Amino acid dipepetide frequency for Mollivirus sibericum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.733AlaAla: 10.733 ± 0.397
2.173AlaCys: 2.173 ± 0.121
5.844AlaAsp: 5.844 ± 0.215
4.662AlaGlu: 4.662 ± 0.192
3.338AlaPhe: 3.338 ± 0.135
5.126AlaGly: 5.126 ± 0.242
1.991AlaHis: 1.991 ± 0.096
4.413AlaIle: 4.413 ± 0.169
4.984AlaLys: 4.984 ± 0.245
9.182AlaLeu: 9.182 ± 0.271
2.908AlaMet: 2.908 ± 0.141
3.304AlaAsn: 3.304 ± 0.143
5.109AlaPro: 5.109 ± 0.232
3.417AlaGln: 3.417 ± 0.148
7.168AlaArg: 7.168 ± 0.233
8.973AlaSer: 8.973 ± 0.264
6.404AlaThr: 6.404 ± 0.218
7.015AlaVal: 7.015 ± 0.208
1.641AlaTrp: 1.641 ± 0.089
2.472AlaTyr: 2.472 ± 0.121
0.0AlaXaa: 0.0 ± 0.0
Cys
2.042CysAla: 2.042 ± 0.112
0.594CysCys: 0.594 ± 0.069
1.499CysAsp: 1.499 ± 0.121
0.99CysGlu: 0.99 ± 0.082
0.69CysPhe: 0.69 ± 0.059
1.233CysGly: 1.233 ± 0.099
0.741CysHis: 0.741 ± 0.058
0.9CysIle: 0.9 ± 0.067
0.9CysLys: 0.9 ± 0.087
2.489CysLeu: 2.489 ± 0.142
0.43CysMet: 0.43 ± 0.049
0.673CysAsn: 0.673 ± 0.062
1.494CysPro: 1.494 ± 0.136
0.798CysGln: 0.798 ± 0.072
1.907CysArg: 1.907 ± 0.125
1.618CysSer: 1.618 ± 0.124
0.917CysThr: 0.917 ± 0.075
1.511CysVal: 1.511 ± 0.095
0.289CysTrp: 0.289 ± 0.046
0.413CysTyr: 0.413 ± 0.047
0.0CysXaa: 0.0 ± 0.0
Asp
6.229AspAla: 6.229 ± 0.189
1.25AspCys: 1.25 ± 0.101
7.032AspAsp: 7.032 ± 0.326
4.877AspGlu: 4.877 ± 0.19
1.793AspPhe: 1.793 ± 0.112
5.267AspGly: 5.267 ± 0.224
1.805AspHis: 1.805 ± 0.112
3.016AspIle: 3.016 ± 0.136
2.54AspLys: 2.54 ± 0.139
5.567AspLeu: 5.567 ± 0.157
1.85AspMet: 1.85 ± 0.092
2.467AspAsn: 2.467 ± 0.109
4.102AspPro: 4.102 ± 0.133
2.399AspGln: 2.399 ± 0.14
3.875AspArg: 3.875 ± 0.163
4.56AspSer: 4.56 ± 0.185
3.168AspThr: 3.168 ± 0.126
4.679AspVal: 4.679 ± 0.165
0.911AspTrp: 0.911 ± 0.067
1.76AspTyr: 1.76 ± 0.111
0.0AspXaa: 0.0 ± 0.0
Glu
6.122GluAla: 6.122 ± 0.224
1.064GluCys: 1.064 ± 0.081
4.537GluAsp: 4.537 ± 0.218
6.229GluGlu: 6.229 ± 0.508
1.132GluPhe: 1.132 ± 0.079
3.293GluGly: 3.293 ± 0.148
1.437GluHis: 1.437 ± 0.074
1.878GluIle: 1.878 ± 0.114
1.731GluLys: 1.731 ± 0.124
2.902GluLeu: 2.902 ± 0.132
1.149GluMet: 1.149 ± 0.079
1.058GluAsn: 1.058 ± 0.083
3.219GluPro: 3.219 ± 0.143
2.501GluGln: 2.501 ± 0.144
4.288GluArg: 4.288 ± 0.162
3.638GluSer: 3.638 ± 0.165
3.615GluThr: 3.615 ± 0.155
3.112GluVal: 3.112 ± 0.146
0.9GluTrp: 0.9 ± 0.078
0.928GluTyr: 0.928 ± 0.069
0.0GluXaa: 0.0 ± 0.0
Phe
3.429PheAla: 3.429 ± 0.126
0.741PheCys: 0.741 ± 0.064
2.455PheAsp: 2.455 ± 0.123
1.567PheGlu: 1.567 ± 0.109
0.9PhePhe: 0.9 ± 0.082
2.478PheGly: 2.478 ± 0.137
0.758PheHis: 0.758 ± 0.074
1.047PheIle: 1.047 ± 0.08
0.894PheLys: 0.894 ± 0.082
2.382PheLeu: 2.382 ± 0.114
0.786PheMet: 0.786 ± 0.075
1.007PheAsn: 1.007 ± 0.07
1.177PhePro: 1.177 ± 0.087
0.588PheGln: 0.588 ± 0.056
1.516PheArg: 1.516 ± 0.097
1.861PheSer: 1.861 ± 0.111
1.177PheThr: 1.177 ± 0.088
2.97PheVal: 2.97 ± 0.115
0.419PheTrp: 0.419 ± 0.045
0.871PheTyr: 0.871 ± 0.071
0.0PheXaa: 0.0 ± 0.0
Gly
5.431GlyAla: 5.431 ± 0.224
1.505GlyCys: 1.505 ± 0.132
4.305GlyAsp: 4.305 ± 0.166
2.908GlyGlu: 2.908 ± 0.144
1.873GlyPhe: 1.873 ± 0.097
5.386GlyGly: 5.386 ± 0.401
1.963GlyHis: 1.963 ± 0.126
2.45GlyIle: 2.45 ± 0.139
2.574GlyLys: 2.574 ± 0.152
5.839GlyLeu: 5.839 ± 0.191
1.545GlyMet: 1.545 ± 0.085
1.912GlyAsn: 1.912 ± 0.118
3.163GlyPro: 3.163 ± 0.161
3.123GlyGln: 3.123 ± 0.15
4.928GlyArg: 4.928 ± 0.203
4.696GlySer: 4.696 ± 0.214
3.553GlyThr: 3.553 ± 0.142
3.943GlyVal: 3.943 ± 0.189
1.149GlyTrp: 1.149 ± 0.106
1.697GlyTyr: 1.697 ± 0.138
0.0GlyXaa: 0.0 ± 0.0
His
2.263HisAla: 2.263 ± 0.131
0.628HisCys: 0.628 ± 0.065
1.59HisAsp: 1.59 ± 0.111
1.171HisGlu: 1.171 ± 0.097
0.781HisPhe: 0.781 ± 0.065
2.003HisGly: 2.003 ± 0.102
1.228HisHis: 1.228 ± 0.132
1.001HisIle: 1.001 ± 0.075
0.894HisLys: 0.894 ± 0.072
2.636HisLeu: 2.636 ± 0.153
0.628HisMet: 0.628 ± 0.051
0.798HisAsn: 0.798 ± 0.08
1.777HisPro: 1.777 ± 0.11
1.12HisGln: 1.12 ± 0.085
2.048HisArg: 2.048 ± 0.128
1.307HisSer: 1.307 ± 0.089
0.996HisThr: 0.996 ± 0.081
1.697HisVal: 1.697 ± 0.105
0.424HisTrp: 0.424 ± 0.052
0.809HisTyr: 0.809 ± 0.068
0.0HisXaa: 0.0 ± 0.0
Ile
3.966IleAla: 3.966 ± 0.155
0.769IleCys: 0.769 ± 0.075
3.496IleAsp: 3.496 ± 0.149
2.24IleGlu: 2.24 ± 0.112
0.979IlePhe: 0.979 ± 0.078
2.263IleGly: 2.263 ± 0.104
0.973IleHis: 0.973 ± 0.071
1.884IleIle: 1.884 ± 0.09
1.663IleLys: 1.663 ± 0.09
3.344IleLeu: 3.344 ± 0.146
1.064IleMet: 1.064 ± 0.064
1.545IleAsn: 1.545 ± 0.107
1.72IlePro: 1.72 ± 0.092
1.188IleGln: 1.188 ± 0.091
2.399IleArg: 2.399 ± 0.11
2.297IleSer: 2.297 ± 0.121
1.827IleThr: 1.827 ± 0.095
3.089IleVal: 3.089 ± 0.129
0.396IleTrp: 0.396 ± 0.04
1.154IleTyr: 1.154 ± 0.079
0.0IleXaa: 0.0 ± 0.0
Lys
4.549LysAla: 4.549 ± 0.223
0.752LysCys: 0.752 ± 0.081
2.354LysAsp: 2.354 ± 0.137
2.042LysGlu: 2.042 ± 0.109
0.883LysPhe: 0.883 ± 0.067
2.563LysGly: 2.563 ± 0.135
1.165LysHis: 1.165 ± 0.096
1.126LysIle: 1.126 ± 0.088
2.325LysLys: 2.325 ± 0.247
1.793LysLeu: 1.793 ± 0.102
0.826LysMet: 0.826 ± 0.062
0.956LysAsn: 0.956 ± 0.086
2.557LysPro: 2.557 ± 0.169
1.375LysGln: 1.375 ± 0.092
3.994LysArg: 3.994 ± 0.197
2.818LysSer: 2.818 ± 0.158
2.653LysThr: 2.653 ± 0.135
2.472LysVal: 2.472 ± 0.132
0.815LysTrp: 0.815 ± 0.081
0.566LysTyr: 0.566 ± 0.061
0.0LysXaa: 0.0 ± 0.0
Leu
10.953LeuAla: 10.953 ± 0.323
2.206LeuCys: 2.206 ± 0.105
6.291LeuAsp: 6.291 ± 0.185
4.566LeuGlu: 4.566 ± 0.189
2.642LeuPhe: 2.642 ± 0.134
5.771LeuGly: 5.771 ± 0.214
1.963LeuHis: 1.963 ± 0.12
2.801LeuIle: 2.801 ± 0.122
2.636LeuLys: 2.636 ± 0.131
8.221LeuLeu: 8.221 ± 0.264
2.059LeuMet: 2.059 ± 0.116
2.229LeuAsn: 2.229 ± 0.107
5.358LeuPro: 5.358 ± 0.191
2.54LeuGln: 2.54 ± 0.137
5.516LeuArg: 5.516 ± 0.214
6.789LeuSer: 6.789 ± 0.236
3.706LeuThr: 3.706 ± 0.172
7.53LeuVal: 7.53 ± 0.255
1.477LeuTrp: 1.477 ± 0.113
2.065LeuTyr: 2.065 ± 0.112
0.0LeuXaa: 0.0 ± 0.0
Met
3.208MetAla: 3.208 ± 0.139
0.532MetCys: 0.532 ± 0.05
1.663MetAsp: 1.663 ± 0.094
1.59MetGlu: 1.59 ± 0.096
0.571MetPhe: 0.571 ± 0.059
1.55MetGly: 1.55 ± 0.094
0.492MetHis: 0.492 ± 0.055
0.764MetIle: 0.764 ± 0.067
0.6MetLys: 0.6 ± 0.059
2.28MetLeu: 2.28 ± 0.122
0.685MetMet: 0.685 ± 0.073
0.617MetAsn: 0.617 ± 0.059
1.771MetPro: 1.771 ± 0.091
0.894MetGln: 0.894 ± 0.078
1.714MetArg: 1.714 ± 0.095
1.986MetSer: 1.986 ± 0.109
1.528MetThr: 1.528 ± 0.105
1.607MetVal: 1.607 ± 0.09
0.334MetTrp: 0.334 ± 0.052
0.339MetTyr: 0.339 ± 0.042
0.0MetXaa: 0.0 ± 0.0
Asn
3.225AsnAla: 3.225 ± 0.142
0.498AsnCys: 0.498 ± 0.063
2.274AsnAsp: 2.274 ± 0.095
1.482AsnGlu: 1.482 ± 0.089
0.962AsnPhe: 0.962 ± 0.069
2.359AsnGly: 2.359 ± 0.156
0.702AsnHis: 0.702 ± 0.061
1.437AsnIle: 1.437 ± 0.087
1.443AsnLys: 1.443 ± 0.117
2.563AsnLeu: 2.563 ± 0.144
0.713AsnMet: 0.713 ± 0.079
1.856AsnAsn: 1.856 ± 0.14
1.777AsnPro: 1.777 ± 0.106
1.064AsnGln: 1.064 ± 0.079
1.867AsnArg: 1.867 ± 0.101
2.19AsnSer: 2.19 ± 0.108
1.573AsnThr: 1.573 ± 0.097
2.054AsnVal: 2.054 ± 0.126
0.43AsnTrp: 0.43 ± 0.057
0.973AsnTyr: 0.973 ± 0.077
0.0AsnXaa: 0.0 ± 0.0
Pro
5.177ProAla: 5.177 ± 0.212
1.284ProCys: 1.284 ± 0.099
3.18ProAsp: 3.18 ± 0.143
3.378ProGlu: 3.378 ± 0.153
1.856ProPhe: 1.856 ± 0.117
2.999ProGly: 2.999 ± 0.137
1.352ProHis: 1.352 ± 0.099
1.946ProIle: 1.946 ± 0.112
2.269ProLys: 2.269 ± 0.152
5.403ProLeu: 5.403 ± 0.237
1.262ProMet: 1.262 ± 0.094
2.065ProAsn: 2.065 ± 0.141
4.798ProPro: 4.798 ± 0.328
2.144ProGln: 2.144 ± 0.153
4.266ProArg: 4.266 ± 0.17
6.687ProSer: 6.687 ± 0.448
3.875ProThr: 3.875 ± 0.163
4.158ProVal: 4.158 ± 0.15
1.081ProTrp: 1.081 ± 0.108
1.516ProTyr: 1.516 ± 0.102
0.0ProXaa: 0.0 ± 0.0
Gln
4.0GlnAla: 4.0 ± 0.16
0.679GlnCys: 0.679 ± 0.067
2.308GlnAsp: 2.308 ± 0.13
2.619GlnGlu: 2.619 ± 0.139
0.781GlnPhe: 0.781 ± 0.069
2.574GlnGly: 2.574 ± 0.124
1.228GlnHis: 1.228 ± 0.095
1.064GlnIle: 1.064 ± 0.084
0.962GlnLys: 0.962 ± 0.076
2.337GlnLeu: 2.337 ± 0.124
0.888GlnMet: 0.888 ± 0.076
0.792GlnAsn: 0.792 ± 0.074
2.563GlnPro: 2.563 ± 0.192
3.106GlnGln: 3.106 ± 0.273
3.168GlnArg: 3.168 ± 0.144
2.529GlnSer: 2.529 ± 0.144
2.19GlnThr: 2.19 ± 0.12
2.478GlnVal: 2.478 ± 0.124
0.668GlnTrp: 0.668 ± 0.09
0.651GlnTyr: 0.651 ± 0.076
0.0GlnXaa: 0.0 ± 0.0
Arg
6.025ArgAla: 6.025 ± 0.251
1.856ArgCys: 1.856 ± 0.108
4.288ArgAsp: 4.288 ± 0.154
3.479ArgGlu: 3.479 ± 0.135
2.235ArgPhe: 2.235 ± 0.121
4.17ArgGly: 4.17 ± 0.157
2.501ArgHis: 2.501 ± 0.138
2.58ArgIle: 2.58 ± 0.125
3.191ArgLys: 3.191 ± 0.185
7.157ArgLeu: 7.157 ± 0.237
1.607ArgMet: 1.607 ± 0.099
2.173ArgAsn: 2.173 ± 0.111
4.962ArgPro: 4.962 ± 0.191
3.214ArgGln: 3.214 ± 0.15
7.044ArgArg: 7.044 ± 0.263
5.386ArgSer: 5.386 ± 0.182
3.932ArgThr: 3.932 ± 0.161
3.87ArgVal: 3.87 ± 0.163
1.369ArgTrp: 1.369 ± 0.104
1.505ArgTyr: 1.505 ± 0.093
0.0ArgXaa: 0.0 ± 0.0
Ser
7.225SerAla: 7.225 ± 0.279
1.545SerCys: 1.545 ± 0.103
4.781SerAsp: 4.781 ± 0.199
2.818SerGlu: 2.818 ± 0.155
2.286SerPhe: 2.286 ± 0.122
4.402SerGly: 4.402 ± 0.187
1.805SerHis: 1.805 ± 0.107
3.27SerIle: 3.27 ± 0.139
2.936SerLys: 2.936 ± 0.171
7.542SerLeu: 7.542 ± 0.279
2.076SerMet: 2.076 ± 0.109
2.75SerAsn: 2.75 ± 0.149
5.403SerPro: 5.403 ± 0.49
2.987SerGln: 2.987 ± 0.154
5.737SerArg: 5.737 ± 0.191
8.481SerSer: 8.481 ± 0.492
4.786SerThr: 4.786 ± 0.173
4.571SerVal: 4.571 ± 0.173
1.256SerTrp: 1.256 ± 0.084
1.347SerTyr: 1.347 ± 0.09
0.0SerXaa: 0.0 ± 0.0
Thr
5.335ThrAla: 5.335 ± 0.195
1.296ThrCys: 1.296 ± 0.117
3.14ThrAsp: 3.14 ± 0.148
2.371ThrGlu: 2.371 ± 0.116
1.782ThrPhe: 1.782 ± 0.119
3.525ThrGly: 3.525 ± 0.163
1.018ThrHis: 1.018 ± 0.078
2.393ThrIle: 2.393 ± 0.113
2.484ThrLys: 2.484 ± 0.152
5.064ThrLeu: 5.064 ± 0.217
1.42ThrMet: 1.42 ± 0.09
1.958ThrAsn: 1.958 ± 0.112
3.44ThrPro: 3.44 ± 0.161
1.844ThrGln: 1.844 ± 0.116
4.011ThrArg: 4.011 ± 0.153
4.39ThrSer: 4.39 ± 0.181
4.707ThrThr: 4.707 ± 0.292
3.87ThrVal: 3.87 ± 0.173
0.877ThrTrp: 0.877 ± 0.071
1.397ThrTyr: 1.397 ± 0.102
0.0ThrXaa: 0.0 ± 0.0
Val
7.474ValAla: 7.474 ± 0.225
1.68ValCys: 1.68 ± 0.098
5.075ValAsp: 5.075 ± 0.167
3.87ValGlu: 3.87 ± 0.162
2.297ValPhe: 2.297 ± 0.125
4.255ValGly: 4.255 ± 0.168
1.612ValHis: 1.612 ± 0.098
2.687ValIle: 2.687 ± 0.119
2.201ValLys: 2.201 ± 0.124
6.597ValLeu: 6.597 ± 0.223
1.607ValMet: 1.607 ± 0.086
1.833ValAsn: 1.833 ± 0.104
4.226ValPro: 4.226 ± 0.187
2.088ValGln: 2.088 ± 0.106
4.26ValArg: 4.26 ± 0.145
5.284ValSer: 5.284 ± 0.176
3.344ValThr: 3.344 ± 0.172
6.444ValVal: 6.444 ± 0.216
0.95ValTrp: 0.95 ± 0.089
1.765ValTyr: 1.765 ± 0.106
0.0ValXaa: 0.0 ± 0.0
Trp
1.279TrpAla: 1.279 ± 0.095
0.475TrpCys: 0.475 ± 0.055
0.984TrpAsp: 0.984 ± 0.091
0.583TrpGlu: 0.583 ± 0.062
0.475TrpPhe: 0.475 ± 0.049
0.656TrpGly: 0.656 ± 0.074
0.526TrpHis: 0.526 ± 0.06
0.73TrpIle: 0.73 ± 0.062
0.577TrpLys: 0.577 ± 0.062
2.065TrpLeu: 2.065 ± 0.146
0.656TrpMet: 0.656 ± 0.062
0.662TrpAsn: 0.662 ± 0.063
0.934TrpPro: 0.934 ± 0.079
0.492TrpGln: 0.492 ± 0.048
1.211TrpArg: 1.211 ± 0.093
1.092TrpSer: 1.092 ± 0.086
1.358TrpThr: 1.358 ± 0.104
0.645TrpVal: 0.645 ± 0.067
0.322TrpTrp: 0.322 ± 0.076
0.294TrpTyr: 0.294 ± 0.037
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.195TyrAla: 2.195 ± 0.114
0.6TyrCys: 0.6 ± 0.061
2.048TyrAsp: 2.048 ± 0.106
1.29TyrGlu: 1.29 ± 0.075
0.769TyrPhe: 0.769 ± 0.072
2.071TyrGly: 2.071 ± 0.13
0.537TyrHis: 0.537 ± 0.054
0.871TyrIle: 0.871 ± 0.071
0.781TyrLys: 0.781 ± 0.056
1.958TyrLeu: 1.958 ± 0.096
0.56TyrMet: 0.56 ± 0.053
0.786TyrAsn: 0.786 ± 0.069
1.149TyrPro: 1.149 ± 0.089
0.702TyrGln: 0.702 ± 0.061
1.624TyrArg: 1.624 ± 0.11
1.426TyrSer: 1.426 ± 0.097
1.013TyrThr: 1.013 ± 0.078
1.833TyrVal: 1.833 ± 0.107
0.311TyrTrp: 0.311 ± 0.043
0.809TyrTyr: 0.809 ± 0.087
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 514 proteins (176753 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski