Amino acid dipepetide frequency for Sagittula stellata E-37

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
16.344AlaAla: 16.344 ± 0.14
1.203AlaCys: 1.203 ± 0.031
6.898AlaAsp: 6.898 ± 0.076
8.452AlaGlu: 8.452 ± 0.103
4.431AlaPhe: 4.431 ± 0.059
10.359AlaGly: 10.359 ± 0.097
2.336AlaHis: 2.336 ± 0.045
5.407AlaIle: 5.407 ± 0.061
3.579AlaLys: 3.579 ± 0.063
14.026AlaLeu: 14.026 ± 0.121
3.923AlaMet: 3.923 ± 0.047
2.556AlaAsn: 2.556 ± 0.043
6.058AlaPro: 6.058 ± 0.092
4.39AlaGln: 4.39 ± 0.061
9.181AlaArg: 9.181 ± 0.108
5.698AlaSer: 5.698 ± 0.064
6.138AlaThr: 6.138 ± 0.073
8.627AlaVal: 8.627 ± 0.1
1.564AlaTrp: 1.564 ± 0.034
2.538AlaTyr: 2.538 ± 0.047
0.0AlaXaa: 0.0 ± 0.0
Cys
1.152CysAla: 1.152 ± 0.027
0.116CysCys: 0.116 ± 0.008
0.626CysAsp: 0.626 ± 0.019
0.452CysGlu: 0.452 ± 0.016
0.344CysPhe: 0.344 ± 0.016
0.978CysGly: 0.978 ± 0.028
0.272CysHis: 0.272 ± 0.012
0.417CysIle: 0.417 ± 0.015
0.217CysLys: 0.217 ± 0.013
0.902CysLeu: 0.902 ± 0.029
0.177CysMet: 0.177 ± 0.013
0.227CysAsn: 0.227 ± 0.012
0.527CysPro: 0.527 ± 0.02
0.223CysGln: 0.223 ± 0.011
0.596CysArg: 0.596 ± 0.021
0.427CysSer: 0.427 ± 0.019
0.488CysThr: 0.488 ± 0.021
0.657CysVal: 0.657 ± 0.02
0.121CysTrp: 0.121 ± 0.01
0.201CysTyr: 0.201 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
7.748AspAla: 7.748 ± 0.085
0.524AspCys: 0.524 ± 0.02
3.593AspAsp: 3.593 ± 0.074
3.515AspGlu: 3.515 ± 0.05
2.303AspPhe: 2.303 ± 0.038
6.047AspGly: 6.047 ± 0.078
1.377AspHis: 1.377 ± 0.032
2.97AspIle: 2.97 ± 0.049
1.667AspLys: 1.667 ± 0.031
6.715AspLeu: 6.715 ± 0.073
1.824AspMet: 1.824 ± 0.032
1.304AspAsn: 1.304 ± 0.03
3.854AspPro: 3.854 ± 0.056
1.617AspGln: 1.617 ± 0.033
4.527AspArg: 4.527 ± 0.059
2.291AspSer: 2.291 ± 0.044
3.415AspThr: 3.415 ± 0.067
4.494AspVal: 4.494 ± 0.058
1.259AspTrp: 1.259 ± 0.031
1.53AspTyr: 1.53 ± 0.039
0.0AspXaa: 0.0 ± 0.0
Glu
8.34GluAla: 8.34 ± 0.103
0.364GluCys: 0.364 ± 0.017
3.708GluAsp: 3.708 ± 0.056
3.836GluGlu: 3.836 ± 0.059
1.665GluPhe: 1.665 ± 0.033
5.009GluGly: 5.009 ± 0.064
1.151GluHis: 1.151 ± 0.028
3.452GluIle: 3.452 ± 0.054
2.127GluLys: 2.127 ± 0.042
4.838GluLeu: 4.838 ± 0.059
1.875GluMet: 1.875 ± 0.043
1.617GluAsn: 1.617 ± 0.034
2.569GluPro: 2.569 ± 0.045
1.869GluGln: 1.869 ± 0.037
4.304GluArg: 4.304 ± 0.064
2.219GluSer: 2.219 ± 0.041
4.111GluThr: 4.111 ± 0.062
4.601GluVal: 4.601 ± 0.053
0.743GluTrp: 0.743 ± 0.023
0.995GluTyr: 0.995 ± 0.027
0.0GluXaa: 0.0 ± 0.0
Phe
4.379PheAla: 4.379 ± 0.066
0.43PheCys: 0.43 ± 0.017
2.891PheAsp: 2.891 ± 0.045
2.214PheGlu: 2.214 ± 0.039
1.44PhePhe: 1.44 ± 0.035
3.846PheGly: 3.846 ± 0.056
0.759PheHis: 0.759 ± 0.024
1.521PheIle: 1.521 ± 0.031
0.814PheLys: 0.814 ± 0.022
3.375PheLeu: 3.375 ± 0.053
0.908PheMet: 0.908 ± 0.027
0.979PheAsn: 0.979 ± 0.025
1.55PhePro: 1.55 ± 0.038
0.987PheGln: 0.987 ± 0.026
2.28PheArg: 2.28 ± 0.042
2.017PheSer: 2.017 ± 0.037
2.081PheThr: 2.081 ± 0.041
2.674PheVal: 2.674 ± 0.046
0.581PheTrp: 0.581 ± 0.02
0.848PheTyr: 0.848 ± 0.026
0.0PheXaa: 0.0 ± 0.0
Gly
10.127GlyAla: 10.127 ± 0.096
0.914GlyCys: 0.914 ± 0.026
4.977GlyAsp: 4.977 ± 0.082
4.692GlyGlu: 4.692 ± 0.061
3.677GlyPhe: 3.677 ± 0.043
7.784GlyGly: 7.784 ± 0.122
2.026GlyHis: 2.026 ± 0.041
4.445GlyIle: 4.445 ± 0.056
2.948GlyLys: 2.948 ± 0.051
9.222GlyLeu: 9.222 ± 0.087
2.708GlyMet: 2.708 ± 0.045
2.219GlyAsn: 2.219 ± 0.054
3.843GlyPro: 3.843 ± 0.052
3.174GlyGln: 3.174 ± 0.054
5.872GlyArg: 5.872 ± 0.066
4.359GlySer: 4.359 ± 0.063
5.351GlyThr: 5.351 ± 0.099
6.589GlyVal: 6.589 ± 0.077
1.503GlyTrp: 1.503 ± 0.036
2.267GlyTyr: 2.267 ± 0.04
0.0GlyXaa: 0.0 ± 0.0
His
2.401HisAla: 2.401 ± 0.042
0.231HisCys: 0.231 ± 0.012
1.366HisAsp: 1.366 ± 0.036
1.055HisGlu: 1.055 ± 0.025
0.819HisPhe: 0.819 ± 0.023
1.994HisGly: 1.994 ± 0.043
0.559HisHis: 0.559 ± 0.021
0.913HisIle: 0.913 ± 0.024
0.5HisLys: 0.5 ± 0.02
2.14HisLeu: 2.14 ± 0.048
0.581HisMet: 0.581 ± 0.021
0.412HisAsn: 0.412 ± 0.017
1.392HisPro: 1.392 ± 0.026
0.562HisGln: 0.562 ± 0.02
1.397HisArg: 1.397 ± 0.033
0.844HisSer: 0.844 ± 0.025
0.89HisThr: 0.89 ± 0.021
1.658HisVal: 1.658 ± 0.038
0.346HisTrp: 0.346 ± 0.016
0.516HisTyr: 0.516 ± 0.017
0.0HisXaa: 0.0 ± 0.0
Ile
6.637IleAla: 6.637 ± 0.075
0.572IleCys: 0.572 ± 0.02
3.425IleAsp: 3.425 ± 0.047
3.194IleGlu: 3.194 ± 0.057
1.722IlePhe: 1.722 ± 0.041
4.659IleGly: 4.659 ± 0.063
0.877IleHis: 0.877 ± 0.028
1.76IleIle: 1.76 ± 0.042
1.169IleLys: 1.169 ± 0.033
4.505IleLeu: 4.505 ± 0.064
1.02IleMet: 1.02 ± 0.028
1.195IleAsn: 1.195 ± 0.029
2.206IlePro: 2.206 ± 0.04
1.103IleGln: 1.103 ± 0.027
3.064IleArg: 3.064 ± 0.042
2.712IleSer: 2.712 ± 0.045
2.562IleThr: 2.562 ± 0.042
3.9IleVal: 3.9 ± 0.058
0.672IleTrp: 0.672 ± 0.022
1.039IleTyr: 1.039 ± 0.027
0.0IleXaa: 0.0 ± 0.0
Lys
3.861LysAla: 3.861 ± 0.054
0.193LysCys: 0.193 ± 0.011
1.764LysAsp: 1.764 ± 0.033
1.528LysGlu: 1.528 ± 0.033
0.796LysPhe: 0.796 ± 0.02
2.765LysGly: 2.765 ± 0.041
0.547LysHis: 0.547 ± 0.018
1.416LysIle: 1.416 ± 0.03
1.092LysLys: 1.092 ± 0.032
2.713LysLeu: 2.713 ± 0.047
0.812LysMet: 0.812 ± 0.022
0.696LysAsn: 0.696 ± 0.023
1.728LysPro: 1.728 ± 0.041
0.774LysGln: 0.774 ± 0.024
2.137LysArg: 2.137 ± 0.042
1.544LysSer: 1.544 ± 0.031
1.934LysThr: 1.934 ± 0.034
2.29LysVal: 2.29 ± 0.041
0.362LysTrp: 0.362 ± 0.015
0.607LysTyr: 0.607 ± 0.02
0.0LysXaa: 0.0 ± 0.0
Leu
12.666LeuAla: 12.666 ± 0.095
1.005LeuCys: 1.005 ± 0.028
6.459LeuAsp: 6.459 ± 0.064
5.311LeuGlu: 5.311 ± 0.071
3.474LeuPhe: 3.474 ± 0.06
8.436LeuGly: 8.436 ± 0.079
1.908LeuHis: 1.908 ± 0.036
4.773LeuIle: 4.773 ± 0.065
3.253LeuLys: 3.253 ± 0.046
8.777LeuLeu: 8.777 ± 0.108
2.746LeuMet: 2.746 ± 0.047
2.608LeuAsn: 2.608 ± 0.044
5.652LeuPro: 5.652 ± 0.064
2.696LeuGln: 2.696 ± 0.044
7.024LeuArg: 7.024 ± 0.077
6.542LeuSer: 6.542 ± 0.074
6.176LeuThr: 6.176 ± 0.067
7.021LeuVal: 7.021 ± 0.077
1.276LeuTrp: 1.276 ± 0.032
1.935LeuTyr: 1.935 ± 0.037
0.0LeuXaa: 0.0 ± 0.0
Met
3.592MetAla: 3.592 ± 0.052
0.199MetCys: 0.199 ± 0.012
1.549MetAsp: 1.549 ± 0.033
1.406MetGlu: 1.406 ± 0.028
0.826MetPhe: 0.826 ± 0.024
2.295MetGly: 2.295 ± 0.042
0.473MetHis: 0.473 ± 0.018
1.52MetIle: 1.52 ± 0.035
1.077MetLys: 1.077 ± 0.029
2.669MetLeu: 2.669 ± 0.043
0.819MetMet: 0.819 ± 0.026
0.879MetAsn: 0.879 ± 0.023
1.632MetPro: 1.632 ± 0.036
0.977MetGln: 0.977 ± 0.025
1.974MetArg: 1.974 ± 0.038
1.812MetSer: 1.812 ± 0.033
2.302MetThr: 2.302 ± 0.038
1.92MetVal: 1.92 ± 0.036
0.245MetTrp: 0.245 ± 0.013
0.361MetTyr: 0.361 ± 0.014
0.0MetXaa: 0.0 ± 0.0
Asn
3.196AsnAla: 3.196 ± 0.047
0.246AsnCys: 0.246 ± 0.012
1.495AsnAsp: 1.495 ± 0.04
1.134AsnGlu: 1.134 ± 0.036
0.88AsnPhe: 0.88 ± 0.025
2.435AsnGly: 2.435 ± 0.051
0.501AsnHis: 0.501 ± 0.021
1.218AsnIle: 1.218 ± 0.032
0.581AsnLys: 0.581 ± 0.021
2.326AsnLeu: 2.326 ± 0.038
0.718AsnMet: 0.718 ± 0.023
0.623AsnAsn: 0.623 ± 0.022
1.733AsnPro: 1.733 ± 0.035
0.649AsnGln: 0.649 ± 0.022
1.718AsnArg: 1.718 ± 0.037
1.047AsnSer: 1.047 ± 0.026
1.391AsnThr: 1.391 ± 0.039
1.822AsnVal: 1.822 ± 0.037
0.379AsnTrp: 0.379 ± 0.018
0.605AsnTyr: 0.605 ± 0.023
0.0AsnXaa: 0.0 ± 0.0
Pro
5.718ProAla: 5.718 ± 0.064
0.392ProCys: 0.392 ± 0.016
4.2ProAsp: 4.2 ± 0.053
4.369ProGlu: 4.369 ± 0.062
1.985ProPhe: 1.985 ± 0.039
4.756ProGly: 4.756 ± 0.068
1.09ProHis: 1.09 ± 0.029
2.031ProIle: 2.031 ± 0.037
1.621ProLys: 1.621 ± 0.032
4.687ProLeu: 4.687 ± 0.065
1.374ProMet: 1.374 ± 0.034
1.232ProAsn: 1.232 ± 0.03
2.335ProPro: 2.335 ± 0.052
1.627ProGln: 1.627 ± 0.037
2.891ProArg: 2.891 ± 0.052
2.583ProSer: 2.583 ± 0.045
2.431ProThr: 2.431 ± 0.043
4.478ProVal: 4.478 ± 0.064
0.729ProTrp: 0.729 ± 0.022
1.154ProTyr: 1.154 ± 0.027
0.0ProXaa: 0.0 ± 0.0
Gln
3.933GlnAla: 3.933 ± 0.056
0.214GlnCys: 0.214 ± 0.012
1.746GlnAsp: 1.746 ± 0.036
1.62GlnGlu: 1.62 ± 0.037
0.988GlnPhe: 0.988 ± 0.027
2.516GlnGly: 2.516 ± 0.039
0.574GlnHis: 0.574 ± 0.019
1.838GlnIle: 1.838 ± 0.036
0.982GlnLys: 0.982 ± 0.025
2.636GlnLeu: 2.636 ± 0.035
1.033GlnMet: 1.033 ± 0.026
0.828GlnAsn: 0.828 ± 0.021
1.616GlnPro: 1.616 ± 0.04
1.106GlnGln: 1.106 ± 0.042
2.095GlnArg: 2.095 ± 0.047
1.696GlnSer: 1.696 ± 0.031
1.793GlnThr: 1.793 ± 0.038
2.366GlnVal: 2.366 ± 0.037
0.382GlnTrp: 0.382 ± 0.018
0.574GlnTyr: 0.574 ± 0.018
0.0GlnXaa: 0.0 ± 0.0
Arg
8.25ArgAla: 8.25 ± 0.087
0.537ArgCys: 0.537 ± 0.019
4.484ArgAsp: 4.484 ± 0.059
3.868ArgGlu: 3.868 ± 0.053
2.774ArgPhe: 2.774 ± 0.044
4.751ArgGly: 4.751 ± 0.065
1.633ArgHis: 1.633 ± 0.043
3.791ArgIle: 3.791 ± 0.049
2.133ArgLys: 2.133 ± 0.038
7.494ArgLeu: 7.494 ± 0.082
2.068ArgMet: 2.068 ± 0.039
1.734ArgAsn: 1.734 ± 0.036
3.382ArgPro: 3.382 ± 0.047
2.345ArgGln: 2.345 ± 0.048
5.324ArgArg: 5.324 ± 0.086
3.275ArgSer: 3.275 ± 0.058
3.249ArgThr: 3.249 ± 0.044
4.884ArgVal: 4.884 ± 0.061
0.976ArgTrp: 0.976 ± 0.026
1.505ArgTyr: 1.505 ± 0.032
0.0ArgXaa: 0.0 ± 0.0
Ser
5.882SerAla: 5.882 ± 0.06
0.41SerCys: 0.41 ± 0.019
3.333SerAsp: 3.333 ± 0.049
2.926SerGlu: 2.926 ± 0.045
2.096SerPhe: 2.096 ± 0.039
5.62SerGly: 5.62 ± 0.076
1.065SerHis: 1.065 ± 0.028
2.321SerIle: 2.321 ± 0.043
1.389SerLys: 1.389 ± 0.029
4.909SerLeu: 4.909 ± 0.054
1.423SerMet: 1.423 ± 0.031
1.254SerAsn: 1.254 ± 0.029
2.469SerPro: 2.469 ± 0.046
1.491SerGln: 1.491 ± 0.032
3.234SerArg: 3.234 ± 0.053
2.564SerSer: 2.564 ± 0.053
2.532SerThr: 2.532 ± 0.041
3.87SerVal: 3.87 ± 0.049
0.706SerTrp: 0.706 ± 0.026
1.207SerTyr: 1.207 ± 0.029
0.0SerXaa: 0.0 ± 0.0
Thr
6.494ThrAla: 6.494 ± 0.074
0.522ThrCys: 0.522 ± 0.018
3.422ThrAsp: 3.422 ± 0.06
3.268ThrGlu: 3.268 ± 0.046
2.119ThrPhe: 2.119 ± 0.037
5.821ThrGly: 5.821 ± 0.075
1.203ThrHis: 1.203 ± 0.031
2.593ThrIle: 2.593 ± 0.042
1.281ThrLys: 1.281 ± 0.03
6.309ThrLeu: 6.309 ± 0.082
1.364ThrMet: 1.364 ± 0.033
1.311ThrAsn: 1.311 ± 0.039
3.463ThrPro: 3.463 ± 0.049
1.604ThrGln: 1.604 ± 0.033
3.718ThrArg: 3.718 ± 0.058
2.844ThrSer: 2.844 ± 0.05
2.93ThrThr: 2.93 ± 0.056
4.616ThrVal: 4.616 ± 0.079
0.781ThrTrp: 0.781 ± 0.023
1.249ThrTyr: 1.249 ± 0.036
0.0ThrXaa: 0.0 ± 0.0
Val
9.162ValAla: 9.162 ± 0.101
0.679ValCys: 0.679 ± 0.02
4.279ValAsp: 4.279 ± 0.06
4.575ValGlu: 4.575 ± 0.059
2.837ValPhe: 2.837 ± 0.049
5.528ValGly: 5.528 ± 0.064
1.397ValHis: 1.397 ± 0.029
4.006ValIle: 4.006 ± 0.057
2.125ValLys: 2.125 ± 0.037
7.729ValLeu: 7.729 ± 0.084
2.217ValMet: 2.217 ± 0.042
2.021ValAsn: 2.021 ± 0.04
3.881ValPro: 3.881 ± 0.056
2.125ValGln: 2.125 ± 0.035
4.487ValArg: 4.487 ± 0.058
4.342ValSer: 4.342 ± 0.048
5.09ValThr: 5.09 ± 0.07
5.916ValVal: 5.916 ± 0.08
1.0ValTrp: 1.0 ± 0.029
1.494ValTyr: 1.494 ± 0.029
0.0ValXaa: 0.0 ± 0.0
Trp
1.368TrpAla: 1.368 ± 0.035
0.153TrpCys: 0.153 ± 0.01
0.767TrpAsp: 0.767 ± 0.023
0.706TrpGlu: 0.706 ± 0.021
0.542TrpPhe: 0.542 ± 0.018
1.035TrpGly: 1.035 ± 0.027
0.358TrpHis: 0.358 ± 0.016
0.694TrpIle: 0.694 ± 0.021
0.448TrpLys: 0.448 ± 0.018
1.643TrpLeu: 1.643 ± 0.037
0.451TrpMet: 0.451 ± 0.019
0.436TrpAsn: 0.436 ± 0.016
0.75TrpPro: 0.75 ± 0.025
0.605TrpGln: 0.605 ± 0.022
1.111TrpArg: 1.111 ± 0.031
0.826TrpSer: 0.826 ± 0.027
0.861TrpThr: 0.861 ± 0.026
0.935TrpVal: 0.935 ± 0.026
0.22TrpTrp: 0.22 ± 0.012
0.288TrpTyr: 0.288 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.455TyrAla: 2.455 ± 0.036
0.216TyrCys: 0.216 ± 0.013
1.593TyrAsp: 1.593 ± 0.042
1.274TyrGlu: 1.274 ± 0.034
0.857TyrPhe: 0.857 ± 0.029
2.063TyrGly: 2.063 ± 0.037
0.469TyrHis: 0.469 ± 0.018
0.904TyrIle: 0.904 ± 0.025
0.554TyrLys: 0.554 ± 0.019
2.126TyrLeu: 2.126 ± 0.041
0.486TyrMet: 0.486 ± 0.018
0.568TyrAsn: 0.568 ± 0.021
1.044TyrPro: 1.044 ± 0.028
0.611TyrGln: 0.611 ± 0.018
1.522TyrArg: 1.522 ± 0.03
1.059TyrSer: 1.059 ± 0.033
1.188TyrThr: 1.188 ± 0.028
1.574TyrVal: 1.574 ± 0.034
0.352TyrTrp: 0.352 ± 0.013
0.548TyrTyr: 0.548 ± 0.023
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5025 proteins (1542756 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski