Human endogenous retrovirus HCML-ARV

Taxonomy: Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes; Ortervirales; Retroviridae; unclassified Retroviridae; Human endogenous retroviruses; Human endogenous retrovirus

Average proteome isoelectric point is 7.59

Get precalculated fractions of proteins

Acidic
pI < 6.8
6.8-7.4
pI > 7.4
Basic
    
All



Virtual 2D-PAGE plot for 3 proteins (isoelectric point calculated using IPC2_protein)

Get csv file with sequences according to given criteria:
        -     Method 

     -  kDa    
                                                                                      

* You can choose from 21 different methods for calculating isoelectric point

Summary statistics related to proteome-wise predictions


    

Protein with the lowest isoelectric point:
>tr|Q7ZGS4|Q7ZGS4_9RETR Retroviral gag protein OS=Human endogenous retrovirus HCML-ARV OX=228277 PE=4 SV=1
MM1 pKa = 7.63LKK3 pKa = 10.26NFKK6 pKa = 10.36KK7 pKa = 10.67GFNGDD12 pKa = 3.62YY13 pKa = 10.08GVTMTPGKK21 pKa = 10.46LRR23 pKa = 11.84ILCEE27 pKa = 4.13IDD29 pKa = 3.06WPTLEE34 pKa = 4.62VGWPSEE40 pKa = 3.91GSLDD44 pKa = 3.4RR45 pKa = 11.84SLVSKK50 pKa = 10.13VWHH53 pKa = 6.23KK54 pKa = 9.68VTGKK58 pKa = 10.11SGHH61 pKa = 6.23SDD63 pKa = 3.07QFPYY67 pKa = 10.4IDD69 pKa = 3.26TWLLQLVQDD78 pKa = 4.23PPQWLRR84 pKa = 11.84GQAAAVLVAKK94 pKa = 10.01GQIAKK99 pKa = 9.83EE100 pKa = 4.55GSRR103 pKa = 11.84STHH106 pKa = 5.62WGKK109 pKa = 8.47STPEE113 pKa = 3.79VLFDD117 pKa = 3.9PTSEE121 pKa = 5.11DD122 pKa = 3.82PLQEE126 pKa = 4.18MAPVIPVLPSPYY138 pKa = 9.24QAEE141 pKa = 4.03RR142 pKa = 11.84LPTFEE147 pKa = 4.49PTVLVPPQDD156 pKa = 3.16KK157 pKa = 10.56HH158 pKa = 7.02IPRR161 pKa = 11.84PPRR164 pKa = 11.84VDD166 pKa = 2.92KK167 pKa = 11.27RR168 pKa = 11.84GGEE171 pKa = 4.17ASGEE175 pKa = 4.3TPPLAACLRR184 pKa = 11.84PKK186 pKa = 10.23TGIQMPLRR194 pKa = 11.84EE195 pKa = 3.95QRR197 pKa = 11.84YY198 pKa = 7.07TGIEE202 pKa = 3.97EE203 pKa = 4.52DD204 pKa = 3.11GHH206 pKa = 5.06MVEE209 pKa = 5.01KK210 pKa = 10.43RR211 pKa = 11.84VFVYY215 pKa = 10.58QPFTSANLLNWKK227 pKa = 9.98NNTLSYY233 pKa = 9.95TEE235 pKa = 4.87KK236 pKa = 10.24PQALIDD242 pKa = 4.01LLQTIIQTHH251 pKa = 5.78NSTRR255 pKa = 11.84ADD257 pKa = 3.52CHH259 pKa = 5.93QLLMFLFNTDD269 pKa = 2.09EE270 pKa = 4.22RR271 pKa = 11.84QRR273 pKa = 11.84VLQAATKK280 pKa = 8.79WVQEE284 pKa = 4.27HH285 pKa = 6.82APADD289 pKa = 3.69YY290 pKa = 10.76QNPQEE295 pKa = 4.42CVRR298 pKa = 11.84TQLPGTDD305 pKa = 4.01PQWDD309 pKa = 3.67PNEE312 pKa = 4.31RR313 pKa = 11.84EE314 pKa = 3.87DD315 pKa = 3.7MQRR318 pKa = 11.84LNRR321 pKa = 11.84DD322 pKa = 3.0RR323 pKa = 11.84EE324 pKa = 4.26AVLEE328 pKa = 3.97GLKK331 pKa = 10.55RR332 pKa = 11.84GAQKK336 pKa = 9.47ATNVNKK342 pKa = 9.77VSEE345 pKa = 4.46VIRR348 pKa = 11.84GKK350 pKa = 10.51EE351 pKa = 3.54EE352 pKa = 4.0SPAQFYY358 pKa = 10.81QRR360 pKa = 11.84LCEE363 pKa = 4.34GYY365 pKa = 10.82RR366 pKa = 11.84MYY368 pKa = 11.01TPFDD372 pKa = 3.52PVSPEE377 pKa = 3.68NQRR380 pKa = 11.84MVNMALVSQSAEE392 pKa = 4.01DD393 pKa = 3.97IRR395 pKa = 11.84RR396 pKa = 11.84KK397 pKa = 9.24LQKK400 pKa = 9.73QDD402 pKa = 3.01GFAGTNTSQLLEE414 pKa = 4.0VANQVFVNRR423 pKa = 11.84DD424 pKa = 3.02AVSPKK429 pKa = 9.56EE430 pKa = 3.75NRR432 pKa = 11.84RR433 pKa = 11.84EE434 pKa = 3.87NEE436 pKa = 3.47RR437 pKa = 11.84QARR440 pKa = 11.84RR441 pKa = 11.84NAEE444 pKa = 3.96LLAAAVGGVSSKK456 pKa = 10.68RR457 pKa = 11.84QGKK460 pKa = 9.35GGPGKK465 pKa = 8.6EE466 pKa = 4.23TQPGCQSLQCNQCAYY481 pKa = 10.08CKK483 pKa = 10.51EE484 pKa = 3.37IGYY487 pKa = 8.55WKK489 pKa = 10.42NKK491 pKa = 9.25CPQLKK496 pKa = 10.08GKK498 pKa = 10.18QGDD501 pKa = 4.11LEE503 pKa = 4.37QEE505 pKa = 4.3VPDD508 pKa = 4.24KK509 pKa = 11.65EE510 pKa = 4.2EE511 pKa = 4.06GALLNLAEE519 pKa = 4.74EE520 pKa = 4.63LLDD523 pKa = 3.77

Molecular weight:
59.02 kDa
Isoelectric point according different methods:






Protein with the highest isoelectric point:
>tr|Q7ZGS4|Q7ZGS4_9RETR Retroviral gag protein OS=Human endogenous retrovirus HCML-ARV OX=228277 PE=4 SV=1
MM1 pKa = 7.63ARR3 pKa = 11.84MTVGGKK9 pKa = 10.16DD10 pKa = 2.84IDD12 pKa = 4.04FLVDD16 pKa = 3.28TGAEE20 pKa = 4.15HH21 pKa = 6.87SVVTAPVAPLSKK33 pKa = 9.73KK34 pKa = 9.21TIDD37 pKa = 3.59IIGAMGVSAKK47 pKa = 9.95QAFCLPRR54 pKa = 11.84TCTVGGHH61 pKa = 5.09KK62 pKa = 10.27VIHH65 pKa = 5.97QFLYY69 pKa = 10.35MPDD72 pKa = 3.85CPLPLLGRR80 pKa = 11.84DD81 pKa = 3.68LLSKK85 pKa = 10.69LRR87 pKa = 11.84ATISFTEE94 pKa = 4.27HH95 pKa = 6.48GSLLLKK101 pKa = 10.92LPGTGVIMTLTVPRR115 pKa = 11.84EE116 pKa = 4.06EE117 pKa = 4.03EE118 pKa = 3.47WRR120 pKa = 11.84LFLTEE125 pKa = 4.16SGQEE129 pKa = 3.76IRR131 pKa = 11.84PALAKK136 pKa = 9.96RR137 pKa = 11.84WPRR140 pKa = 11.84VWAEE144 pKa = 4.13DD145 pKa = 3.97NPPGLAVNQAPVLIEE160 pKa = 4.16VKK162 pKa = 10.47PGAQPVRR169 pKa = 11.84QKK171 pKa = 10.57QYY173 pKa = 9.4PVPRR177 pKa = 11.84EE178 pKa = 3.98ALEE181 pKa = 4.94GIQVPLKK188 pKa = 10.17CLRR191 pKa = 11.84TFGMIVPCQSPWNTPLLPVPEE212 pKa = 5.37PKK214 pKa = 10.23TKK216 pKa = 10.41DD217 pKa = 3.24YY218 pKa = 11.13WPGQDD223 pKa = 4.26LRR225 pKa = 11.84LVKK228 pKa = 10.3QATVTLHH235 pKa = 6.24PAVPNPYY242 pKa = 8.66TLLGLLPAEE251 pKa = 4.96DD252 pKa = 3.94SCFTCLDD259 pKa = 3.54LKK261 pKa = 11.19DD262 pKa = 3.98AFFSIRR268 pKa = 11.84FAPEE272 pKa = 3.69SQKK275 pKa = 10.98LFAFQWEE282 pKa = 4.4DD283 pKa = 3.47PEE285 pKa = 5.34SGVTTQYY292 pKa = 9.45TWTWLPQGFKK302 pKa = 10.67NSPTIFGEE310 pKa = 3.92EE311 pKa = 4.24LARR314 pKa = 11.84DD315 pKa = 3.78LQKK318 pKa = 11.19CPTRR322 pKa = 11.84DD323 pKa = 3.47LGCVLLQYY331 pKa = 11.08VDD333 pKa = 5.2DD334 pKa = 5.23LLLGHH339 pKa = 6.79PTAVGCAKK347 pKa = 9.79GTDD350 pKa = 3.06ALLRR354 pKa = 11.84HH355 pKa = 6.45LEE357 pKa = 4.13DD358 pKa = 3.96CGYY361 pKa = 10.72KK362 pKa = 10.05VSKK365 pKa = 10.39KK366 pKa = 9.79KK367 pKa = 10.77AQICRR372 pKa = 11.84PQVRR376 pKa = 11.84YY377 pKa = 10.19LGFTIRR383 pKa = 11.84QGEE386 pKa = 4.05RR387 pKa = 11.84SLGSEE392 pKa = 4.54RR393 pKa = 11.84KK394 pKa = 8.9QVICTLPEE402 pKa = 4.11PKK404 pKa = 9.78SRR406 pKa = 11.84KK407 pKa = 6.87QVRR410 pKa = 11.84KK411 pKa = 9.13FLGAAGFCRR420 pKa = 11.84LWIPNFAVLAKK431 pKa = 9.96PLYY434 pKa = 10.18EE435 pKa = 3.94VTKK438 pKa = 10.04WGDD441 pKa = 3.31RR442 pKa = 11.84EE443 pKa = 4.01PFEE446 pKa = 4.96WGSQQQQAFRR456 pKa = 11.84EE457 pKa = 4.34LKK459 pKa = 9.44EE460 pKa = 4.27KK461 pKa = 10.77LMSAPALGLPNLTKK475 pKa = 10.63PFTLYY480 pKa = 10.2VSEE483 pKa = 4.24RR484 pKa = 11.84EE485 pKa = 4.05KK486 pKa = 10.46MAVRR490 pKa = 11.84VLTQTVGPWPRR501 pKa = 11.84PVAYY505 pKa = 10.33LSKK508 pKa = 10.82QLDD511 pKa = 4.2GVSKK515 pKa = 10.42GWPPCLRR522 pKa = 11.84ALAATALLVQEE533 pKa = 4.5AVKK536 pKa = 9.29LTLGQNLNIKK546 pKa = 9.68APHH549 pKa = 6.32AMVTLINTKK558 pKa = 8.1GHH560 pKa = 6.06HH561 pKa = 6.14WLTNARR567 pKa = 11.84LTKK570 pKa = 10.08YY571 pKa = 10.49QSLLCEE577 pKa = 4.23NPRR580 pKa = 11.84ITIEE584 pKa = 3.6ICNTLNPTTLLLVSEE599 pKa = 5.29GPVEE603 pKa = 4.12HH604 pKa = 7.47DD605 pKa = 3.45CVEE608 pKa = 4.29VLDD611 pKa = 4.29SVYY614 pKa = 10.96SSRR617 pKa = 11.84PDD619 pKa = 3.86LQDD622 pKa = 3.45QPWAPVDD629 pKa = 3.15WEE631 pKa = 4.66LYY633 pKa = 8.59MDD635 pKa = 4.7GGSFINPQGEE645 pKa = 4.03RR646 pKa = 11.84GAGYY650 pKa = 10.73AVVTLDD656 pKa = 3.38TVVEE660 pKa = 4.15ARR662 pKa = 11.84SLPQATSAQKK672 pKa = 10.89AEE674 pKa = 4.68LIAFIRR680 pKa = 11.84ALEE683 pKa = 4.06LSEE686 pKa = 4.83GEE688 pKa = 4.43TVNIYY693 pKa = 10.01TDD695 pKa = 2.81SRR697 pKa = 11.84YY698 pKa = 9.87PFLTLQVHH706 pKa = 5.21EE707 pKa = 4.79ASYY710 pKa = 10.98KK711 pKa = 10.61EE712 pKa = 3.97KK713 pKa = 11.0GLLNSGGKK721 pKa = 9.51DD722 pKa = 2.53IKK724 pKa = 10.48YY725 pKa = 9.12QQEE728 pKa = 3.77ILQLLEE734 pKa = 4.96AVWKK738 pKa = 7.04PHH740 pKa = 5.46KK741 pKa = 10.21VAVMHH746 pKa = 6.47CRR748 pKa = 11.84GHH750 pKa = 5.39QRR752 pKa = 11.84ASTLVGLGNSRR763 pKa = 11.84ADD765 pKa = 3.32ARR767 pKa = 11.84KK768 pKa = 9.04AASAPFRR775 pKa = 11.84ASVTAPLLPQAPDD788 pKa = 3.73LLPTYY793 pKa = 10.67SKK795 pKa = 11.0EE796 pKa = 4.3EE797 pKa = 3.94KK798 pKa = 10.48DD799 pKa = 3.53FLQAEE804 pKa = 5.33GGQVMEE810 pKa = 5.01EE811 pKa = 3.95GWIRR815 pKa = 11.84LPDD818 pKa = 3.49GRR820 pKa = 11.84EE821 pKa = 3.79AVPQLLGAAVVLAVHH836 pKa = 6.4KK837 pKa = 6.85TTHH840 pKa = 6.85LGQEE844 pKa = 4.32SLEE847 pKa = 4.21KK848 pKa = 10.87LLVRR852 pKa = 11.84YY853 pKa = 8.39FYY855 pKa = 10.5ILHH858 pKa = 6.75LSALAKK864 pKa = 9.76TVTQRR869 pKa = 11.84CVTCPKK875 pKa = 10.25HH876 pKa = 5.98NAKK879 pKa = 10.08QGPAVPPVIQAYY891 pKa = 9.37GAAPFEE897 pKa = 4.37DD898 pKa = 3.74VQVDD902 pKa = 4.04FTEE905 pKa = 4.31MPKK908 pKa = 10.71CGGNKK913 pKa = 9.18YY914 pKa = 10.7LLVLVCTYY922 pKa = 10.9SGGWRR927 pKa = 11.84LIQHH931 pKa = 7.17KK932 pKa = 9.93LRR934 pKa = 11.84KK935 pKa = 8.92LVKK938 pKa = 8.68LTCVLLRR945 pKa = 11.84DD946 pKa = 4.64PIPRR950 pKa = 11.84FGLPLRR956 pKa = 11.84IGSDD960 pKa = 3.05NGPAFVADD968 pKa = 4.47LVQKK972 pKa = 10.03RR973 pKa = 11.84AKK975 pKa = 10.59VLGNTWKK982 pKa = 10.35LHH984 pKa = 4.82AAYY987 pKa = 10.0RR988 pKa = 11.84PQSSGKK994 pKa = 9.05VEE996 pKa = 3.87QMNWTIKK1003 pKa = 9.43NSKK1006 pKa = 10.34GKK1008 pKa = 9.72VCQEE1012 pKa = 4.39TGLKK1016 pKa = 9.21WIQALPMVLFKK1027 pKa = 10.57IRR1029 pKa = 11.84CTPSKK1034 pKa = 9.46RR1035 pKa = 11.84TGYY1038 pKa = 10.04SPYY1041 pKa = 9.84EE1042 pKa = 4.04ILYY1045 pKa = 9.54HH1046 pKa = 6.5RR1047 pKa = 11.84PPPILRR1053 pKa = 11.84GLPGTPRR1060 pKa = 11.84EE1061 pKa = 4.07LGEE1064 pKa = 5.09IEE1066 pKa = 5.17LQRR1069 pKa = 11.84QLQALGKK1076 pKa = 8.06ITQTISAWVNEE1087 pKa = 4.32RR1088 pKa = 11.84CPVSLFSPVHH1098 pKa = 5.89PFSPGNRR1105 pKa = 11.84VWIKK1109 pKa = 9.86DD1110 pKa = 3.33WNVASLCPRR1119 pKa = 11.84WKK1121 pKa = 10.69GPQTVILTTPTAVKK1135 pKa = 10.8VEE1137 pKa = 4.4GVPAWIHH1144 pKa = 5.39HH1145 pKa = 5.76SRR1147 pKa = 11.84VKK1149 pKa = 10.31PAVPEE1154 pKa = 4.03TSEE1157 pKa = 4.0VRR1159 pKa = 11.84PSPEE1163 pKa = 3.84DD1164 pKa = 3.32PCRR1167 pKa = 11.84VTLKK1171 pKa = 9.54KK1172 pKa = 7.36TTSPAPVTPGSS1183 pKa = 3.42

Molecular weight:
131.47 kDa
Isoelectric point according different methods:






Peptides (in silico digests for buttom-up proteomics)

Below you can find in silico digests of the whole proteome with Trypsin, Chymotrypsin, Trypsin+LysC, LysN, ArgC proteases suitable for different mass spec machines.

Try
ESI
ChTry
ESI
ArgC
ESI
LysN
ESI
TryLysC
ESI

Try
MALDI
ChTry
MALDI
ArgC
MALDI
LysN
MALDI
TryLysC
MALDI

Try
LTQ
ChTry
LTQ
ArgC
LTQ
LysN
LTQ
TryLysC
LTQ

Try
MSlow
ChTry
MSlow
ArgC
MSlow
LysN
MSlow
TryLysC
MSlow

Try
MShigh
ChTry
MShigh
ArgC
MShigh
LysN
MShigh
TryLysC
MShigh

General Statistics

Number of major isoforms

Number of additional isoforms

Number of all proteins

Number of amino acids

Min. Seq. Length

Max. Seq. Length

Avg. Seq. Length

Avg. Mol. Weight

3

0

3

2388

523

1183

796.0

89.21

Amino acid frequency

Ala

Cys

Asp

Glu

Phe

Gly

His

Ile

Lys

Leu

6.658 ± 0.612

2.596 ± 0.334

3.727 ± 0.403

6.03 ± 0.656

3.015 ± 0.275

6.826 ± 0.039

2.052 ± 0.179

4.523 ± 1.097

6.407 ± 0.032

10.469 ± 0.849

Met

Asn

Gln

Pro

Arg

Ser

Thr

Val

Trp

Tyr

1.34 ± 0.195

3.601 ± 0.834

7.58 ± 0.79

5.695 ± 0.752

5.486 ± 0.431

4.899 ± 0.044

6.826 ± 0.675

7.161 ± 0.492

2.387 ± 0.234

2.722 ± 0.322

Note: For amino acid frequency statistics the error has been estimated with the bootstraping (x100) at the protein level

Most of the basic statistics you can see at this page can be downloaded from this CSV file

For dipeptide frequency statistics click here
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski