Amino acid dipepetide frequency for Peptoniphilus sp. oral taxon 386 str. F0131

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.793AlaAla: 3.793 ± 0.129
0.601AlaCys: 0.601 ± 0.041
3.069AlaAsp: 3.069 ± 0.078
3.685AlaGlu: 3.685 ± 0.096
2.508AlaPhe: 2.508 ± 0.081
3.768AlaGly: 3.768 ± 0.106
0.856AlaHis: 0.856 ± 0.047
5.666AlaIle: 5.666 ± 0.119
5.053AlaLys: 5.053 ± 0.103
5.554AlaLeu: 5.554 ± 0.131
1.734AlaMet: 1.734 ± 0.068
2.767AlaAsn: 2.767 ± 0.077
1.573AlaPro: 1.573 ± 0.071
1.513AlaGln: 1.513 ± 0.058
2.11AlaArg: 2.11 ± 0.08
3.196AlaSer: 3.196 ± 0.083
2.986AlaThr: 2.986 ± 0.107
3.987AlaVal: 3.987 ± 0.093
0.304AlaTrp: 0.304 ± 0.024
2.027AlaTyr: 2.027 ± 0.068
0.0AlaXaa: 0.0 ± 0.0
Cys
0.539CysAla: 0.539 ± 0.036
0.107CysCys: 0.107 ± 0.018
0.61CysAsp: 0.61 ± 0.036
0.7CysGlu: 0.7 ± 0.046
0.342CysPhe: 0.342 ± 0.027
1.064CysGly: 1.064 ± 0.05
0.183CysHis: 0.183 ± 0.019
0.883CysIle: 0.883 ± 0.05
0.708CysLys: 0.708 ± 0.039
0.691CysLeu: 0.691 ± 0.042
0.215CysMet: 0.215 ± 0.023
0.55CysAsn: 0.55 ± 0.039
0.447CysPro: 0.447 ± 0.037
0.165CysGln: 0.165 ± 0.019
0.302CysArg: 0.302 ± 0.029
0.662CysSer: 0.662 ± 0.041
0.425CysThr: 0.425 ± 0.028
0.556CysVal: 0.556 ± 0.041
0.054CysTrp: 0.054 ± 0.01
0.436CysTyr: 0.436 ± 0.029
0.0CysXaa: 0.0 ± 0.0
Asp
2.923AspAla: 2.923 ± 0.087
0.53AspCys: 0.53 ± 0.036
3.194AspAsp: 3.194 ± 0.099
5.817AspGlu: 5.817 ± 0.128
3.075AspPhe: 3.075 ± 0.09
3.88AspGly: 3.88 ± 0.113
0.563AspHis: 0.563 ± 0.035
6.095AspIle: 6.095 ± 0.14
5.145AspLys: 5.145 ± 0.111
4.937AspLeu: 4.937 ± 0.114
1.482AspMet: 1.482 ± 0.055
3.104AspAsn: 3.104 ± 0.091
1.328AspPro: 1.328 ± 0.056
0.762AspGln: 0.762 ± 0.049
2.295AspArg: 2.295 ± 0.079
3.265AspSer: 3.265 ± 0.085
2.53AspThr: 2.53 ± 0.085
3.889AspVal: 3.889 ± 0.092
0.349AspTrp: 0.349 ± 0.029
2.789AspTyr: 2.789 ± 0.092
0.0AspXaa: 0.0 ± 0.0
Glu
3.822GluAla: 3.822 ± 0.116
0.57GluCys: 0.57 ± 0.036
4.637GluAsp: 4.637 ± 0.128
6.937GluGlu: 6.937 ± 0.163
3.482GluPhe: 3.482 ± 0.077
3.545GluGly: 3.545 ± 0.102
0.986GluHis: 0.986 ± 0.052
8.354GluIle: 8.354 ± 0.154
8.533GluLys: 8.533 ± 0.176
7.427GluLeu: 7.427 ± 0.161
2.025GluMet: 2.025 ± 0.069
6.363GluAsn: 6.363 ± 0.129
1.531GluPro: 1.531 ± 0.066
1.873GluGln: 1.873 ± 0.07
2.749GluArg: 2.749 ± 0.077
3.705GluSer: 3.705 ± 0.1
3.082GluThr: 3.082 ± 0.08
4.955GluVal: 4.955 ± 0.129
0.36GluTrp: 0.36 ± 0.03
3.478GluTyr: 3.478 ± 0.097
0.0GluXaa: 0.0 ± 0.0
Phe
2.541PheAla: 2.541 ± 0.087
0.469PheCys: 0.469 ± 0.033
2.894PheAsp: 2.894 ± 0.081
3.788PheGlu: 3.788 ± 0.092
2.011PhePhe: 2.011 ± 0.073
2.979PheGly: 2.979 ± 0.08
0.503PheHis: 0.503 ± 0.036
4.336PheIle: 4.336 ± 0.113
4.034PheLys: 4.034 ± 0.121
4.367PheLeu: 4.367 ± 0.108
1.247PheMet: 1.247 ± 0.053
2.825PheAsn: 2.825 ± 0.096
1.144PhePro: 1.144 ± 0.052
0.711PheGln: 0.711 ± 0.048
1.45PheArg: 1.45 ± 0.055
3.303PheSer: 3.303 ± 0.092
2.289PheThr: 2.289 ± 0.073
2.823PheVal: 2.823 ± 0.082
0.306PheTrp: 0.306 ± 0.026
1.889PheTyr: 1.889 ± 0.067
0.0PheXaa: 0.0 ± 0.0
Gly
4.217GlyAla: 4.217 ± 0.128
0.679GlyCys: 0.679 ± 0.043
3.288GlyAsp: 3.288 ± 0.093
4.108GlyGlu: 4.108 ± 0.109
3.06GlyPhe: 3.06 ± 0.086
4.231GlyGly: 4.231 ± 0.141
0.997GlyHis: 0.997 ± 0.056
6.459GlyIle: 6.459 ± 0.133
5.462GlyLys: 5.462 ± 0.121
5.359GlyLeu: 5.359 ± 0.132
1.665GlyMet: 1.665 ± 0.07
3.464GlyAsn: 3.464 ± 0.1
1.2GlyPro: 1.2 ± 0.062
1.417GlyGln: 1.417 ± 0.062
2.445GlyArg: 2.445 ± 0.084
3.779GlySer: 3.779 ± 0.089
3.183GlyThr: 3.183 ± 0.083
4.347GlyVal: 4.347 ± 0.117
0.396GlyTrp: 0.396 ± 0.033
3.205GlyTyr: 3.205 ± 0.102
0.0GlyXaa: 0.0 ± 0.0
His
0.693HisAla: 0.693 ± 0.039
0.203HisCys: 0.203 ± 0.022
0.715HisAsp: 0.715 ± 0.04
0.796HisGlu: 0.796 ± 0.043
0.7HisPhe: 0.7 ± 0.04
0.919HisGly: 0.919 ± 0.05
0.237HisHis: 0.237 ± 0.027
1.144HisIle: 1.144 ± 0.044
0.865HisLys: 0.865 ± 0.049
1.126HisLeu: 1.126 ± 0.052
0.293HisMet: 0.293 ± 0.028
0.679HisAsn: 0.679 ± 0.04
0.577HisPro: 0.577 ± 0.038
0.337HisGln: 0.337 ± 0.028
0.514HisArg: 0.514 ± 0.034
0.818HisSer: 0.818 ± 0.044
0.659HisThr: 0.659 ± 0.042
0.72HisVal: 0.72 ± 0.041
0.11HisTrp: 0.11 ± 0.017
0.507HisTyr: 0.507 ± 0.032
0.0HisXaa: 0.0 ± 0.0
Ile
5.927IleAla: 5.927 ± 0.12
1.075IleCys: 1.075 ± 0.052
6.066IleAsp: 6.066 ± 0.14
8.104IleGlu: 8.104 ± 0.163
4.47IlePhe: 4.47 ± 0.114
6.052IleGly: 6.052 ± 0.136
1.057IleHis: 1.057 ± 0.047
9.051IleIle: 9.051 ± 0.181
8.151IleLys: 8.151 ± 0.138
9.554IleLeu: 9.554 ± 0.194
2.184IleMet: 2.184 ± 0.07
5.777IleAsn: 5.777 ± 0.149
3.118IlePro: 3.118 ± 0.092
1.964IleGln: 1.964 ± 0.07
3.341IleArg: 3.341 ± 0.096
7.36IleSer: 7.36 ± 0.147
4.599IleThr: 4.599 ± 0.102
6.45IleVal: 6.45 ± 0.148
0.474IleTrp: 0.474 ± 0.036
3.786IleTyr: 3.786 ± 0.095
0.0IleXaa: 0.0 ± 0.0
Lys
4.637LysAla: 4.637 ± 0.096
0.713LysCys: 0.713 ± 0.05
5.411LysAsp: 5.411 ± 0.122
7.375LysGlu: 7.375 ± 0.129
3.833LysPhe: 3.833 ± 0.1
4.177LysGly: 4.177 ± 0.109
0.95LysHis: 0.95 ± 0.044
9.487LysIle: 9.487 ± 0.186
8.475LysLys: 8.475 ± 0.18
8.003LysLeu: 8.003 ± 0.13
2.568LysMet: 2.568 ± 0.076
7.619LysAsn: 7.619 ± 0.186
1.817LysPro: 1.817 ± 0.065
1.9LysGln: 1.9 ± 0.065
3.2LysArg: 3.2 ± 0.083
5.426LysSer: 5.426 ± 0.126
4.228LysThr: 4.228 ± 0.104
5.377LysVal: 5.377 ± 0.125
0.494LysTrp: 0.494 ± 0.038
4.389LysTyr: 4.389 ± 0.117
0.0LysXaa: 0.0 ± 0.0
Leu
4.903LeuAla: 4.903 ± 0.128
0.854LeuCys: 0.854 ± 0.046
5.107LeuAsp: 5.107 ± 0.106
6.653LeuGlu: 6.653 ± 0.163
4.065LeuPhe: 4.065 ± 0.12
5.706LeuGly: 5.706 ± 0.134
1.006LeuHis: 1.006 ± 0.048
8.629LeuIle: 8.629 ± 0.201
9.049LeuLys: 9.049 ± 0.143
7.802LeuLeu: 7.802 ± 0.172
2.313LeuMet: 2.313 ± 0.075
6.128LeuAsn: 6.128 ± 0.13
2.677LeuPro: 2.677 ± 0.089
1.828LeuGln: 1.828 ± 0.068
3.402LeuArg: 3.402 ± 0.089
7.065LeuSer: 7.065 ± 0.147
4.275LeuThr: 4.275 ± 0.099
5.058LeuVal: 5.058 ± 0.126
0.485LeuTrp: 0.485 ± 0.036
3.332LeuTyr: 3.332 ± 0.107
0.0LeuXaa: 0.0 ± 0.0
Met
1.795MetAla: 1.795 ± 0.061
0.23MetCys: 0.23 ± 0.022
1.475MetAsp: 1.475 ± 0.053
1.859MetGlu: 1.859 ± 0.068
0.95MetPhe: 0.95 ± 0.054
1.944MetGly: 1.944 ± 0.069
0.291MetHis: 0.291 ± 0.024
2.304MetIle: 2.304 ± 0.068
2.49MetLys: 2.49 ± 0.074
2.367MetLeu: 2.367 ± 0.078
0.762MetMet: 0.762 ± 0.045
1.667MetAsn: 1.667 ± 0.066
0.876MetPro: 0.876 ± 0.044
0.675MetGln: 0.675 ± 0.035
0.936MetArg: 0.936 ± 0.047
1.761MetSer: 1.761 ± 0.064
1.269MetThr: 1.269 ± 0.059
1.406MetVal: 1.406 ± 0.065
0.136MetTrp: 0.136 ± 0.015
0.901MetTyr: 0.901 ± 0.037
0.0MetXaa: 0.0 ± 0.0
Asn
3.185AsnAla: 3.185 ± 0.086
0.59AsnCys: 0.59 ± 0.037
2.854AsnAsp: 2.854 ± 0.086
4.363AsnGlu: 4.363 ± 0.103
3.127AsnPhe: 3.127 ± 0.095
3.819AsnGly: 3.819 ± 0.116
0.749AsnHis: 0.749 ± 0.04
6.671AsnIle: 6.671 ± 0.151
5.569AsnLys: 5.569 ± 0.131
6.267AsnLeu: 6.267 ± 0.137
1.667AsnMet: 1.667 ± 0.069
3.585AsnAsn: 3.585 ± 0.124
2.043AsnPro: 2.043 ± 0.074
1.238AsnGln: 1.238 ± 0.062
2.532AsnArg: 2.532 ± 0.087
4.356AsnSer: 4.356 ± 0.123
2.926AsnThr: 2.926 ± 0.081
3.596AsnVal: 3.596 ± 0.086
0.411AsnTrp: 0.411 ± 0.038
2.888AsnTyr: 2.888 ± 0.083
0.0AsnXaa: 0.0 ± 0.0
Pro
1.526ProAla: 1.526 ± 0.072
0.23ProCys: 0.23 ± 0.026
1.511ProAsp: 1.511 ± 0.061
2.201ProGlu: 2.201 ± 0.088
1.164ProPhe: 1.164 ± 0.05
1.656ProGly: 1.656 ± 0.073
0.436ProHis: 0.436 ± 0.033
2.695ProIle: 2.695 ± 0.071
2.313ProLys: 2.313 ± 0.069
2.226ProLeu: 2.226 ± 0.083
0.807ProMet: 0.807 ± 0.043
1.515ProAsn: 1.515 ± 0.06
0.608ProPro: 0.608 ± 0.046
0.825ProGln: 0.825 ± 0.049
0.836ProArg: 0.836 ± 0.042
1.593ProSer: 1.593 ± 0.061
1.582ProThr: 1.582 ± 0.063
2.038ProVal: 2.038 ± 0.075
0.19ProTrp: 0.19 ± 0.024
1.155ProTyr: 1.155 ± 0.048
0.0ProXaa: 0.0 ± 0.0
Gln
1.249GlnAla: 1.249 ± 0.061
0.179GlnCys: 0.179 ± 0.018
1.102GlnAsp: 1.102 ± 0.052
1.421GlnGlu: 1.421 ± 0.063
0.925GlnPhe: 0.925 ± 0.051
1.363GlnGly: 1.363 ± 0.056
0.261GlnHis: 0.261 ± 0.028
2.175GlnIle: 2.175 ± 0.067
2.121GlnLys: 2.121 ± 0.086
1.853GlnLeu: 1.853 ± 0.066
0.677GlnMet: 0.677 ± 0.038
1.426GlnAsn: 1.426 ± 0.063
0.498GlnPro: 0.498 ± 0.035
0.51GlnGln: 0.51 ± 0.036
0.972GlnArg: 0.972 ± 0.046
1.314GlnSer: 1.314 ± 0.055
1.053GlnThr: 1.053 ± 0.049
1.343GlnVal: 1.343 ± 0.052
0.161GlnTrp: 0.161 ± 0.019
0.811GlnTyr: 0.811 ± 0.047
0.0GlnXaa: 0.0 ± 0.0
Arg
2.291ArgAla: 2.291 ± 0.072
0.373ArgCys: 0.373 ± 0.029
2.362ArgAsp: 2.362 ± 0.066
3.853ArgGlu: 3.853 ± 0.11
1.535ArgPhe: 1.535 ± 0.051
2.342ArgGly: 2.342 ± 0.068
0.443ArgHis: 0.443 ± 0.036
3.368ArgIle: 3.368 ± 0.084
2.986ArgLys: 2.986 ± 0.098
2.932ArgLeu: 2.932 ± 0.083
0.923ArgMet: 0.923 ± 0.06
2.101ArgAsn: 2.101 ± 0.072
1.012ArgPro: 1.012 ± 0.052
0.97ArgGln: 0.97 ± 0.048
1.553ArgArg: 1.553 ± 0.077
1.618ArgSer: 1.618 ± 0.066
1.616ArgThr: 1.616 ± 0.064
2.38ArgVal: 2.38 ± 0.071
0.177ArgTrp: 0.177 ± 0.021
1.442ArgTyr: 1.442 ± 0.062
0.0ArgXaa: 0.0 ± 0.0
Ser
3.621SerAla: 3.621 ± 0.096
0.61SerCys: 0.61 ± 0.039
3.797SerAsp: 3.797 ± 0.107
4.689SerGlu: 4.689 ± 0.108
3.08SerPhe: 3.08 ± 0.081
4.479SerGly: 4.479 ± 0.096
0.889SerHis: 0.889 ± 0.048
6.352SerIle: 6.352 ± 0.127
5.981SerLys: 5.981 ± 0.136
5.619SerLeu: 5.619 ± 0.129
1.631SerMet: 1.631 ± 0.063
3.676SerAsn: 3.676 ± 0.108
1.556SerPro: 1.556 ± 0.058
1.497SerGln: 1.497 ± 0.066
2.105SerArg: 2.105 ± 0.069
4.204SerSer: 4.204 ± 0.118
2.827SerThr: 2.827 ± 0.081
4.11SerVal: 4.11 ± 0.105
0.351SerTrp: 0.351 ± 0.027
2.823SerTyr: 2.823 ± 0.083
0.0SerXaa: 0.0 ± 0.0
Thr
2.823ThrAla: 2.823 ± 0.081
0.463ThrCys: 0.463 ± 0.036
2.789ThrAsp: 2.789 ± 0.072
3.321ThrGlu: 3.321 ± 0.101
2.11ThrPhe: 2.11 ± 0.083
3.522ThrGly: 3.522 ± 0.108
0.713ThrHis: 0.713 ± 0.04
4.575ThrIle: 4.575 ± 0.115
3.547ThrLys: 3.547 ± 0.085
4.199ThrLeu: 4.199 ± 0.107
1.178ThrMet: 1.178 ± 0.056
2.579ThrAsn: 2.579 ± 0.086
1.821ThrPro: 1.821 ± 0.082
1.106ThrGln: 1.106 ± 0.054
1.493ThrArg: 1.493 ± 0.056
2.99ThrSer: 2.99 ± 0.092
2.55ThrThr: 2.55 ± 0.085
3.764ThrVal: 3.764 ± 0.123
0.286ThrTrp: 0.286 ± 0.03
1.739ThrTyr: 1.739 ± 0.065
0.0ThrXaa: 0.0 ± 0.0
Val
3.869ValAla: 3.869 ± 0.105
0.666ValCys: 0.666 ± 0.04
4.059ValAsp: 4.059 ± 0.101
4.941ValGlu: 4.941 ± 0.11
3.001ValPhe: 3.001 ± 0.097
4.392ValGly: 4.392 ± 0.132
0.796ValHis: 0.796 ± 0.044
5.885ValIle: 5.885 ± 0.119
5.471ValLys: 5.471 ± 0.115
5.842ValLeu: 5.842 ± 0.122
1.504ValMet: 1.504 ± 0.065
3.464ValAsn: 3.464 ± 0.084
1.987ValPro: 1.987 ± 0.066
1.144ValGln: 1.144 ± 0.047
2.177ValArg: 2.177 ± 0.074
4.329ValSer: 4.329 ± 0.096
3.162ValThr: 3.162 ± 0.111
4.649ValVal: 4.649 ± 0.125
0.4ValTrp: 0.4 ± 0.035
2.369ValTyr: 2.369 ± 0.091
0.0ValXaa: 0.0 ± 0.0
Trp
0.369TrpAla: 0.369 ± 0.03
0.065TrpCys: 0.065 ± 0.013
0.329TrpAsp: 0.329 ± 0.028
0.38TrpGlu: 0.38 ± 0.03
0.226TrpPhe: 0.226 ± 0.028
0.445TrpGly: 0.445 ± 0.036
0.107TrpHis: 0.107 ± 0.017
0.55TrpIle: 0.55 ± 0.035
0.534TrpLys: 0.534 ± 0.042
0.393TrpLeu: 0.393 ± 0.033
0.197TrpMet: 0.197 ± 0.019
0.369TrpAsn: 0.369 ± 0.037
0.145TrpPro: 0.145 ± 0.02
0.154TrpGln: 0.154 ± 0.02
0.261TrpArg: 0.261 ± 0.026
0.311TrpSer: 0.311 ± 0.027
0.329TrpThr: 0.329 ± 0.036
0.244TrpVal: 0.244 ± 0.029
0.049TrpTrp: 0.049 ± 0.009
0.275TrpTyr: 0.275 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.027TyrAla: 2.027 ± 0.068
0.429TyrCys: 0.429 ± 0.03
2.684TyrAsp: 2.684 ± 0.088
3.419TyrGlu: 3.419 ± 0.101
2.246TyrPhe: 2.246 ± 0.075
2.677TyrGly: 2.677 ± 0.063
0.59TyrHis: 0.59 ± 0.038
3.882TyrIle: 3.882 ± 0.094
3.596TyrLys: 3.596 ± 0.101
3.819TyrLeu: 3.819 ± 0.099
1.021TyrMet: 1.021 ± 0.045
2.776TyrAsn: 2.776 ± 0.101
1.151TyrPro: 1.151 ± 0.054
0.825TyrGln: 0.825 ± 0.044
1.602TyrArg: 1.602 ± 0.052
2.841TyrSer: 2.841 ± 0.091
1.998TyrThr: 1.998 ± 0.085
2.416TyrVal: 2.416 ± 0.07
0.239TyrTrp: 0.239 ± 0.026
1.92TyrTyr: 1.92 ± 0.091
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1404 proteins (447445 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski