Amino acid dipepetide frequency for Facklamia miroungae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.261AlaAla: 4.261 ± 0.127
0.479AlaCys: 0.479 ± 0.032
3.523AlaAsp: 3.523 ± 0.092
4.34AlaGlu: 4.34 ± 0.105
3.143AlaPhe: 3.143 ± 0.082
4.625AlaGly: 4.625 ± 0.105
1.152AlaHis: 1.152 ± 0.047
6.136AlaIle: 6.136 ± 0.12
4.792AlaLys: 4.792 ± 0.08
6.745AlaLeu: 6.745 ± 0.127
1.979AlaMet: 1.979 ± 0.069
3.223AlaAsn: 3.223 ± 0.078
1.773AlaPro: 1.773 ± 0.064
2.77AlaGln: 2.77 ± 0.071
2.376AlaArg: 2.376 ± 0.068
4.26AlaSer: 4.26 ± 0.091
3.278AlaThr: 3.278 ± 0.084
4.21AlaVal: 4.21 ± 0.076
0.545AlaTrp: 0.545 ± 0.032
2.722AlaTyr: 2.722 ± 0.077
0.0AlaXaa: 0.0 ± 0.0
Cys
0.334CysAla: 0.334 ± 0.024
0.066CysCys: 0.066 ± 0.011
0.3CysAsp: 0.3 ± 0.023
0.31CysGlu: 0.31 ± 0.022
0.29CysPhe: 0.29 ± 0.025
0.525CysGly: 0.525 ± 0.029
0.205CysHis: 0.205 ± 0.019
0.409CysIle: 0.409 ± 0.024
0.264CysLys: 0.264 ± 0.023
0.721CysLeu: 0.721 ± 0.038
0.126CysMet: 0.126 ± 0.014
0.201CysAsn: 0.201 ± 0.018
0.251CysPro: 0.251 ± 0.022
0.37CysGln: 0.37 ± 0.028
0.234CysArg: 0.234 ± 0.02
0.382CysSer: 0.382 ± 0.024
0.245CysThr: 0.245 ± 0.02
0.293CysVal: 0.293 ± 0.021
0.034CysTrp: 0.034 ± 0.007
0.216CysTyr: 0.216 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
2.956AspAla: 2.956 ± 0.074
0.327AspCys: 0.327 ± 0.024
2.63AspAsp: 2.63 ± 0.078
4.103AspGlu: 4.103 ± 0.107
2.971AspPhe: 2.971 ± 0.078
3.097AspGly: 3.097 ± 0.115
1.464AspHis: 1.464 ± 0.062
4.113AspIle: 4.113 ± 0.074
3.503AspLys: 3.503 ± 0.081
6.428AspLeu: 6.428 ± 0.115
1.205AspMet: 1.205 ± 0.042
2.303AspAsn: 2.303 ± 0.077
2.301AspPro: 2.301 ± 0.067
3.881AspGln: 3.881 ± 0.108
2.434AspArg: 2.434 ± 0.07
3.174AspSer: 3.174 ± 0.09
2.296AspThr: 2.296 ± 0.08
2.939AspVal: 2.939 ± 0.077
0.678AspTrp: 0.678 ± 0.039
2.79AspTyr: 2.79 ± 0.069
0.0AspXaa: 0.0 ± 0.0
Glu
5.308GluAla: 5.308 ± 0.116
0.312GluCys: 0.312 ± 0.023
4.318GluAsp: 4.318 ± 0.099
6.985GluGlu: 6.985 ± 0.146
2.501GluPhe: 2.501 ± 0.063
4.219GluGly: 4.219 ± 0.097
1.144GluHis: 1.144 ± 0.043
6.14GluIle: 6.14 ± 0.112
5.886GluLys: 5.886 ± 0.107
6.736GluLeu: 6.736 ± 0.134
2.199GluMet: 2.199 ± 0.068
3.961GluAsn: 3.961 ± 0.101
1.831GluPro: 1.831 ± 0.063
2.663GluGln: 2.663 ± 0.07
3.053GluArg: 3.053 ± 0.081
3.885GluSer: 3.885 ± 0.091
3.864GluThr: 3.864 ± 0.109
5.086GluVal: 5.086 ± 0.106
0.665GluTrp: 0.665 ± 0.032
2.357GluTyr: 2.357 ± 0.069
0.0GluXaa: 0.0 ± 0.0
Phe
2.911PheAla: 2.911 ± 0.083
0.305PheCys: 0.305 ± 0.023
2.882PheAsp: 2.882 ± 0.077
3.171PheGlu: 3.171 ± 0.078
2.235PhePhe: 2.235 ± 0.075
2.92PheGly: 2.92 ± 0.084
0.743PheHis: 0.743 ± 0.035
3.873PheIle: 3.873 ± 0.104
2.957PheLys: 2.957 ± 0.07
4.394PheLeu: 4.394 ± 0.111
1.266PheMet: 1.266 ± 0.048
2.449PheAsn: 2.449 ± 0.073
1.48PhePro: 1.48 ± 0.048
1.681PheGln: 1.681 ± 0.055
1.374PheArg: 1.374 ± 0.042
3.332PheSer: 3.332 ± 0.088
2.432PheThr: 2.432 ± 0.079
2.656PheVal: 2.656 ± 0.066
0.428PheTrp: 0.428 ± 0.026
1.911PheTyr: 1.911 ± 0.071
0.0PheXaa: 0.0 ± 0.0
Gly
3.876GlyAla: 3.876 ± 0.099
0.392GlyCys: 0.392 ± 0.028
2.961GlyAsp: 2.961 ± 0.09
3.835GlyGlu: 3.835 ± 0.085
2.956GlyPhe: 2.956 ± 0.073
3.99GlyGly: 3.99 ± 0.099
1.326GlyHis: 1.326 ± 0.053
5.542GlyIle: 5.542 ± 0.101
4.35GlyLys: 4.35 ± 0.104
6.414GlyLeu: 6.414 ± 0.123
1.761GlyMet: 1.761 ± 0.057
2.618GlyAsn: 2.618 ± 0.077
1.563GlyPro: 1.563 ± 0.056
3.01GlyGln: 3.01 ± 0.069
2.446GlyArg: 2.446 ± 0.07
3.849GlySer: 3.849 ± 0.093
3.16GlyThr: 3.16 ± 0.098
4.342GlyVal: 4.342 ± 0.088
0.51GlyTrp: 0.51 ± 0.031
2.526GlyTyr: 2.526 ± 0.074
0.0GlyXaa: 0.0 ± 0.0
His
1.113HisAla: 1.113 ± 0.046
0.121HisCys: 0.121 ± 0.013
1.018HisAsp: 1.018 ± 0.05
1.156HisGlu: 1.156 ± 0.047
1.22HisPhe: 1.22 ± 0.043
1.122HisGly: 1.122 ± 0.041
0.655HisHis: 0.655 ± 0.038
1.294HisIle: 1.294 ± 0.043
0.92HisLys: 0.92 ± 0.04
2.359HisLeu: 2.359 ± 0.073
0.407HisMet: 0.407 ± 0.024
0.747HisAsn: 0.747 ± 0.033
1.077HisPro: 1.077 ± 0.045
1.256HisGln: 1.256 ± 0.053
0.869HisArg: 0.869 ± 0.037
1.239HisSer: 1.239 ± 0.053
0.941HisThr: 0.941 ± 0.042
1.035HisVal: 1.035 ± 0.047
0.208HisTrp: 0.208 ± 0.021
1.052HisTyr: 1.052 ± 0.042
0.0HisXaa: 0.0 ± 0.0
Ile
6.119IleAla: 6.119 ± 0.103
0.62IleCys: 0.62 ± 0.032
5.328IleAsp: 5.328 ± 0.105
6.344IleGlu: 6.344 ± 0.101
3.673IlePhe: 3.673 ± 0.102
5.547IleGly: 5.547 ± 0.121
1.609IleHis: 1.609 ± 0.05
7.198IleIle: 7.198 ± 0.161
5.294IleLys: 5.294 ± 0.109
8.052IleLeu: 8.052 ± 0.175
1.884IleMet: 1.884 ± 0.066
4.456IleAsn: 4.456 ± 0.092
3.235IlePro: 3.235 ± 0.077
3.728IleGln: 3.728 ± 0.081
3.046IleArg: 3.046 ± 0.077
5.328IleSer: 5.328 ± 0.106
4.181IleThr: 4.181 ± 0.108
5.369IleVal: 5.369 ± 0.097
0.631IleTrp: 0.631 ± 0.034
3.077IleTyr: 3.077 ± 0.079
0.0IleXaa: 0.0 ± 0.0
Lys
4.599LysAla: 4.599 ± 0.097
0.269LysCys: 0.269 ± 0.024
4.159LysAsp: 4.159 ± 0.083
6.721LysGlu: 6.721 ± 0.113
2.143LysPhe: 2.143 ± 0.06
3.794LysGly: 3.794 ± 0.07
1.174LysHis: 1.174 ± 0.039
5.431LysIle: 5.431 ± 0.111
5.093LysLys: 5.093 ± 0.099
5.806LysLeu: 5.806 ± 0.092
2.023LysMet: 2.023 ± 0.064
3.82LysAsn: 3.82 ± 0.101
2.006LysPro: 2.006 ± 0.062
2.935LysGln: 2.935 ± 0.084
2.68LysArg: 2.68 ± 0.07
3.474LysSer: 3.474 ± 0.078
3.573LysThr: 3.573 ± 0.073
4.526LysVal: 4.526 ± 0.108
0.581LysTrp: 0.581 ± 0.032
2.499LysTyr: 2.499 ± 0.076
0.0LysXaa: 0.0 ± 0.0
Leu
7.769LeuAla: 7.769 ± 0.146
0.513LeuCys: 0.513 ± 0.027
5.548LeuAsp: 5.548 ± 0.095
6.842LeuGlu: 6.842 ± 0.11
4.544LeuPhe: 4.544 ± 0.131
5.894LeuGly: 5.894 ± 0.125
1.548LeuHis: 1.548 ± 0.055
9.038LeuIle: 9.038 ± 0.164
7.089LeuLys: 7.089 ± 0.116
10.262LeuLeu: 10.262 ± 0.2
2.888LeuMet: 2.888 ± 0.078
5.383LeuAsn: 5.383 ± 0.093
3.842LeuPro: 3.842 ± 0.088
3.251LeuGln: 3.251 ± 0.102
3.382LeuArg: 3.382 ± 0.082
7.625LeuSer: 7.625 ± 0.134
5.741LeuThr: 5.741 ± 0.107
6.102LeuVal: 6.102 ± 0.121
0.711LeuTrp: 0.711 ± 0.037
3.293LeuTyr: 3.293 ± 0.084
0.0LeuXaa: 0.0 ± 0.0
Met
2.005MetAla: 2.005 ± 0.068
0.114MetCys: 0.114 ± 0.013
1.463MetAsp: 1.463 ± 0.051
1.708MetGlu: 1.708 ± 0.058
0.851MetPhe: 0.851 ± 0.037
1.698MetGly: 1.698 ± 0.054
0.387MetHis: 0.387 ± 0.023
2.415MetIle: 2.415 ± 0.072
2.006MetLys: 2.006 ± 0.06
2.243MetLeu: 2.243 ± 0.059
0.803MetMet: 0.803 ± 0.039
1.495MetAsn: 1.495 ± 0.045
0.96MetPro: 0.96 ± 0.044
1.038MetGln: 1.038 ± 0.047
1.016MetArg: 1.016 ± 0.036
1.621MetSer: 1.621 ± 0.054
1.774MetThr: 1.774 ± 0.053
1.844MetVal: 1.844 ± 0.049
0.14MetTrp: 0.14 ± 0.015
0.661MetTyr: 0.661 ± 0.031
0.0MetXaa: 0.0 ± 0.0
Asn
2.63AsnAla: 2.63 ± 0.069
0.305AsnCys: 0.305 ± 0.023
2.695AsnAsp: 2.695 ± 0.082
3.6AsnGlu: 3.6 ± 0.074
2.299AsnPhe: 2.299 ± 0.071
2.881AsnGly: 2.881 ± 0.103
1.323AsnHis: 1.323 ± 0.048
3.915AsnIle: 3.915 ± 0.098
3.573AsnLys: 3.573 ± 0.088
4.919AsnLeu: 4.919 ± 0.095
1.168AsnMet: 1.168 ± 0.044
2.639AsnAsn: 2.639 ± 0.088
2.167AsnPro: 2.167 ± 0.069
3.159AsnGln: 3.159 ± 0.084
2.114AsnArg: 2.114 ± 0.06
2.705AsnSer: 2.705 ± 0.071
2.247AsnThr: 2.247 ± 0.085
2.7AsnVal: 2.7 ± 0.08
0.482AsnTrp: 0.482 ± 0.035
2.415AsnTyr: 2.415 ± 0.064
0.0AsnXaa: 0.0 ± 0.0
Pro
2.195ProAla: 2.195 ± 0.072
0.148ProCys: 0.148 ± 0.016
2.056ProAsp: 2.056 ± 0.084
2.765ProGlu: 2.765 ± 0.08
1.81ProPhe: 1.81 ± 0.056
2.083ProGly: 2.083 ± 0.064
0.759ProHis: 0.759 ± 0.036
2.899ProIle: 2.899 ± 0.067
1.918ProLys: 1.918 ± 0.059
3.336ProLeu: 3.336 ± 0.084
0.823ProMet: 0.823 ± 0.039
1.839ProAsn: 1.839 ± 0.062
0.619ProPro: 0.619 ± 0.033
1.442ProGln: 1.442 ± 0.063
0.999ProArg: 0.999 ± 0.044
2.363ProSer: 2.363 ± 0.063
1.931ProThr: 1.931 ± 0.062
2.354ProVal: 2.354 ± 0.063
0.245ProTrp: 0.245 ± 0.022
1.333ProTyr: 1.333 ± 0.053
0.0ProXaa: 0.0 ± 0.0
Gln
4.147GlnAla: 4.147 ± 0.101
0.147GlnCys: 0.147 ± 0.017
2.223GlnAsp: 2.223 ± 0.06
3.648GlnGlu: 3.648 ± 0.094
1.805GlnPhe: 1.805 ± 0.058
2.34GlnGly: 2.34 ± 0.063
0.747GlnHis: 0.747 ± 0.038
3.818GlnIle: 3.818 ± 0.087
3.036GlnLys: 3.036 ± 0.098
4.836GlnLeu: 4.836 ± 0.105
1.241GlnMet: 1.241 ± 0.047
1.991GlnAsn: 1.991 ± 0.056
1.497GlnPro: 1.497 ± 0.054
1.805GlnGln: 1.805 ± 0.075
1.764GlnArg: 1.764 ± 0.064
2.896GlnSer: 2.896 ± 0.082
2.564GlnThr: 2.564 ± 0.068
3.396GlnVal: 3.396 ± 0.089
0.438GlnTrp: 0.438 ± 0.028
1.393GlnTyr: 1.393 ± 0.054
0.0GlnXaa: 0.0 ± 0.0
Arg
2.119ArgAla: 2.119 ± 0.069
0.218ArgCys: 0.218 ± 0.021
1.899ArgAsp: 1.899 ± 0.067
2.702ArgGlu: 2.702 ± 0.073
1.771ArgPhe: 1.771 ± 0.057
2.006ArgGly: 2.006 ± 0.072
0.784ArgHis: 0.784 ± 0.034
3.326ArgIle: 3.326 ± 0.082
2.761ArgLys: 2.761 ± 0.071
4.105ArgLeu: 4.105 ± 0.079
1.123ArgMet: 1.123 ± 0.041
1.822ArgAsn: 1.822 ± 0.058
1.319ArgPro: 1.319 ± 0.054
1.989ArgGln: 1.989 ± 0.067
1.636ArgArg: 1.636 ± 0.064
2.245ArgSer: 2.245 ± 0.075
1.684ArgThr: 1.684 ± 0.057
2.463ArgVal: 2.463 ± 0.065
0.302ArgTrp: 0.302 ± 0.024
1.602ArgTyr: 1.602 ± 0.054
0.0ArgXaa: 0.0 ± 0.0
Ser
3.556SerAla: 3.556 ± 0.075
0.338SerCys: 0.338 ± 0.025
3.355SerAsp: 3.355 ± 0.088
4.101SerGlu: 4.101 ± 0.1
3.184SerPhe: 3.184 ± 0.082
4.11SerGly: 4.11 ± 0.084
1.386SerHis: 1.386 ± 0.049
5.349SerIle: 5.349 ± 0.098
4.169SerLys: 4.169 ± 0.094
6.893SerLeu: 6.893 ± 0.128
1.594SerMet: 1.594 ± 0.051
3.172SerAsn: 3.172 ± 0.081
1.94SerPro: 1.94 ± 0.057
3.358SerGln: 3.358 ± 0.083
2.383SerArg: 2.383 ± 0.065
3.958SerSer: 3.958 ± 0.089
3.068SerThr: 3.068 ± 0.076
3.823SerVal: 3.823 ± 0.077
0.547SerTrp: 0.547 ± 0.032
2.461SerTyr: 2.461 ± 0.07
0.0SerXaa: 0.0 ± 0.0
Thr
3.329ThrAla: 3.329 ± 0.09
0.329ThrCys: 0.329 ± 0.028
2.714ThrAsp: 2.714 ± 0.091
3.232ThrGlu: 3.232 ± 0.096
2.475ThrPhe: 2.475 ± 0.069
3.576ThrGly: 3.576 ± 0.082
1.079ThrHis: 1.079 ± 0.038
4.737ThrIle: 4.737 ± 0.098
3.101ThrLys: 3.101 ± 0.098
5.221ThrLeu: 5.221 ± 0.099
1.164ThrMet: 1.164 ± 0.051
2.538ThrAsn: 2.538 ± 0.094
2.12ThrPro: 2.12 ± 0.085
2.006ThrGln: 2.006 ± 0.073
1.739ThrArg: 1.739 ± 0.054
3.397ThrSer: 3.397 ± 0.084
2.993ThrThr: 2.993 ± 0.122
3.525ThrVal: 3.525 ± 0.105
0.464ThrTrp: 0.464 ± 0.035
2.146ThrTyr: 2.146 ± 0.084
0.0ThrXaa: 0.0 ± 0.0
Val
4.292ValAla: 4.292 ± 0.097
0.409ValCys: 0.409 ± 0.028
3.943ValAsp: 3.943 ± 0.094
4.694ValGlu: 4.694 ± 0.106
2.923ValPhe: 2.923 ± 0.07
4.173ValGly: 4.173 ± 0.086
1.047ValHis: 1.047 ± 0.039
5.548ValIle: 5.548 ± 0.097
4.103ValLys: 4.103 ± 0.094
6.055ValLeu: 6.055 ± 0.106
1.594ValMet: 1.594 ± 0.058
3.165ValAsn: 3.165 ± 0.087
2.197ValPro: 2.197 ± 0.076
2.156ValGln: 2.156 ± 0.061
2.242ValArg: 2.242 ± 0.062
4.215ValSer: 4.215 ± 0.098
3.709ValThr: 3.709 ± 0.12
4.296ValVal: 4.296 ± 0.097
0.476ValTrp: 0.476 ± 0.028
2.293ValTyr: 2.293 ± 0.059
0.0ValXaa: 0.0 ± 0.0
Trp
0.436TrpAla: 0.436 ± 0.027
0.046TrpCys: 0.046 ± 0.008
0.435TrpAsp: 0.435 ± 0.03
0.508TrpGlu: 0.508 ± 0.031
0.382TrpPhe: 0.382 ± 0.029
0.527TrpGly: 0.527 ± 0.029
0.203TrpHis: 0.203 ± 0.019
0.774TrpIle: 0.774 ± 0.039
0.552TrpLys: 0.552 ± 0.03
1.123TrpLeu: 1.123 ± 0.053
0.297TrpMet: 0.297 ± 0.022
0.397TrpAsn: 0.397 ± 0.028
0.251TrpPro: 0.251 ± 0.02
0.549TrpGln: 0.549 ± 0.031
0.326TrpArg: 0.326 ± 0.022
0.462TrpSer: 0.462 ± 0.032
0.392TrpThr: 0.392 ± 0.026
0.518TrpVal: 0.518 ± 0.026
0.104TrpTrp: 0.104 ± 0.015
0.252TrpTyr: 0.252 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.376TyrAla: 2.376 ± 0.061
0.317TyrCys: 0.317 ± 0.023
2.146TyrAsp: 2.146 ± 0.066
2.349TyrGlu: 2.349 ± 0.068
2.224TyrPhe: 2.224 ± 0.07
2.301TyrGly: 2.301 ± 0.062
1.076TyrHis: 1.076 ± 0.046
2.767TyrIle: 2.767 ± 0.062
1.938TyrLys: 1.938 ± 0.067
4.616TyrLeu: 4.616 ± 0.097
0.695TyrMet: 0.695 ± 0.035
1.715TyrAsn: 1.715 ± 0.053
1.49TyrPro: 1.49 ± 0.057
2.683TyrGln: 2.683 ± 0.078
1.766TyrArg: 1.766 ± 0.057
2.335TyrSer: 2.335 ± 0.066
1.81TyrThr: 1.81 ± 0.077
2.052TyrVal: 2.052 ± 0.065
0.344TyrTrp: 0.344 ± 0.025
1.855TyrTyr: 1.855 ± 0.062
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1889 proteins (586659 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski