Amino acid dipepetide frequency for Chryseobacterium sp. MOF25P

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.893AlaAla: 3.893 ± 0.081	0.49AlaCys: 0.49 ± 0.02	3.241AlaAsp: 3.241 ± 0.045	4.128AlaGlu: 4.128 ± 0.064	3.051AlaPhe: 3.051 ± 0.049	3.995AlaGly: 3.995 ± 0.068	0.924AlaHis: 0.924 ± 0.026	4.528AlaIle: 4.528 ± 0.067	4.796AlaLys: 4.796 ± 0.067	5.46AlaLeu: 5.46 ± 0.059	1.423AlaMet: 1.423 ± 0.036	3.328AlaAsn: 3.328 ± 0.053	1.719AlaPro: 1.719 ± 0.043	2.507AlaGln: 2.507 ± 0.047	1.704AlaArg: 1.704 ± 0.037	3.816AlaSer: 3.816 ± 0.064	3.473AlaThr: 3.473 ± 0.077	3.957AlaVal: 3.957 ± 0.058	0.559AlaTrp: 0.559 ± 0.02	2.235AlaTyr: 2.235 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	0.404CysAla: 0.404 ± 0.02	0.089CysCys: 0.089 ± 0.009	0.411CysAsp: 0.411 ± 0.018	0.438CysGlu: 0.438 ± 0.018	0.465CysPhe: 0.465 ± 0.021	0.603CysGly: 0.603 ± 0.026	0.154CysHis: 0.154 ± 0.01	0.596CysIle: 0.596 ± 0.024	0.508CysLys: 0.508 ± 0.02	0.615CysLeu: 0.615 ± 0.02	0.141CysMet: 0.141 ± 0.01	0.421CysAsn: 0.421 ± 0.02	0.321CysPro: 0.321 ± 0.02	0.21CysGln: 0.21 ± 0.014	0.214CysArg: 0.214 ± 0.014	0.527CysSer: 0.527 ± 0.025	0.408CysThr: 0.408 ± 0.019	0.438CysVal: 0.438 ± 0.018	0.069CysTrp: 0.069 ± 0.007	0.314CysTyr: 0.314 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	3.185AspAla: 3.185 ± 0.049	0.383AspCys: 0.383 ± 0.017	2.755AspAsp: 2.755 ± 0.049	4.086AspGlu: 4.086 ± 0.075	3.957AspPhe: 3.957 ± 0.061	3.458AspGly: 3.458 ± 0.079	0.905AspHis: 0.905 ± 0.029	4.133AspIle: 4.133 ± 0.06	4.479AspLys: 4.479 ± 0.066	5.116AspLeu: 5.116 ± 0.063	1.068AspMet: 1.068 ± 0.031	3.004AspAsn: 3.004 ± 0.048	1.565AspPro: 1.565 ± 0.036	1.704AspGln: 1.704 ± 0.035	1.699AspArg: 1.699 ± 0.036	3.244AspSer: 3.244 ± 0.052	2.32AspThr: 2.32 ± 0.044	3.272AspVal: 3.272 ± 0.054	0.747AspTrp: 0.747 ± 0.025	2.71AspTyr: 2.71 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	3.751GluAla: 3.751 ± 0.06	0.375GluCys: 0.375 ± 0.018	3.359GluAsp: 3.359 ± 0.066	4.835GluGlu: 4.835 ± 0.082	3.319GluPhe: 3.319 ± 0.05	3.336GluGly: 3.336 ± 0.062	0.984GluHis: 0.984 ± 0.027	6.269GluIle: 6.269 ± 0.08	7.248GluLys: 7.248 ± 0.092	5.786GluLeu: 5.786 ± 0.067	1.689GluMet: 1.689 ± 0.036	5.835GluAsn: 5.835 ± 0.085	1.328GluPro: 1.328 ± 0.038	2.125GluGln: 2.125 ± 0.046	2.305GluArg: 2.305 ± 0.045	3.467GluSer: 3.467 ± 0.065	3.53GluThr: 3.53 ± 0.054	3.96GluVal: 3.96 ± 0.057	0.686GluTrp: 0.686 ± 0.022	2.507GluTyr: 2.507 ± 0.043	0.0GluXaa: 0.0 ± 0.0
Phe	3.282PheAla: 3.282 ± 0.054	0.499PheCys: 0.499 ± 0.021	3.227PheAsp: 3.227 ± 0.053	3.48PheGlu: 3.48 ± 0.052	3.041PhePhe: 3.041 ± 0.065	3.661PheGly: 3.661 ± 0.056	0.924PheHis: 0.924 ± 0.024	4.289PheIle: 4.289 ± 0.072	4.039PheLys: 4.039 ± 0.059	5.174PheLeu: 5.174 ± 0.069	1.13PheMet: 1.13 ± 0.028	3.469PheAsn: 3.469 ± 0.052	1.895PhePro: 1.895 ± 0.039	1.749PheGln: 1.749 ± 0.039	1.709PheArg: 1.709 ± 0.041	4.374PheSer: 4.374 ± 0.062	3.273PheThr: 3.273 ± 0.048	3.125PheVal: 3.125 ± 0.051	0.604PheTrp: 0.604 ± 0.024	2.468PheTyr: 2.468 ± 0.043	0.0PheXaa: 0.0 ± 0.0
Gly	3.751GlyAla: 3.751 ± 0.068	0.541GlyCys: 0.541 ± 0.028	2.933GlyAsp: 2.933 ± 0.051	3.385GlyGlu: 3.385 ± 0.051	3.609GlyPhe: 3.609 ± 0.057	4.223GlyGly: 4.223 ± 0.08	0.897GlyHis: 0.897 ± 0.029	5.228GlyIle: 5.228 ± 0.081	5.455GlyLys: 5.455 ± 0.074	5.231GlyLeu: 5.231 ± 0.067	1.531GlyMet: 1.531 ± 0.037	4.216GlyAsn: 4.216 ± 0.065	1.053GlyPro: 1.053 ± 0.026	1.827GlyGln: 1.827 ± 0.035	1.932GlyArg: 1.932 ± 0.043	3.92GlySer: 3.92 ± 0.056	3.963GlyThr: 3.963 ± 0.072	3.802GlyVal: 3.802 ± 0.058	0.762GlyTrp: 0.762 ± 0.025	2.638GlyTyr: 2.638 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	0.812HisAla: 0.812 ± 0.026	0.169HisCys: 0.169 ± 0.011	0.769HisAsp: 0.769 ± 0.026	0.934HisGlu: 0.934 ± 0.028	1.13HisPhe: 1.13 ± 0.03	0.957HisGly: 0.957 ± 0.032	0.47HisHis: 0.47 ± 0.025	1.19HisIle: 1.19 ± 0.03	1.093HisLys: 1.093 ± 0.032	1.621HisLeu: 1.621 ± 0.035	0.304HisMet: 0.304 ± 0.017	0.913HisAsn: 0.913 ± 0.028	0.774HisPro: 0.774 ± 0.027	0.761HisGln: 0.761 ± 0.025	0.592HisArg: 0.592 ± 0.018	1.127HisSer: 1.127 ± 0.033	0.79HisThr: 0.79 ± 0.025	0.729HisVal: 0.729 ± 0.027	0.212HisTrp: 0.212 ± 0.012	0.772HisTyr: 0.772 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	5.059IleAla: 5.059 ± 0.069	0.675IleCys: 0.675 ± 0.024	4.729IleAsp: 4.729 ± 0.062	5.336IleGlu: 5.336 ± 0.068	4.256IlePhe: 4.256 ± 0.083	4.66IleGly: 4.66 ± 0.069	1.282IleHis: 1.282 ± 0.031	6.59IleIle: 6.59 ± 0.098	6.308IleLys: 6.308 ± 0.078	7.655IleLeu: 7.655 ± 0.082	1.427IleMet: 1.427 ± 0.031	5.254IleAsn: 5.254 ± 0.065	3.254IlePro: 3.254 ± 0.055	2.823IleGln: 2.823 ± 0.044	2.344IleArg: 2.344 ± 0.053	6.405IleSer: 6.405 ± 0.074	4.656IleThr: 4.656 ± 0.068	4.588IleVal: 4.588 ± 0.062	0.711IleTrp: 0.711 ± 0.025	3.076IleTyr: 3.076 ± 0.049	0.0IleXaa: 0.0 ± 0.0
Lys	4.801LysAla: 4.801 ± 0.064	0.373LysCys: 0.373 ± 0.018	5.084LysAsp: 5.084 ± 0.078	6.429LysGlu: 6.429 ± 0.077	3.714LysPhe: 3.714 ± 0.063	4.376LysGly: 4.376 ± 0.067	1.256LysHis: 1.256 ± 0.032	7.864LysIle: 7.864 ± 0.084	8.086LysLys: 8.086 ± 0.096	6.874LysLeu: 6.874 ± 0.087	2.499LysMet: 2.499 ± 0.042	6.991LysAsn: 6.991 ± 0.08	2.572LysPro: 2.572 ± 0.053	2.712LysGln: 2.712 ± 0.049	2.552LysArg: 2.552 ± 0.051	5.081LysSer: 5.081 ± 0.059	5.236LysThr: 5.236 ± 0.07	4.839LysVal: 4.839 ± 0.065	0.788LysTrp: 0.788 ± 0.026	3.539LysTyr: 3.539 ± 0.053	0.0LysXaa: 0.0 ± 0.0
Leu	5.279LeuAla: 5.279 ± 0.066	0.679LeuCys: 0.679 ± 0.025	4.767LeuAsp: 4.767 ± 0.059	5.893LeuGlu: 5.893 ± 0.088	4.82LeuPhe: 4.82 ± 0.07	5.55LeuGly: 5.55 ± 0.077	1.46LeuHis: 1.46 ± 0.032	6.977LeuIle: 6.977 ± 0.086	8.327LeuLys: 8.327 ± 0.088	7.98LeuLeu: 7.98 ± 0.108	2.213LeuMet: 2.213 ± 0.042	6.044LeuAsn: 6.044 ± 0.075	3.398LeuPro: 3.398 ± 0.048	3.349LeuGln: 3.349 ± 0.053	2.811LeuArg: 2.811 ± 0.051	6.775LeuSer: 6.775 ± 0.075	4.82LeuThr: 4.82 ± 0.063	4.844LeuVal: 4.844 ± 0.074	0.767LeuTrp: 0.767 ± 0.027	3.15LeuTyr: 3.15 ± 0.053	0.0LeuXaa: 0.0 ± 0.0
Met	1.425MetAla: 1.425 ± 0.032	0.117MetCys: 0.117 ± 0.009	1.103MetAsp: 1.103 ± 0.033	1.456MetGlu: 1.456 ± 0.036	0.94MetPhe: 0.94 ± 0.027	1.349MetGly: 1.349 ± 0.038	0.357MetHis: 0.357 ± 0.016	1.774MetIle: 1.774 ± 0.039	2.697MetLys: 2.697 ± 0.048	1.891MetLeu: 1.891 ± 0.041	0.708MetMet: 0.708 ± 0.026	1.598MetAsn: 1.598 ± 0.035	0.794MetPro: 0.794 ± 0.023	0.803MetGln: 0.803 ± 0.025	0.787MetArg: 0.787 ± 0.026	1.454MetSer: 1.454 ± 0.028	1.216MetThr: 1.216 ± 0.032	1.295MetVal: 1.295 ± 0.033	0.17MetTrp: 0.17 ± 0.012	0.734MetTyr: 0.734 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	3.879AsnAla: 3.879 ± 0.062	0.466AsnCys: 0.466 ± 0.024	3.373AsnAsp: 3.373 ± 0.054	4.128AsnGlu: 4.128 ± 0.058	3.805AsnPhe: 3.805 ± 0.059	4.23AsnGly: 4.23 ± 0.062	1.175AsnHis: 1.175 ± 0.029	5.839AsnIle: 5.839 ± 0.069	4.837AsnLys: 4.837 ± 0.068	6.138AsnLeu: 6.138 ± 0.077	1.348AsnMet: 1.348 ± 0.031	4.428AsnAsn: 4.428 ± 0.07	2.945AsnPro: 2.945 ± 0.045	2.612AsnGln: 2.612 ± 0.05	2.106AsnArg: 2.106 ± 0.039	4.542AsnSer: 4.542 ± 0.066	3.604AsnThr: 3.604 ± 0.066	3.774AsnVal: 3.774 ± 0.054	0.814AsnTrp: 0.814 ± 0.027	3.25AsnTyr: 3.25 ± 0.052	0.0AsnXaa: 0.0 ± 0.0
Pro	1.975ProAla: 1.975 ± 0.045	0.198ProCys: 0.198 ± 0.012	1.866ProAsp: 1.866 ± 0.037	2.804ProGlu: 2.804 ± 0.049	1.842ProPhe: 1.842 ± 0.036	1.704ProGly: 1.704 ± 0.038	0.518ProHis: 0.518 ± 0.02	2.463ProIle: 2.463 ± 0.045	2.661ProLys: 2.661 ± 0.046	2.648ProLeu: 2.648 ± 0.047	0.737ProMet: 0.737 ± 0.025	2.274ProAsn: 2.274 ± 0.049	0.82ProPro: 0.82 ± 0.032	1.253ProGln: 1.253 ± 0.034	0.834ProArg: 0.834 ± 0.024	2.151ProSer: 2.151 ± 0.039	1.991ProThr: 1.991 ± 0.043	2.312ProVal: 2.312 ± 0.046	0.277ProTrp: 0.277 ± 0.013	1.337ProTyr: 1.337 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	1.777GlnAla: 1.777 ± 0.041	0.17GlnCys: 0.17 ± 0.01	1.673GlnAsp: 1.673 ± 0.032	2.272GlnGlu: 2.272 ± 0.045	1.853GlnPhe: 1.853 ± 0.034	1.752GlnGly: 1.752 ± 0.037	0.565GlnHis: 0.565 ± 0.022	3.031GlnIle: 3.031 ± 0.051	3.576GlnLys: 3.576 ± 0.058	3.291GlnLeu: 3.291 ± 0.048	0.886GlnMet: 0.886 ± 0.026	2.934GlnAsn: 2.934 ± 0.047	1.092GlnPro: 1.092 ± 0.029	1.508GlnGln: 1.508 ± 0.042	1.175GlnArg: 1.175 ± 0.026	2.143GlnSer: 2.143 ± 0.043	2.052GlnThr: 2.052 ± 0.043	1.803GlnVal: 1.803 ± 0.039	0.38GlnTrp: 0.38 ± 0.019	1.573GlnTyr: 1.573 ± 0.039	0.0GlnXaa: 0.0 ± 0.0
Arg	1.682ArgAla: 1.682 ± 0.037	0.18ArgCys: 0.18 ± 0.014	1.601ArgAsp: 1.601 ± 0.035	2.09ArgGlu: 2.09 ± 0.043	1.836ArgPhe: 1.836 ± 0.036	1.633ArgGly: 1.633 ± 0.037	0.495ArgHis: 0.495 ± 0.019	2.691ArgIle: 2.691 ± 0.049	2.982ArgLys: 2.982 ± 0.052	2.822ArgLeu: 2.822 ± 0.046	0.825ArgMet: 0.825 ± 0.024	2.191ArgAsn: 2.191 ± 0.043	0.958ArgPro: 0.958 ± 0.026	1.066ArgGln: 1.066 ± 0.03	1.149ArgArg: 1.149 ± 0.031	1.862ArgSer: 1.862 ± 0.043	1.654ArgThr: 1.654 ± 0.037	1.765ArgVal: 1.765 ± 0.036	0.329ArgTrp: 0.329 ± 0.018	1.3ArgTyr: 1.3 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	4.001SerAla: 4.001 ± 0.063	0.664SerCys: 0.664 ± 0.021	3.549SerAsp: 3.549 ± 0.056	4.559SerGlu: 4.559 ± 0.061	4.019SerPhe: 4.019 ± 0.053	4.788SerGly: 4.788 ± 0.073	1.047SerHis: 1.047 ± 0.031	5.106SerIle: 5.106 ± 0.067	5.325SerLys: 5.325 ± 0.07	6.214SerLeu: 6.214 ± 0.076	1.354SerMet: 1.354 ± 0.032	3.91SerAsn: 3.91 ± 0.063	2.182SerPro: 2.182 ± 0.042	2.524SerGln: 2.524 ± 0.042	1.975SerArg: 1.975 ± 0.036	4.559SerSer: 4.559 ± 0.072	3.811SerThr: 3.811 ± 0.068	4.172SerVal: 4.172 ± 0.059	0.728SerTrp: 0.728 ± 0.024	2.88SerTyr: 2.88 ± 0.048	0.0SerXaa: 0.0 ± 0.0
Thr	3.824ThrAla: 3.824 ± 0.068	0.339ThrCys: 0.339 ± 0.016	3.189ThrAsp: 3.189 ± 0.054	3.617ThrGlu: 3.617 ± 0.048	2.998ThrPhe: 2.998 ± 0.05	3.89ThrGly: 3.89 ± 0.069	0.881ThrHis: 0.881 ± 0.027	4.347ThrIle: 4.347 ± 0.067	4.254ThrLys: 4.254 ± 0.061	5.094ThrLeu: 5.094 ± 0.065	0.974ThrMet: 0.974 ± 0.025	3.294ThrAsn: 3.294 ± 0.052	2.287ThrPro: 2.287 ± 0.048	2.004ThrGln: 2.004 ± 0.045	1.486ThrArg: 1.486 ± 0.031	3.842ThrSer: 3.842 ± 0.08	3.495ThrThr: 3.495 ± 0.077	3.755ThrVal: 3.755 ± 0.059	0.55ThrTrp: 0.55 ± 0.019	2.311ThrTyr: 2.311 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	3.637ValAla: 3.637 ± 0.057	0.489ValCys: 0.489 ± 0.02	3.167ValAsp: 3.167 ± 0.051	3.779ValGlu: 3.779 ± 0.06	3.422ValPhe: 3.422 ± 0.052	3.597ValGly: 3.597 ± 0.064	0.818ValHis: 0.818 ± 0.019	4.491ValIle: 4.491 ± 0.061	4.876ValLys: 4.876 ± 0.064	5.434ValLeu: 5.434 ± 0.071	1.335ValMet: 1.335 ± 0.032	3.686ValAsn: 3.686 ± 0.054	2.004ValPro: 2.004 ± 0.046	1.785ValGln: 1.785 ± 0.042	1.829ValArg: 1.829 ± 0.039	4.403ValSer: 4.403 ± 0.06	3.29ValThr: 3.29 ± 0.068	3.632ValVal: 3.632 ± 0.058	0.597ValTrp: 0.597 ± 0.023	2.446ValTyr: 2.446 ± 0.053	0.0ValXaa: 0.0 ± 0.0
Trp	0.586TrpAla: 0.586 ± 0.023	0.098TrpCys: 0.098 ± 0.009	0.583TrpAsp: 0.583 ± 0.023	0.664TrpGlu: 0.664 ± 0.028	0.568TrpPhe: 0.568 ± 0.021	0.663TrpGly: 0.663 ± 0.025	0.179TrpHis: 0.179 ± 0.012	0.744TrpIle: 0.744 ± 0.026	0.985TrpLys: 0.985 ± 0.03	0.873TrpLeu: 0.873 ± 0.024	0.329TrpMet: 0.329 ± 0.015	0.776TrpAsn: 0.776 ± 0.027	0.169TrpPro: 0.169 ± 0.012	0.418TrpGln: 0.418 ± 0.017	0.348TrpArg: 0.348 ± 0.016	0.684TrpSer: 0.684 ± 0.026	0.553TrpThr: 0.553 ± 0.02	0.618TrpVal: 0.618 ± 0.017	0.139TrpTrp: 0.139 ± 0.01	0.401TrpTyr: 0.401 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.223TyrAla: 2.223 ± 0.041	0.351TyrCys: 0.351 ± 0.017	2.412TyrAsp: 2.412 ± 0.043	2.382TyrGlu: 2.382 ± 0.048	2.769TyrPhe: 2.769 ± 0.051	2.472TyrGly: 2.472 ± 0.049	0.829TyrHis: 0.829 ± 0.026	2.94TyrIle: 2.94 ± 0.049	3.132TyrLys: 3.132 ± 0.056	3.987TyrLeu: 3.987 ± 0.064	0.744TyrMet: 0.744 ± 0.022	2.726TyrAsn: 2.726 ± 0.05	1.536TyrPro: 1.536 ± 0.038	1.765TyrGln: 1.765 ± 0.036	1.557TyrArg: 1.557 ± 0.035	2.99TyrSer: 2.99 ± 0.049	2.296TyrThr: 2.296 ± 0.045	2.037TyrVal: 2.037 ± 0.043	0.491TyrTrp: 0.491 ± 0.02	2.081TyrTyr: 2.081 ± 0.05	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4239 proteins (1340762 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---