Amino acid dipepetide frequency for Flavobacterium phage vB_FspP_elemoA_13-1E

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.407AlaAla: 2.407 ± 0.699
0.523AlaCys: 0.523 ± 0.288
2.459AlaAsp: 2.459 ± 0.324
4.134AlaGlu: 4.134 ± 0.683
2.983AlaPhe: 2.983 ± 0.523
3.035AlaGly: 3.035 ± 0.52
0.785AlaHis: 0.785 ± 0.178
5.023AlaIle: 5.023 ± 0.613
5.233AlaLys: 5.233 ± 0.911
4.186AlaLeu: 4.186 ± 0.493
1.047AlaMet: 1.047 ± 0.237
3.663AlaAsn: 3.663 ± 0.625
1.151AlaPro: 1.151 ± 0.263
1.779AlaGln: 1.779 ± 0.401
2.145AlaArg: 2.145 ± 0.312
4.186AlaSer: 4.186 ± 0.75
3.035AlaThr: 3.035 ± 0.677
3.192AlaVal: 3.192 ± 0.52
0.105AlaTrp: 0.105 ± 0.082
2.302AlaTyr: 2.302 ± 0.31
0.0AlaXaa: 0.0 ± 0.0
Cys
0.262CysAla: 0.262 ± 0.169
0.052CysCys: 0.052 ± 0.064
0.576CysAsp: 0.576 ± 0.19
0.733CysGlu: 0.733 ± 0.231
0.419CysPhe: 0.419 ± 0.128
0.366CysGly: 0.366 ± 0.163
0.262CysHis: 0.262 ± 0.132
0.576CysIle: 0.576 ± 0.207
0.523CysLys: 0.523 ± 0.222
0.785CysLeu: 0.785 ± 0.268
0.157CysMet: 0.157 ± 0.106
0.262CysAsn: 0.262 ± 0.147
0.157CysPro: 0.157 ± 0.11
0.157CysGln: 0.157 ± 0.095
0.366CysArg: 0.366 ± 0.167
0.262CysSer: 0.262 ± 0.147
0.471CysThr: 0.471 ± 0.177
0.366CysVal: 0.366 ± 0.151
0.105CysTrp: 0.105 ± 0.096
0.314CysTyr: 0.314 ± 0.152
0.0CysXaa: 0.0 ± 0.0
Asp
4.029AspAla: 4.029 ± 0.57
0.523AspCys: 0.523 ± 0.201
4.291AspAsp: 4.291 ± 0.408
4.238AspGlu: 4.238 ± 0.581
4.657AspPhe: 4.657 ± 0.426
4.238AspGly: 4.238 ± 0.504
0.471AspHis: 0.471 ± 0.163
5.18AspIle: 5.18 ± 0.558
7.116AspLys: 7.116 ± 0.804
6.174AspLeu: 6.174 ± 0.575
1.831AspMet: 1.831 ± 0.283
5.18AspAsn: 5.18 ± 0.637
1.151AspPro: 1.151 ± 0.235
1.413AspGln: 1.413 ± 0.253
2.093AspArg: 2.093 ± 0.306
4.709AspSer: 4.709 ± 0.594
3.872AspThr: 3.872 ± 0.451
3.977AspVal: 3.977 ± 0.414
0.89AspTrp: 0.89 ± 0.212
2.983AspTyr: 2.983 ± 0.687
0.0AspXaa: 0.0 ± 0.0
Glu
4.029GluAla: 4.029 ± 0.5
0.262GluCys: 0.262 ± 0.134
5.651GluAsp: 5.651 ± 0.585
6.122GluGlu: 6.122 ± 0.847
4.395GluPhe: 4.395 ± 0.58
4.5GluGly: 4.5 ± 0.442
0.785GluHis: 0.785 ± 0.265
6.017GluIle: 6.017 ± 0.494
5.18GluLys: 5.18 ± 0.683
6.802GluLeu: 6.802 ± 0.728
1.57GluMet: 1.57 ± 0.317
4.081GluAsn: 4.081 ± 0.617
1.256GluPro: 1.256 ± 0.272
2.721GluGln: 2.721 ± 0.455
2.407GluArg: 2.407 ± 0.326
5.128GluSer: 5.128 ± 0.581
3.087GluThr: 3.087 ± 0.462
5.285GluVal: 5.285 ± 0.473
0.837GluTrp: 0.837 ± 0.175
3.715GluTyr: 3.715 ± 0.45
0.0GluXaa: 0.0 ± 0.0
Phe
1.674PheAla: 1.674 ± 0.336
0.523PheCys: 0.523 ± 0.189
3.82PheAsp: 3.82 ± 0.395
3.924PheGlu: 3.924 ± 0.508
1.831PhePhe: 1.831 ± 0.34
2.459PheGly: 2.459 ± 0.419
0.89PheHis: 0.89 ± 0.247
3.506PheIle: 3.506 ± 0.389
4.291PheLys: 4.291 ± 0.595
3.454PheLeu: 3.454 ± 0.717
1.203PheMet: 1.203 ± 0.23
4.343PheAsn: 4.343 ± 0.462
0.785PhePro: 0.785 ± 0.188
1.151PheGln: 1.151 ± 0.251
1.308PheArg: 1.308 ± 0.357
3.61PheSer: 3.61 ± 0.381
2.721PheThr: 2.721 ± 0.468
1.831PheVal: 1.831 ± 0.249
0.419PheTrp: 0.419 ± 0.169
1.779PheTyr: 1.779 ± 0.396
0.0PheXaa: 0.0 ± 0.0
Gly
2.616GlyAla: 2.616 ± 0.567
0.262GlyCys: 0.262 ± 0.136
3.558GlyAsp: 3.558 ± 0.354
3.349GlyGlu: 3.349 ± 0.394
2.826GlyPhe: 2.826 ± 0.351
4.186GlyGly: 4.186 ± 0.588
0.628GlyHis: 0.628 ± 0.24
5.076GlyIle: 5.076 ± 0.652
4.866GlyLys: 4.866 ± 0.657
5.076GlyLeu: 5.076 ± 0.727
1.465GlyMet: 1.465 ± 0.26
3.454GlyAsn: 3.454 ± 0.535
1.099GlyPro: 1.099 ± 0.478
1.674GlyGln: 1.674 ± 0.311
2.459GlyArg: 2.459 ± 0.293
4.343GlySer: 4.343 ± 0.532
4.134GlyThr: 4.134 ± 0.656
4.343GlyVal: 4.343 ± 0.636
0.471GlyTrp: 0.471 ± 0.176
3.297GlyTyr: 3.297 ± 0.378
0.0GlyXaa: 0.0 ± 0.0
His
0.523HisAla: 0.523 ± 0.185
0.314HisCys: 0.314 ± 0.146
0.785HisAsp: 0.785 ± 0.27
0.419HisGlu: 0.419 ± 0.132
0.523HisPhe: 0.523 ± 0.199
0.419HisGly: 0.419 ± 0.165
0.419HisHis: 0.419 ± 0.197
1.099HisIle: 1.099 ± 0.292
1.465HisLys: 1.465 ± 0.419
0.68HisLeu: 0.68 ± 0.22
0.052HisMet: 0.052 ± 0.054
0.785HisAsn: 0.785 ± 0.211
0.628HisPro: 0.628 ± 0.195
0.628HisGln: 0.628 ± 0.153
0.419HisArg: 0.419 ± 0.174
0.942HisSer: 0.942 ± 0.223
0.628HisThr: 0.628 ± 0.214
0.209HisVal: 0.209 ± 0.139
0.157HisTrp: 0.157 ± 0.093
0.628HisTyr: 0.628 ± 0.205
0.0HisXaa: 0.0 ± 0.0
Ile
4.343IleAla: 4.343 ± 0.44
0.366IleCys: 0.366 ± 0.173
7.116IleAsp: 7.116 ± 0.608
5.965IleGlu: 5.965 ± 0.572
2.564IlePhe: 2.564 ± 0.464
3.82IleGly: 3.82 ± 0.421
1.099IleHis: 1.099 ± 0.247
5.494IleIle: 5.494 ± 0.652
7.43IleLys: 7.43 ± 0.893
4.866IleLeu: 4.866 ± 0.588
1.203IleMet: 1.203 ± 0.342
6.436IleAsn: 6.436 ± 0.595
1.831IlePro: 1.831 ± 0.293
2.512IleGln: 2.512 ± 0.426
2.459IleArg: 2.459 ± 0.402
6.174IleSer: 6.174 ± 0.698
4.814IleThr: 4.814 ± 0.581
5.39IleVal: 5.39 ± 0.716
0.628IleTrp: 0.628 ± 0.165
2.669IleTyr: 2.669 ± 0.403
0.0IleXaa: 0.0 ± 0.0
Lys
5.808LysAla: 5.808 ± 0.981
0.576LysCys: 0.576 ± 0.255
6.698LysAsp: 6.698 ± 0.617
8.058LysGlu: 8.058 ± 0.869
2.983LysPhe: 2.983 ± 0.417
4.919LysGly: 4.919 ± 0.547
1.047LysHis: 1.047 ± 0.25
7.116LysIle: 7.116 ± 0.76
8.686LysLys: 8.686 ± 1.068
7.273LysLeu: 7.273 ± 1.047
2.93LysMet: 2.93 ± 0.486
6.07LysAsn: 6.07 ± 0.585
2.983LysPro: 2.983 ± 0.398
2.564LysGln: 2.564 ± 0.569
3.192LysArg: 3.192 ± 0.631
5.599LysSer: 5.599 ± 0.623
4.762LysThr: 4.762 ± 0.551
6.331LysVal: 6.331 ± 0.618
0.68LysTrp: 0.68 ± 0.187
4.657LysTyr: 4.657 ± 0.375
0.0LysXaa: 0.0 ± 0.0
Leu
3.977LeuAla: 3.977 ± 0.48
0.628LeuCys: 0.628 ± 0.258
5.756LeuAsp: 5.756 ± 0.569
5.965LeuGlu: 5.965 ± 0.649
3.454LeuPhe: 3.454 ± 0.447
4.134LeuGly: 4.134 ± 0.61
0.942LeuHis: 0.942 ± 0.204
5.39LeuIle: 5.39 ± 0.724
7.116LeuLys: 7.116 ± 0.869
6.645LeuLeu: 6.645 ± 0.777
1.884LeuMet: 1.884 ± 0.387
6.279LeuAsn: 6.279 ± 0.478
3.192LeuPro: 3.192 ± 0.329
2.564LeuGln: 2.564 ± 0.451
1.831LeuArg: 1.831 ± 0.398
6.436LeuSer: 6.436 ± 0.661
4.395LeuThr: 4.395 ± 0.488
3.82LeuVal: 3.82 ± 0.445
0.785LeuTrp: 0.785 ± 0.246
3.192LeuTyr: 3.192 ± 0.472
0.0LeuXaa: 0.0 ± 0.0
Met
2.25MetAla: 2.25 ± 0.326
0.209MetCys: 0.209 ± 0.136
0.68MetAsp: 0.68 ± 0.149
1.622MetGlu: 1.622 ± 0.239
0.837MetPhe: 0.837 ± 0.188
0.89MetGly: 0.89 ± 0.276
0.262MetHis: 0.262 ± 0.12
1.622MetIle: 1.622 ± 0.348
2.669MetLys: 2.669 ± 0.536
1.151MetLeu: 1.151 ± 0.282
0.576MetMet: 0.576 ± 0.21
2.145MetAsn: 2.145 ± 0.371
0.419MetPro: 0.419 ± 0.163
1.047MetGln: 1.047 ± 0.217
0.994MetArg: 0.994 ± 0.282
1.57MetSer: 1.57 ± 0.292
1.151MetThr: 1.151 ± 0.259
1.151MetVal: 1.151 ± 0.205
0.209MetTrp: 0.209 ± 0.119
1.36MetTyr: 1.36 ± 0.307
0.0MetXaa: 0.0 ± 0.0
Asn
4.395AsnAla: 4.395 ± 0.769
0.628AsnCys: 0.628 ± 0.218
4.395AsnAsp: 4.395 ± 0.569
4.552AsnGlu: 4.552 ± 0.538
2.983AsnPhe: 2.983 ± 0.399
5.023AsnGly: 5.023 ± 0.454
0.628AsnHis: 0.628 ± 0.19
5.128AsnIle: 5.128 ± 0.625
7.169AsnLys: 7.169 ± 0.768
4.5AsnLeu: 4.5 ± 0.687
1.831AsnMet: 1.831 ± 0.29
6.017AsnAsn: 6.017 ± 0.526
2.459AsnPro: 2.459 ± 0.396
3.192AsnGln: 3.192 ± 0.498
3.61AsnArg: 3.61 ± 0.505
4.448AsnSer: 4.448 ± 0.519
3.506AsnThr: 3.506 ± 0.378
4.395AsnVal: 4.395 ± 0.762
0.523AsnTrp: 0.523 ± 0.183
2.773AsnTyr: 2.773 ± 0.396
0.0AsnXaa: 0.0 ± 0.0
Pro
0.837ProAla: 0.837 ± 0.291
0.105ProCys: 0.105 ± 0.081
1.831ProAsp: 1.831 ± 0.331
2.093ProGlu: 2.093 ± 0.344
1.308ProPhe: 1.308 ± 0.289
1.36ProGly: 1.36 ± 0.237
0.209ProHis: 0.209 ± 0.112
2.198ProIle: 2.198 ± 0.255
1.674ProLys: 1.674 ± 0.402
1.988ProLeu: 1.988 ± 0.342
0.733ProMet: 0.733 ± 0.181
2.041ProAsn: 2.041 ± 0.348
0.68ProPro: 0.68 ± 0.177
0.733ProGln: 0.733 ± 0.208
1.308ProArg: 1.308 ± 0.234
2.826ProSer: 2.826 ± 0.468
2.564ProThr: 2.564 ± 0.37
1.517ProVal: 1.517 ± 0.238
0.052ProTrp: 0.052 ± 0.051
1.099ProTyr: 1.099 ± 0.213
0.0ProXaa: 0.0 ± 0.0
Gln
2.25GlnAla: 2.25 ± 0.373
0.0GlnCys: 0.0 ± 0.0
1.936GlnAsp: 1.936 ± 0.37
2.826GlnGlu: 2.826 ± 0.521
0.994GlnPhe: 0.994 ± 0.188
1.884GlnGly: 1.884 ± 0.55
0.262GlnHis: 0.262 ± 0.116
2.355GlnIle: 2.355 ± 0.334
2.826GlnLys: 2.826 ± 0.505
1.988GlnLeu: 1.988 ± 0.312
1.099GlnMet: 1.099 ± 0.328
1.674GlnAsn: 1.674 ± 0.227
0.733GlnPro: 0.733 ± 0.185
0.994GlnGln: 0.994 ± 0.281
1.047GlnArg: 1.047 ± 0.343
2.616GlnSer: 2.616 ± 0.327
1.308GlnThr: 1.308 ± 0.271
1.988GlnVal: 1.988 ± 0.291
0.366GlnTrp: 0.366 ± 0.12
1.36GlnTyr: 1.36 ± 0.244
0.0GlnXaa: 0.0 ± 0.0
Arg
1.936ArgAla: 1.936 ± 0.341
0.419ArgCys: 0.419 ± 0.187
2.459ArgAsp: 2.459 ± 0.449
2.355ArgGlu: 2.355 ± 0.356
1.517ArgPhe: 1.517 ± 0.275
2.721ArgGly: 2.721 ± 0.42
0.785ArgHis: 0.785 ± 0.248
2.669ArgIle: 2.669 ± 0.421
3.14ArgLys: 3.14 ± 0.485
3.297ArgLeu: 3.297 ± 0.459
0.785ArgMet: 0.785 ± 0.27
1.674ArgAsn: 1.674 ± 0.306
0.994ArgPro: 0.994 ± 0.231
0.837ArgGln: 0.837 ± 0.212
1.413ArgArg: 1.413 ± 0.333
1.779ArgSer: 1.779 ± 0.293
1.413ArgThr: 1.413 ± 0.323
2.407ArgVal: 2.407 ± 0.316
0.419ArgTrp: 0.419 ± 0.166
1.936ArgTyr: 1.936 ± 0.338
0.0ArgXaa: 0.0 ± 0.0
Ser
2.878SerAla: 2.878 ± 0.368
0.523SerCys: 0.523 ± 0.207
5.39SerAsp: 5.39 ± 0.503
5.39SerGlu: 5.39 ± 0.599
3.349SerPhe: 3.349 ± 0.645
5.076SerGly: 5.076 ± 0.467
0.419SerHis: 0.419 ± 0.166
5.651SerIle: 5.651 ± 0.556
7.221SerLys: 7.221 ± 0.842
5.337SerLeu: 5.337 ± 0.512
1.674SerMet: 1.674 ± 0.313
5.599SerAsn: 5.599 ± 0.457
1.831SerPro: 1.831 ± 0.371
1.622SerGln: 1.622 ± 0.22
2.407SerArg: 2.407 ± 0.342
5.023SerSer: 5.023 ± 0.646
3.192SerThr: 3.192 ± 0.409
4.971SerVal: 4.971 ± 0.63
0.628SerTrp: 0.628 ± 0.188
3.767SerTyr: 3.767 ± 0.521
0.0SerXaa: 0.0 ± 0.0
Thr
2.878ThrAla: 2.878 ± 0.415
0.209ThrCys: 0.209 ± 0.133
3.872ThrAsp: 3.872 ± 0.51
3.767ThrGlu: 3.767 ± 0.517
1.831ThrPhe: 1.831 ± 0.388
3.349ThrGly: 3.349 ± 0.46
0.628ThrHis: 0.628 ± 0.234
4.238ThrIle: 4.238 ± 0.663
5.808ThrLys: 5.808 ± 0.608
4.866ThrLeu: 4.866 ± 0.658
0.523ThrMet: 0.523 ± 0.198
3.767ThrAsn: 3.767 ± 0.572
2.983ThrPro: 2.983 ± 0.384
1.57ThrGln: 1.57 ± 0.315
1.57ThrArg: 1.57 ± 0.244
3.977ThrSer: 3.977 ± 0.454
5.023ThrThr: 5.023 ± 0.668
2.407ThrVal: 2.407 ± 0.486
0.576ThrTrp: 0.576 ± 0.143
2.826ThrTyr: 2.826 ± 0.454
0.0ThrXaa: 0.0 ± 0.0
Val
3.349ValAla: 3.349 ± 0.538
0.471ValCys: 0.471 ± 0.176
3.977ValAsp: 3.977 ± 0.372
4.866ValGlu: 4.866 ± 0.537
2.93ValPhe: 2.93 ± 0.336
3.715ValGly: 3.715 ± 0.473
0.523ValHis: 0.523 ± 0.198
4.971ValIle: 4.971 ± 0.682
5.756ValLys: 5.756 ± 0.551
4.971ValLeu: 4.971 ± 0.52
0.837ValMet: 0.837 ± 0.224
4.029ValAsn: 4.029 ± 0.64
1.622ValPro: 1.622 ± 0.315
1.517ValGln: 1.517 ± 0.215
2.041ValArg: 2.041 ± 0.301
4.605ValSer: 4.605 ± 0.636
3.192ValThr: 3.192 ± 0.578
3.82ValVal: 3.82 ± 0.625
0.523ValTrp: 0.523 ± 0.173
2.878ValTyr: 2.878 ± 0.549
0.0ValXaa: 0.0 ± 0.0
Trp
0.471TrpAla: 0.471 ± 0.15
0.052TrpCys: 0.052 ± 0.054
0.471TrpAsp: 0.471 ± 0.147
0.523TrpGlu: 0.523 ± 0.139
0.733TrpPhe: 0.733 ± 0.246
0.576TrpGly: 0.576 ± 0.192
0.052TrpHis: 0.052 ± 0.059
0.366TrpIle: 0.366 ± 0.147
0.68TrpLys: 0.68 ± 0.181
0.68TrpLeu: 0.68 ± 0.167
0.366TrpMet: 0.366 ± 0.135
0.733TrpAsn: 0.733 ± 0.182
0.0TrpPro: 0.0 ± 0.0
0.366TrpGln: 0.366 ± 0.16
0.628TrpArg: 0.628 ± 0.172
0.837TrpSer: 0.837 ± 0.262
0.366TrpThr: 0.366 ± 0.181
0.576TrpVal: 0.576 ± 0.216
0.052TrpTrp: 0.052 ± 0.057
0.314TrpTyr: 0.314 ± 0.162
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.459TyrAla: 2.459 ± 0.371
0.523TyrCys: 0.523 ± 0.204
3.297TyrAsp: 3.297 ± 0.485
2.93TyrGlu: 2.93 ± 0.411
2.407TyrPhe: 2.407 ± 0.549
2.512TyrGly: 2.512 ± 0.425
0.628TyrHis: 0.628 ± 0.177
3.506TyrIle: 3.506 ± 0.529
4.081TyrLys: 4.081 ± 0.437
3.715TyrLeu: 3.715 ± 0.542
0.994TyrMet: 0.994 ± 0.177
3.924TyrAsn: 3.924 ± 0.516
1.203TyrPro: 1.203 ± 0.227
1.465TyrGln: 1.465 ± 0.281
1.256TyrArg: 1.256 ± 0.274
2.878TyrSer: 2.878 ± 0.562
3.035TyrThr: 3.035 ± 0.463
2.616TyrVal: 2.616 ± 0.425
0.419TyrTrp: 0.419 ± 0.178
2.198TyrTyr: 2.198 ± 0.414
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 89 proteins (19112 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski