Amino acid dipepetide frequency for Ottowia oryzae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.554AlaAla: 20.554 ± 0.244	1.286AlaCys: 1.286 ± 0.031	7.306AlaAsp: 7.306 ± 0.088	6.75AlaGlu: 6.75 ± 0.105	3.986AlaPhe: 3.986 ± 0.056	11.208AlaGly: 11.208 ± 0.124	2.958AlaHis: 2.958 ± 0.057	4.921AlaIle: 4.921 ± 0.07	4.014AlaLys: 4.014 ± 0.084	16.022AlaLeu: 16.022 ± 0.171	3.608AlaMet: 3.608 ± 0.056	2.989AlaAsn: 2.989 ± 0.068	8.192AlaPro: 8.192 ± 0.142	6.856AlaGln: 6.856 ± 0.097	9.616AlaArg: 9.616 ± 0.109	6.928AlaSer: 6.928 ± 0.101	6.748AlaThr: 6.748 ± 0.086	9.597AlaVal: 9.597 ± 0.122	2.195AlaTrp: 2.195 ± 0.045	2.552AlaTyr: 2.552 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	1.233CysAla: 1.233 ± 0.037	0.106CysCys: 0.106 ± 0.01	0.472CysAsp: 0.472 ± 0.025	0.434CysGlu: 0.434 ± 0.019	0.275CysPhe: 0.275 ± 0.016	0.931CysGly: 0.931 ± 0.03	0.26CysHis: 0.26 ± 0.018	0.359CysIle: 0.359 ± 0.018	0.195CysLys: 0.195 ± 0.013	0.745CysLeu: 0.745 ± 0.028	0.194CysMet: 0.194 ± 0.013	0.198CysAsn: 0.198 ± 0.015	0.472CysPro: 0.472 ± 0.022	0.276CysGln: 0.276 ± 0.017	0.484CysArg: 0.484 ± 0.023	0.443CysSer: 0.443 ± 0.022	0.563CysThr: 0.563 ± 0.028	0.687CysVal: 0.687 ± 0.024	0.111CysTrp: 0.111 ± 0.011	0.166CysTyr: 0.166 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.686AspAla: 7.686 ± 0.096	0.428AspCys: 0.428 ± 0.02	2.749AspAsp: 2.749 ± 0.056	3.105AspGlu: 3.105 ± 0.059	1.92AspPhe: 1.92 ± 0.048	4.576AspGly: 4.576 ± 0.061	1.02AspHis: 1.02 ± 0.032	2.136AspIle: 2.136 ± 0.044	1.785AspLys: 1.785 ± 0.046	5.178AspLeu: 5.178 ± 0.074	1.272AspMet: 1.272 ± 0.033	1.208AspAsn: 1.208 ± 0.032	2.806AspPro: 2.806 ± 0.052	1.867AspGln: 1.867 ± 0.045	3.209AspArg: 3.209 ± 0.063	2.181AspSer: 2.181 ± 0.043	2.585AspThr: 2.585 ± 0.053	4.294AspVal: 4.294 ± 0.064	1.012AspTrp: 1.012 ± 0.032	1.365AspTyr: 1.365 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	6.488GluAla: 6.488 ± 0.117	0.334GluCys: 0.334 ± 0.022	2.034GluAsp: 2.034 ± 0.05	2.024GluGlu: 2.024 ± 0.049	1.586GluPhe: 1.586 ± 0.037	3.836GluGly: 3.836 ± 0.067	1.22GluHis: 1.22 ± 0.035	2.157GluIle: 2.157 ± 0.056	1.714GluLys: 1.714 ± 0.05	5.475GluLeu: 5.475 ± 0.074	1.119GluMet: 1.119 ± 0.035	1.08GluAsn: 1.08 ± 0.033	2.462GluPro: 2.462 ± 0.049	2.4GluGln: 2.4 ± 0.052	4.332GluArg: 4.332 ± 0.069	2.267GluSer: 2.267 ± 0.046	2.139GluThr: 2.139 ± 0.041	3.854GluVal: 3.854 ± 0.063	0.729GluTrp: 0.729 ± 0.029	0.985GluTyr: 0.985 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	4.094PheAla: 4.094 ± 0.069	0.357PheCys: 0.357 ± 0.02	2.339PheAsp: 2.339 ± 0.043	1.782PheGlu: 1.782 ± 0.038	1.262PhePhe: 1.262 ± 0.036	3.221PheGly: 3.221 ± 0.053	0.64PheHis: 0.64 ± 0.024	1.445PheIle: 1.445 ± 0.043	1.075PheLys: 1.075 ± 0.037	2.716PheLeu: 2.716 ± 0.051	0.832PheMet: 0.832 ± 0.028	1.078PheAsn: 1.078 ± 0.034	1.415PhePro: 1.415 ± 0.034	1.02PheGln: 1.02 ± 0.031	1.698PheArg: 1.698 ± 0.044	1.943PheSer: 1.943 ± 0.043	1.93PheThr: 1.93 ± 0.046	2.549PheVal: 2.549 ± 0.055	0.519PheTrp: 0.519 ± 0.024	0.834PheTyr: 0.834 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	10.926GlyAla: 10.926 ± 0.127	0.865GlyCys: 0.865 ± 0.032	4.309GlyAsp: 4.309 ± 0.06	4.273GlyGlu: 4.273 ± 0.053	3.113GlyPhe: 3.113 ± 0.051	7.503GlyGly: 7.503 ± 0.128	1.95GlyHis: 1.95 ± 0.044	3.47GlyIle: 3.47 ± 0.067	3.146GlyLys: 3.146 ± 0.063	8.814GlyLeu: 8.814 ± 0.123	2.388GlyMet: 2.388 ± 0.047	2.172GlyAsn: 2.172 ± 0.051	3.352GlyPro: 3.352 ± 0.054	3.946GlyGln: 3.946 ± 0.066	5.449GlyArg: 5.449 ± 0.082	4.365GlySer: 4.365 ± 0.067	4.534GlyThr: 4.534 ± 0.078	6.82GlyVal: 6.82 ± 0.076	1.649GlyTrp: 1.649 ± 0.042	2.243GlyTyr: 2.243 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	2.988HisAla: 2.988 ± 0.058	0.267HisCys: 0.267 ± 0.015	1.111HisAsp: 1.111 ± 0.035	1.058HisGlu: 1.058 ± 0.034	0.825HisPhe: 0.825 ± 0.027	2.177HisGly: 2.177 ± 0.046	0.603HisHis: 0.603 ± 0.028	0.937HisIle: 0.937 ± 0.031	0.517HisLys: 0.517 ± 0.027	2.172HisLeu: 2.172 ± 0.041	0.499HisMet: 0.499 ± 0.023	0.506HisAsn: 0.506 ± 0.019	1.514HisPro: 1.514 ± 0.048	0.753HisGln: 0.753 ± 0.029	1.426HisArg: 1.426 ± 0.041	0.975HisSer: 0.975 ± 0.026	1.204HisThr: 1.204 ± 0.034	1.607HisVal: 1.607 ± 0.04	0.445HisTrp: 0.445 ± 0.024	0.576HisTyr: 0.576 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	5.644IleAla: 5.644 ± 0.068	0.349IleCys: 0.349 ± 0.019	2.911IleAsp: 2.911 ± 0.063	2.72IleGlu: 2.72 ± 0.056	1.099IlePhe: 1.099 ± 0.035	3.911IleGly: 3.911 ± 0.071	0.799IleHis: 0.799 ± 0.03	1.367IleIle: 1.367 ± 0.045	1.383IleLys: 1.383 ± 0.046	2.905IleLeu: 2.905 ± 0.057	0.736IleMet: 0.736 ± 0.028	1.297IleAsn: 1.297 ± 0.037	1.83IlePro: 1.83 ± 0.042	1.314IleGln: 1.314 ± 0.035	2.231IleArg: 2.231 ± 0.042	2.103IleSer: 2.103 ± 0.04	2.344IleThr: 2.344 ± 0.058	3.22IleVal: 3.22 ± 0.058	0.473IleTrp: 0.473 ± 0.024	0.905IleTyr: 0.905 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	4.224LysAla: 4.224 ± 0.098	0.15LysCys: 0.15 ± 0.011	1.682LysAsp: 1.682 ± 0.043	1.377LysGlu: 1.377 ± 0.049	0.848LysPhe: 0.848 ± 0.029	2.434LysGly: 2.434 ± 0.057	0.587LysHis: 0.587 ± 0.023	1.291LysIle: 1.291 ± 0.044	1.388LysLys: 1.388 ± 0.053	3.367LysLeu: 3.367 ± 0.061	0.76LysMet: 0.76 ± 0.031	0.886LysAsn: 0.886 ± 0.03	2.04LysPro: 2.04 ± 0.049	1.212LysGln: 1.212 ± 0.037	2.023LysArg: 2.023 ± 0.049	1.68LysSer: 1.68 ± 0.043	1.803LysThr: 1.803 ± 0.047	2.465LysVal: 2.465 ± 0.054	0.358LysTrp: 0.358 ± 0.021	0.615LysTyr: 0.615 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	15.6LeuAla: 15.6 ± 0.159	0.916LeuCys: 0.916 ± 0.031	5.469LeuAsp: 5.469 ± 0.071	4.223LeuGlu: 4.223 ± 0.072	3.137LeuPhe: 3.137 ± 0.063	8.8LeuGly: 8.8 ± 0.098	2.302LeuHis: 2.302 ± 0.049	4.321LeuIle: 4.321 ± 0.074	3.501LeuLys: 3.501 ± 0.066	10.854LeuLeu: 10.854 ± 0.155	2.593LeuMet: 2.593 ± 0.052	2.71LeuAsn: 2.71 ± 0.058	6.461LeuPro: 6.461 ± 0.085	4.365LeuGln: 4.365 ± 0.073	7.747LeuArg: 7.747 ± 0.096	5.829LeuSer: 5.829 ± 0.075	5.643LeuThr: 5.643 ± 0.069	7.672LeuVal: 7.672 ± 0.096	1.468LeuTrp: 1.468 ± 0.044	1.97LeuTyr: 1.97 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	3.353MetAla: 3.353 ± 0.056	0.166MetCys: 0.166 ± 0.012	1.123MetAsp: 1.123 ± 0.036	0.98MetGlu: 0.98 ± 0.031	0.68MetPhe: 0.68 ± 0.024	2.034MetGly: 2.034 ± 0.046	0.529MetHis: 0.529 ± 0.024	0.888MetIle: 0.888 ± 0.033	0.957MetLys: 0.957 ± 0.034	2.595MetLeu: 2.595 ± 0.056	0.554MetMet: 0.554 ± 0.026	0.843MetAsn: 0.843 ± 0.028	1.595MetPro: 1.595 ± 0.043	1.077MetGln: 1.077 ± 0.03	1.695MetArg: 1.695 ± 0.037	1.521MetSer: 1.521 ± 0.04	1.498MetThr: 1.498 ± 0.036	1.777MetVal: 1.777 ± 0.042	0.22MetTrp: 0.22 ± 0.013	0.398MetTyr: 0.398 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.492AsnAla: 3.492 ± 0.053	0.232AsnCys: 0.232 ± 0.017	1.318AsnAsp: 1.318 ± 0.037	1.073AsnGlu: 1.073 ± 0.034	0.886AsnPhe: 0.886 ± 0.03	2.169AsnGly: 2.169 ± 0.046	0.519AsnHis: 0.519 ± 0.021	1.034AsnIle: 1.034 ± 0.035	0.757AsnLys: 0.757 ± 0.028	2.481AsnLeu: 2.481 ± 0.047	0.576AsnMet: 0.576 ± 0.027	0.694AsnAsn: 0.694 ± 0.027	1.864AsnPro: 1.864 ± 0.05	0.94AsnGln: 0.94 ± 0.033	1.48AsnArg: 1.48 ± 0.038	1.141AsnSer: 1.141 ± 0.035	1.412AsnThr: 1.412 ± 0.035	1.942AsnVal: 1.942 ± 0.038	0.435AsnTrp: 0.435 ± 0.02	0.662AsnTyr: 0.662 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	8.614ProAla: 8.614 ± 0.118	0.374ProCys: 0.374 ± 0.02	3.358ProAsp: 3.358 ± 0.058	3.263ProGlu: 3.263 ± 0.056	1.758ProPhe: 1.758 ± 0.04	5.021ProGly: 5.021 ± 0.073	1.229ProHis: 1.229 ± 0.038	1.926ProIle: 1.926 ± 0.045	1.491ProLys: 1.491 ± 0.038	5.45ProLeu: 5.45 ± 0.08	1.348ProMet: 1.348 ± 0.034	1.372ProAsn: 1.372 ± 0.035	3.424ProPro: 3.424 ± 0.08	2.367ProGln: 2.367 ± 0.049	3.352ProArg: 3.352 ± 0.064	3.081ProSer: 3.081 ± 0.057	3.126ProThr: 3.126 ± 0.06	4.524ProVal: 4.524 ± 0.065	0.891ProTrp: 0.891 ± 0.029	1.223ProTyr: 1.223 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	6.347GlnAla: 6.347 ± 0.088	0.269GlnCys: 0.269 ± 0.015	1.796GlnAsp: 1.796 ± 0.043	1.48GlnGlu: 1.48 ± 0.041	1.3GlnPhe: 1.3 ± 0.035	3.396GlnGly: 3.396 ± 0.058	0.979GlnHis: 0.979 ± 0.034	1.809GlnIle: 1.809 ± 0.039	1.145GlnLys: 1.145 ± 0.033	4.651GlnLeu: 4.651 ± 0.067	1.018GlnMet: 1.018 ± 0.03	0.841GlnAsn: 0.841 ± 0.029	2.762GlnPro: 2.762 ± 0.058	2.016GlnGln: 2.016 ± 0.054	3.889GlnArg: 3.889 ± 0.064	2.048GlnSer: 2.048 ± 0.049	2.034GlnThr: 2.034 ± 0.041	3.261GlnVal: 3.261 ± 0.055	0.757GlnTrp: 0.757 ± 0.029	0.767GlnTyr: 0.767 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	8.682ArgAla: 8.682 ± 0.106	0.562ArgCys: 0.562 ± 0.026	3.53ArgAsp: 3.53 ± 0.059	3.818ArgGlu: 3.818 ± 0.072	2.539ArgPhe: 2.539 ± 0.052	4.903ArgGly: 4.903 ± 0.073	1.793ArgHis: 1.793 ± 0.047	2.994ArgIle: 2.994 ± 0.054	1.858ArgLys: 1.858 ± 0.043	7.676ArgLeu: 7.676 ± 0.093	1.86ArgMet: 1.86 ± 0.037	1.597ArgAsn: 1.597 ± 0.04	3.558ArgPro: 3.558 ± 0.069	3.168ArgGln: 3.168 ± 0.063	5.08ArgArg: 5.08 ± 0.088	3.129ArgSer: 3.129 ± 0.055	3.373ArgThr: 3.373 ± 0.059	5.319ArgVal: 5.319 ± 0.072	1.291ArgTrp: 1.291 ± 0.043	1.822ArgTyr: 1.822 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	7.236SerAla: 7.236 ± 0.109	0.403SerCys: 0.403 ± 0.022	2.459SerAsp: 2.459 ± 0.047	2.219SerGlu: 2.219 ± 0.051	1.844SerPhe: 1.844 ± 0.042	5.134SerGly: 5.134 ± 0.083	1.128SerHis: 1.128 ± 0.031	2.012SerIle: 2.012 ± 0.046	1.395SerLys: 1.395 ± 0.041	5.067SerLeu: 5.067 ± 0.066	1.213SerMet: 1.213 ± 0.034	1.302SerAsn: 1.302 ± 0.035	3.01SerPro: 3.01 ± 0.055	1.846SerGln: 1.846 ± 0.042	3.161SerArg: 3.161 ± 0.06	2.686SerSer: 2.686 ± 0.062	2.815SerThr: 2.815 ± 0.052	3.81SerVal: 3.81 ± 0.055	0.718SerTrp: 0.718 ± 0.025	1.183SerTyr: 1.183 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	6.661ThrAla: 6.661 ± 0.089	0.439ThrCys: 0.439 ± 0.023	2.565ThrAsp: 2.565 ± 0.041	2.413ThrGlu: 2.413 ± 0.052	1.619ThrPhe: 1.619 ± 0.037	4.881ThrGly: 4.881 ± 0.072	1.229ThrHis: 1.229 ± 0.034	1.946ThrIle: 1.946 ± 0.045	1.333ThrLys: 1.333 ± 0.037	6.341ThrLeu: 6.341 ± 0.088	1.048ThrMet: 1.048 ± 0.033	1.285ThrAsn: 1.285 ± 0.04	3.937ThrPro: 3.937 ± 0.066	2.131ThrGln: 2.131 ± 0.05	3.36ThrArg: 3.36 ± 0.057	2.581ThrSer: 2.581 ± 0.054	2.815ThrThr: 2.815 ± 0.059	4.348ThrVal: 4.348 ± 0.076	0.743ThrTrp: 0.743 ± 0.031	1.09ThrTyr: 1.09 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	10.122ValAla: 10.122 ± 0.114	0.71ValCys: 0.71 ± 0.029	4.009ValAsp: 4.009 ± 0.069	3.654ValGlu: 3.654 ± 0.058	2.662ValPhe: 2.662 ± 0.053	6.025ValGly: 6.025 ± 0.084	1.607ValHis: 1.607 ± 0.044	3.178ValIle: 3.178 ± 0.053	2.404ValLys: 2.404 ± 0.067	8.47ValLeu: 8.47 ± 0.105	1.986ValMet: 1.986 ± 0.046	2.087ValAsn: 2.087 ± 0.05	4.446ValPro: 4.446 ± 0.064	3.265ValGln: 3.265 ± 0.06	5.287ValArg: 5.287 ± 0.081	3.79ValSer: 3.79 ± 0.062	4.256ValThr: 4.256 ± 0.068	6.448ValVal: 6.448 ± 0.099	1.147ValTrp: 1.147 ± 0.032	1.543ValTyr: 1.543 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.775TrpAla: 1.775 ± 0.05	0.167TrpCys: 0.167 ± 0.012	0.643TrpAsp: 0.643 ± 0.026	0.477TrpGlu: 0.477 ± 0.023	0.544TrpPhe: 0.544 ± 0.022	1.118TrpGly: 1.118 ± 0.036	0.366TrpHis: 0.366 ± 0.017	0.591TrpIle: 0.591 ± 0.022	0.429TrpLys: 0.429 ± 0.021	2.291TrpLeu: 2.291 ± 0.054	0.467TrpMet: 0.467 ± 0.023	0.394TrpAsn: 0.394 ± 0.021	0.889TrpPro: 0.889 ± 0.035	0.87TrpGln: 0.87 ± 0.027	1.439TrpArg: 1.439 ± 0.04	0.817TrpSer: 0.817 ± 0.032	0.734TrpThr: 0.734 ± 0.031	1.175TrpVal: 1.175 ± 0.038	0.326TrpTrp: 0.326 ± 0.02	0.312TrpTyr: 0.312 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.568TyrAla: 2.568 ± 0.044	0.226TyrCys: 0.226 ± 0.014	1.198TyrAsp: 1.198 ± 0.033	1.114TyrGlu: 1.114 ± 0.032	0.868TyrPhe: 0.868 ± 0.03	2.009TyrGly: 2.009 ± 0.042	0.441TyrHis: 0.441 ± 0.02	0.757TyrIle: 0.757 ± 0.029	0.706TyrLys: 0.706 ± 0.028	2.311TyrLeu: 2.311 ± 0.051	0.411TyrMet: 0.411 ± 0.021	0.568TyrAsn: 0.568 ± 0.023	1.16TyrPro: 1.16 ± 0.034	0.872TyrGln: 0.872 ± 0.025	1.593TyrArg: 1.593 ± 0.038	1.13TyrSer: 1.13 ± 0.032	1.21TyrThr: 1.21 ± 0.038	1.728TyrVal: 1.728 ± 0.042	0.337TyrTrp: 0.337 ± 0.017	0.57TyrTyr: 0.57 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3420 proteins (1104964 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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