Amino acid dipepetide frequency for Chlorobium chlorochromatii (strain CaD3)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.213AlaAla: 9.213 ± 0.221
0.885AlaCys: 0.885 ± 0.067
4.987AlaAsp: 4.987 ± 0.24
6.0AlaGlu: 6.0 ± 0.163
3.489AlaPhe: 3.489 ± 0.106
7.559AlaGly: 7.559 ± 0.572
1.837AlaHis: 1.837 ± 0.086
6.332AlaIle: 6.332 ± 0.128
4.15AlaLys: 4.15 ± 0.106
10.81AlaLeu: 10.81 ± 0.253
2.42AlaMet: 2.42 ± 0.117
3.629AlaAsn: 3.629 ± 0.248
3.378AlaPro: 3.378 ± 0.139
3.298AlaGln: 3.298 ± 0.095
3.726AlaArg: 3.726 ± 0.147
5.728AlaSer: 5.728 ± 0.272
6.913AlaThr: 6.913 ± 0.489
6.019AlaVal: 6.019 ± 0.165
0.941AlaTrp: 0.941 ± 0.052
2.36AlaTyr: 2.36 ± 0.067
0.0AlaXaa: 0.0 ± 0.0
Cys
0.731CysAla: 0.731 ± 0.063
0.195CysCys: 0.195 ± 0.022
0.507CysAsp: 0.507 ± 0.039
0.492CysGlu: 0.492 ± 0.038
0.405CysPhe: 0.405 ± 0.028
0.869CysGly: 0.869 ± 0.063
0.328CysHis: 0.328 ± 0.039
0.572CysIle: 0.572 ± 0.049
0.463CysLys: 0.463 ± 0.037
0.733CysLeu: 0.733 ± 0.057
0.252CysMet: 0.252 ± 0.024
0.536CysAsn: 0.536 ± 0.042
0.473CysPro: 0.473 ± 0.038
0.304CysGln: 0.304 ± 0.027
0.516CysArg: 0.516 ± 0.046
0.7CysSer: 0.7 ± 0.055
0.521CysThr: 0.521 ± 0.041
0.529CysVal: 0.529 ± 0.048
0.1CysTrp: 0.1 ± 0.013
0.375CysTyr: 0.375 ± 0.035
0.0CysXaa: 0.0 ± 0.0
Asp
5.202AspAla: 5.202 ± 0.253
0.437AspCys: 0.437 ± 0.033
2.824AspAsp: 2.824 ± 0.151
3.393AspGlu: 3.393 ± 0.103
2.338AspPhe: 2.338 ± 0.072
4.587AspGly: 4.587 ± 0.396
0.803AspHis: 0.803 ± 0.041
3.895AspIle: 3.895 ± 0.173
2.409AspLys: 2.409 ± 0.086
4.409AspLeu: 4.409 ± 0.161
1.196AspMet: 1.196 ± 0.049
2.16AspAsn: 2.16 ± 0.096
1.793AspPro: 1.793 ± 0.076
1.1AspGln: 1.1 ± 0.065
2.044AspArg: 2.044 ± 0.085
3.099AspSer: 3.099 ± 0.185
2.921AspThr: 2.921 ± 0.207
4.411AspVal: 4.411 ± 0.314
0.595AspTrp: 0.595 ± 0.046
2.034AspTyr: 2.034 ± 0.075
0.0AspXaa: 0.0 ± 0.0
Glu
6.132GluAla: 6.132 ± 0.151
0.56GluCys: 0.56 ± 0.051
2.298GluAsp: 2.298 ± 0.083
4.311GluGlu: 4.311 ± 0.21
2.281GluPhe: 2.281 ± 0.084
3.758GluGly: 3.758 ± 0.1
1.609GluHis: 1.609 ± 0.096
3.823GluIle: 3.823 ± 0.1
3.967GluLys: 3.967 ± 0.187
7.188GluLeu: 7.188 ± 0.248
1.58GluMet: 1.58 ± 0.089
2.488GluAsn: 2.488 ± 0.1
2.093GluPro: 2.093 ± 0.118
3.299GluGln: 3.299 ± 0.134
3.943GluArg: 3.943 ± 0.217
3.637GluSer: 3.637 ± 0.071
2.93GluThr: 2.93 ± 0.096
4.353GluVal: 4.353 ± 0.105
0.771GluTrp: 0.771 ± 0.045
1.713GluTyr: 1.713 ± 0.079
0.0GluXaa: 0.0 ± 0.0
Phe
3.79PheAla: 3.79 ± 0.118
0.459PheCys: 0.459 ± 0.041
2.384PheAsp: 2.384 ± 0.088
2.5PheGlu: 2.5 ± 0.091
2.042PhePhe: 2.042 ± 0.111
3.113PheGly: 3.113 ± 0.084
0.784PheHis: 0.784 ± 0.059
2.582PheIle: 2.582 ± 0.112
1.674PheLys: 1.674 ± 0.077
3.583PheLeu: 3.583 ± 0.186
0.908PheMet: 0.908 ± 0.053
1.722PheAsn: 1.722 ± 0.067
1.55PhePro: 1.55 ± 0.111
1.276PheGln: 1.276 ± 0.059
1.878PheArg: 1.878 ± 0.104
3.074PheSer: 3.074 ± 0.099
2.732PheThr: 2.732 ± 0.121
2.944PheVal: 2.944 ± 0.102
0.457PheTrp: 0.457 ± 0.035
1.374PheTyr: 1.374 ± 0.086
0.0PheXaa: 0.0 ± 0.0
Gly
6.331GlyAla: 6.331 ± 0.388
0.804GlyCys: 0.804 ± 0.067
3.915GlyAsp: 3.915 ± 0.299
4.202GlyGlu: 4.202 ± 0.113
3.014GlyPhe: 3.014 ± 0.09
5.512GlyGly: 5.512 ± 0.42
1.285GlyHis: 1.285 ± 0.053
4.902GlyIle: 4.902 ± 0.104
4.426GlyLys: 4.426 ± 0.151
5.739GlyLeu: 5.739 ± 0.14
2.136GlyMet: 2.136 ± 0.084
3.829GlyAsn: 3.829 ± 0.445
1.033GlyPro: 1.033 ± 0.053
1.934GlyGln: 1.934 ± 0.063
2.868GlyArg: 2.868 ± 0.105
5.51GlySer: 5.51 ± 0.587
5.372GlyThr: 5.372 ± 0.589
5.243GlyVal: 5.243 ± 0.173
0.745GlyTrp: 0.745 ± 0.038
2.474GlyTyr: 2.474 ± 0.081
0.0GlyXaa: 0.0 ± 0.0
His
1.812HisAla: 1.812 ± 0.088
0.312HisCys: 0.312 ± 0.031
0.997HisAsp: 0.997 ± 0.045
1.298HisGlu: 1.298 ± 0.082
1.101HisPhe: 1.101 ± 0.062
1.556HisGly: 1.556 ± 0.08
0.836HisHis: 0.836 ± 0.062
1.42HisIle: 1.42 ± 0.059
0.9HisLys: 0.9 ± 0.07
2.257HisLeu: 2.257 ± 0.077
0.372HisMet: 0.372 ± 0.026
1.049HisAsn: 1.049 ± 0.073
1.2HisPro: 1.2 ± 0.083
0.775HisGln: 0.775 ± 0.056
1.045HisArg: 1.045 ± 0.078
1.33HisSer: 1.33 ± 0.072
1.132HisThr: 1.132 ± 0.072
1.262HisVal: 1.262 ± 0.062
0.225HisTrp: 0.225 ± 0.021
0.964HisTyr: 0.964 ± 0.061
0.0HisXaa: 0.0 ± 0.0
Ile
6.81IleAla: 6.81 ± 0.177
0.644IleCys: 0.644 ± 0.05
3.762IleAsp: 3.762 ± 0.127
4.611IleGlu: 4.611 ± 0.118
2.278IlePhe: 2.278 ± 0.099
4.809IleGly: 4.809 ± 0.122
1.277IleHis: 1.277 ± 0.073
4.037IleIle: 4.037 ± 0.136
2.963IleLys: 2.963 ± 0.107
4.825IleLeu: 4.825 ± 0.122
1.192IleMet: 1.192 ± 0.074
2.967IleAsn: 2.967 ± 0.135
2.496IlePro: 2.496 ± 0.135
1.836IleGln: 1.836 ± 0.056
3.093IleArg: 3.093 ± 0.106
4.727IleSer: 4.727 ± 0.199
5.358IleThr: 5.358 ± 0.486
4.434IleVal: 4.434 ± 0.129
0.463IleTrp: 0.463 ± 0.031
1.75IleTyr: 1.75 ± 0.066
0.0IleXaa: 0.0 ± 0.0
Lys
4.635LysAla: 4.635 ± 0.106
0.335LysCys: 0.335 ± 0.028
2.044LysAsp: 2.044 ± 0.071
3.55LysGlu: 3.55 ± 0.158
1.372LysPhe: 1.372 ± 0.077
3.361LysGly: 3.361 ± 0.089
1.065LysHis: 1.065 ± 0.067
3.13LysIle: 3.13 ± 0.137
3.442LysLys: 3.442 ± 0.188
4.626LysLeu: 4.626 ± 0.146
1.246LysMet: 1.246 ± 0.074
2.453LysAsn: 2.453 ± 0.119
2.089LysPro: 2.089 ± 0.099
2.188LysGln: 2.188 ± 0.104
2.546LysArg: 2.546 ± 0.151
3.195LysSer: 3.195 ± 0.095
2.708LysThr: 2.708 ± 0.078
3.451LysVal: 3.451 ± 0.095
0.453LysTrp: 0.453 ± 0.026
1.372LysTyr: 1.372 ± 0.068
0.0LysXaa: 0.0 ± 0.0
Leu
9.178LeuAla: 9.178 ± 0.184
0.993LeuCys: 0.993 ± 0.068
5.251LeuAsp: 5.251 ± 0.134
6.175LeuGlu: 6.175 ± 0.187
4.678LeuPhe: 4.678 ± 0.211
6.134LeuGly: 6.134 ± 0.123
2.59LeuHis: 2.59 ± 0.163
5.162LeuIle: 5.162 ± 0.165
4.881LeuLys: 4.881 ± 0.151
11.447LeuLeu: 11.447 ± 0.443
2.342LeuMet: 2.342 ± 0.121
4.002LeuAsn: 4.002 ± 0.15
4.477LeuPro: 4.477 ± 0.234
4.797LeuGln: 4.797 ± 0.144
5.1LeuArg: 5.1 ± 0.182
7.045LeuSer: 7.045 ± 0.16
6.143LeuThr: 6.143 ± 0.368
6.251LeuVal: 6.251 ± 0.108
0.924LeuTrp: 0.924 ± 0.059
2.921LeuTyr: 2.921 ± 0.108
0.0LeuXaa: 0.0 ± 0.0
Met
2.22MetAla: 2.22 ± 0.1
0.155MetCys: 0.155 ± 0.015
0.953MetAsp: 0.953 ± 0.039
1.512MetGlu: 1.512 ± 0.088
0.776MetPhe: 0.776 ± 0.05
1.418MetGly: 1.418 ± 0.072
0.481MetHis: 0.481 ± 0.034
1.218MetIle: 1.218 ± 0.076
1.521MetLys: 1.521 ± 0.087
2.574MetLeu: 2.574 ± 0.115
0.683MetMet: 0.683 ± 0.048
1.046MetAsn: 1.046 ± 0.046
1.22MetPro: 1.22 ± 0.072
1.308MetGln: 1.308 ± 0.074
1.221MetArg: 1.221 ± 0.069
1.449MetSer: 1.449 ± 0.059
1.153MetThr: 1.153 ± 0.056
2.089MetVal: 2.089 ± 0.095
0.148MetTrp: 0.148 ± 0.021
0.525MetTyr: 0.525 ± 0.033
0.0MetXaa: 0.0 ± 0.0
Asn
4.114AsnAla: 4.114 ± 0.218
0.416AsnCys: 0.416 ± 0.036
2.705AsnAsp: 2.705 ± 0.242
2.557AsnGlu: 2.557 ± 0.077
1.79AsnPhe: 1.79 ± 0.112
3.734AsnGly: 3.734 ± 0.291
0.964AsnHis: 0.964 ± 0.035
3.313AsnIle: 3.313 ± 0.258
1.925AsnLys: 1.925 ± 0.07
3.847AsnLeu: 3.847 ± 0.095
0.855AsnMet: 0.855 ± 0.04
2.444AsnAsn: 2.444 ± 0.085
2.31AsnPro: 2.31 ± 0.096
1.397AsnGln: 1.397 ± 0.043
2.041AsnArg: 2.041 ± 0.076
2.833AsnSer: 2.833 ± 0.108
2.284AsnThr: 2.284 ± 0.133
3.126AsnVal: 3.126 ± 0.206
0.424AsnTrp: 0.424 ± 0.027
1.572AsnTyr: 1.572 ± 0.066
0.0AsnXaa: 0.0 ± 0.0
Pro
3.314ProAla: 3.314 ± 0.124
0.324ProCys: 0.324 ± 0.03
2.332ProAsp: 2.332 ± 0.121
2.934ProGlu: 2.934 ± 0.164
1.804ProPhe: 1.804 ± 0.104
1.624ProGly: 1.624 ± 0.081
0.971ProHis: 0.971 ± 0.069
2.312ProIle: 2.312 ± 0.122
1.729ProLys: 1.729 ± 0.104
4.309ProLeu: 4.309 ± 0.239
0.879ProMet: 0.879 ± 0.057
1.754ProAsn: 1.754 ± 0.082
1.461ProPro: 1.461 ± 0.092
1.501ProGln: 1.501 ± 0.097
1.358ProArg: 1.358 ± 0.09
2.669ProSer: 2.669 ± 0.112
2.888ProThr: 2.888 ± 0.166
2.578ProVal: 2.578 ± 0.11
0.357ProTrp: 0.357 ± 0.026
1.301ProTyr: 1.301 ± 0.072
0.0ProXaa: 0.0 ± 0.0
Gln
4.005GlnAla: 4.005 ± 0.103
0.367GlnCys: 0.367 ± 0.036
1.292GlnAsp: 1.292 ± 0.132
2.62GlnGlu: 2.62 ± 0.098
1.21GlnPhe: 1.21 ± 0.062
2.338GlnGly: 2.338 ± 0.078
1.069GlnHis: 1.069 ± 0.066
2.056GlnIle: 2.056 ± 0.075
2.238GlnLys: 2.238 ± 0.116
4.114GlnLeu: 4.114 ± 0.138
0.896GlnMet: 0.896 ± 0.056
1.374GlnAsn: 1.374 ± 0.04
1.672GlnPro: 1.672 ± 0.096
2.564GlnGln: 2.564 ± 0.144
2.23GlnArg: 2.23 ± 0.126
2.385GlnSer: 2.385 ± 0.088
1.944GlnThr: 1.944 ± 0.083
2.304GlnVal: 2.304 ± 0.049
0.497GlnTrp: 0.497 ± 0.044
0.927GlnTyr: 0.927 ± 0.047
0.0GlnXaa: 0.0 ± 0.0
Arg
3.425ArgAla: 3.425 ± 0.111
0.507ArgCys: 0.507 ± 0.045
2.321ArgAsp: 2.321 ± 0.113
3.266ArgGlu: 3.266 ± 0.174
2.348ArgPhe: 2.348 ± 0.124
2.37ArgGly: 2.37 ± 0.107
1.277ArgHis: 1.277 ± 0.093
3.155ArgIle: 3.155 ± 0.148
2.56ArgLys: 2.56 ± 0.133
5.022ArgLeu: 5.022 ± 0.207
1.237ArgMet: 1.237 ± 0.083
2.14ArgAsn: 2.14 ± 0.121
1.564ArgPro: 1.564 ± 0.095
2.232ArgGln: 2.232 ± 0.144
2.396ArgArg: 2.396 ± 0.158
2.848ArgSer: 2.848 ± 0.111
2.28ArgThr: 2.28 ± 0.074
2.926ArgVal: 2.926 ± 0.08
0.54ArgTrp: 0.54 ± 0.035
2.12ArgTyr: 2.12 ± 0.1
0.0ArgXaa: 0.0 ± 0.0
Ser
6.166SerAla: 6.166 ± 0.355
0.644SerCys: 0.644 ± 0.051
3.647SerAsp: 3.647 ± 0.273
3.474SerGlu: 3.474 ± 0.074
2.995SerPhe: 2.995 ± 0.091
6.128SerGly: 6.128 ± 0.592
1.341SerHis: 1.341 ± 0.057
4.353SerIle: 4.353 ± 0.179
2.83SerLys: 2.83 ± 0.081
6.692SerLeu: 6.692 ± 0.124
1.521SerMet: 1.521 ± 0.05
3.227SerAsn: 3.227 ± 0.204
2.445SerPro: 2.445 ± 0.117
1.904SerGln: 1.904 ± 0.053
2.833SerArg: 2.833 ± 0.147
4.943SerSer: 4.943 ± 0.271
4.253SerThr: 4.253 ± 0.386
5.112SerVal: 5.112 ± 0.27
0.691SerTrp: 0.691 ± 0.036
2.05SerTyr: 2.05 ± 0.08
0.0SerXaa: 0.0 ± 0.0
Thr
6.047ThrAla: 6.047 ± 0.527
0.461ThrCys: 0.461 ± 0.038
3.298ThrAsp: 3.298 ± 0.312
3.034ThrGlu: 3.034 ± 0.11
2.616ThrPhe: 2.616 ± 0.12
4.695ThrGly: 4.695 ± 0.465
1.089ThrHis: 1.089 ± 0.045
5.568ThrIle: 5.568 ± 0.383
2.245ThrLys: 2.245 ± 0.065
7.525ThrLeu: 7.525 ± 0.385
1.448ThrMet: 1.448 ± 0.078
2.722ThrAsn: 2.722 ± 0.244
3.013ThrPro: 3.013 ± 0.117
1.782ThrGln: 1.782 ± 0.102
2.124ThrArg: 2.124 ± 0.097
4.189ThrSer: 4.189 ± 0.388
5.148ThrThr: 5.148 ± 0.591
5.164ThrVal: 5.164 ± 0.535
0.571ThrTrp: 0.571 ± 0.035
1.834ThrTyr: 1.834 ± 0.101
0.0ThrXaa: 0.0 ± 0.0
Val
7.312ValAla: 7.312 ± 0.141
0.643ValCys: 0.643 ± 0.046
3.886ValAsp: 3.886 ± 0.207
4.399ValGlu: 4.399 ± 0.091
2.304ValPhe: 2.304 ± 0.088
4.849ValGly: 4.849 ± 0.286
1.196ValHis: 1.196 ± 0.06
4.255ValIle: 4.255 ± 0.102
2.986ValLys: 2.986 ± 0.069
6.496ValLeu: 6.496 ± 0.15
1.686ValMet: 1.686 ± 0.091
2.88ValAsn: 2.88 ± 0.219
2.71ValPro: 2.71 ± 0.137
2.594ValGln: 2.594 ± 0.084
3.235ValArg: 3.235 ± 0.094
5.088ValSer: 5.088 ± 0.409
5.604ValThr: 5.604 ± 0.549
5.808ValVal: 5.808 ± 0.127
0.677ValTrp: 0.677 ± 0.054
1.674ValTyr: 1.674 ± 0.045
0.0ValXaa: 0.0 ± 0.0
Trp
0.677TrpAla: 0.677 ± 0.038
0.092TrpCys: 0.092 ± 0.012
0.507TrpAsp: 0.507 ± 0.033
0.589TrpGlu: 0.589 ± 0.036
0.541TrpPhe: 0.541 ± 0.045
0.533TrpGly: 0.533 ± 0.03
0.256TrpHis: 0.256 ± 0.023
0.565TrpIle: 0.565 ± 0.036
0.56TrpLys: 0.56 ± 0.033
1.218TrpLeu: 1.218 ± 0.072
0.284TrpMet: 0.284 ± 0.025
0.529TrpAsn: 0.529 ± 0.029
0.213TrpPro: 0.213 ± 0.022
0.699TrpGln: 0.699 ± 0.044
0.507TrpArg: 0.507 ± 0.04
0.745TrpSer: 0.745 ± 0.046
0.503TrpThr: 0.503 ± 0.062
0.529TrpVal: 0.529 ± 0.035
0.147TrpTrp: 0.147 ± 0.018
0.359TrpTyr: 0.359 ± 0.032
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.562TyrAla: 2.562 ± 0.085
0.369TyrCys: 0.369 ± 0.031
1.74TyrAsp: 1.74 ± 0.067
1.818TyrGlu: 1.818 ± 0.09
1.444TyrPhe: 1.444 ± 0.069
2.328TyrGly: 2.328 ± 0.085
0.785TyrHis: 0.785 ± 0.055
1.68TyrIle: 1.68 ± 0.071
1.392TyrLys: 1.392 ± 0.054
3.075TyrLeu: 3.075 ± 0.106
0.539TyrMet: 0.539 ± 0.033
1.698TyrAsn: 1.698 ± 0.094
1.208TyrPro: 1.208 ± 0.077
1.314TyrGln: 1.314 ± 0.063
1.826TyrArg: 1.826 ± 0.097
2.054TyrSer: 2.054 ± 0.075
1.789TyrThr: 1.789 ± 0.09
1.749TyrVal: 1.749 ± 0.061
0.328TyrTrp: 0.328 ± 0.03
1.106TyrTyr: 1.106 ± 0.084
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1986 proteins (750128 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski