Amino acid dipepetide frequency for Massilimicrobiota sp. An134

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.033AlaAla: 3.033 ± 0.082
0.916AlaCys: 0.916 ± 0.037
2.534AlaAsp: 2.534 ± 0.054
2.25AlaGlu: 2.25 ± 0.064
2.7AlaPhe: 2.7 ± 0.06
3.61AlaGly: 3.61 ± 0.082
1.387AlaHis: 1.387 ± 0.049
5.363AlaIle: 5.363 ± 0.097
4.53AlaLys: 4.53 ± 0.091
6.216AlaLeu: 6.216 ± 0.103
1.987AlaMet: 1.987 ± 0.053
2.377AlaAsn: 2.377 ± 0.062
1.441AlaPro: 1.441 ± 0.048
2.203AlaGln: 2.203 ± 0.064
1.991AlaArg: 1.991 ± 0.061
3.55AlaSer: 3.55 ± 0.07
2.953AlaThr: 2.953 ± 0.068
3.573AlaVal: 3.573 ± 0.082
0.383AlaTrp: 0.383 ± 0.023
2.71AlaTyr: 2.71 ± 0.062
0.0AlaXaa: 0.0 ± 0.0
Cys
0.737CysAla: 0.737 ± 0.033
0.242CysCys: 0.242 ± 0.018
0.899CysAsp: 0.899 ± 0.036
0.754CysGlu: 0.754 ± 0.03
0.771CysPhe: 0.771 ± 0.036
1.078CysGly: 1.078 ± 0.04
0.506CysHis: 0.506 ± 0.028
1.365CysIle: 1.365 ± 0.045
0.607CysLys: 0.607 ± 0.032
1.47CysLeu: 1.47 ± 0.046
0.402CysMet: 0.402 ± 0.023
0.455CysAsn: 0.455 ± 0.029
0.554CysPro: 0.554 ± 0.028
0.86CysGln: 0.86 ± 0.032
0.427CysArg: 0.427 ± 0.023
0.783CysSer: 0.783 ± 0.03
0.561CysThr: 0.561 ± 0.029
0.915CysVal: 0.915 ± 0.037
0.082CysTrp: 0.082 ± 0.01
0.71CysTyr: 0.71 ± 0.032
0.0CysXaa: 0.0 ± 0.0
Asp
3.111AspAla: 3.111 ± 0.072
0.767AspCys: 0.767 ± 0.04
3.816AspAsp: 3.816 ± 0.077
5.228AspGlu: 5.228 ± 0.094
3.068AspPhe: 3.068 ± 0.067
3.679AspGly: 3.679 ± 0.082
1.505AspHis: 1.505 ± 0.052
6.073AspIle: 6.073 ± 0.087
3.697AspLys: 3.697 ± 0.068
5.541AspLeu: 5.541 ± 0.079
2.017AspMet: 2.017 ± 0.051
2.551AspAsn: 2.551 ± 0.062
1.508AspPro: 1.508 ± 0.052
2.461AspGln: 2.461 ± 0.059
1.762AspArg: 1.762 ± 0.048
2.909AspSer: 2.909 ± 0.07
2.672AspThr: 2.672 ± 0.065
4.13AspVal: 4.13 ± 0.076
0.461AspTrp: 0.461 ± 0.027
3.65AspTyr: 3.65 ± 0.079
0.0AspXaa: 0.0 ± 0.0
Glu
4.023GluAla: 4.023 ± 0.083
0.797GluCys: 0.797 ± 0.032
4.245GluAsp: 4.245 ± 0.084
5.336GluGlu: 5.336 ± 0.112
2.631GluPhe: 2.631 ± 0.058
3.345GluGly: 3.345 ± 0.079
1.501GluHis: 1.501 ± 0.048
5.676GluIle: 5.676 ± 0.09
6.296GluLys: 6.296 ± 0.1
6.196GluLeu: 6.196 ± 0.091
2.372GluMet: 2.372 ± 0.057
4.328GluAsn: 4.328 ± 0.077
1.398GluPro: 1.398 ± 0.044
2.428GluGln: 2.428 ± 0.061
2.46GluArg: 2.46 ± 0.059
3.255GluSer: 3.255 ± 0.076
3.254GluThr: 3.254 ± 0.066
4.198GluVal: 4.198 ± 0.077
0.52GluTrp: 0.52 ± 0.029
3.234GluTyr: 3.234 ± 0.073
0.0GluXaa: 0.0 ± 0.0
Phe
2.279PheAla: 2.279 ± 0.059
0.596PheCys: 0.596 ± 0.03
3.119PheAsp: 3.119 ± 0.064
3.076PheGlu: 3.076 ± 0.07
2.132PhePhe: 2.132 ± 0.07
2.631PheGly: 2.631 ± 0.065
1.331PheHis: 1.331 ± 0.039
4.408PheIle: 4.408 ± 0.097
2.599PheLys: 2.599 ± 0.057
4.155PheLeu: 4.155 ± 0.095
1.331PheMet: 1.331 ± 0.04
1.898PheAsn: 1.898 ± 0.052
1.298PhePro: 1.298 ± 0.041
2.07PheGln: 2.07 ± 0.062
1.157PheArg: 1.157 ± 0.04
2.751PheSer: 2.751 ± 0.073
2.061PheThr: 2.061 ± 0.059
3.077PheVal: 3.077 ± 0.063
0.3PheTrp: 0.3 ± 0.02
2.205PheTyr: 2.205 ± 0.062
0.0PheXaa: 0.0 ± 0.0
Gly
3.585GlyAla: 3.585 ± 0.081
1.016GlyCys: 1.016 ± 0.038
2.951GlyAsp: 2.951 ± 0.068
3.549GlyGlu: 3.549 ± 0.063
2.871GlyPhe: 2.871 ± 0.061
3.654GlyGly: 3.654 ± 0.085
1.545GlyHis: 1.545 ± 0.045
5.717GlyIle: 5.717 ± 0.091
4.43GlyLys: 4.43 ± 0.083
5.222GlyLeu: 5.222 ± 0.09
1.907GlyMet: 1.907 ± 0.058
2.465GlyAsn: 2.465 ± 0.069
1.14GlyPro: 1.14 ± 0.047
2.248GlyGln: 2.248 ± 0.063
2.009GlyArg: 2.009 ± 0.057
3.101GlySer: 3.101 ± 0.082
3.278GlyThr: 3.278 ± 0.08
4.064GlyVal: 4.064 ± 0.084
0.478GlyTrp: 0.478 ± 0.023
3.273GlyTyr: 3.273 ± 0.081
0.0GlyXaa: 0.0 ± 0.0
His
1.156HisAla: 1.156 ± 0.041
0.473HisCys: 0.473 ± 0.027
1.628HisAsp: 1.628 ± 0.044
1.608HisGlu: 1.608 ± 0.047
1.362HisPhe: 1.362 ± 0.049
1.481HisGly: 1.481 ± 0.046
1.134HisHis: 1.134 ± 0.041
2.599HisIle: 2.599 ± 0.056
1.377HisLys: 1.377 ± 0.044
2.572HisLeu: 2.572 ± 0.072
0.732HisMet: 0.732 ± 0.034
0.983HisAsn: 0.983 ± 0.04
1.016HisPro: 1.016 ± 0.041
1.61HisGln: 1.61 ± 0.054
0.856HisArg: 0.856 ± 0.035
1.252HisSer: 1.252 ± 0.043
1.125HisThr: 1.125 ± 0.042
1.616HisVal: 1.616 ± 0.046
0.165HisTrp: 0.165 ± 0.016
1.438HisTyr: 1.438 ± 0.05
0.0HisXaa: 0.0 ± 0.0
Ile
5.514IleAla: 5.514 ± 0.088
1.524IleCys: 1.524 ± 0.043
6.092IleAsp: 6.092 ± 0.093
6.448IleGlu: 6.448 ± 0.09
3.795IlePhe: 3.795 ± 0.093
5.375IleGly: 5.375 ± 0.103
2.378IleHis: 2.378 ± 0.055
7.297IleIle: 7.297 ± 0.128
5.595IleLys: 5.595 ± 0.09
8.127IleLeu: 8.127 ± 0.119
2.335IleMet: 2.335 ± 0.063
3.97IleAsn: 3.97 ± 0.079
3.277IlePro: 3.277 ± 0.075
4.281IleGln: 4.281 ± 0.094
2.768IleArg: 2.768 ± 0.057
5.383IleSer: 5.383 ± 0.088
4.088IleThr: 4.088 ± 0.078
6.013IleVal: 6.013 ± 0.095
0.528IleTrp: 0.528 ± 0.03
4.086IleTyr: 4.086 ± 0.07
0.0IleXaa: 0.0 ± 0.0
Lys
4.442LysAla: 4.442 ± 0.098
0.724LysCys: 0.724 ± 0.033
5.236LysAsp: 5.236 ± 0.08
6.969LysGlu: 6.969 ± 0.11
1.88LysPhe: 1.88 ± 0.053
3.857LysGly: 3.857 ± 0.076
1.682LysHis: 1.682 ± 0.049
5.857LysIle: 5.857 ± 0.092
7.045LysLys: 7.045 ± 0.121
5.334LysLeu: 5.334 ± 0.096
2.485LysMet: 2.485 ± 0.061
4.273LysAsn: 4.273 ± 0.088
1.923LysPro: 1.923 ± 0.052
3.298LysGln: 3.298 ± 0.08
3.069LysArg: 3.069 ± 0.079
3.546LysSer: 3.546 ± 0.075
3.96LysThr: 3.96 ± 0.073
4.566LysVal: 4.566 ± 0.094
0.581LysTrp: 0.581 ± 0.029
3.498LysTyr: 3.498 ± 0.07
0.0LysXaa: 0.0 ± 0.0
Leu
5.457LeuAla: 5.457 ± 0.087
1.466LeuCys: 1.466 ± 0.047
5.743LeuAsp: 5.743 ± 0.098
6.176LeuGlu: 6.176 ± 0.094
4.297LeuPhe: 4.297 ± 0.1
5.46LeuGly: 5.46 ± 0.095
1.956LeuHis: 1.956 ± 0.055
7.436LeuIle: 7.436 ± 0.098
7.964LeuLys: 7.964 ± 0.111
8.928LeuLeu: 8.928 ± 0.129
2.852LeuMet: 2.852 ± 0.07
4.777LeuAsn: 4.777 ± 0.083
3.119LeuPro: 3.119 ± 0.069
3.433LeuGln: 3.433 ± 0.077
3.156LeuArg: 3.156 ± 0.071
6.74LeuSer: 6.74 ± 0.106
5.063LeuThr: 5.063 ± 0.093
5.123LeuVal: 5.123 ± 0.091
0.647LeuTrp: 0.647 ± 0.03
4.023LeuTyr: 4.023 ± 0.089
0.0LeuXaa: 0.0 ± 0.0
Met
1.8MetAla: 1.8 ± 0.053
0.382MetCys: 0.382 ± 0.022
1.761MetAsp: 1.761 ± 0.05
1.881MetGlu: 1.881 ± 0.049
1.177MetPhe: 1.177 ± 0.04
1.731MetGly: 1.731 ± 0.045
0.532MetHis: 0.532 ± 0.025
3.167MetIle: 3.167 ± 0.071
3.214MetLys: 3.214 ± 0.064
2.523MetLeu: 2.523 ± 0.06
1.15MetMet: 1.15 ± 0.044
2.069MetAsn: 2.069 ± 0.06
0.876MetPro: 0.876 ± 0.029
1.122MetGln: 1.122 ± 0.038
1.066MetArg: 1.066 ± 0.038
1.959MetSer: 1.959 ± 0.055
1.773MetThr: 1.773 ± 0.05
1.607MetVal: 1.607 ± 0.049
0.158MetTrp: 0.158 ± 0.015
1.095MetTyr: 1.095 ± 0.039
0.0MetXaa: 0.0 ± 0.0
Asn
2.751AsnAla: 2.751 ± 0.07
0.592AsnCys: 0.592 ± 0.032
3.133AsnAsp: 3.133 ± 0.072
3.581AsnGlu: 3.581 ± 0.065
1.646AsnPhe: 1.646 ± 0.051
3.182AsnGly: 3.182 ± 0.075
1.535AsnHis: 1.535 ± 0.049
4.372AsnIle: 4.372 ± 0.093
3.4AsnLys: 3.4 ± 0.072
3.545AsnLeu: 3.545 ± 0.074
1.422AsnMet: 1.422 ± 0.046
2.368AsnAsn: 2.368 ± 0.063
1.903AsnPro: 1.903 ± 0.053
2.903AsnGln: 2.903 ± 0.067
1.695AsnArg: 1.695 ± 0.048
2.335AsnSer: 2.335 ± 0.06
2.195AsnThr: 2.195 ± 0.059
2.973AsnVal: 2.973 ± 0.061
0.36AsnTrp: 0.36 ± 0.026
2.228AsnTyr: 2.228 ± 0.054
0.0AsnXaa: 0.0 ± 0.0
Pro
1.486ProAla: 1.486 ± 0.05
0.375ProCys: 0.375 ± 0.022
1.705ProAsp: 1.705 ± 0.051
2.045ProGlu: 2.045 ± 0.054
1.571ProPhe: 1.571 ± 0.049
1.457ProGly: 1.457 ± 0.048
0.882ProHis: 0.882 ± 0.035
2.57ProIle: 2.57 ± 0.064
1.643ProLys: 1.643 ± 0.049
2.874ProLeu: 2.874 ± 0.073
0.868ProMet: 0.868 ± 0.034
1.149ProAsn: 1.149 ± 0.046
0.526ProPro: 0.526 ± 0.034
1.429ProGln: 1.429 ± 0.046
0.975ProArg: 0.975 ± 0.037
1.754ProSer: 1.754 ± 0.051
1.695ProThr: 1.695 ± 0.042
2.169ProVal: 2.169 ± 0.053
0.234ProTrp: 0.234 ± 0.018
1.768ProTyr: 1.768 ± 0.054
0.0ProXaa: 0.0 ± 0.0
Gln
2.436GlnAla: 2.436 ± 0.064
0.549GlnCys: 0.549 ± 0.029
2.681GlnAsp: 2.681 ± 0.058
3.135GlnGlu: 3.135 ± 0.078
1.742GlnPhe: 1.742 ± 0.051
2.159GlnGly: 2.159 ± 0.058
1.019GlnHis: 1.019 ± 0.04
3.628GlnIle: 3.628 ± 0.074
4.194GlnLys: 4.194 ± 0.092
4.151GlnLeu: 4.151 ± 0.082
1.521GlnMet: 1.521 ± 0.05
2.733GlnAsn: 2.733 ± 0.068
1.11GlnPro: 1.11 ± 0.037
2.214GlnGln: 2.214 ± 0.076
1.75GlnArg: 1.75 ± 0.051
2.584GlnSer: 2.584 ± 0.056
2.242GlnThr: 2.242 ± 0.064
2.422GlnVal: 2.422 ± 0.066
0.415GlnTrp: 0.415 ± 0.024
2.475GlnTyr: 2.475 ± 0.059
0.0GlnXaa: 0.0 ± 0.0
Arg
1.59ArgAla: 1.59 ± 0.046
0.455ArgCys: 0.455 ± 0.027
1.814ArgAsp: 1.814 ± 0.045
2.372ArgGlu: 2.372 ± 0.06
1.552ArgPhe: 1.552 ± 0.046
1.8ArgGly: 1.8 ± 0.054
0.959ArgHis: 0.959 ± 0.034
3.104ArgIle: 3.104 ± 0.071
2.704ArgLys: 2.704 ± 0.067
3.354ArgLeu: 3.354 ± 0.071
1.173ArgMet: 1.173 ± 0.04
1.725ArgAsn: 1.725 ± 0.048
0.957ArgPro: 0.957 ± 0.041
1.628ArgGln: 1.628 ± 0.05
1.456ArgArg: 1.456 ± 0.047
1.596ArgSer: 1.596 ± 0.049
1.572ArgThr: 1.572 ± 0.045
2.139ArgVal: 2.139 ± 0.059
0.262ArgTrp: 0.262 ± 0.021
2.061ArgTyr: 2.061 ± 0.06
0.0ArgXaa: 0.0 ± 0.0
Ser
2.927SerAla: 2.927 ± 0.067
0.715SerCys: 0.715 ± 0.035
2.978SerAsp: 2.978 ± 0.08
2.95SerGlu: 2.95 ± 0.062
3.186SerPhe: 3.186 ± 0.072
3.478SerGly: 3.478 ± 0.076
1.702SerHis: 1.702 ± 0.045
5.127SerIle: 5.127 ± 0.077
3.745SerLys: 3.745 ± 0.082
6.582SerLeu: 6.582 ± 0.102
1.697SerMet: 1.697 ± 0.048
2.224SerAsn: 2.224 ± 0.064
1.543SerPro: 1.543 ± 0.046
3.269SerGln: 3.269 ± 0.075
2.118SerArg: 2.118 ± 0.057
4.017SerSer: 4.017 ± 0.09
3.012SerThr: 3.012 ± 0.072
3.439SerVal: 3.439 ± 0.078
0.459SerTrp: 0.459 ± 0.028
2.812SerTyr: 2.812 ± 0.062
0.0SerXaa: 0.0 ± 0.0
Thr
2.658ThrAla: 2.658 ± 0.07
0.68ThrCys: 0.68 ± 0.031
2.476ThrAsp: 2.476 ± 0.062
2.252ThrGlu: 2.252 ± 0.054
2.526ThrPhe: 2.526 ± 0.062
3.338ThrGly: 3.338 ± 0.087
1.423ThrHis: 1.423 ± 0.046
4.686ThrIle: 4.686 ± 0.098
3.309ThrLys: 3.309 ± 0.074
5.394ThrLeu: 5.394 ± 0.091
1.419ThrMet: 1.419 ± 0.04
2.2ThrAsn: 2.2 ± 0.062
1.919ThrPro: 1.919 ± 0.05
1.947ThrGln: 1.947 ± 0.053
1.604ThrArg: 1.604 ± 0.049
3.249ThrSer: 3.249 ± 0.069
2.797ThrThr: 2.797 ± 0.086
3.36ThrVal: 3.36 ± 0.078
0.38ThrTrp: 0.38 ± 0.023
2.609ThrTyr: 2.609 ± 0.07
0.0ThrXaa: 0.0 ± 0.0
Val
3.7ValAla: 3.7 ± 0.075
1.07ValCys: 1.07 ± 0.04
4.033ValAsp: 4.033 ± 0.086
4.272ValGlu: 4.272 ± 0.081
2.843ValPhe: 2.843 ± 0.077
3.804ValGly: 3.804 ± 0.072
1.328ValHis: 1.328 ± 0.049
5.769ValIle: 5.769 ± 0.102
4.495ValLys: 4.495 ± 0.08
6.089ValLeu: 6.089 ± 0.099
1.831ValMet: 1.831 ± 0.049
2.981ValAsn: 2.981 ± 0.054
1.841ValPro: 1.841 ± 0.05
2.192ValGln: 2.192 ± 0.059
1.855ValArg: 1.855 ± 0.05
4.119ValSer: 4.119 ± 0.075
3.191ValThr: 3.191 ± 0.076
4.49ValVal: 4.49 ± 0.093
0.424ValTrp: 0.424 ± 0.022
2.826ValTyr: 2.826 ± 0.069
0.0ValXaa: 0.0 ± 0.0
Trp
0.379TrpAla: 0.379 ± 0.023
0.13TrpCys: 0.13 ± 0.012
0.418TrpAsp: 0.418 ± 0.025
0.367TrpGlu: 0.367 ± 0.022
0.363TrpPhe: 0.363 ± 0.024
0.528TrpGly: 0.528 ± 0.03
0.169TrpHis: 0.169 ± 0.015
0.719TrpIle: 0.719 ± 0.033
0.528TrpLys: 0.528 ± 0.03
0.759TrpLeu: 0.759 ± 0.032
0.202TrpMet: 0.202 ± 0.016
0.447TrpAsn: 0.447 ± 0.029
0.118TrpPro: 0.118 ± 0.013
0.325TrpGln: 0.325 ± 0.021
0.238TrpArg: 0.238 ± 0.018
0.391TrpSer: 0.391 ± 0.024
0.321TrpThr: 0.321 ± 0.023
0.411TrpVal: 0.411 ± 0.023
0.098TrpTrp: 0.098 ± 0.012
0.378TrpTyr: 0.378 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.645TyrAla: 2.645 ± 0.058
0.707TyrCys: 0.707 ± 0.038
3.342TyrAsp: 3.342 ± 0.078
3.246TyrGlu: 3.246 ± 0.071
2.362TyrPhe: 2.362 ± 0.059
2.858TyrGly: 2.858 ± 0.064
1.707TyrHis: 1.707 ± 0.057
3.941TyrIle: 3.941 ± 0.074
2.852TyrLys: 2.852 ± 0.068
4.783TyrLeu: 4.783 ± 0.085
1.339TyrMet: 1.339 ± 0.042
2.145TyrAsn: 2.145 ± 0.065
1.709TyrPro: 1.709 ± 0.049
3.238TyrGln: 3.238 ± 0.079
1.86TyrArg: 1.86 ± 0.05
2.705TyrSer: 2.705 ± 0.064
2.414TyrThr: 2.414 ± 0.061
2.868TyrVal: 2.868 ± 0.063
0.354TyrTrp: 0.354 ± 0.024
2.448TyrTyr: 2.448 ± 0.08
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2537 proteins (746771 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski