Amino acid dipepetide frequency for Georgenia subflava

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
22.138AlaAla: 22.138 ± 0.196
0.744AlaCys: 0.744 ± 0.03
8.947AlaAsp: 8.947 ± 0.1
9.292AlaGlu: 9.292 ± 0.118
3.181AlaPhe: 3.181 ± 0.059
14.278AlaGly: 14.278 ± 0.129
2.658AlaHis: 2.658 ± 0.053
3.878AlaIle: 3.878 ± 0.067
1.99AlaLys: 1.99 ± 0.048
14.137AlaLeu: 14.137 ± 0.131
2.875AlaMet: 2.875 ± 0.05
1.927AlaAsn: 1.927 ± 0.039
7.076AlaPro: 7.076 ± 0.09
3.749AlaGln: 3.749 ± 0.05
10.558AlaArg: 10.558 ± 0.118
5.9AlaSer: 5.9 ± 0.077
8.266AlaThr: 8.266 ± 0.089
13.52AlaVal: 13.52 ± 0.114
1.875AlaTrp: 1.875 ± 0.049
2.277AlaTyr: 2.277 ± 0.047
0.0AlaXaa: 0.0 ± 0.0
Cys
0.718CysAla: 0.718 ± 0.026
0.075CysCys: 0.075 ± 0.008
0.335CysAsp: 0.335 ± 0.017
0.291CysGlu: 0.291 ± 0.018
0.156CysPhe: 0.156 ± 0.011
0.607CysGly: 0.607 ± 0.026
0.136CysHis: 0.136 ± 0.012
0.136CysIle: 0.136 ± 0.012
0.047CysLys: 0.047 ± 0.006
0.494CysLeu: 0.494 ± 0.022
0.067CysMet: 0.067 ± 0.007
0.088CysAsn: 0.088 ± 0.007
0.344CysPro: 0.344 ± 0.019
0.144CysGln: 0.144 ± 0.012
0.414CysArg: 0.414 ± 0.019
0.312CysSer: 0.312 ± 0.019
0.362CysThr: 0.362 ± 0.016
0.415CysVal: 0.415 ± 0.021
0.08CysTrp: 0.08 ± 0.008
0.097CysTyr: 0.097 ± 0.008
0.0CysXaa: 0.0 ± 0.0
Asp
8.728AspAla: 8.728 ± 0.09
0.247AspCys: 0.247 ± 0.015
4.548AspAsp: 4.548 ± 0.068
4.216AspGlu: 4.216 ± 0.063
1.433AspPhe: 1.433 ± 0.033
7.183AspGly: 7.183 ± 0.099
1.431AspHis: 1.431 ± 0.036
1.794AspIle: 1.794 ± 0.043
0.802AspLys: 0.802 ± 0.028
7.033AspLeu: 7.033 ± 0.084
0.784AspMet: 0.784 ± 0.024
0.834AspAsn: 0.834 ± 0.026
4.456AspPro: 4.456 ± 0.069
1.576AspGln: 1.576 ± 0.042
4.678AspArg: 4.678 ± 0.068
2.307AspSer: 2.307 ± 0.042
2.813AspThr: 2.813 ± 0.057
6.707AspVal: 6.707 ± 0.075
0.883AspTrp: 0.883 ± 0.028
1.116AspTyr: 1.116 ± 0.035
0.0AspXaa: 0.0 ± 0.0
Glu
7.27GluAla: 7.27 ± 0.101
0.226GluCys: 0.226 ± 0.016
3.271GluAsp: 3.271 ± 0.055
3.598GluGlu: 3.598 ± 0.06
1.289GluPhe: 1.289 ± 0.029
4.163GluGly: 4.163 ± 0.052
1.857GluHis: 1.857 ± 0.04
2.476GluIle: 2.476 ± 0.052
1.097GluLys: 1.097 ± 0.037
7.2GluLeu: 7.2 ± 0.086
1.028GluMet: 1.028 ± 0.031
1.162GluAsn: 1.162 ± 0.034
3.723GluPro: 3.723 ± 0.07
2.399GluGln: 2.399 ± 0.048
5.39GluArg: 5.39 ± 0.083
2.596GluSer: 2.596 ± 0.041
3.063GluThr: 3.063 ± 0.056
5.595GluVal: 5.595 ± 0.074
0.709GluTrp: 0.709 ± 0.025
0.989GluTyr: 0.989 ± 0.029
0.0GluXaa: 0.0 ± 0.0
Phe
3.378PheAla: 3.378 ± 0.062
0.192PheCys: 0.192 ± 0.011
1.871PheAsp: 1.871 ± 0.042
1.436PheGlu: 1.436 ± 0.037
0.886PhePhe: 0.886 ± 0.031
2.655PheGly: 2.655 ± 0.058
0.504PheHis: 0.504 ± 0.02
0.761PheIle: 0.761 ± 0.027
0.319PheLys: 0.319 ± 0.016
2.485PheLeu: 2.485 ± 0.051
0.399PheMet: 0.399 ± 0.022
0.521PheAsn: 0.521 ± 0.024
1.218PhePro: 1.218 ± 0.034
0.61PheGln: 0.61 ± 0.024
1.533PheArg: 1.533 ± 0.036
1.425PheSer: 1.425 ± 0.038
1.862PheThr: 1.862 ± 0.043
2.605PheVal: 2.605 ± 0.057
0.411PheTrp: 0.411 ± 0.019
0.596PheTyr: 0.596 ± 0.025
0.0PheXaa: 0.0 ± 0.0
Gly
12.234GlyAla: 12.234 ± 0.122
0.56GlyCys: 0.56 ± 0.021
5.419GlyAsp: 5.419 ± 0.089
5.531GlyGlu: 5.531 ± 0.081
2.536GlyPhe: 2.536 ± 0.048
8.551GlyGly: 8.551 ± 0.096
2.11GlyHis: 2.11 ± 0.048
3.537GlyIle: 3.537 ± 0.054
1.811GlyLys: 1.811 ± 0.045
9.346GlyLeu: 9.346 ± 0.091
2.05GlyMet: 2.05 ± 0.043
1.604GlyAsn: 1.604 ± 0.04
5.044GlyPro: 5.044 ± 0.078
2.753GlyGln: 2.753 ± 0.048
7.583GlyArg: 7.583 ± 0.076
5.336GlySer: 5.336 ± 0.075
6.739GlyThr: 6.739 ± 0.082
8.155GlyVal: 8.155 ± 0.099
1.722GlyTrp: 1.722 ± 0.038
2.132GlyTyr: 2.132 ± 0.042
0.0GlyXaa: 0.0 ± 0.0
His
2.664HisAla: 2.664 ± 0.058
0.123HisCys: 0.123 ± 0.01
1.538HisAsp: 1.538 ± 0.04
1.292HisGlu: 1.292 ± 0.033
0.503HisPhe: 0.503 ± 0.02
2.255HisGly: 2.255 ± 0.049
0.7HisHis: 0.7 ± 0.025
0.567HisIle: 0.567 ± 0.022
0.274HisLys: 0.274 ± 0.019
2.521HisLeu: 2.521 ± 0.048
0.267HisMet: 0.267 ± 0.013
0.358HisAsn: 0.358 ± 0.016
1.522HisPro: 1.522 ± 0.038
0.581HisGln: 0.581 ± 0.022
1.904HisArg: 1.904 ± 0.043
0.847HisSer: 0.847 ± 0.024
1.093HisThr: 1.093 ± 0.033
2.036HisVal: 2.036 ± 0.045
0.3HisTrp: 0.3 ± 0.016
0.412HisTyr: 0.412 ± 0.021
0.0HisXaa: 0.0 ± 0.0
Ile
4.738IleAla: 4.738 ± 0.072
0.188IleCys: 0.188 ± 0.013
2.56IleAsp: 2.56 ± 0.046
2.002IleGlu: 2.002 ± 0.04
0.998IlePhe: 0.998 ± 0.03
3.412IleGly: 3.412 ± 0.068
0.564IleHis: 0.564 ± 0.022
1.136IleIle: 1.136 ± 0.037
0.541IleLys: 0.541 ± 0.023
2.661IleLeu: 2.661 ± 0.053
0.507IleMet: 0.507 ± 0.021
0.666IleAsn: 0.666 ± 0.025
1.61IlePro: 1.61 ± 0.039
0.66IleGln: 0.66 ± 0.025
1.885IleArg: 1.885 ± 0.04
1.764IleSer: 1.764 ± 0.043
2.225IleThr: 2.225 ± 0.051
3.138IleVal: 3.138 ± 0.051
0.383IleTrp: 0.383 ± 0.019
0.636IleTyr: 0.636 ± 0.025
0.0IleXaa: 0.0 ± 0.0
Lys
1.847LysAla: 1.847 ± 0.051
0.048LysCys: 0.048 ± 0.007
0.968LysAsp: 0.968 ± 0.03
0.843LysGlu: 0.843 ± 0.031
0.372LysPhe: 0.372 ± 0.018
1.202LysGly: 1.202 ± 0.037
0.347LysHis: 0.347 ± 0.015
0.69LysIle: 0.69 ± 0.027
0.514LysLys: 0.514 ± 0.03
1.3LysLeu: 1.3 ± 0.035
0.308LysMet: 0.308 ± 0.017
0.419LysAsn: 0.419 ± 0.021
0.776LysPro: 0.776 ± 0.029
0.481LysGln: 0.481 ± 0.022
1.026LysArg: 1.026 ± 0.037
0.782LysSer: 0.782 ± 0.03
0.921LysThr: 0.921 ± 0.029
1.52LysVal: 1.52 ± 0.044
0.165LysTrp: 0.165 ± 0.012
0.319LysTyr: 0.319 ± 0.017
0.0LysXaa: 0.0 ± 0.0
Leu
16.195LeuAla: 16.195 ± 0.155
0.559LeuCys: 0.559 ± 0.019
7.033LeuAsp: 7.033 ± 0.089
5.507LeuGlu: 5.507 ± 0.068
2.404LeuPhe: 2.404 ± 0.052
9.962LeuGly: 9.962 ± 0.094
1.995LeuHis: 1.995 ± 0.048
2.871LeuIle: 2.871 ± 0.067
1.28LeuLys: 1.28 ± 0.037
10.892LeuLeu: 10.892 ± 0.134
1.588LeuMet: 1.588 ± 0.037
1.478LeuAsn: 1.478 ± 0.037
5.796LeuPro: 5.796 ± 0.074
2.296LeuGln: 2.296 ± 0.044
8.003LeuArg: 8.003 ± 0.086
5.08LeuSer: 5.08 ± 0.072
6.914LeuThr: 6.914 ± 0.079
10.617LeuVal: 10.617 ± 0.111
1.232LeuTrp: 1.232 ± 0.036
1.559LeuTyr: 1.559 ± 0.041
0.0LeuXaa: 0.0 ± 0.0
Met
2.361MetAla: 2.361 ± 0.045
0.093MetCys: 0.093 ± 0.009
0.996MetAsp: 0.996 ± 0.03
0.696MetGlu: 0.696 ± 0.021
0.478MetPhe: 0.478 ± 0.021
1.289MetGly: 1.289 ± 0.035
0.338MetHis: 0.338 ± 0.018
0.702MetIle: 0.702 ± 0.028
0.309MetLys: 0.309 ± 0.015
1.904MetLeu: 1.904 ± 0.039
0.302MetMet: 0.302 ± 0.018
0.377MetAsn: 0.377 ± 0.018
1.071MetPro: 1.071 ± 0.032
0.405MetGln: 0.405 ± 0.018
1.467MetArg: 1.467 ± 0.032
1.429MetSer: 1.429 ± 0.034
1.675MetThr: 1.675 ± 0.033
1.58MetVal: 1.58 ± 0.044
0.211MetTrp: 0.211 ± 0.013
0.299MetTyr: 0.299 ± 0.015
0.0MetXaa: 0.0 ± 0.0
Asn
1.994AsnAla: 1.994 ± 0.042
0.079AsnCys: 0.079 ± 0.009
0.968AsnAsp: 0.968 ± 0.034
0.883AsnGlu: 0.883 ± 0.03
0.491AsnPhe: 0.491 ± 0.024
1.543AsnGly: 1.543 ± 0.04
0.407AsnHis: 0.407 ± 0.018
0.659AsnIle: 0.659 ± 0.024
0.295AsnLys: 0.295 ± 0.018
1.778AsnLeu: 1.778 ± 0.043
0.257AsnMet: 0.257 ± 0.016
0.392AsnAsn: 0.392 ± 0.02
1.276AsnPro: 1.276 ± 0.03
0.47AsnGln: 0.47 ± 0.022
1.111AsnArg: 1.111 ± 0.028
0.754AsnSer: 0.754 ± 0.028
0.94AsnThr: 0.94 ± 0.028
1.447AsnVal: 1.447 ± 0.03
0.222AsnTrp: 0.222 ± 0.014
0.425AsnTyr: 0.425 ± 0.02
0.0AsnXaa: 0.0 ± 0.0
Pro
8.702ProAla: 8.702 ± 0.105
0.23ProCys: 0.23 ± 0.014
4.335ProAsp: 4.335 ± 0.065
4.12ProGlu: 4.12 ± 0.062
1.485ProPhe: 1.485 ± 0.036
6.355ProGly: 6.355 ± 0.076
1.212ProHis: 1.212 ± 0.032
1.304ProIle: 1.304 ± 0.032
0.72ProLys: 0.72 ± 0.027
4.755ProLeu: 4.755 ± 0.055
0.993ProMet: 0.993 ± 0.03
0.789ProAsn: 0.789 ± 0.024
2.964ProPro: 2.964 ± 0.067
1.442ProGln: 1.442 ± 0.036
3.809ProArg: 3.809 ± 0.053
2.96ProSer: 2.96 ± 0.052
3.746ProThr: 3.746 ± 0.074
5.58ProVal: 5.58 ± 0.069
0.905ProTrp: 0.905 ± 0.029
1.08ProTyr: 1.08 ± 0.033
0.0ProXaa: 0.0 ± 0.0
Gln
3.584GlnAla: 3.584 ± 0.061
0.113GlnCys: 0.113 ± 0.009
1.386GlnAsp: 1.386 ± 0.035
1.408GlnGlu: 1.408 ± 0.039
0.644GlnPhe: 0.644 ± 0.025
1.992GlnGly: 1.992 ± 0.046
0.66GlnHis: 0.66 ± 0.024
1.141GlnIle: 1.141 ± 0.035
0.36GlnLys: 0.36 ± 0.017
2.992GlnLeu: 2.992 ± 0.051
0.561GlnMet: 0.561 ± 0.021
0.482GlnAsn: 0.482 ± 0.019
1.472GlnPro: 1.472 ± 0.041
1.022GlnGln: 1.022 ± 0.036
2.199GlnArg: 2.199 ± 0.042
1.11GlnSer: 1.11 ± 0.032
1.375GlnThr: 1.375 ± 0.032
3.037GlnVal: 3.037 ± 0.056
0.398GlnTrp: 0.398 ± 0.019
0.563GlnTyr: 0.563 ± 0.025
0.0GlnXaa: 0.0 ± 0.0
Arg
10.12ArgAla: 10.12 ± 0.115
0.429ArgCys: 0.429 ± 0.021
4.192ArgAsp: 4.192 ± 0.059
4.623ArgGlu: 4.623 ± 0.064
1.96ArgPhe: 1.96 ± 0.039
5.891ArgGly: 5.891 ± 0.081
1.886ArgHis: 1.886 ± 0.042
2.731ArgIle: 2.731 ± 0.047
1.166ArgLys: 1.166 ± 0.032
8.029ArgLeu: 8.029 ± 0.106
1.675ArgMet: 1.675 ± 0.036
1.12ArgAsn: 1.12 ± 0.026
4.79ArgPro: 4.79 ± 0.068
2.122ArgGln: 2.122 ± 0.049
8.175ArgArg: 8.175 ± 0.113
4.305ArgSer: 4.305 ± 0.061
5.374ArgThr: 5.374 ± 0.07
6.076ArgVal: 6.076 ± 0.067
1.424ArgTrp: 1.424 ± 0.036
1.602ArgTyr: 1.602 ± 0.038
0.0ArgXaa: 0.0 ± 0.0
Ser
6.641SerAla: 6.641 ± 0.075
0.271SerCys: 0.271 ± 0.015
2.692SerAsp: 2.692 ± 0.05
2.452SerGlu: 2.452 ± 0.043
1.483SerPhe: 1.483 ± 0.041
5.377SerGly: 5.377 ± 0.073
0.94SerHis: 0.94 ± 0.028
1.589SerIle: 1.589 ± 0.041
0.692SerLys: 0.692 ± 0.029
4.828SerLeu: 4.828 ± 0.069
1.078SerMet: 1.078 ± 0.032
0.858SerAsn: 0.858 ± 0.026
3.07SerPro: 3.07 ± 0.057
1.222SerGln: 1.222 ± 0.029
3.61SerArg: 3.61 ± 0.06
2.891SerSer: 2.891 ± 0.061
3.487SerThr: 3.487 ± 0.064
4.451SerVal: 4.451 ± 0.065
0.947SerTrp: 0.947 ± 0.024
1.094SerTyr: 1.094 ± 0.029
0.0SerXaa: 0.0 ± 0.0
Thr
8.649ThrAla: 8.649 ± 0.09
0.349ThrCys: 0.349 ± 0.017
3.94ThrAsp: 3.94 ± 0.064
3.566ThrGlu: 3.566 ± 0.057
1.972ThrPhe: 1.972 ± 0.041
6.822ThrGly: 6.822 ± 0.066
1.197ThrHis: 1.197 ± 0.034
2.232ThrIle: 2.232 ± 0.047
0.937ThrLys: 0.937 ± 0.032
5.887ThrLeu: 5.887 ± 0.073
1.132ThrMet: 1.132 ± 0.033
1.04ThrAsn: 1.04 ± 0.031
3.686ThrPro: 3.686 ± 0.059
1.412ThrGln: 1.412 ± 0.034
3.879ThrArg: 3.879 ± 0.049
3.464ThrSer: 3.464 ± 0.054
4.641ThrThr: 4.641 ± 0.068
6.514ThrVal: 6.514 ± 0.083
1.02ThrTrp: 1.02 ± 0.031
1.343ThrTyr: 1.343 ± 0.036
0.0ThrXaa: 0.0 ± 0.0
Val
13.388ValAla: 13.388 ± 0.103
0.563ValCys: 0.563 ± 0.02
6.357ValAsp: 6.357 ± 0.076
5.641ValGlu: 5.641 ± 0.071
2.277ValPhe: 2.277 ± 0.051
8.199ValGly: 8.199 ± 0.087
2.076ValHis: 2.076 ± 0.043
3.128ValIle: 3.128 ± 0.052
1.228ValLys: 1.228 ± 0.038
11.223ValLeu: 11.223 ± 0.115
1.562ValMet: 1.562 ± 0.033
1.562ValAsn: 1.562 ± 0.034
5.768ValPro: 5.768 ± 0.079
2.127ValGln: 2.127 ± 0.043
7.543ValArg: 7.543 ± 0.087
4.494ValSer: 4.494 ± 0.073
6.125ValThr: 6.125 ± 0.072
11.362ValVal: 11.362 ± 0.115
1.133ValTrp: 1.133 ± 0.032
1.542ValTyr: 1.542 ± 0.04
0.0ValXaa: 0.0 ± 0.0
Trp
1.668TrpAla: 1.668 ± 0.042
0.108TrpCys: 0.108 ± 0.01
0.895TrpAsp: 0.895 ± 0.03
0.677TrpGlu: 0.677 ± 0.024
0.49TrpPhe: 0.49 ± 0.021
1.036TrpGly: 1.036 ± 0.032
0.364TrpHis: 0.364 ± 0.016
0.475TrpIle: 0.475 ± 0.022
0.205TrpLys: 0.205 ± 0.014
1.66TrpLeu: 1.66 ± 0.046
0.295TrpMet: 0.295 ± 0.018
0.365TrpAsn: 0.365 ± 0.019
0.777TrpPro: 0.777 ± 0.025
0.528TrpGln: 0.528 ± 0.023
1.282TrpArg: 1.282 ± 0.035
0.984TrpSer: 0.984 ± 0.029
1.008TrpThr: 1.008 ± 0.033
1.196TrpVal: 1.196 ± 0.033
0.391TrpTrp: 0.391 ± 0.017
0.298TrpTyr: 0.298 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.249TyrAla: 2.249 ± 0.049
0.119TyrCys: 0.119 ± 0.009
1.317TyrAsp: 1.317 ± 0.035
1.025TyrGlu: 1.025 ± 0.029
0.629TyrPhe: 0.629 ± 0.021
1.98TyrGly: 1.98 ± 0.053
0.373TyrHis: 0.373 ± 0.02
0.467TyrIle: 0.467 ± 0.017
0.26TyrLys: 0.26 ± 0.015
2.138TyrLeu: 2.138 ± 0.042
0.254TyrMet: 0.254 ± 0.014
0.35TyrAsn: 0.35 ± 0.017
1.05TyrPro: 1.05 ± 0.03
0.501TyrGln: 0.501 ± 0.02
1.639TyrArg: 1.639 ± 0.04
0.933TyrSer: 0.933 ± 0.029
1.054TyrThr: 1.054 ± 0.031
1.748TyrVal: 1.748 ± 0.039
0.293TyrTrp: 0.293 ± 0.016
0.41TyrTyr: 0.41 ± 0.019
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3778 proteins (1231966 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski