.876ProTrp: 0.876 ± 0.027
1.112ProTyr: 1.112 ± 0.032
0.0ProXaa: 0.0 ± 0.0
Gln
5.084GlnAla: 5.084 ± 0.077
0.283GlnCys: 0.283 ± 0.016
1.802GlnAsp: 1.802 ± 0.042
1.967GlnGlu: 1.967 ± 0.044
0.929GlnPhe: 0.929 ± 0.027
3.151GlnGly: 3.151 ± 0.05
0.889GlnHis: 0.889 ± 0.03
1.313GlnIle: 1.313 ± 0.038
0.819GlnLys: 0.819 ± 0.029
3.847GlnLeu: 3.847 ± 0.059
0.766GlnMet: 0.766 ± 0.03
0.744GlnAsn: 0.744 ± 0.022
1.823GlnPro: 1.823 ± 0.044
1.885GlnGln: 1.885 ± 0.05
3.529GlnArg: 3.529 ± 0.06
1.832GlnSer: 1.832 ± 0.034
1.504GlnThr: 1.504 ± 0.035
2.675GlnVal: 2.675 ± 0.049
0.578GlnTrp: 0.578 ± 0.022
0.718GlnTyr: 0.718 ± 0.024
0.0GlnXaa: 0.0 ± 0.0
Arg
6.962ArgAla: 6.962 ± 0.083
0.635ArgCys: 0.635 ± 0.022
4.763ArgAsp: 4.763 ± 0.066
5.478ArgGlu: 5.478 ± 0.079
2.984ArgPhe: 2.984 ± 0.057
4.867ArgGly: 4.867 ± 0.075
2.669ArgHis: 2.669 ± 0.046
3.402ArgIle: 3.402 ± 0.059
1.646ArgLys: 1.646 ± 0.041
10.566ArgLeu: 10.566 ± 0.125
1.75ArgMet: 1.75 ± 0.038
1.588ArgAsn: 1.588 ± 0.037
3.271ArgPro: 3.271 ± 0.054
3.493ArgGln: 3.493 ± 0.058
6.78ArgArg: 6.78 ± 0.102
3.268ArgSer: 3.268 ± 0.049
2.92ArgThr: 2.92 ± 0.049
5.182ArgVal: 5.182 ± 0.067
1.216ArgTrp: 1.216 ± 0.032
2.182ArgTyr: 2.182 ± 0.04
0.0ArgXaa: 0.0 ± 0.0
Ser
5.485SerAla: 5.485 ± 0.067
0.434SerCys: 0.434 ± 0.02
3.018SerAsp: 3.018 ± 0.049
3.16SerGlu: 3.16 ± 0.058
1.891SerPhe: 1.891 ± 0.045
5.18SerGly: 5.18 ± 0.076
1.31SerHis: 1.31 ± 0.035
2.391SerIle: 2.391 ± 0.048
1.117SerLys: 1.117 ± 0.032
6.846SerLeu: 6.846 ± 0.081
1.488SerMet: 1.488 ± 0.036
1.219SerAsn: 1.219 ± 0.032
2.96SerPro: 2.96 ± 0.051
1.972SerGln: 1.972 ± 0.043
4.436SerArg: 4.436 ± 0.073
3.08SerSer: 3.08 ± 0.052
2.697SerThr: 2.697 ± 0.052
3.92SerVal: 3.92 ± 0.06
0.765SerTrp: 0.765 ± 0.03
1.179SerTyr: 1.179 ± 0.034
0.0SerXaa: 0.0 ± 0.0
Thr
5.121ThrAla: 5.121 ± 0.063
0.421ThrCys: 0.421 ± 0.017
2.527ThrAsp: 2.527 ± 0.053
2.729ThrGlu: 2.729 ± 0.051
1.771ThrPhe: 1.771 ± 0.039
4.263ThrGly: 4.263 ± 0.061
1.159ThrHis: 1.159 ± 0.033
2.025ThrIle: 2.025 ± 0.043
0.879ThrLys: 0.879 ± 0.029
7.236ThrLeu: 7.236 ± 0.092
1.055ThrMet: 1.055 ± 0.028
1.114ThrAsn: 1.114 ± 0.036
3.516ThrPro: 3.516 ± 0.058
1.711ThrGln: 1.711 ± 0.038
3.734ThrArg: 3.734 ± 0.06
2.83ThrSer: 2.83 ± 0.05
2.715ThrThr: 2.715 ± 0.055
3.282ThrVal: 3.282 ± 0.051
0.726ThrTrp: 0.726 ± 0.023
1.069ThrTyr: 1.069 ± 0.03
0.0ThrXaa: 0.0 ± 0.0
Val
8.191ValAla: 8.191 ± 0.086
0.65ValCys: 0.65 ± 0.023
4.434ValAsp: 4.434 ± 0.062
5.045ValGlu: 5.045 ± 0.075
2.478ValPhe: 2.478 ± 0.052
5.51ValGly: 5.51 ± 0.075
1.517ValHis: 1.517 ± 0.037
3.833ValIle: 3.833 ± 0.058
1.822ValLys: 1.822 ± 0.046
7.427ValLeu: 7.427 ± 0.096
2.087ValMet: 2.087 ± 0.042
1.875ValAsn: 1.875 ± 0.045
3.494ValPro: 3.494 ± 0.054
2.04ValGln: 2.04 ± 0.042
4.462ValArg: 4.462 ± 0.065
4.233ValSer: 4.233 ± 0.069
4.143ValThr: 4.143 ± 0.068
5.775ValVal: 5.775 ± 0.093
0.882ValTrp: 0.882 ± 0.031
1.472ValTyr: 1.472 ± 0.036
0.0ValXaa: 0.0 ± 0.0
Trp
1.168TrpAla: 1.168 ± 0.032
0.185TrpCys: 0.185 ± 0.011
0.581TrpAsp: 0.581 ± 0.026
0.702TrpGlu: 0.702 ± 0.024
0.503TrpPhe: 0.503 ± 0.021
0.976TrpGly: 0.976 ± 0.031
0.446TrpHis: 0.446 ± 0.019
0.62TrpIle: 0.62 ± 0.027
0.403TrpLys: 0.403 ± 0.018
2.441TrpLeu: 2.441 ± 0.051
0.413TrpMet: 0.413 ± 0.017
0.391TrpAsn: 0.391 ± 0.016
0.819TrpPro: 0.819 ± 0.03
0.906TrpGln: 0.906 ± 0.027
1.419TrpArg: 1.419 ± 0.035
0.806TrpSer: 0.806 ± 0.029
0.65TrpThr: 0.65 ± 0.027
0.943TrpVal: 0.943 ± 0.029
0.335TrpTrp: 0.335 ± 0.018
0.324TrpTyr: 0.324 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.309TyrAla: 2.309 ± 0.037
0.257TyrCys: 0.257 ± 0.015
1.321TyrAsp: 1.321 ± 0.036
1.126TyrGlu: 1.126 ± 0.03
0.862TyrPhe: 0.862 ± 0.027
1.989TyrGly: 1.989 ± 0.037
0.686TyrHis: 0.686 ± 0.025
0.833TyrIle: 0.833 ± 0.028
0.49TyrLys: 0.49 ± 0.022
2.833TyrLeu: 2.833 ± 0.049
0.453TyrMet: 0.453 ± 0.02
0.533TyrAsn: 0.533 ± 0.025
1.257TyrPro: 1.257 ± 0.035
0.986TyrGln: 0.986 ± 0.032
2.238TyrArg: 2.238 ± 0.051
1.192TyrSer: 1.192 ± 0.031
1.18TyrThr: 1.18 ± 0.034
1.529TyrVal: 1.529 ± 0.034
0.381TyrTrp: 0.381 ± 0.018
0.669TyrTyr: 0.669 ± 0.026
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3622 proteins (1202401 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski