Amino acid dipepetide frequency for Pacificimonas flava

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.791AlaAla: 20.791 ± 0.239	1.028AlaCys: 1.028 ± 0.032	8.063AlaAsp: 8.063 ± 0.097	8.905AlaGlu: 8.905 ± 0.104	4.263AlaPhe: 4.263 ± 0.075	12.034AlaGly: 12.034 ± 0.133	2.22AlaHis: 2.22 ± 0.042	5.806AlaIle: 5.806 ± 0.082	3.578AlaLys: 3.578 ± 0.07	13.851AlaLeu: 13.851 ± 0.156	3.569AlaMet: 3.569 ± 0.06	2.966AlaAsn: 2.966 ± 0.055	6.175AlaPro: 6.175 ± 0.09	3.977AlaGln: 3.977 ± 0.067	9.664AlaArg: 9.664 ± 0.118	6.424AlaSer: 6.424 ± 0.089	5.152AlaThr: 5.152 ± 0.083	8.579AlaVal: 8.579 ± 0.115	1.395AlaTrp: 1.395 ± 0.041	2.618AlaTyr: 2.618 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	0.925CysAla: 0.925 ± 0.028	0.096CysCys: 0.096 ± 0.011	0.489CysAsp: 0.489 ± 0.022	0.438CysGlu: 0.438 ± 0.021	0.251CysPhe: 0.251 ± 0.017	0.837CysGly: 0.837 ± 0.033	0.187CysHis: 0.187 ± 0.016	0.332CysIle: 0.332 ± 0.02	0.132CysLys: 0.132 ± 0.012	0.656CysLeu: 0.656 ± 0.03	0.13CysMet: 0.13 ± 0.011	0.177CysAsn: 0.177 ± 0.013	0.393CysPro: 0.393 ± 0.021	0.204CysGln: 0.204 ± 0.016	0.573CysArg: 0.573 ± 0.023	0.393CysSer: 0.393 ± 0.022	0.378CysThr: 0.378 ± 0.018	0.475CysVal: 0.475 ± 0.024	0.092CysTrp: 0.092 ± 0.01	0.162CysTyr: 0.162 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.87AspAla: 7.87 ± 0.095	0.454AspCys: 0.454 ± 0.023	3.654AspAsp: 3.654 ± 0.07	4.094AspGlu: 4.094 ± 0.085	2.342AspPhe: 2.342 ± 0.06	5.653AspGly: 5.653 ± 0.1	1.182AspHis: 1.182 ± 0.041	3.32AspIle: 3.32 ± 0.067	1.475AspLys: 1.475 ± 0.044	6.505AspLeu: 6.505 ± 0.089	1.72AspMet: 1.72 ± 0.043	1.229AspAsn: 1.229 ± 0.059	3.683AspPro: 3.683 ± 0.067	1.648AspGln: 1.648 ± 0.04	4.939AspArg: 4.939 ± 0.081	2.488AspSer: 2.488 ± 0.053	2.847AspThr: 2.847 ± 0.059	4.258AspVal: 4.258 ± 0.077	1.143AspTrp: 1.143 ± 0.039	1.712AspTyr: 1.712 ± 0.048	0.0AspXaa: 0.0 ± 0.0
Glu	8.375GluAla: 8.375 ± 0.111	0.303GluCys: 0.303 ± 0.019	3.832GluAsp: 3.832 ± 0.069	4.064GluGlu: 4.064 ± 0.086	1.61GluPhe: 1.61 ± 0.042	5.157GluGly: 5.157 ± 0.073	1.111GluHis: 1.111 ± 0.035	3.295GluIle: 3.295 ± 0.055	2.041GluLys: 2.041 ± 0.058	5.34GluLeu: 5.34 ± 0.09	1.638GluMet: 1.638 ± 0.048	1.69GluAsn: 1.69 ± 0.046	2.844GluPro: 2.844 ± 0.054	2.12GluGln: 2.12 ± 0.047	6.003GluArg: 6.003 ± 0.098	2.654GluSer: 2.654 ± 0.05	3.876GluThr: 3.876 ± 0.062	3.824GluVal: 3.824 ± 0.069	0.802GluTrp: 0.802 ± 0.03	1.105GluTyr: 1.105 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	4.58PheAla: 4.58 ± 0.07	0.324PheCys: 0.324 ± 0.017	2.719PheAsp: 2.719 ± 0.063	2.286PheGlu: 2.286 ± 0.048	1.32PhePhe: 1.32 ± 0.041	3.594PheGly: 3.594 ± 0.067	0.623PheHis: 0.623 ± 0.027	1.459PheIle: 1.459 ± 0.041	0.702PheLys: 0.702 ± 0.023	3.319PheLeu: 3.319 ± 0.065	0.75PheMet: 0.75 ± 0.027	0.91PheAsn: 0.91 ± 0.031	1.516PhePro: 1.516 ± 0.039	0.97PheGln: 0.97 ± 0.028	2.326PheArg: 2.326 ± 0.053	2.191PheSer: 2.191 ± 0.055	1.944PheThr: 1.944 ± 0.044	2.588PheVal: 2.588 ± 0.049	0.536PheTrp: 0.536 ± 0.026	0.934PheTyr: 0.934 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	10.798GlyAla: 10.798 ± 0.117	0.734GlyCys: 0.734 ± 0.028	5.271GlyAsp: 5.271 ± 0.077	5.752GlyGlu: 5.752 ± 0.076	3.617GlyPhe: 3.617 ± 0.071	8.656GlyGly: 8.656 ± 0.134	1.79GlyHis: 1.79 ± 0.048	4.591GlyIle: 4.591 ± 0.07	2.828GlyLys: 2.828 ± 0.058	8.57GlyLeu: 8.57 ± 0.107	2.452GlyMet: 2.452 ± 0.051	2.269GlyAsn: 2.269 ± 0.054	3.703GlyPro: 3.703 ± 0.062	2.825GlyGln: 2.825 ± 0.054	6.947GlyArg: 6.947 ± 0.09	4.876GlySer: 4.876 ± 0.082	5.205GlyThr: 5.205 ± 0.078	5.835GlyVal: 5.835 ± 0.089	1.402GlyTrp: 1.402 ± 0.047	2.259GlyTyr: 2.259 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	2.216HisAla: 2.216 ± 0.052	0.209HisCys: 0.209 ± 0.016	1.15HisAsp: 1.15 ± 0.032	1.117HisGlu: 1.117 ± 0.037	0.771HisPhe: 0.771 ± 0.028	1.832HisGly: 1.832 ± 0.049	0.518HisHis: 0.518 ± 0.028	0.921HisIle: 0.921 ± 0.033	0.388HisLys: 0.388 ± 0.023	1.835HisLeu: 1.835 ± 0.047	0.487HisMet: 0.487 ± 0.023	0.404HisAsn: 0.404 ± 0.022	1.184HisPro: 1.184 ± 0.039	0.491HisGln: 0.491 ± 0.023	1.388HisArg: 1.388 ± 0.038	0.959HisSer: 0.959 ± 0.028	0.704HisThr: 0.704 ± 0.025	1.412HisVal: 1.412 ± 0.038	0.278HisTrp: 0.278 ± 0.017	0.54HisTyr: 0.54 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	7.212IleAla: 7.212 ± 0.092	0.427IleCys: 0.427 ± 0.022	3.608IleAsp: 3.608 ± 0.06	3.559IleGlu: 3.559 ± 0.057	1.569IlePhe: 1.569 ± 0.043	5.011IleGly: 5.011 ± 0.081	0.718IleHis: 0.718 ± 0.03	1.978IleIle: 1.978 ± 0.05	1.009IleLys: 1.009 ± 0.036	4.157IleLeu: 4.157 ± 0.079	1.008IleMet: 1.008 ± 0.032	1.122IleAsn: 1.122 ± 0.035	2.24IlePro: 2.24 ± 0.047	1.038IleGln: 1.038 ± 0.036	3.046IleArg: 3.046 ± 0.064	2.659IleSer: 2.659 ± 0.052	2.341IleThr: 2.341 ± 0.05	4.166IleVal: 4.166 ± 0.068	0.584IleTrp: 0.584 ± 0.024	1.046IleTyr: 1.046 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	3.528LysAla: 3.528 ± 0.069	0.144LysCys: 0.144 ± 0.012	1.687LysAsp: 1.687 ± 0.049	1.407LysGlu: 1.407 ± 0.041	0.721LysPhe: 0.721 ± 0.025	2.261LysGly: 2.261 ± 0.055	0.485LysHis: 0.485 ± 0.024	1.346LysIle: 1.346 ± 0.039	1.044LysLys: 1.044 ± 0.046	2.63LysLeu: 2.63 ± 0.052	0.695LysMet: 0.695 ± 0.034	0.681LysAsn: 0.681 ± 0.028	1.605LysPro: 1.605 ± 0.044	0.781LysGln: 0.781 ± 0.028	2.3LysArg: 2.3 ± 0.049	1.553LysSer: 1.553 ± 0.047	1.794LysThr: 1.794 ± 0.048	1.869LysVal: 1.869 ± 0.044	0.325LysTrp: 0.325 ± 0.017	0.539LysTyr: 0.539 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	13.145LeuAla: 13.145 ± 0.157	0.756LeuCys: 0.756 ± 0.028	5.88LeuAsp: 5.88 ± 0.087	5.256LeuGlu: 5.256 ± 0.088	3.592LeuPhe: 3.592 ± 0.065	8.311LeuGly: 8.311 ± 0.112	1.792LeuHis: 1.792 ± 0.047	5.0LeuIle: 5.0 ± 0.072	3.02LeuLys: 3.02 ± 0.057	9.2LeuLeu: 9.2 ± 0.129	2.319LeuMet: 2.319 ± 0.053	2.455LeuAsn: 2.455 ± 0.047	5.613LeuPro: 5.613 ± 0.079	2.766LeuGln: 2.766 ± 0.057	6.83LeuArg: 6.83 ± 0.088	6.747LeuSer: 6.747 ± 0.082	5.779LeuThr: 5.779 ± 0.077	6.832LeuVal: 6.832 ± 0.091	1.171LeuTrp: 1.171 ± 0.04	1.984LeuTyr: 1.984 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	3.074MetAla: 3.074 ± 0.055	0.12MetCys: 0.12 ± 0.012	1.241MetAsp: 1.241 ± 0.04	1.214MetGlu: 1.214 ± 0.03	0.738MetPhe: 0.738 ± 0.029	1.898MetGly: 1.898 ± 0.058	0.527MetHis: 0.527 ± 0.025	1.262MetIle: 1.262 ± 0.035	0.96MetLys: 0.96 ± 0.035	2.572MetLeu: 2.572 ± 0.052	0.693MetMet: 0.693 ± 0.03	0.763MetAsn: 0.763 ± 0.03	1.479MetPro: 1.479 ± 0.044	0.892MetGln: 0.892 ± 0.029	1.961MetArg: 1.961 ± 0.042	1.57MetSer: 1.57 ± 0.04	1.873MetThr: 1.873 ± 0.04	1.487MetVal: 1.487 ± 0.042	0.23MetTrp: 0.23 ± 0.019	0.316MetTyr: 0.316 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.181AsnAla: 3.181 ± 0.063	0.203AsnCys: 0.203 ± 0.014	1.355AsnAsp: 1.355 ± 0.037	1.308AsnGlu: 1.308 ± 0.034	0.963AsnPhe: 0.963 ± 0.04	2.297AsnGly: 2.297 ± 0.057	0.411AsnHis: 0.411 ± 0.023	1.315AsnIle: 1.315 ± 0.037	0.533AsnLys: 0.533 ± 0.025	2.419AsnLeu: 2.419 ± 0.053	0.639AsnMet: 0.639 ± 0.026	0.556AsnAsn: 0.556 ± 0.026	1.641AsnPro: 1.641 ± 0.041	0.702AsnGln: 0.702 ± 0.027	1.783AsnArg: 1.783 ± 0.036	1.205AsnSer: 1.205 ± 0.057	1.084AsnThr: 1.084 ± 0.032	1.881AsnVal: 1.881 ± 0.048	0.411AsnTrp: 0.411 ± 0.021	0.686AsnTyr: 0.686 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	6.809ProAla: 6.809 ± 0.095	0.292ProCys: 0.292 ± 0.02	3.992ProAsp: 3.992 ± 0.062	3.694ProGlu: 3.694 ± 0.064	1.97ProPhe: 1.97 ± 0.053	4.859ProGly: 4.859 ± 0.081	1.055ProHis: 1.055 ± 0.034	2.239ProIle: 2.239 ± 0.046	1.453ProLys: 1.453 ± 0.044	4.994ProLeu: 4.994 ± 0.079	1.087ProMet: 1.087 ± 0.033	1.273ProAsn: 1.273 ± 0.039	2.961ProPro: 2.961 ± 0.076	1.765ProGln: 1.765 ± 0.048	3.106ProArg: 3.106 ± 0.061	2.643ProSer: 2.643 ± 0.05	2.292ProThr: 2.292 ± 0.05	4.175ProVal: 4.175 ± 0.065	0.635ProTrp: 0.635 ± 0.029	1.113ProTyr: 1.113 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	4.002GlnAla: 4.002 ± 0.075	0.154GlnCys: 0.154 ± 0.013	1.652GlnAsp: 1.652 ± 0.041	1.618GlnGlu: 1.618 ± 0.045	1.042GlnPhe: 1.042 ± 0.033	2.337GlnGly: 2.337 ± 0.052	0.595GlnHis: 0.595 ± 0.027	1.63GlnIle: 1.63 ± 0.04	0.873GlnLys: 0.873 ± 0.034	2.821GlnLeu: 2.821 ± 0.06	0.846GlnMet: 0.846 ± 0.03	0.861GlnAsn: 0.861 ± 0.031	1.812GlnPro: 1.812 ± 0.049	1.243GlnGln: 1.243 ± 0.043	2.598GlnArg: 2.598 ± 0.053	1.651GlnSer: 1.651 ± 0.041	1.709GlnThr: 1.709 ± 0.048	2.183GlnVal: 2.183 ± 0.053	0.313GlnTrp: 0.313 ± 0.015	0.582GlnTyr: 0.582 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	9.095ArgAla: 9.095 ± 0.106	0.512ArgCys: 0.512 ± 0.024	4.228ArgAsp: 4.228 ± 0.068	4.331ArgGlu: 4.331 ± 0.08	3.118ArgPhe: 3.118 ± 0.058	5.619ArgGly: 5.619 ± 0.087	1.559ArgHis: 1.559 ± 0.039	4.193ArgIle: 4.193 ± 0.06	2.036ArgLys: 2.036 ± 0.044	8.351ArgLeu: 8.351 ± 0.117	2.012ArgMet: 2.012 ± 0.05	1.761ArgAsn: 1.761 ± 0.043	3.858ArgPro: 3.858 ± 0.075	2.707ArgGln: 2.707 ± 0.062	6.748ArgArg: 6.748 ± 0.104	4.055ArgSer: 4.055 ± 0.07	3.987ArgThr: 3.987 ± 0.064	4.748ArgVal: 4.748 ± 0.076	1.082ArgTrp: 1.082 ± 0.04	1.916ArgTyr: 1.916 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	6.98SerAla: 6.98 ± 0.092	0.372SerCys: 0.372 ± 0.021	3.509SerAsp: 3.509 ± 0.08	3.156SerGlu: 3.156 ± 0.058	2.142SerPhe: 2.142 ± 0.046	5.893SerGly: 5.893 ± 0.098	0.914SerHis: 0.914 ± 0.031	2.517SerIle: 2.517 ± 0.055	1.262SerLys: 1.262 ± 0.042	5.214SerLeu: 5.214 ± 0.082	1.214SerMet: 1.214 ± 0.036	1.314SerAsn: 1.314 ± 0.043	2.766SerPro: 2.766 ± 0.061	1.577SerGln: 1.577 ± 0.042	3.723SerArg: 3.723 ± 0.07	2.95SerSer: 2.95 ± 0.061	2.4SerThr: 2.4 ± 0.05	3.815SerVal: 3.815 ± 0.062	0.76SerTrp: 0.76 ± 0.027	1.341SerTyr: 1.341 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	6.501ThrAla: 6.501 ± 0.079	0.35ThrCys: 0.35 ± 0.019	3.02ThrAsp: 3.02 ± 0.06	2.787ThrGlu: 2.787 ± 0.055	1.828ThrPhe: 1.828 ± 0.049	5.45ThrGly: 5.45 ± 0.079	0.958ThrHis: 0.958 ± 0.031	2.61ThrIle: 2.61 ± 0.049	1.25ThrLys: 1.25 ± 0.043	5.614ThrLeu: 5.614 ± 0.087	1.186ThrMet: 1.186 ± 0.036	1.249ThrAsn: 1.249 ± 0.032	3.168ThrPro: 3.168 ± 0.059	1.486ThrGln: 1.486 ± 0.04	3.324ThrArg: 3.324 ± 0.055	2.663ThrSer: 2.663 ± 0.056	2.373ThrThr: 2.373 ± 0.052	4.132ThrVal: 4.132 ± 0.073	0.557ThrTrp: 0.557 ± 0.025	1.212ThrTyr: 1.212 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	8.173ValAla: 8.173 ± 0.109	0.541ValCys: 0.541 ± 0.026	4.421ValAsp: 4.421 ± 0.068	4.748ValGlu: 4.748 ± 0.069	2.33ValPhe: 2.33 ± 0.055	5.508ValGly: 5.508 ± 0.087	1.39ValHis: 1.39 ± 0.038	3.235ValIle: 3.235 ± 0.066	1.89ValLys: 1.89 ± 0.051	6.675ValLeu: 6.675 ± 0.089	1.608ValMet: 1.608 ± 0.042	1.906ValAsn: 1.906 ± 0.053	4.07ValPro: 4.07 ± 0.066	2.006ValGln: 2.006 ± 0.044	5.405ValArg: 5.405 ± 0.086	4.191ValSer: 4.191 ± 0.06	4.106ValThr: 4.106 ± 0.063	4.866ValVal: 4.866 ± 0.084	0.812ValTrp: 0.812 ± 0.031	1.429ValTyr: 1.429 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.262TrpAla: 1.262 ± 0.036	0.115TrpCys: 0.115 ± 0.012	0.708TrpAsp: 0.708 ± 0.029	0.573TrpGlu: 0.573 ± 0.027	0.513TrpPhe: 0.513 ± 0.028	0.854TrpGly: 0.854 ± 0.033	0.332TrpHis: 0.332 ± 0.021	0.63TrpIle: 0.63 ± 0.027	0.404TrpLys: 0.404 ± 0.022	1.553TrpLeu: 1.553 ± 0.041	0.367TrpMet: 0.367 ± 0.02	0.423TrpAsn: 0.423 ± 0.023	0.634TrpPro: 0.634 ± 0.026	0.65TrpGln: 0.65 ± 0.029	1.279TrpArg: 1.279 ± 0.036	0.772TrpSer: 0.772 ± 0.031	0.824TrpThr: 0.824 ± 0.031	0.702TrpVal: 0.702 ± 0.029	0.246TrpTrp: 0.246 ± 0.018	0.272TrpTyr: 0.272 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.542TyrAla: 2.542 ± 0.051	0.184TyrCys: 0.184 ± 0.015	1.736TyrAsp: 1.736 ± 0.048	1.379TyrGlu: 1.379 ± 0.034	0.894TyrPhe: 0.894 ± 0.031	2.318TyrGly: 2.318 ± 0.051	0.434TyrHis: 0.434 ± 0.021	0.817TyrIle: 0.817 ± 0.027	0.518TyrLys: 0.518 ± 0.025	2.171TyrLeu: 2.171 ± 0.05	0.45TyrMet: 0.45 ± 0.023	0.566TyrAsn: 0.566 ± 0.026	1.062TyrPro: 1.062 ± 0.031	0.674TyrGln: 0.674 ± 0.023	1.973TyrArg: 1.973 ± 0.051	1.174TyrSer: 1.174 ± 0.04	1.05TyrThr: 1.05 ± 0.035	1.483TyrVal: 1.483 ± 0.036	0.339TyrTrp: 0.339 ± 0.019	0.587TyrTyr: 0.587 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3056 proteins (965605 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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