Amino acid dipepetide frequency for Mycobacterium phage Fushigi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.514AlaAla: 12.514 ± 1.075
0.645AlaCys: 0.645 ± 0.193
6.966AlaAsp: 6.966 ± 0.59
6.257AlaGlu: 6.257 ± 0.749
2.967AlaPhe: 2.967 ± 0.514
7.869AlaGly: 7.869 ± 0.757
1.484AlaHis: 1.484 ± 0.41
4.193AlaIle: 4.193 ± 0.5
4.386AlaLys: 4.386 ± 0.534
8.902AlaLeu: 8.902 ± 0.756
2.58AlaMet: 2.58 ± 0.421
2.322AlaAsn: 2.322 ± 0.334
4.967AlaPro: 4.967 ± 0.686
2.645AlaGln: 2.645 ± 0.5
6.192AlaArg: 6.192 ± 0.64
5.031AlaSer: 5.031 ± 0.571
5.354AlaThr: 5.354 ± 0.57
8.385AlaVal: 8.385 ± 0.736
2.0AlaTrp: 2.0 ± 0.372
2.645AlaTyr: 2.645 ± 0.421
0.0AlaXaa: 0.0 ± 0.0
Cys
0.645CysAla: 0.645 ± 0.221
0.0CysCys: 0.0 ± 0.0
0.774CysAsp: 0.774 ± 0.185
0.774CysGlu: 0.774 ± 0.23
0.323CysPhe: 0.323 ± 0.135
0.194CysGly: 0.194 ± 0.115
0.194CysHis: 0.194 ± 0.113
0.516CysIle: 0.516 ± 0.22
0.258CysLys: 0.258 ± 0.138
0.323CysLeu: 0.323 ± 0.171
0.065CysMet: 0.065 ± 0.062
0.258CysAsn: 0.258 ± 0.112
0.323CysPro: 0.323 ± 0.135
0.129CysGln: 0.129 ± 0.087
0.387CysArg: 0.387 ± 0.181
0.194CysSer: 0.194 ± 0.095
0.387CysThr: 0.387 ± 0.156
0.258CysVal: 0.258 ± 0.136
0.323CysTrp: 0.323 ± 0.134
0.194CysTyr: 0.194 ± 0.102
0.0CysXaa: 0.0 ± 0.0
Asp
6.644AspAla: 6.644 ± 0.579
0.516AspCys: 0.516 ± 0.208
4.515AspAsp: 4.515 ± 0.473
3.741AspGlu: 3.741 ± 0.488
2.451AspPhe: 2.451 ± 0.327
5.999AspGly: 5.999 ± 0.643
1.097AspHis: 1.097 ± 0.29
2.645AspIle: 2.645 ± 0.429
2.58AspLys: 2.58 ± 0.488
6.644AspLeu: 6.644 ± 0.729
1.419AspMet: 1.419 ± 0.251
2.0AspAsn: 2.0 ± 0.394
5.031AspPro: 5.031 ± 0.528
1.806AspGln: 1.806 ± 0.317
3.87AspArg: 3.87 ± 0.468
3.419AspSer: 3.419 ± 0.564
3.87AspThr: 3.87 ± 0.463
4.773AspVal: 4.773 ± 0.516
1.806AspTrp: 1.806 ± 0.326
1.935AspTyr: 1.935 ± 0.351
0.0AspXaa: 0.0 ± 0.0
Glu
5.87GluAla: 5.87 ± 0.744
0.71GluCys: 0.71 ± 0.267
4.58GluAsp: 4.58 ± 0.518
4.644GluGlu: 4.644 ± 0.516
2.322GluPhe: 2.322 ± 0.386
4.128GluGly: 4.128 ± 0.627
1.355GluHis: 1.355 ± 0.314
3.29GluIle: 3.29 ± 0.446
3.29GluLys: 3.29 ± 0.417
6.257GluLeu: 6.257 ± 0.643
1.419GluMet: 1.419 ± 0.289
2.0GluAsn: 2.0 ± 0.341
2.451GluPro: 2.451 ± 0.388
2.322GluGln: 2.322 ± 0.312
3.741GluArg: 3.741 ± 0.592
3.741GluSer: 3.741 ± 0.459
3.87GluThr: 3.87 ± 0.504
5.418GluVal: 5.418 ± 0.578
1.677GluTrp: 1.677 ± 0.389
2.193GluTyr: 2.193 ± 0.487
0.0GluXaa: 0.0 ± 0.0
Phe
2.709PheAla: 2.709 ± 0.412
0.194PheCys: 0.194 ± 0.107
2.774PheAsp: 2.774 ± 0.358
2.064PheGlu: 2.064 ± 0.346
0.71PhePhe: 0.71 ± 0.251
3.548PheGly: 3.548 ± 0.5
0.581PheHis: 0.581 ± 0.198
1.355PheIle: 1.355 ± 0.292
1.419PheLys: 1.419 ± 0.275
2.516PheLeu: 2.516 ± 0.45
0.581PheMet: 0.581 ± 0.208
1.097PheAsn: 1.097 ± 0.278
1.677PhePro: 1.677 ± 0.3
0.903PheGln: 0.903 ± 0.214
2.064PheArg: 2.064 ± 0.41
1.613PheSer: 1.613 ± 0.3
2.322PheThr: 2.322 ± 0.419
2.322PheVal: 2.322 ± 0.395
0.516PheTrp: 0.516 ± 0.147
0.968PheTyr: 0.968 ± 0.208
0.0PheXaa: 0.0 ± 0.0
Gly
7.16GlyAla: 7.16 ± 0.896
0.645GlyCys: 0.645 ± 0.193
5.934GlyAsp: 5.934 ± 0.513
4.322GlyGlu: 4.322 ± 0.492
2.903GlyPhe: 2.903 ± 0.506
8.385GlyGly: 8.385 ± 1.391
1.935GlyHis: 1.935 ± 0.39
4.386GlyIle: 4.386 ± 0.816
3.612GlyLys: 3.612 ± 0.551
7.676GlyLeu: 7.676 ± 0.892
1.806GlyMet: 1.806 ± 0.341
3.419GlyAsn: 3.419 ± 0.451
4.128GlyPro: 4.128 ± 0.594
2.193GlyGln: 2.193 ± 0.349
4.709GlyArg: 4.709 ± 0.475
6.063GlySer: 6.063 ± 0.698
5.289GlyThr: 5.289 ± 0.583
5.612GlyVal: 5.612 ± 0.599
2.58GlyTrp: 2.58 ± 0.397
2.709GlyTyr: 2.709 ± 0.387
0.0GlyXaa: 0.0 ± 0.0
His
1.677HisAla: 1.677 ± 0.331
0.129HisCys: 0.129 ± 0.097
1.29HisAsp: 1.29 ± 0.28
1.355HisGlu: 1.355 ± 0.315
0.645HisPhe: 0.645 ± 0.18
1.677HisGly: 1.677 ± 0.345
0.774HisHis: 0.774 ± 0.239
1.29HisIle: 1.29 ± 0.247
0.968HisLys: 0.968 ± 0.312
1.355HisLeu: 1.355 ± 0.314
0.323HisMet: 0.323 ± 0.161
0.581HisAsn: 0.581 ± 0.181
1.29HisPro: 1.29 ± 0.256
0.774HisGln: 0.774 ± 0.198
1.548HisArg: 1.548 ± 0.311
0.903HisSer: 0.903 ± 0.191
1.161HisThr: 1.161 ± 0.264
1.613HisVal: 1.613 ± 0.287
0.516HisTrp: 0.516 ± 0.169
0.774HisTyr: 0.774 ± 0.212
0.0HisXaa: 0.0 ± 0.0
Ile
5.676IleAla: 5.676 ± 0.586
0.323IleCys: 0.323 ± 0.127
3.483IleAsp: 3.483 ± 0.369
3.741IleGlu: 3.741 ± 0.483
1.032IlePhe: 1.032 ± 0.242
4.193IleGly: 4.193 ± 0.472
1.161IleHis: 1.161 ± 0.288
1.742IleIle: 1.742 ± 0.27
1.806IleLys: 1.806 ± 0.363
3.29IleLeu: 3.29 ± 0.47
0.774IleMet: 0.774 ± 0.233
1.677IleAsn: 1.677 ± 0.285
3.225IlePro: 3.225 ± 0.399
1.548IleGln: 1.548 ± 0.353
3.225IleArg: 3.225 ± 0.429
3.419IleSer: 3.419 ± 0.543
3.483IleThr: 3.483 ± 0.467
2.838IleVal: 2.838 ± 0.53
0.645IleTrp: 0.645 ± 0.187
1.677IleTyr: 1.677 ± 0.283
0.0IleXaa: 0.0 ± 0.0
Lys
3.548LysAla: 3.548 ± 0.559
0.129LysCys: 0.129 ± 0.113
2.322LysAsp: 2.322 ± 0.43
2.322LysGlu: 2.322 ± 0.417
1.419LysPhe: 1.419 ± 0.311
2.516LysGly: 2.516 ± 0.427
1.29LysHis: 1.29 ± 0.244
2.58LysIle: 2.58 ± 0.459
2.258LysLys: 2.258 ± 0.495
3.612LysLeu: 3.612 ± 0.507
0.968LysMet: 0.968 ± 0.214
1.419LysAsn: 1.419 ± 0.271
2.387LysPro: 2.387 ± 0.413
1.806LysGln: 1.806 ± 0.419
3.096LysArg: 3.096 ± 0.612
2.774LysSer: 2.774 ± 0.362
2.645LysThr: 2.645 ± 0.386
3.032LysVal: 3.032 ± 0.445
0.71LysTrp: 0.71 ± 0.192
1.097LysTyr: 1.097 ± 0.344
0.0LysXaa: 0.0 ± 0.0
Leu
9.16LeuAla: 9.16 ± 0.833
0.194LeuCys: 0.194 ± 0.105
5.999LeuAsp: 5.999 ± 0.508
5.225LeuGlu: 5.225 ± 0.55
1.871LeuPhe: 1.871 ± 0.347
7.031LeuGly: 7.031 ± 0.88
1.484LeuHis: 1.484 ± 0.315
4.773LeuIle: 4.773 ± 0.545
4.128LeuLys: 4.128 ± 0.521
5.999LeuLeu: 5.999 ± 0.577
1.613LeuMet: 1.613 ± 0.301
3.096LeuAsn: 3.096 ± 0.43
6.386LeuPro: 6.386 ± 0.561
2.322LeuGln: 2.322 ± 0.466
5.999LeuArg: 5.999 ± 0.602
5.676LeuSer: 5.676 ± 0.527
5.483LeuThr: 5.483 ± 0.492
4.773LeuVal: 4.773 ± 0.658
1.161LeuTrp: 1.161 ± 0.355
2.58LeuTyr: 2.58 ± 0.391
0.0LeuXaa: 0.0 ± 0.0
Met
2.58MetAla: 2.58 ± 0.368
0.0MetCys: 0.0 ± 0.0
1.097MetAsp: 1.097 ± 0.223
1.419MetGlu: 1.419 ± 0.319
0.581MetPhe: 0.581 ± 0.187
1.355MetGly: 1.355 ± 0.283
0.387MetHis: 0.387 ± 0.139
0.516MetIle: 0.516 ± 0.176
1.226MetLys: 1.226 ± 0.254
1.032MetLeu: 1.032 ± 0.291
0.194MetMet: 0.194 ± 0.136
1.097MetAsn: 1.097 ± 0.23
1.226MetPro: 1.226 ± 0.283
0.581MetGln: 0.581 ± 0.174
1.097MetArg: 1.097 ± 0.269
2.064MetSer: 2.064 ± 0.405
2.193MetThr: 2.193 ± 0.41
1.161MetVal: 1.161 ± 0.276
0.194MetTrp: 0.194 ± 0.121
0.516MetTyr: 0.516 ± 0.201
0.0MetXaa: 0.0 ± 0.0
Asn
3.225AsnAla: 3.225 ± 0.505
0.065AsnCys: 0.065 ± 0.071
2.387AsnAsp: 2.387 ± 0.383
1.871AsnGlu: 1.871 ± 0.346
1.032AsnPhe: 1.032 ± 0.265
3.29AsnGly: 3.29 ± 0.392
0.774AsnHis: 0.774 ± 0.214
1.742AsnIle: 1.742 ± 0.35
0.516AsnLys: 0.516 ± 0.179
2.387AsnLeu: 2.387 ± 0.314
0.71AsnMet: 0.71 ± 0.172
0.839AsnAsn: 0.839 ± 0.192
2.709AsnPro: 2.709 ± 0.341
1.161AsnGln: 1.161 ± 0.239
1.355AsnArg: 1.355 ± 0.339
1.871AsnSer: 1.871 ± 0.351
1.806AsnThr: 1.806 ± 0.32
2.838AsnVal: 2.838 ± 0.429
0.839AsnTrp: 0.839 ± 0.188
1.226AsnTyr: 1.226 ± 0.297
0.0AsnXaa: 0.0 ± 0.0
Pro
4.773ProAla: 4.773 ± 0.545
0.258ProCys: 0.258 ± 0.124
4.064ProAsp: 4.064 ± 0.417
4.644ProGlu: 4.644 ± 0.505
2.0ProPhe: 2.0 ± 0.408
5.225ProGly: 5.225 ± 0.659
1.097ProHis: 1.097 ± 0.275
2.58ProIle: 2.58 ± 0.383
2.129ProLys: 2.129 ± 0.28
4.322ProLeu: 4.322 ± 0.552
1.032ProMet: 1.032 ± 0.267
1.935ProAsn: 1.935 ± 0.283
2.774ProPro: 2.774 ± 0.485
1.484ProGln: 1.484 ± 0.322
3.096ProArg: 3.096 ± 0.442
4.193ProSer: 4.193 ± 0.547
3.741ProThr: 3.741 ± 0.555
3.999ProVal: 3.999 ± 0.423
0.903ProTrp: 0.903 ± 0.317
1.742ProTyr: 1.742 ± 0.354
0.0ProXaa: 0.0 ± 0.0
Gln
3.096GlnAla: 3.096 ± 0.484
0.065GlnCys: 0.065 ± 0.076
1.484GlnAsp: 1.484 ± 0.354
1.613GlnGlu: 1.613 ± 0.292
1.032GlnPhe: 1.032 ± 0.234
2.258GlnGly: 2.258 ± 0.332
0.516GlnHis: 0.516 ± 0.194
2.838GlnIle: 2.838 ± 0.482
1.161GlnLys: 1.161 ± 0.287
3.483GlnLeu: 3.483 ± 0.444
0.774GlnMet: 0.774 ± 0.233
0.452GlnAsn: 0.452 ± 0.166
1.613GlnPro: 1.613 ± 0.341
1.677GlnGln: 1.677 ± 0.309
1.742GlnArg: 1.742 ± 0.322
1.742GlnSer: 1.742 ± 0.335
1.613GlnThr: 1.613 ± 0.333
2.322GlnVal: 2.322 ± 0.32
0.645GlnTrp: 0.645 ± 0.161
0.516GlnTyr: 0.516 ± 0.175
0.0GlnXaa: 0.0 ± 0.0
Arg
5.676ArgAla: 5.676 ± 0.568
0.839ArgCys: 0.839 ± 0.265
3.225ArgAsp: 3.225 ± 0.386
4.515ArgGlu: 4.515 ± 0.601
2.0ArgPhe: 2.0 ± 0.422
5.547ArgGly: 5.547 ± 0.715
1.161ArgHis: 1.161 ± 0.266
2.774ArgIle: 2.774 ± 0.468
3.29ArgLys: 3.29 ± 0.539
5.934ArgLeu: 5.934 ± 0.64
2.129ArgMet: 2.129 ± 0.313
2.387ArgAsn: 2.387 ± 0.437
2.838ArgPro: 2.838 ± 0.468
1.742ArgGln: 1.742 ± 0.294
5.547ArgArg: 5.547 ± 0.803
3.354ArgSer: 3.354 ± 0.43
2.903ArgThr: 2.903 ± 0.55
5.096ArgVal: 5.096 ± 0.561
1.097ArgTrp: 1.097 ± 0.254
1.613ArgTyr: 1.613 ± 0.286
0.0ArgXaa: 0.0 ± 0.0
Ser
6.708SerAla: 6.708 ± 0.705
0.516SerCys: 0.516 ± 0.207
3.999SerAsp: 3.999 ± 0.469
4.064SerGlu: 4.064 ± 0.461
2.322SerPhe: 2.322 ± 0.483
5.999SerGly: 5.999 ± 0.646
1.613SerHis: 1.613 ± 0.28
2.774SerIle: 2.774 ± 0.412
2.0SerLys: 2.0 ± 0.313
5.031SerLeu: 5.031 ± 0.566
1.161SerMet: 1.161 ± 0.24
2.129SerAsn: 2.129 ± 0.379
2.903SerPro: 2.903 ± 0.438
1.806SerGln: 1.806 ± 0.3
3.483SerArg: 3.483 ± 0.459
3.741SerSer: 3.741 ± 0.548
3.354SerThr: 3.354 ± 0.447
4.515SerVal: 4.515 ± 0.517
1.29SerTrp: 1.29 ± 0.312
1.226SerTyr: 1.226 ± 0.302
0.0SerXaa: 0.0 ± 0.0
Thr
6.063ThrAla: 6.063 ± 0.593
0.194ThrCys: 0.194 ± 0.106
3.999ThrAsp: 3.999 ± 0.464
3.999ThrGlu: 3.999 ± 0.52
2.258ThrPhe: 2.258 ± 0.41
6.708ThrGly: 6.708 ± 0.633
1.161ThrHis: 1.161 ± 0.313
2.967ThrIle: 2.967 ± 0.53
2.645ThrLys: 2.645 ± 0.396
5.934ThrLeu: 5.934 ± 0.608
0.839ThrMet: 0.839 ± 0.226
1.871ThrAsn: 1.871 ± 0.341
3.806ThrPro: 3.806 ± 0.389
1.677ThrGln: 1.677 ± 0.324
3.419ThrArg: 3.419 ± 0.619
3.419ThrSer: 3.419 ± 0.61
4.064ThrThr: 4.064 ± 0.513
5.031ThrVal: 5.031 ± 0.553
1.161ThrTrp: 1.161 ± 0.272
1.806ThrTyr: 1.806 ± 0.355
0.0ThrXaa: 0.0 ± 0.0
Val
7.224ValAla: 7.224 ± 0.819
0.452ValCys: 0.452 ± 0.141
5.16ValAsp: 5.16 ± 0.663
5.225ValGlu: 5.225 ± 0.575
2.58ValPhe: 2.58 ± 0.399
5.225ValGly: 5.225 ± 0.792
1.484ValHis: 1.484 ± 0.269
3.29ValIle: 3.29 ± 0.482
2.967ValLys: 2.967 ± 0.506
5.354ValLeu: 5.354 ± 0.585
1.097ValMet: 1.097 ± 0.289
2.387ValAsn: 2.387 ± 0.316
3.999ValPro: 3.999 ± 0.479
2.064ValGln: 2.064 ± 0.402
5.483ValArg: 5.483 ± 0.709
4.644ValSer: 4.644 ± 0.496
5.547ValThr: 5.547 ± 0.644
5.225ValVal: 5.225 ± 0.725
1.29ValTrp: 1.29 ± 0.31
2.322ValTyr: 2.322 ± 0.403
0.0ValXaa: 0.0 ± 0.0
Trp
1.484TrpAla: 1.484 ± 0.331
0.194TrpCys: 0.194 ± 0.097
1.355TrpAsp: 1.355 ± 0.275
1.097TrpGlu: 1.097 ± 0.242
0.968TrpPhe: 0.968 ± 0.247
1.742TrpGly: 1.742 ± 0.301
0.387TrpHis: 0.387 ± 0.163
1.226TrpIle: 1.226 ± 0.249
0.387TrpLys: 0.387 ± 0.227
2.064TrpLeu: 2.064 ± 0.339
0.387TrpMet: 0.387 ± 0.158
0.452TrpAsn: 0.452 ± 0.149
0.903TrpPro: 0.903 ± 0.274
0.903TrpGln: 0.903 ± 0.223
1.032TrpArg: 1.032 ± 0.265
1.032TrpSer: 1.032 ± 0.256
1.742TrpThr: 1.742 ± 0.326
1.935TrpVal: 1.935 ± 0.302
0.516TrpTrp: 0.516 ± 0.236
0.452TrpTyr: 0.452 ± 0.208
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.871TyrAla: 1.871 ± 0.357
0.452TyrCys: 0.452 ± 0.184
1.355TyrAsp: 1.355 ± 0.369
2.387TyrGlu: 2.387 ± 0.405
0.516TyrPhe: 0.516 ± 0.144
2.58TyrGly: 2.58 ± 0.433
0.71TyrHis: 0.71 ± 0.194
1.484TyrIle: 1.484 ± 0.328
0.903TyrLys: 0.903 ± 0.177
2.838TyrLeu: 2.838 ± 0.375
0.581TyrMet: 0.581 ± 0.143
1.226TyrAsn: 1.226 ± 0.253
1.419TyrPro: 1.419 ± 0.293
1.097TyrGln: 1.097 ± 0.274
2.58TyrArg: 2.58 ± 0.341
1.742TyrSer: 1.742 ± 0.323
2.193TyrThr: 2.193 ± 0.399
1.871TyrVal: 1.871 ± 0.346
0.387TyrTrp: 0.387 ± 0.134
0.71TyrTyr: 0.71 ± 0.248
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 86 proteins (15504 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski