Amino acid dipepetide frequency for Listeria phage vB_LmoS_188

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.641AlaAla: 4.641 ± 0.731
0.253AlaCys: 0.253 ± 0.14
4.725AlaAsp: 4.725 ± 0.702
5.4AlaGlu: 5.4 ± 0.759
2.025AlaPhe: 2.025 ± 0.389
4.472AlaGly: 4.472 ± 1.039
1.012AlaHis: 1.012 ± 0.34
4.556AlaIle: 4.556 ± 0.637
7.003AlaLys: 7.003 ± 0.924
5.484AlaLeu: 5.484 ± 0.87
2.616AlaMet: 2.616 ± 0.392
3.966AlaAsn: 3.966 ± 1.091
2.362AlaPro: 2.362 ± 0.573
2.278AlaGln: 2.278 ± 0.422
1.941AlaArg: 1.941 ± 0.486
5.147AlaSer: 5.147 ± 0.799
4.472AlaThr: 4.472 ± 0.492
3.966AlaVal: 3.966 ± 0.633
0.844AlaTrp: 0.844 ± 0.217
2.362AlaTyr: 2.362 ± 0.571
0.0AlaXaa: 0.0 ± 0.0
Cys
0.506CysAla: 0.506 ± 0.211
0.0CysCys: 0.0 ± 0.0
0.422CysAsp: 0.422 ± 0.203
0.506CysGlu: 0.506 ± 0.223
0.253CysPhe: 0.253 ± 0.146
0.759CysGly: 0.759 ± 0.304
0.169CysHis: 0.169 ± 0.116
0.169CysIle: 0.169 ± 0.123
0.675CysLys: 0.675 ± 0.309
0.337CysLeu: 0.337 ± 0.169
0.337CysMet: 0.337 ± 0.168
0.169CysAsn: 0.169 ± 0.123
0.337CysPro: 0.337 ± 0.167
0.084CysGln: 0.084 ± 0.082
0.253CysArg: 0.253 ± 0.131
0.253CysSer: 0.253 ± 0.136
0.253CysThr: 0.253 ± 0.139
0.591CysVal: 0.591 ± 0.251
0.0CysTrp: 0.0 ± 0.0
0.253CysTyr: 0.253 ± 0.131
0.0CysXaa: 0.0 ± 0.0
Asp
3.122AspAla: 3.122 ± 0.411
0.253AspCys: 0.253 ± 0.139
3.712AspAsp: 3.712 ± 0.503
6.75AspGlu: 6.75 ± 0.764
3.122AspPhe: 3.122 ± 0.469
5.4AspGly: 5.4 ± 0.845
0.422AspHis: 0.422 ± 0.226
4.387AspIle: 4.387 ± 0.414
6.159AspLys: 6.159 ± 0.905
5.569AspLeu: 5.569 ± 0.731
1.687AspMet: 1.687 ± 0.37
4.05AspAsn: 4.05 ± 0.561
1.434AspPro: 1.434 ± 0.366
1.434AspGln: 1.434 ± 0.341
1.687AspArg: 1.687 ± 0.362
4.05AspSer: 4.05 ± 0.615
2.869AspThr: 2.869 ± 0.42
3.628AspVal: 3.628 ± 0.446
0.591AspTrp: 0.591 ± 0.188
2.531AspTyr: 2.531 ± 0.427
0.0AspXaa: 0.0 ± 0.0
Glu
5.147GluAla: 5.147 ± 0.726
0.759GluCys: 0.759 ± 0.307
3.712GluAsp: 3.712 ± 0.576
5.4GluGlu: 5.4 ± 0.823
3.122GluPhe: 3.122 ± 0.488
3.291GluGly: 3.291 ± 0.551
1.519GluHis: 1.519 ± 0.385
6.581GluIle: 6.581 ± 0.838
6.328GluLys: 6.328 ± 0.795
7.003GluLeu: 7.003 ± 0.819
3.037GluMet: 3.037 ± 0.519
4.472GluAsn: 4.472 ± 0.709
2.447GluPro: 2.447 ± 0.51
3.712GluGln: 3.712 ± 0.798
3.375GluArg: 3.375 ± 0.663
4.219GluSer: 4.219 ± 0.45
4.894GluThr: 4.894 ± 0.8
5.737GluVal: 5.737 ± 0.68
1.35GluTrp: 1.35 ± 0.328
3.037GluTyr: 3.037 ± 0.469
0.0GluXaa: 0.0 ± 0.0
Phe
2.616PheAla: 2.616 ± 0.304
0.506PheCys: 0.506 ± 0.21
2.7PheAsp: 2.7 ± 0.496
3.712PheGlu: 3.712 ± 0.65
1.181PhePhe: 1.181 ± 0.347
2.194PheGly: 2.194 ± 0.455
0.422PheHis: 0.422 ± 0.159
3.206PheIle: 3.206 ± 0.435
3.291PheLys: 3.291 ± 0.522
2.447PheLeu: 2.447 ± 0.51
0.844PheMet: 0.844 ± 0.238
3.037PheAsn: 3.037 ± 0.371
1.097PhePro: 1.097 ± 0.246
1.097PheGln: 1.097 ± 0.33
1.856PheArg: 1.856 ± 0.423
3.037PheSer: 3.037 ± 0.567
2.447PheThr: 2.447 ± 0.493
2.447PheVal: 2.447 ± 0.433
0.506PheTrp: 0.506 ± 0.18
0.928PheTyr: 0.928 ± 0.277
0.0PheXaa: 0.0 ± 0.0
Gly
3.375GlyAla: 3.375 ± 0.555
0.337GlyCys: 0.337 ± 0.149
3.544GlyAsp: 3.544 ± 0.498
4.303GlyGlu: 4.303 ± 0.653
2.7GlyPhe: 2.7 ± 0.484
3.628GlyGly: 3.628 ± 0.528
0.506GlyHis: 0.506 ± 0.211
4.05GlyIle: 4.05 ± 0.595
4.978GlyLys: 4.978 ± 0.511
4.978GlyLeu: 4.978 ± 0.831
1.772GlyMet: 1.772 ± 0.447
3.206GlyAsn: 3.206 ± 0.702
0.928GlyPro: 0.928 ± 0.298
2.025GlyGln: 2.025 ± 0.438
1.856GlyArg: 1.856 ± 0.352
3.459GlySer: 3.459 ± 0.547
3.797GlyThr: 3.797 ± 0.648
3.206GlyVal: 3.206 ± 0.486
1.097GlyTrp: 1.097 ± 0.312
3.375GlyTyr: 3.375 ± 0.551
0.0GlyXaa: 0.0 ± 0.0
His
1.181HisAla: 1.181 ± 0.35
0.0HisCys: 0.0 ± 0.0
0.928HisAsp: 0.928 ± 0.273
1.687HisGlu: 1.687 ± 0.459
0.675HisPhe: 0.675 ± 0.27
0.675HisGly: 0.675 ± 0.222
0.422HisHis: 0.422 ± 0.245
1.097HisIle: 1.097 ± 0.353
0.759HisLys: 0.759 ± 0.214
1.434HisLeu: 1.434 ± 0.411
0.0HisMet: 0.0 ± 0.0
0.169HisAsn: 0.169 ± 0.127
0.506HisPro: 0.506 ± 0.2
0.169HisGln: 0.169 ± 0.116
0.422HisArg: 0.422 ± 0.2
1.266HisSer: 1.266 ± 0.353
0.506HisThr: 0.506 ± 0.193
0.675HisVal: 0.675 ± 0.239
0.084HisTrp: 0.084 ± 0.082
0.928HisTyr: 0.928 ± 0.294
0.0HisXaa: 0.0 ± 0.0
Ile
5.147IleAla: 5.147 ± 0.796
0.337IleCys: 0.337 ± 0.191
4.556IleAsp: 4.556 ± 0.618
5.316IleGlu: 5.316 ± 0.689
2.531IlePhe: 2.531 ± 0.457
2.953IleGly: 2.953 ± 0.516
1.687IleHis: 1.687 ± 0.393
3.628IleIle: 3.628 ± 0.453
6.075IleLys: 6.075 ± 0.736
4.303IleLeu: 4.303 ± 0.621
1.266IleMet: 1.266 ± 0.316
5.231IleAsn: 5.231 ± 0.648
1.941IlePro: 1.941 ± 0.387
2.953IleGln: 2.953 ± 0.515
2.784IleArg: 2.784 ± 0.415
4.387IleSer: 4.387 ± 0.493
4.556IleThr: 4.556 ± 0.73
4.134IleVal: 4.134 ± 0.511
0.675IleTrp: 0.675 ± 0.194
2.362IleTyr: 2.362 ± 0.465
0.0IleXaa: 0.0 ± 0.0
Lys
6.328LysAla: 6.328 ± 1.228
0.337LysCys: 0.337 ± 0.174
5.147LysAsp: 5.147 ± 0.517
8.522LysGlu: 8.522 ± 0.967
3.037LysPhe: 3.037 ± 0.512
5.316LysGly: 5.316 ± 0.661
1.35LysHis: 1.35 ± 0.384
6.075LysIle: 6.075 ± 0.799
8.353LysLys: 8.353 ± 1.032
7.003LysLeu: 7.003 ± 0.808
2.616LysMet: 2.616 ± 0.473
6.75LysAsn: 6.75 ± 0.823
2.616LysPro: 2.616 ± 0.654
3.712LysGln: 3.712 ± 0.586
2.869LysArg: 2.869 ± 0.604
4.725LysSer: 4.725 ± 0.609
6.834LysThr: 6.834 ± 1.158
5.062LysVal: 5.062 ± 0.56
1.35LysTrp: 1.35 ± 0.258
3.712LysTyr: 3.712 ± 0.528
0.0LysXaa: 0.0 ± 0.0
Leu
5.991LeuAla: 5.991 ± 0.664
0.675LeuCys: 0.675 ± 0.292
5.737LeuAsp: 5.737 ± 0.705
5.653LeuGlu: 5.653 ± 0.742
2.362LeuPhe: 2.362 ± 0.564
4.134LeuGly: 4.134 ± 0.613
0.506LeuHis: 0.506 ± 0.206
5.569LeuIle: 5.569 ± 0.82
6.666LeuLys: 6.666 ± 0.682
7.256LeuLeu: 7.256 ± 0.752
1.603LeuMet: 1.603 ± 0.364
6.328LeuAsn: 6.328 ± 0.805
2.616LeuPro: 2.616 ± 0.371
3.037LeuGln: 3.037 ± 0.532
3.628LeuArg: 3.628 ± 0.654
5.231LeuSer: 5.231 ± 0.552
6.075LeuThr: 6.075 ± 0.692
3.712LeuVal: 3.712 ± 0.439
0.675LeuTrp: 0.675 ± 0.207
2.869LeuTyr: 2.869 ± 0.487
0.0LeuXaa: 0.0 ± 0.0
Met
2.362MetAla: 2.362 ± 0.384
0.253MetCys: 0.253 ± 0.194
1.603MetAsp: 1.603 ± 0.327
1.519MetGlu: 1.519 ± 0.366
0.675MetPhe: 0.675 ± 0.253
1.266MetGly: 1.266 ± 0.296
0.337MetHis: 0.337 ± 0.202
1.772MetIle: 1.772 ± 0.446
1.941MetLys: 1.941 ± 0.357
1.941MetLeu: 1.941 ± 0.3
0.928MetMet: 0.928 ± 0.307
1.603MetAsn: 1.603 ± 0.396
0.591MetPro: 0.591 ± 0.183
1.181MetGln: 1.181 ± 0.323
1.097MetArg: 1.097 ± 0.253
2.7MetSer: 2.7 ± 0.498
2.447MetThr: 2.447 ± 0.479
0.928MetVal: 0.928 ± 0.272
0.253MetTrp: 0.253 ± 0.189
0.844MetTyr: 0.844 ± 0.285
0.0MetXaa: 0.0 ± 0.0
Asn
4.556AsnAla: 4.556 ± 0.733
0.422AsnCys: 0.422 ± 0.201
3.966AsnAsp: 3.966 ± 0.546
5.822AsnGlu: 5.822 ± 0.68
2.278AsnPhe: 2.278 ± 0.474
4.472AsnGly: 4.472 ± 0.504
1.266AsnHis: 1.266 ± 0.29
3.881AsnIle: 3.881 ± 0.61
6.244AsnLys: 6.244 ± 1.024
4.472AsnLeu: 4.472 ± 0.586
1.772AsnMet: 1.772 ± 0.479
4.725AsnAsn: 4.725 ± 0.673
1.772AsnPro: 1.772 ± 0.384
2.869AsnGln: 2.869 ± 0.638
2.109AsnArg: 2.109 ± 0.397
3.966AsnSer: 3.966 ± 0.571
3.122AsnThr: 3.122 ± 0.506
3.797AsnVal: 3.797 ± 0.562
0.759AsnTrp: 0.759 ± 0.335
3.375AsnTyr: 3.375 ± 0.545
0.0AsnXaa: 0.0 ± 0.0
Pro
2.616ProAla: 2.616 ± 0.334
0.0ProCys: 0.0 ± 0.0
2.025ProAsp: 2.025 ± 0.437
2.194ProGlu: 2.194 ± 0.431
1.181ProPhe: 1.181 ± 0.359
1.097ProGly: 1.097 ± 0.388
0.253ProHis: 0.253 ± 0.124
1.941ProIle: 1.941 ± 0.352
2.194ProLys: 2.194 ± 0.425
2.194ProLeu: 2.194 ± 0.426
0.422ProMet: 0.422 ± 0.176
1.35ProAsn: 1.35 ± 0.351
1.266ProPro: 1.266 ± 0.404
1.097ProGln: 1.097 ± 0.25
1.266ProArg: 1.266 ± 0.282
2.278ProSer: 2.278 ± 0.349
1.519ProThr: 1.519 ± 0.366
2.194ProVal: 2.194 ± 0.435
0.169ProTrp: 0.169 ± 0.119
0.337ProTyr: 0.337 ± 0.154
0.0ProXaa: 0.0 ± 0.0
Gln
2.362GlnAla: 2.362 ± 0.383
0.337GlnCys: 0.337 ± 0.173
1.687GlnAsp: 1.687 ± 0.364
2.447GlnGlu: 2.447 ± 0.596
1.941GlnPhe: 1.941 ± 0.382
1.266GlnGly: 1.266 ± 0.234
0.337GlnHis: 0.337 ± 0.193
2.869GlnIle: 2.869 ± 0.489
5.147GlnLys: 5.147 ± 0.833
2.362GlnLeu: 2.362 ± 0.512
0.422GlnMet: 0.422 ± 0.199
2.784GlnAsn: 2.784 ± 0.389
0.506GlnPro: 0.506 ± 0.224
2.531GlnGln: 2.531 ± 0.376
1.181GlnArg: 1.181 ± 0.333
2.109GlnSer: 2.109 ± 0.341
2.362GlnThr: 2.362 ± 0.447
2.7GlnVal: 2.7 ± 0.486
0.337GlnTrp: 0.337 ± 0.15
1.434GlnTyr: 1.434 ± 0.303
0.0GlnXaa: 0.0 ± 0.0
Arg
1.772ArgAla: 1.772 ± 0.381
0.253ArgCys: 0.253 ± 0.142
2.278ArgAsp: 2.278 ± 0.356
3.122ArgGlu: 3.122 ± 0.615
1.603ArgPhe: 1.603 ± 0.369
1.772ArgGly: 1.772 ± 0.405
0.675ArgHis: 0.675 ± 0.286
1.687ArgIle: 1.687 ± 0.431
4.387ArgLys: 4.387 ± 0.497
2.869ArgLeu: 2.869 ± 0.577
0.759ArgMet: 0.759 ± 0.213
2.447ArgAsn: 2.447 ± 0.464
0.844ArgPro: 0.844 ± 0.259
0.591ArgGln: 0.591 ± 0.186
1.181ArgArg: 1.181 ± 0.406
2.109ArgSer: 2.109 ± 0.647
2.025ArgThr: 2.025 ± 0.37
2.616ArgVal: 2.616 ± 0.475
0.591ArgTrp: 0.591 ± 0.172
2.194ArgTyr: 2.194 ± 0.51
0.0ArgXaa: 0.0 ± 0.0
Ser
3.797SerAla: 3.797 ± 0.647
0.506SerCys: 0.506 ± 0.231
4.472SerAsp: 4.472 ± 0.66
5.316SerGlu: 5.316 ± 0.599
2.784SerPhe: 2.784 ± 0.599
4.725SerGly: 4.725 ± 0.69
0.759SerHis: 0.759 ± 0.202
4.556SerIle: 4.556 ± 0.762
6.328SerLys: 6.328 ± 0.691
5.737SerLeu: 5.737 ± 0.799
1.856SerMet: 1.856 ± 0.431
4.387SerAsn: 4.387 ± 0.512
0.844SerPro: 0.844 ± 0.237
1.941SerGln: 1.941 ± 0.403
1.856SerArg: 1.856 ± 0.294
3.206SerSer: 3.206 ± 0.41
3.712SerThr: 3.712 ± 0.504
3.966SerVal: 3.966 ± 0.793
0.337SerTrp: 0.337 ± 0.146
2.7SerTyr: 2.7 ± 0.393
0.0SerXaa: 0.0 ± 0.0
Thr
5.316ThrAla: 5.316 ± 0.857
0.422ThrCys: 0.422 ± 0.2
3.628ThrAsp: 3.628 ± 0.462
3.712ThrGlu: 3.712 ± 0.632
3.206ThrPhe: 3.206 ± 0.55
3.459ThrGly: 3.459 ± 0.526
0.591ThrHis: 0.591 ± 0.221
4.303ThrIle: 4.303 ± 0.512
5.484ThrLys: 5.484 ± 0.602
5.484ThrLeu: 5.484 ± 0.555
1.687ThrMet: 1.687 ± 0.422
3.966ThrAsn: 3.966 ± 0.562
2.616ThrPro: 2.616 ± 0.421
2.362ThrGln: 2.362 ± 0.607
2.362ThrArg: 2.362 ± 0.426
4.219ThrSer: 4.219 ± 0.564
3.966ThrThr: 3.966 ± 0.577
3.544ThrVal: 3.544 ± 0.609
0.675ThrTrp: 0.675 ± 0.212
2.784ThrTyr: 2.784 ± 0.474
0.0ThrXaa: 0.0 ± 0.0
Val
5.147ValAla: 5.147 ± 0.69
0.253ValCys: 0.253 ± 0.199
4.219ValAsp: 4.219 ± 0.486
3.375ValGlu: 3.375 ± 0.497
2.953ValPhe: 2.953 ± 0.55
3.797ValGly: 3.797 ± 0.662
0.506ValHis: 0.506 ± 0.242
3.206ValIle: 3.206 ± 0.449
5.569ValLys: 5.569 ± 0.906
4.725ValLeu: 4.725 ± 0.653
1.434ValMet: 1.434 ± 0.364
3.628ValAsn: 3.628 ± 0.59
1.687ValPro: 1.687 ± 0.349
2.362ValGln: 2.362 ± 0.353
2.109ValArg: 2.109 ± 0.417
3.797ValSer: 3.797 ± 0.462
4.978ValThr: 4.978 ± 0.666
3.459ValVal: 3.459 ± 0.652
0.422ValTrp: 0.422 ± 0.166
2.109ValTyr: 2.109 ± 0.499
0.0ValXaa: 0.0 ± 0.0
Trp
0.591TrpAla: 0.591 ± 0.25
0.084TrpCys: 0.084 ± 0.082
0.844TrpAsp: 0.844 ± 0.257
0.844TrpGlu: 0.844 ± 0.38
0.337TrpPhe: 0.337 ± 0.177
0.506TrpGly: 0.506 ± 0.184
0.253TrpHis: 0.253 ± 0.137
0.759TrpIle: 0.759 ± 0.226
0.928TrpLys: 0.928 ± 0.318
1.266TrpLeu: 1.266 ± 0.32
0.169TrpMet: 0.169 ± 0.128
0.759TrpAsn: 0.759 ± 0.247
0.084TrpPro: 0.084 ± 0.096
0.253TrpGln: 0.253 ± 0.162
0.422TrpArg: 0.422 ± 0.222
1.181TrpSer: 1.181 ± 0.443
0.422TrpThr: 0.422 ± 0.197
0.759TrpVal: 0.759 ± 0.285
0.169TrpTrp: 0.169 ± 0.117
0.844TrpTyr: 0.844 ± 0.498
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.953TyrAla: 2.953 ± 0.467
0.337TyrCys: 0.337 ± 0.194
2.953TyrAsp: 2.953 ± 0.624
3.544TyrGlu: 3.544 ± 0.636
1.603TyrPhe: 1.603 ± 0.419
1.941TyrGly: 1.941 ± 0.435
0.591TyrHis: 0.591 ± 0.22
2.616TyrIle: 2.616 ± 0.538
3.206TyrLys: 3.206 ± 0.633
3.459TyrLeu: 3.459 ± 0.647
0.928TyrMet: 0.928 ± 0.25
2.616TyrAsn: 2.616 ± 0.324
1.097TyrPro: 1.097 ± 0.327
1.434TyrGln: 1.434 ± 0.338
1.519TyrArg: 1.519 ± 0.398
2.447TyrSer: 2.447 ± 0.438
2.531TyrThr: 2.531 ± 0.374
2.616TyrVal: 2.616 ± 0.449
0.591TyrTrp: 0.591 ± 0.245
2.869TyrTyr: 2.869 ± 0.531
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 60 proteins (11853 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski